The effect of nitric oxide synthase inhibition with and without inhibition of prostaglandins on blood flow in different human skeletal ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-06

AUTHORS

Ilkka Heinonen, Bengt Saltin, Ylva Hellsten, Kari K. Kalliokoski

ABSTRACT

PURPOSE: Animal studies suggest that the inhibition of nitric oxide synthase (NOS) affects blood flow differently in different skeletal muscles according to their muscle fibre type composition (oxidative vs glycolytic). Quadriceps femoris (QF) muscle consists of four different muscle parts: vastus intermedius (VI), rectus femoris (RF), vastus medialis (VM), and vastus lateralis (VL) of which VI is located deep within the muscle group and is generally regarded to consist mostly of oxidative muscle fibres. METHODS: We studied the effect of NOS inhibition on blood flow in these four different muscles by positron emission tomography in eight young healthy men at rest and during one-leg dynamic exercise, with and without combined blockade with prostaglandins. RESULTS: At rest blood flow in the VI (2.6 ± 1.1 ml/100 g/min) was significantly higher than in VL (1.9 ± 0.6 ml/100 g/min, p = 0.015) and RF (1.7 ± 0.6 ml/100 g/min, p = 0.0015), but comparable to VM (2.4 ± 1.1 ml/100 g/min). NOS inhibition alone or with prostaglandins reduced blood flow by almost 50% (p < 0.001), but decrements were similar in all four muscles (drug × muscle interaction, p = 0.43). During exercise blood flow was also the highest in VI (45.4 ± 5.5 ml/100 g/min) and higher compared to VL (35.0 ± 5.5 ml/100 g/min), RF (38.4 ± 7.4 ml/100 g/min), and VM (36.2 ± 6.8 ml/100 g/min). NOS inhibition alone did not reduce exercise hyperemia (p = 0.51), but combined NOS and prostaglandin inhibition reduced blood flow during exercise (p = 0.002), similarly in all muscles (drug × muscle interaction, p = 0.99). CONCLUSION: NOS inhibition, with or without prostaglandins inhibition, affects blood flow similarly in different human QF muscles both at rest and during low-to-moderate intensity exercise. More... »

PAGES

1175-1180

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00421-017-3604-2

DOI

http://dx.doi.org/10.1007/s00421-017-3604-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1085038290

