The MELD score predicts the short-term and overall survival after liver transplantation in patients with primary sclerosing cholangitis or autoimmune ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-12

AUTHORS

Katrin Hoffmann, Ulf Hinz, Norbert Hillebrand, Tom Ganten, Daniel Gotthardt, Thomas Longerich, Peter Schirmacher, Peter Schemmer

ABSTRACT

PURPOSE: Liver transplantation (LT) is well established in patients with autoimmune liver disease. Despite excellent outcomes, organ scarcity demands careful patients' selection and timing of transplantation. METHODS: This retrospective study analyzes data of 79 consecutive patients with primary sclerosing cholangitis (PSC), autoimmune hepatitis (AIH), and overlap syndrome, undergoing LT between 2001 and 2012. Overall survival (OS) and graft survival were assessed using Kaplan-Meier estimate. Multivariate survival analysis was performed to identify prognostic factors by using Cox regression model. RESULTS: After 59.6-month median follow-up, the 5-year OS and graft survival were 75.3 and 68.8%, respectively. The 5-year survival rates for patients with PSC (n=57), AIH (n=17), and overlap syndrome (n=5) were 76.3, 76.0, and 60.0%. The 90-day mortality rate of 70.0% was significantly higher in patients with a labMELD score≥20 (n=10) compared to 26.1% in 69 patients with a labMELD<20 (p=0.009). A lab Model for End-Stage Liver Disease (MELD) score≥20 was an independent predictor of impaired OS (p=0.050, hazard ratio 2.5). The 5-year OS was 55.7% in patients with a labMELD score≥20 compared to 84.7% in patients with a labMELD score<20. CONCLUSION: The recipients' MELD score is a predictor for the short-term outcome after LT in patients with autoimmune liver disease. Meticulous selection for transplant listing remains necessary to safe scarce donor organs. More... »

PAGES

1001-1009

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00423-014-1237-z

DOI

http://dx.doi.org/10.1007/s00423-014-1237-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015494975

