Concomitant external pneumatic compression treatment with consecutive days of high intensity interval training reduces markers of proteolysis View Full Text


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Article Info

DATE

2017-10-26

AUTHORS

Cody T. Haun, Michael D. Roberts, Matthew A. Romero, Shelby C. Osburn, James C. Healy, Angelique N. Moore, Christopher B. Mobley, Paul A. Roberson, Wesley C. Kephart, Petey W. Mumford, Michael D. Goodlett, David D. Pascoe, Jeffrey S. Martin

ABSTRACT

PurposeTo compare the effects of external pneumatic compression (EPC) and sham when used concurrently with high intensity interval training (HIIT) on performance-related outcomes and recovery-related molecular measures.MethodsEighteen recreationally endurance-trained male participants (age: 21.6 ± 2.4 years, BMI: 25.7 ± 0.5 kg/m2, VO2peak: 51.3 ± 0.9 mL/kg/min) were randomized to balanced sham and EPC treatment groups. Three consecutive days of HIIT followed by EPC/sham treatment (Days 2–4) and 3 consecutive days of recovery (Days 5–7) with EPC/sham only on Days 5–6 were employed. Venipuncture, flexibility and pressure-to-pain threshold (PPT) measurements were made throughout. Vastus lateralis muscle was biopsied at PRE (i.e., Day 1), 1-h post-EPC/sham treatment on Day 2 (POST1), and 24-h post-EPC/sham treatment on Day 7 (POST2). 6-km run time trial performance was tested at PRE and POST2.ResultsNo group × time interaction was observed for flexibility, PPT, or serum measures of creatine kinase (CK), hsCRP, and 8-isoprostane. However, there was a main effect of time for serum CK (p = 0.005). Change from PRE in 6-km run times at POST2 were not significantly different between groups. Significant between-groups differences existed for change from PRE in atrogin-1 mRNA (p = 0.018) at the POST1 time point (EPC: − 19.7 ± 8.1%, sham: + 7.7 ± 5.9%) and atrogin-1 protein concentration (p = 0.013) at the POST2 time point (EPC: − 31.8 ± 7.5%, sham: + 96.0 ± 34.7%). In addition, change from PRE in poly-Ub proteins was significantly different between groups at both the POST1 (EPC: − 26.0 ± 10.3%, sham: + 34.8 ± 28.5%; p = 0.046) and POST2 (EPC: − 33.7 ± 17.2%, sham: + 21.4 ± 14.9%; p = 0.037) time points.ConclusionsEPC when used concurrently with HIIT and in subsequent recovery days reduces skeletal muscle markers of proteolysis. More... »

PAGES

2587-2600

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00421-017-3746-2

DOI

http://dx.doi.org/10.1007/s00421-017-3746-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1092403878

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29075862


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24 schema:description PurposeTo compare the effects of external pneumatic compression (EPC) and sham when used concurrently with high intensity interval training (HIIT) on performance-related outcomes and recovery-related molecular measures.MethodsEighteen recreationally endurance-trained male participants (age: 21.6 ± 2.4 years, BMI: 25.7 ± 0.5 kg/m2, VO2peak: 51.3 ± 0.9 mL/kg/min) were randomized to balanced sham and EPC treatment groups. Three consecutive days of HIIT followed by EPC/sham treatment (Days 2–4) and 3 consecutive days of recovery (Days 5–7) with EPC/sham only on Days 5–6 were employed. Venipuncture, flexibility and pressure-to-pain threshold (PPT) measurements were made throughout. Vastus lateralis muscle was biopsied at PRE (i.e., Day 1), 1-h post-EPC/sham treatment on Day 2 (POST1), and 24-h post-EPC/sham treatment on Day 7 (POST2). 6-km run time trial performance was tested at PRE and POST2.ResultsNo group × time interaction was observed for flexibility, PPT, or serum measures of creatine kinase (CK), hsCRP, and 8-isoprostane. However, there was a main effect of time for serum CK (p = 0.005). Change from PRE in 6-km run times at POST2 were not significantly different between groups. Significant between-groups differences existed for change from PRE in atrogin-1 mRNA (p = 0.018) at the POST1 time point (EPC: − 19.7 ± 8.1%, sham: + 7.7 ± 5.9%) and atrogin-1 protein concentration (p = 0.013) at the POST2 time point (EPC: − 31.8 ± 7.5%, sham: + 96.0 ± 34.7%). In addition, change from PRE in poly-Ub proteins was significantly different between groups at both the POST1 (EPC: − 26.0 ± 10.3%, sham: + 34.8 ± 28.5%; p = 0.046) and POST2 (EPC: − 33.7 ± 17.2%, sham: + 21.4 ± 14.9%; p = 0.037) time points.ConclusionsEPC when used concurrently with HIIT and in subsequent recovery days reduces skeletal muscle markers of proteolysis.
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31 schema:keywords ConclusionsEPC
32 Concomitant external pneumatic compression treatment
33 EPC treatment groups
34 EPC/sham
35 EPC/sham treatment
36 MethodsEighteen
37 POST1
38 POST1 time point
39 POST2
40 POST2 time point
41 PurposeTo
42 addition
43 atrogin-1 mRNA
44 atrogin-1 protein concentration
45 balanced sham
46 changes
47 compression
48 compression treatment
49 concentration
50 consecutive days
51 creatine kinase
52 day 2
53 day 5
54 day 7
55 days
56 differences
57 effect
58 endurance-trained male participants
59 external pneumatic compression
60 external pneumatic compression treatment
61 flexibility
62 group
63 group differences
64 high intensity interval training
65 hsCRP
66 intensity interval training
67 interaction
68 interval training
69 kinase
70 lateralis muscle
71 mRNA
72 main effect
73 male participants
74 markers
75 markers of proteolysis
76 measurements
77 measures
78 molecular measures
79 muscle
80 muscle markers
81 outcomes
82 pain threshold measurements
83 participants
84 performance
85 performance-related outcomes
86 pneumatic compression
87 pneumatic compression treatment
88 point
89 poly-Ub proteins
90 ppt
91 pre
92 pressure
93 protein
94 protein concentration
95 proteolysis
96 recovery
97 recovery days
98 recovery-related molecular measures
99 run time
100 serum creatine kinase
101 serum measures
102 sham
103 sham treatment
104 skeletal muscle markers
105 subsequent recovery days
106 threshold measurements
107 time
108 time interaction
109 time points
110 time trial performance
111 training
112 treatment
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115 vastus lateralis muscle
116 venipuncture
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