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28432421


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1106", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Human Movement and Sports Science", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Exercise", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Muscle, Skeletal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nitric Oxide Synthase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prostaglandin Antagonists", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Regional Blood Flow", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "omega-N-Methylarginine", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Erasmus University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.5645.2", 
          "name": [
            "Turku PET Centre, University of Turku, PO Box 52, 20521, Turku, Finland", 
            "Department of Clinical Physiology and Nuclear Medicine, University of Turku, Turku, Finland", 
            "Division of Experimental Cardiology, Thoraxcenter, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Heinonen", 
        "givenName": "Ilkka", 
        "id": "sg:person.01036617440.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036617440.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Copenhagen", 
          "id": "https://www.grid.ac/institutes/grid.5254.6", 
          "name": [
            "Copenhagen Muscle Research Center, University of Copenhagen, Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saltin", 
        "givenName": "Bengt", 
        "id": "sg:person.0626445044.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626445044.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Copenhagen", 
          "id": "https://www.grid.ac/institutes/grid.5254.6", 
          "name": [
            "Exercise and Sport Sciences, Section of Human Physiology, University of Copenhagen, Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hellsten", 
        "givenName": "Ylva", 
        "id": "sg:person.0731746535.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731746535.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Turku PET Centre", 
          "id": "https://www.grid.ac/institutes/grid.470895.7", 
          "name": [
            "Turku PET Centre, University of Turku, PO Box 52, 20521, Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kalliokoski", 
        "givenName": "Kari K.", 
        "id": "sg:person.01210110752.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210110752.34"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1113/jphysiol.2006.127423", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003360487"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1249/jes.0000000000000074", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003625680"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1249/jes.0000000000000074", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003625680"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1249/jes.0000000000000074", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003625680"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1249/jes.0000000000000074", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003625680"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1249/jes.0000000000000044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003942172"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1249/jes.0000000000000044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003942172"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1249/jes.0000000000000044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003942172"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1249/jes.0000000000000044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003942172"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpheart.00925.2012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004572118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1469-7793.2001.0257j.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006715247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/japplphysiol.00567.2007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006794796"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/japplphysiol.00745.2009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007538471"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-510x(73)90023-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008393632"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-510x(73)90023-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008393632"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00421-012-2329-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009054106", 
          "https://doi.org/10.1007/s00421-012-2329-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1249/mss.0000000000000178", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009098944"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1249/mss.0000000000000178", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009098944"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cphy.c100048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010738582"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fphys.2012.00411", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019508017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1743-7075-10-43", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019938111", 
          "https://doi.org/10.1186/1743-7075-10-43"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpregu.00056.2010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021725323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpregu.00631.2009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023064703"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpheart.00996.2010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024911270"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/expphysiol.2013.076927", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025990719"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01003594", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027604973", 
          "https://doi.org/10.1007/bf01003594"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jlcr.25804401381", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031476084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.2009.183723", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035544083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.51.8.2572", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035620962"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/japplphysiol.00732.2011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038262627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/physiol.00067.2013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041942887"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.niox.2014.09.157", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049808602"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0052191", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051377132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpregu.00245.2011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052849577"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.48.9.1815", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070744282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpheart.1999.276.6.h1951", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074473790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jappl.1994.77.3.1288", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082400818"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083042811", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-06", 
    "datePublishedReg": "2017-06-01", 
    "description": "PURPOSE: Animal studies suggest that the inhibition of nitric oxide synthase (NOS) affects blood flow differently in different skeletal muscles according to their muscle fibre type composition (oxidative vs glycolytic). Quadriceps femoris (QF) muscle consists of four different muscle parts: vastus intermedius (VI), rectus femoris (RF), vastus medialis (VM), and vastus lateralis (VL) of which VI is located deep within the muscle group and is generally regarded to consist mostly of oxidative muscle fibres.\nMETHODS: We studied the effect of NOS inhibition on blood flow in these four different muscles by positron emission tomography in eight young healthy men at rest and during one-leg dynamic exercise, with and without combined blockade with prostaglandins.\nRESULTS: At rest blood flow in the VI (2.6\u00a0\u00b1\u00a01.1\u00a0ml/100\u00a0g/min) was significantly higher than in VL (1.9\u00a0\u00b1\u00a00.6\u00a0ml/100\u00a0g/min, p\u00a0=\u00a00.015) and RF (1.7\u00a0\u00b1\u00a00.6\u00a0ml/100\u00a0g/min, p\u00a0=\u00a00.0015), but comparable to VM (2.4\u00a0\u00b1\u00a01.1\u00a0ml/100\u00a0g/min). NOS inhibition alone or with prostaglandins reduced blood flow by almost 50% (p\u00a0<\u00a00.001), but decrements were similar in all four muscles (drug\u00a0\u00d7\u00a0muscle interaction, p\u00a0=\u00a00.43). During exercise blood flow was also the highest in VI (45.4\u00a0\u00b1\u00a05.5\u00a0ml/100\u00a0g/min) and higher compared to VL (35.0\u00a0\u00b1\u00a05.5\u00a0ml/100\u00a0g/min), RF (38.4\u00a0\u00b1\u00a07.4\u00a0ml/100\u00a0g/min), and VM (36.2\u00a0\u00b1\u00a06.8\u00a0ml/100\u00a0g/min). NOS inhibition alone did not reduce exercise hyperemia (p\u00a0=\u00a00.51), but combined NOS and prostaglandin inhibition reduced blood flow during exercise (p\u00a0=\u00a00.002), similarly in all muscles (drug\u00a0\u00d7\u00a0muscle interaction, p\u00a0=\u00a00.99).\nCONCLUSION: NOS inhibition, with or without prostaglandins inhibition, affects blood flow similarly in different human QF muscles both at rest and during low-to-moderate intensity exercise.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00421-017-3604-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1319730", 
        "issn": [
          "1439-6319", 
          "1432-1025"
        ], 
        "name": "European Journal of Applied Physiology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "117"
      }
    ], 
    "name": "The effect of nitric oxide synthase inhibition with and without inhibition of prostaglandins on blood flow in different human skeletal muscles", 
    "pagination": "1175-1180", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "d0129b36a2bd9376df3a6aea02cddb19d65d315d05d795120b287a601fb5117f"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28432421"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100954790"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00421-017-3604-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1085038290"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00421-017-3604-2", 
      "https://app.dimensions.ai/details/publication/pub.1085038290"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:00", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000347_0000000347/records_89816_00000003.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs00421-017-3604-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00421-017-3604-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00421-017-3604-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00421-017-3604-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00421-017-3604-2'


 

This table displays all metadata directly associated to this object as RDF triples.