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25106131


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Public Health and Health Services", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Autoimmune Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biopsy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cholangitis, Sclerosing", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Graft Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver Transplantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Predictive Value of Tests", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Heidelberg University", 
          "id": "https://www.grid.ac/institutes/grid.7700.0", 
          "name": [
            "Department of General and Transplant Surgery, Ruprecht-Karls-University, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hoffmann", 
        "givenName": "Katrin", 
        "id": "sg:person.01003466206.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003466206.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Heidelberg University", 
          "id": "https://www.grid.ac/institutes/grid.7700.0", 
          "name": [
            "Department of General and Transplant Surgery, Ruprecht-Karls-University, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hinz", 
        "givenName": "Ulf", 
        "id": "sg:person.01017305270.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017305270.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Heidelberg University", 
          "id": "https://www.grid.ac/institutes/grid.7700.0", 
          "name": [
            "Department of General and Transplant Surgery, Ruprecht-Karls-University, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hillebrand", 
        "givenName": "Norbert", 
        "id": "sg:person.0703056670.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703056670.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Internal Medicine, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ganten", 
        "givenName": "Tom", 
        "id": "sg:person.01000040242.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000040242.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Internal Medicine, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gotthardt", 
        "givenName": "Daniel", 
        "id": "sg:person.01171625607.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171625607.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Charit\u00e9", 
          "id": "https://www.grid.ac/institutes/grid.6363.0", 
          "name": [
            "Institute of Pathology, Im Neuenheimer Feld 224, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Longerich", 
        "givenName": "Thomas", 
        "id": "sg:person.01302256406.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302256406.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Charit\u00e9", 
          "id": "https://www.grid.ac/institutes/grid.6363.0", 
          "name": [
            "Institute of Pathology, Im Neuenheimer Feld 224, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schirmacher", 
        "givenName": "Peter", 
        "id": "sg:person.01072556301.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072556301.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Heidelberg University", 
          "id": "https://www.grid.ac/institutes/grid.7700.0", 
          "name": [
            "Department of General and Transplant Surgery, Ruprecht-Karls-University, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schemmer", 
        "givenName": "Peter", 
        "id": "sg:person.01000165004.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000165004.34"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00423-014-1214-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003391751", 
          "https://doi.org/10.1007/s00423-014-1214-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00423-014-1214-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003391751", 
          "https://doi.org/10.1007/s00423-014-1214-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra043898", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006369276"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra043898", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006369276"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2036.2006.03104.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006575497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/jhep.2001.22481", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007063259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/jlts.2003.50027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010485183"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.45.2008.vi1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011260700"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.transproceed.2007.02.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017858213"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/lt.20721", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018151409"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/lt.20721", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018151409"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.21563", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023890826"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.sla.0000133083.54934.ae", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024049438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.sla.0000133083.54934.ae", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024049438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.sla.0000133083.54934.ae", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024049438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0168-8278(99)80297-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029540225"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00595-009-4114-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029729388", 
          "https://doi.org/10.1007/s00595-009-4114-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00595-009-4114-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029729388", 
          "https://doi.org/10.1007/s00595-009-4114-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-0012.2008.00943.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030361840"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra050408", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030566977"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/j.1572-0241.2007.01136.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031232889", 
          "https://doi.org/10.1111/j.1572-0241.2007.01136.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0098782", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031823340"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/tp.0b013e3181a75b37", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032742305"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/tp.0b013e3181a75b37", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032742305"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/tp.0b013e3181a75b37", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032742305"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-0012.2004.00117.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035592732"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-0012.2011.01483.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037700086"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-0012.2008.00897.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040832710"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.22178", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045056052"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1432-2277.2010.01161.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045056251"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1432-2277.2010.01161.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045056251"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1590/s1679-45082012000100012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046333865"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.510300501", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046572474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-2006-933565", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057458400"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.14.3368", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071360482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.14.3388", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071360485"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076838803", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077045722", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077979655", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-12", 
    "datePublishedReg": "2014-12-01", 
    "description": "PURPOSE: Liver transplantation (LT) is well established in patients with autoimmune liver disease. Despite excellent outcomes, organ scarcity demands careful patients' selection and timing of transplantation.\nMETHODS: This retrospective study analyzes data of 79 consecutive patients with primary sclerosing cholangitis (PSC), autoimmune hepatitis (AIH), and overlap syndrome, undergoing LT between 2001 and 2012. Overall survival (OS) and graft survival were assessed using Kaplan-Meier estimate. Multivariate survival analysis was performed to identify prognostic factors by using Cox regression model.\nRESULTS: After 59.6-month median follow-up, the 5-year OS and graft survival were 75.3 and 68.8%, respectively. The 5-year survival rates for patients with PSC (n=57), AIH (n=17), and overlap syndrome (n=5) were 76.3, 76.0, and 60.0%. The 90-day mortality rate of 70.0% was significantly higher in patients with a labMELD score\u226520 (n=10) compared to 26.1% in 69 patients with a labMELD<20 (p=0.009). A lab Model for End-Stage Liver Disease (MELD) score\u226520 was an independent predictor of impaired OS (p=0.050, hazard ratio 2.5). The 5-year OS was 55.7% in patients with a labMELD score\u226520 compared to 84.7% in patients with a labMELD score<20.\nCONCLUSION: The recipients' MELD score is a predictor for the short-term outcome after LT in patients with autoimmune liver disease. Meticulous selection for transplant listing remains necessary to safe scarce donor organs.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00423-014-1237-z", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1295031", 
        "issn": [
          "1435-2443", 
          "1435-2451"
        ], 
        "name": "Langenbeck's Archives of Surgery", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "8", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "399"
      }
    ], 
    "name": "The MELD score predicts the short-term and overall survival after liver transplantation in patients with primary sclerosing cholangitis or autoimmune liver diseases", 
    "pagination": "1001-1009", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "49d394f479c953d66d02804262e887bd476fafd72fbea08655347e72fe58bbcb"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25106131"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9808285"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00423-014-1237-z"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1015494975"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00423-014-1237-z", 
      "https://app.dimensions.ai/details/publication/pub.1015494975"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T13:07", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000487.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s00423-014-1237-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00423-014-1237-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00423-014-1237-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00423-014-1237-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00423-014-1237-z'


 

This table displays all metadata directly associated to this object as RDF triples.

