Can the new RCP R0/R1 classification predict the clinical outcome in ductal adenocarcinoma of the pancreatic head? View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-06-14

AUTHORS

M. S. Janot, S. Kersting, O. Belyaev, A. Matuschek, A. M. Chromik, D. Suelberg, W. Uhl, A. Tannapfel, U. Bergmann

ABSTRACT

PurposeAccording to the International Union Against Cancer (UICC), R1 is defined as the microscopic presence of tumor cells at the surface of the resection margin (RM). In contrast, the Royal College of Pathologists (RCP) suggested to declare R1 already when tumor cells are found within 1 mm of the RM. The aim of this study was to determine the significance of the RM concerning the prognosis of pancreatic ductal adenocarcinoma (PDAC).MethodsFrom 2007 to 2009, 62 patients underwent a curative operation for PDAC of the pancreatic head. The relevance of R status on cumulative overall survival (OS) was assessed on univariate and multivariate analysis for both the classic R classification (UICC) and the suggestion of the RCP.ResultsFollowing the UICC criteria, a positive RM was detected in 8 %. Along with grading and lymph node ratio, R status revealed a significant impact on OS on univariate and multivariate analysis. Applying the suggestion of the RCP, R1 rate rose to 26 % resulting in no significant impact on OS in univariate analysis.ConclusionsOur study has shown that the RCP suggestion for R status has no impact on the prognosis of PDAC. In contrast, our data confirmed the UICC R classification of RM as well as N category, grading, and lymph node ratio as significant prognostic factors. More... »

PAGES

917-925

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00423-012-0953-5

DOI

http://dx.doi.org/10.1007/s00423-012-0953-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020772696

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22695970


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47 International Union
48 MethodsFrom 2007
49 R classification
50 R status
51 R1
52 R1 rate
53 RCP
54 Royal College
55 UICC criteria
56 Union
57 adenocarcinoma
58 aim
59 analysis
60 cancer
61 categories
62 cells
63 classification
64 clinical outcomes
65 contrast
66 criteria
67 cumulative overall survival
68 curative operation
69 data
70 ductal adenocarcinoma
71 factors
72 grading
73 head
74 impact
75 lymph
76 margin
77 microscopic presence
78 multivariate analysis
79 operation
80 outcomes
81 overall survival
82 pancreatic ductal adenocarcinoma
83 pancreatic head
84 pathologists
85 patients
86 positive resection margins
87 presence
88 prognosis
89 prognosis of PDAC
90 prognostic factors
91 rate
92 ratio
93 relevance
94 resection margins
95 significance
96 significant impact
97 significant prognostic factors
98 status
99 study
100 suggestions
101 surface
102 survival
103 tumor cells
104 univariate
105 univariate analysis
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