2007-05
AUTHORSMichael Schäffer, Robert Schier, Markus Napirei, Stefan Michalski, Thilo Traska, Richard Viebahn
ABSTRACTBACKGROUND AND AIMS: Clinically, the immunosuppressive drug sirolimus, used in organ transplantation, appears to impair wound healing. Little is known about the mechanisms of action. We investigated the effect of sirolimus on wound healing, and we analyzed the expression of stimulating mediators of angiogenesis (VEGF, vascular endothelial growth factor) and collagen synthesis (nitric oxide) in wounds. MATERIALS AND METHODS: Groups of ten rats underwent dorsal skin incision, and polyvinyl alcohol sponges were implanted subcutaneously. Beginning at the day of wounding, rats were treated with 0.5, 2.0, or 5.0 mg sirolimus/kg/day. Animals were killed 10 days later to determine wound breaking strength and reparative collagen deposition. Expression of VEGF and nitric oxide was studied in wounds. RESULTS: Splenic lymphocyte proliferative activity was significantly decreased by sirolimus (p < 0.05). Sirolimus levels in wound fluid were found to be approximately two- to fivefold higher than blood levels (p < 0.01). Sirolimus (2.0 and 5.0 mg kg(-1) day(-1)) reduced wound breaking strength (p < 0.01) and wound collagen deposition (p < 0.05). This was paralleled by decreased expression of VEGF and nitric oxide in wounds. CONCLUSION: Experimentally, our data show that sirolimus impairs wound healing, and this is reflected by diminished expression of VEGF and nitric oxide in the wound. More... »
PAGES297-303
http://scigraph.springernature.com/pub.10.1007/s00423-007-0174-5
DOIhttp://dx.doi.org/10.1007/s00423-007-0174-5
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curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00423-007-0174-5'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00423-007-0174-5'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00423-007-0174-5'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00423-007-0174-5'
This table displays all metadata directly associated to this object as RDF triples.
298 TRIPLES
21 PREDICATES
85 URIs
37 LITERALS
25 BLANK NODES