275 TRIPLES      21 PREDICATES      74 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00423-014-1237-z schema:about N1cabc40d478c4602bb6479176e41bb65
2 N2496b16f3be14c63b67a0d3ec16a7f6d
3 N366f89cf39934eea919f79b545581cba
4 N43af6694a27e467ca648c4374af32008
5 N59a87432dc3f4714921d344c3f784436
6 N647577bae1d84952b738458d6b116414
7 N8950359c017d463ba61247fa261d9bc1
8 N9a854ec7cd7c4c3f91c205b99aa1e545
9 Na87b9e97d9e04b9eb0269a8fbd665654
10 Naa6096feacd04b768a10488ab6c987a6
11 Ne02ad8f57a36416a9b7ded79e2e0f773
12 Ne6c8d42936ad493f93fa1fbcc8d6f1ac
13 Nea52259898c342da800ceb2b97e11de1
14 Nfac5dc0c21244423a75698c51a5a619f
15 Nff123eafd66b4a279378cfc6e353e597
16 anzsrc-for:11
17 anzsrc-for:1117
18 schema:author N01cbcd8e208d48e68cd8d064ecea697d
19 schema:citation sg:pub.10.1007/s00423-014-1214-6
20 sg:pub.10.1007/s00595-009-4114-6
21 sg:pub.10.1111/j.1572-0241.2007.01136.x
22 https://app.dimensions.ai/details/publication/pub.1076838803
23 https://app.dimensions.ai/details/publication/pub.1077045722
24 https://app.dimensions.ai/details/publication/pub.1077979655
25 https://doi.org/10.1002/hep.21563
26 https://doi.org/10.1002/hep.22178
27 https://doi.org/10.1002/hep.510300501
28 https://doi.org/10.1002/lt.20721
29 https://doi.org/10.1016/j.transproceed.2007.02.030
30 https://doi.org/10.1016/s0168-8278(99)80297-9
31 https://doi.org/10.1053/jhep.2001.22481
32 https://doi.org/10.1053/jlts.2003.50027
33 https://doi.org/10.1055/s-2006-933565
34 https://doi.org/10.1056/nejmra043898
35 https://doi.org/10.1056/nejmra050408
36 https://doi.org/10.1097/01.sla.0000133083.54934.ae
37 https://doi.org/10.1097/tp.0b013e3181a75b37
38 https://doi.org/10.1111/j.1365-2036.2006.03104.x
39 https://doi.org/10.1111/j.1399-0012.2004.00117.x
40 https://doi.org/10.1111/j.1399-0012.2008.00897.x
41 https://doi.org/10.1111/j.1399-0012.2008.00943.x
42 https://doi.org/10.1111/j.1399-0012.2011.01483.x
43 https://doi.org/10.1111/j.1432-2277.2010.01161.x
44 https://doi.org/10.1136/gut.45.2008.vi1
45 https://doi.org/10.1371/journal.pone.0098782
46 https://doi.org/10.1590/s1679-45082012000100012
47 https://doi.org/10.3748/wjg.14.3368
48 https://doi.org/10.3748/wjg.14.3388
49 schema:datePublished 2014-12
50 schema:datePublishedReg 2014-12-01
51 schema:description PURPOSE: Liver transplantation (LT) is well established in patients with autoimmune liver disease. Despite excellent outcomes, organ scarcity demands careful patients' selection and timing of transplantation. METHODS: This retrospective study analyzes data of 79 consecutive patients with primary sclerosing cholangitis (PSC), autoimmune hepatitis (AIH), and overlap syndrome, undergoing LT between 2001 and 2012. Overall survival (OS) and graft survival were assessed using Kaplan-Meier estimate. Multivariate survival analysis was performed to identify prognostic factors by using Cox regression model. RESULTS: After 59.6-month median follow-up, the 5-year OS and graft survival were 75.3 and 68.8%, respectively. The 5-year survival rates for patients with PSC (n=57), AIH (n=17), and overlap syndrome (n=5) were 76.3, 76.0, and 60.0%. The 90-day mortality rate of 70.0% was significantly higher in patients with a labMELD score≥20 (n=10) compared to 26.1% in 69 patients with a labMELD<20 (p=0.009). A lab Model for End-Stage Liver Disease (MELD) score≥20 was an independent predictor of impaired OS (p=0.050, hazard ratio 2.5). The 5-year OS was 55.7% in patients with a labMELD score≥20 compared to 84.7% in patients with a labMELD score<20. CONCLUSION: The recipients' MELD score is a predictor for the short-term outcome after LT in patients with autoimmune liver disease. Meticulous selection for transplant listing remains necessary to safe scarce donor organs.
52 schema:genre research_article
53 schema:inLanguage en
54 schema:isAccessibleForFree false
55 schema:isPartOf N5c9dbb6097f947a1a1516b30a9dfb6ec
56 Na9e846ebf8b94a72bad6d56bd0e5b362
57 sg:journal.1295031
