NALP expression in Paneth cells provides a novel track in IBD signaling View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-04

AUTHORS

Nadia Slavova, Anja Drescher, Alexander Visekruna, Sonja Dullat, Anton J. Kroesen, Joerg-Peter Ritz, Heinz J. Buhr

ABSTRACT

PURPOSE: Paneth cells are part of the innate mucosal immunity of the gut with possible regulatory function. This study intends to identify the gene expression pattern of the orthotopic and metaplastic Paneth cells, searching for differences between metaplastic occurrence between Crohn's disease and ulcerative colitis. METHODS: Paneth cells were collected in RNAse-free conditions via micro dissection. RNA isolation and super amplification was followed by microarray analysis of whole genome expression activity of the orthotopic and metaplastic Paneth cells. Immunohistology of beta-catenin and Frizzled-5 receptor was performed. RESULTS: Histological analysis showed no morphological or secretory change (Frizzled-5 receptor and beta-catenin) in orthotopic and metaplastic Paneth cells. Microarray analysis indicated an increased, but not mutant activation of Wnt/beta-catenin signaling and firstly showed expression of NALP 1, 7, 8 and 11 in metaplastic Paneth cells. CONCLUSIONS: Paneth cells might play a NALP-mediated role in the pathogenesis of IBD. More... »

PAGES

351-357

References to SciGraph publications

  • 2010-02. Defective Paneth Cell—Mediated Host Defense in Pediatric Ileal Crohn's Disease in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2003-02. NALPs: a novel protein family involved in inflammation in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00423-010-0611-8

    DOI

    http://dx.doi.org/10.1007/s00423-010-0611-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1049659555

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20333398


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