58 schema:name The MELD score predicts the short-term and overall survival after liver transplantation in patients with primary sclerosing cholangitis or autoimmune liver diseases
59 schema:pagination 1001-1009
60 schema:productId N0ef682569f9e427097def93b29f32d5f
61 N3fe5557d14b54d5989730ef4e45fac83
62 N97abea5848b94fc5b64873aad100f4c3
63 Nc12cb4435f434d97b4d6c5ecaa626947
64 Ne69fc98ff5b54e2fb8ecfa4dbce2ec71
65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015494975
66 https://doi.org/10.1007/s00423-014-1237-z
67 schema:sdDatePublished 2019-04-10T13:07
68 schema:sdLicense https://scigraph.springernature.com/explorer/license/
69 schema:sdPublisher Ncc5682804ae74f30b522828d3710adcb
70 schema:url http://link.springer.com/10.1007/s00423-014-1237-z
71 sgo:license sg:explorer/license/
72 sgo:sdDataset articles
73 rdf:type schema:ScholarlyArticle
74 N00fdadd8f50d462a958d19602ddbfc55 rdf:first sg:person.01017305270.94
75 rdf:rest N4eb661137a09430bb8d317df5ce73aea
76 N01a1f05833104a90bf1d77782281b157 rdf:first sg:person.01000165004.34
77 rdf:rest rdf:nil
78 N01cbcd8e208d48e68cd8d064ecea697d rdf:first sg:person.01003466206.59
79 rdf:rest N00fdadd8f50d462a958d19602ddbfc55
80 N0ef682569f9e427097def93b29f32d5f schema:name pubmed_id
81 schema:value 25106131
82 rdf:type schema:PropertyValue
83 N1cabc40d478c4602bb6479176e41bb65 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Biopsy
85 rdf:type schema:DefinedTerm
86 N2496b16f3be14c63b67a0d3ec16a7f6d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Adult
88 rdf:type schema:DefinedTerm
89 N24f1ce69e916447cb7f9629b4e303b99 schema:name Department of Internal Medicine, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany
90 rdf:type schema:Organization
91 N366f89cf39934eea919f79b545581cba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Autoimmune Diseases
93 rdf:type schema:DefinedTerm
94 N3fe5557d14b54d5989730ef4e45fac83 schema:name doi
95 schema:value 10.1007/s00423-014-1237-z
96 rdf:type schema:PropertyValue
97 N43af6694a27e467ca648c4374af32008 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Male
99 rdf:type schema:DefinedTerm
100 N4eb661137a09430bb8d317df5ce73aea rdf:first sg:person.0703056670.26
101 rdf:rest Nae8d4520616546bdbc1332f27e5412c6
102 N59a87432dc3f4714921d344c3f784436 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Retrospective Studies
104 rdf:type schema:DefinedTerm
105 N5c9dbb6097f947a1a1516b30a9dfb6ec schema:volumeNumber 399
106 rdf:type schema:PublicationVolume
107 N632279c43be24602a6b0bce97c909930 rdf:first sg:person.01072556301.62
108 rdf:rest N01a1f05833104a90bf1d77782281b157
109 N647577bae1d84952b738458d6b116414 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Female
111 rdf:type schema:DefinedTerm
112 N677bd7614b5948369e5b51771e3c775a rdf:first sg:person.01171625607.00
113 rdf:rest Ne285fbe6c4914456b8c89355bc8b0c7d
114 N7036940ff84543d09de335693ff2abf7 schema:name Department of Internal Medicine, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany
115 rdf:type schema:Organization
116 N8950359c017d463ba61247fa261d9bc1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Survival Rate
118 rdf:type schema:DefinedTerm
119 N97abea5848b94fc5b64873aad100f4c3 schema:name nlm_unique_id
120 schema:value 9808285
121 rdf:type schema:PropertyValue
122 N9a854ec7cd7c4c3f91c205b99aa1e545 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Middle Aged
124 rdf:type schema:DefinedTerm
125 Na87b9e97d9e04b9eb0269a8fbd665654 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Predictive Value of Tests
127 rdf:type schema:DefinedTerm
128 Na9e846ebf8b94a72bad6d56bd0e5b362 schema:issueNumber 8
129 rdf:type schema:PublicationIssue
130 Naa6096feacd04b768a10488ab6c987a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Cholangitis, Sclerosing
132 rdf:type schema:DefinedTerm
133 Nae8d4520616546bdbc1332f27e5412c6 rdf:first sg:person.01000040242.75
134 rdf:rest N677bd7614b5948369e5b51771e3c775a
135 Nc12cb4435f434d97b4d6c5ecaa626947 schema:name dimensions_id
136 schema:value pub.1015494975
137 rdf:type schema:PropertyValue
138 Ncc5682804ae74f30b522828d3710adcb schema:name Springer Nature - SN SciGraph project
139 rdf:type schema:Organization
140 Ne02ad8f57a36416a9b7ded79e2e0f773 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Liver Diseases
142 rdf:type schema:DefinedTerm
143 Ne285fbe6c4914456b8c89355bc8b0c7d rdf:first sg:person.01302256406.10
144 rdf:rest N632279c43be24602a6b0bce97c909930
145 Ne69fc98ff5b54e2fb8ecfa4dbce2ec71 schema:name readcube_id
146 schema:value 49d394f479c953d66d02804262e887bd476fafd72fbea08655347e72fe58bbcb
147 rdf:type schema:PropertyValue
148 Ne6c8d42936ad493f93fa1fbcc8d6f1ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Humans
150 rdf:type schema:DefinedTerm
151 Nea52259898c342da800ceb2b97e11de1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Liver Transplantation
153 rdf:type schema:DefinedTerm
154 Nfac5dc0c21244423a75698c51a5a619f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Follow-Up Studies
156 rdf:type schema:DefinedTerm
157 Nff123eafd66b4a279378cfc6e353e597 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Graft Survival
159 rdf:type schema:DefinedTerm
160 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
161 schema:name Medical and Health Sciences
162 rdf:type schema:DefinedTerm
163 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
164 schema:name Public Health and Health Services
165 rdf:type schema:DefinedTerm
166 sg:journal.1295031 schema:issn 1435-2443
167 1435-2451
168 schema:name Langenbeck's Archives of Surgery
169 rdf:type schema:Periodical
170 sg:person.01000040242.75 schema:affiliation N24f1ce69e916447cb7f9629b4e303b99
171 schema:familyName Ganten
172 schema:givenName Tom
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000040242.75
174 rdf:type schema:Person
175 sg:person.01000165004.34 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
176 schema:familyName Schemmer
177 schema:givenName Peter
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000165004.34
179 rdf:type schema:Person
180 sg:person.01003466206.59 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
181 schema:familyName Hoffmann
182 schema:givenName Katrin
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003466206.59
184 rdf:type schema:Person
185 sg:person.01017305270.94 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
186 schema:familyName Hinz
187 schema:givenName Ulf
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017305270.94
189 rdf:type schema:Person
190 sg:person.01072556301.62 schema:affiliation https://www.grid.ac/institutes/grid.6363.0
191 schema:familyName Schirmacher
192 schema:givenName Peter
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072556301.62
194 rdf:type schema:Person
195 sg:person.01171625607.00 schema:affiliation N7036940ff84543d09de335693ff2abf7
196 schema:familyName Gotthardt
197 schema:givenName Daniel
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171625607.00
199 rdf:type schema:Person
200 sg:person.01302256406.10 schema:affiliation https://www.grid.ac/institutes/grid.6363.0
201 schema:familyName Longerich
202 schema:givenName Thomas
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302256406.10
204 rdf:type schema:Person
205 sg:person.0703056670.26 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
206 schema:familyName Hillebrand
207 schema:givenName Norbert
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703056670.26
209 rdf:type schema:Person
210 sg:pub.10.1007/s00423-014-1214-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003391751
211 https://doi.org/10.1007/s00423-014-1214-6
212 rdf:type schema:CreativeWork
213 sg:pub.10.1007/s00595-009-4114-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029729388
214 https://doi.org/10.1007/s00595-009-4114-6
215 rdf:type schema:CreativeWork
216 sg:pub.10.1111/j.1572-0241.2007.01136.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031232889
217 https://doi.org/10.1111/j.1572-0241.2007.01136.x
218 rdf:type schema:CreativeWork
219 https://app.dimensions.ai/details/publication/pub.1076838803 schema:CreativeWork
220 https://app.dimensions.ai/details/publication/pub.1077045722 schema:CreativeWork
221 https://app.dimensions.ai/details/publication/pub.1077979655 schema:CreativeWork
222 https://doi.org/10.1002/hep.21563 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023890826
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1002/hep.22178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045056052
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1002/hep.510300501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046572474
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1002/lt.20721 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018151409
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/j.transproceed.2007.02.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017858213
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/s0168-8278(99)80297-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029540225
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1053/jhep.2001.22481 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007063259
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1053/jlts.2003.50027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010485183
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1055/s-2006-933565 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057458400
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1056/nejmra043898 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006369276
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1056/nejmra050408 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030566977
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1097/01.sla.0000133083.54934.ae schema:sameAs https://app.dimensions.ai/details/publication/pub.1024049438
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1097/tp.0b013e3181a75b37 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032742305
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1111/j.1365-2036.2006.03104.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006575497
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1111/j.1399-0012.2004.00117.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035592732
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1111/j.1399-0012.2008.00897.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040832710
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1111/j.1399-0012.2008.00943.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030361840
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1111/j.1399-0012.2011.01483.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037700086
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1111/j.1432-2277.2010.01161.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1045056251
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1136/gut.45.2008.vi1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011260700
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1371/journal.pone.0098782 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031823340
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1590/s1679-45082012000100012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046333865
265 rdf:type schema:CreativeWork
266 https://doi.org/10.3748/wjg.14.3368 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071360482
267 rdf:type schema:CreativeWork
268 https://doi.org/10.3748/wjg.14.3388 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071360485
269 rdf:type schema:CreativeWork
270 https://www.grid.ac/institutes/grid.6363.0 schema:alternateName Charité
271 schema:name Institute of Pathology, Im Neuenheimer Feld 224, 69120, Heidelberg, Germany
272 rdf:type schema:Organization
273 https://www.grid.ac/institutes/grid.7700.0 schema:alternateName Heidelberg University
274 schema:name Department of General and Transplant Surgery, Ruprecht-Karls-University, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany
275 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...