231 TRIPLES      21 PREDICATES      69 URIs      31 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00421-017-3604-2 schema:about N009f7ff158d34430a5870aea227f23b1
2 N10aad06eb8f54ae4a474813df20196ee
3 N154e44b6a2fb41889582ebbea543e9ca
4 N2bd7b013781446838adaa214d94d9369
5 N59bed75f39c34550acb800e387ae4269
6 N7c2127078c104d559a54088e47d76496
7 N7f454f801cf8474a9dc0d6ab1ccc45c9
8 N8afa5004c5da4412a98b45b0e8d5b2b8
9 N9724e58ad0594f57ad2a6c037fa50fae
10 Ndf118d0f851e4b09bd5f1b72a6553cf7
11 anzsrc-for:11
12 anzsrc-for:1106
13 schema:author Na9ee9813de884a1782c1ec3ca02adea5
14 schema:citation sg:pub.10.1007/bf01003594
15 sg:pub.10.1007/s00421-012-2329-5
16 sg:pub.10.1186/1743-7075-10-43
17 https://app.dimensions.ai/details/publication/pub.1083042811
18 https://doi.org/10.1002/cphy.c100048
19 https://doi.org/10.1002/jlcr.25804401381
20 https://doi.org/10.1016/0022-510x(73)90023-3
21 https://doi.org/10.1016/j.niox.2014.09.157
22 https://doi.org/10.1111/j.1469-7793.2001.0257j.x
23 https://doi.org/10.1113/expphysiol.2013.076927
24 https://doi.org/10.1113/jphysiol.2006.127423
25 https://doi.org/10.1113/jphysiol.2009.183723
26 https://doi.org/10.1152/ajpheart.00925.2012
27 https://doi.org/10.1152/ajpheart.00996.2010
28 https://doi.org/10.1152/ajpheart.1999.276.6.h1951
29 https://doi.org/10.1152/ajpregu.00056.2010
30 https://doi.org/10.1152/ajpregu.00245.2011
31 https://doi.org/10.1152/ajpregu.00631.2009
32 https://doi.org/10.1152/jappl.1994.77.3.1288
33 https://doi.org/10.1152/japplphysiol.00567.2007
34 https://doi.org/10.1152/japplphysiol.00732.2011
35 https://doi.org/10.1152/japplphysiol.00745.2009
36 https://doi.org/10.1152/physiol.00067.2013
37 https://doi.org/10.1249/jes.0000000000000044
38 https://doi.org/10.1249/jes.0000000000000074
39 https://doi.org/10.1249/mss.0000000000000178
40 https://doi.org/10.1371/journal.pone.0052191
41 https://doi.org/10.2337/diabetes.48.9.1815
42 https://doi.org/10.2337/diabetes.51.8.2572
43 https://doi.org/10.3389/fphys.2012.00411
44 schema:datePublished 2017-06
45 schema:datePublishedReg 2017-06-01
46 schema:description PURPOSE: Animal studies suggest that the inhibition of nitric oxide synthase (NOS) affects blood flow differently in different skeletal muscles according to their muscle fibre type composition (oxidative vs glycolytic). Quadriceps femoris (QF) muscle consists of four different muscle parts: vastus intermedius (VI), rectus femoris (RF), vastus medialis (VM), and vastus lateralis (VL) of which VI is located deep within the muscle group and is generally regarded to consist mostly of oxidative muscle fibres. METHODS: We studied the effect of NOS inhibition on blood flow in these four different muscles by positron emission tomography in eight young healthy men at rest and during one-leg dynamic exercise, with and without combined blockade with prostaglandins. RESULTS: At rest blood flow in the VI (2.6 ± 1.1 ml/100 g/min) was significantly higher than in VL (1.9 ± 0.6 ml/100 g/min, p = 0.015) and RF (1.7 ± 0.6 ml/100 g/min, p = 0.0015), but comparable to VM (2.4 ± 1.1 ml/100 g/min). NOS inhibition alone or with prostaglandins reduced blood flow by almost 50% (p < 0.001), but decrements were similar in all four muscles (drug × muscle interaction, p = 0.43). During exercise blood flow was also the highest in VI (45.4 ± 5.5 ml/100 g/min) and higher compared to VL (35.0 ± 5.5 ml/100 g/min), RF (38.4 ± 7.4 ml/100 g/min), and VM (36.2 ± 6.8 ml/100 g/min). NOS inhibition alone did not reduce exercise hyperemia (p = 0.51), but combined NOS and prostaglandin inhibition reduced blood flow during exercise (p = 0.002), similarly in all muscles (drug × muscle interaction, p = 0.99). CONCLUSION: NOS inhibition, with or without prostaglandins inhibition, affects blood flow similarly in different human QF muscles both at rest and during low-to-moderate intensity exercise.
47 schema:genre research_article
48 schema:inLanguage en
49 schema:isAccessibleForFree false
50 schema:isPartOf N23e81f873f87484c865a52cbfbe084c4
51 Nd34916c233d14aaaa548020f7cc2bf2a
52 sg:journal.1319730
53 schema:name The effect of nitric oxide synthase inhibition with and without inhibition of prostaglandins on blood flow in different human skeletal muscles
54 schema:pagination 1175-1180
55 schema:productId N34bb9e8e97ec49c6a3d50715117f8dd2
56 N76172c6c32cf4cf8835722002bf7ed0a
57 N8d1cc3cc071b410d8a24d0a91b0d71a2
58 Ne303659167a246c5b5138a5babaea1eb
59 Nfe03ebfeac784b5e8eb850967440a02f
60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085038290
61 https://doi.org/10.1007/s00421-017-3604-2
62 schema:sdDatePublished 2019-04-11T10:00
63 schema:sdLicense https://scigraph.springernature.com/explorer/license/
64 schema:sdPublisher Nbcdff5b26e49401889304e1c495972dd
65 schema:url https://link.springer.com/10.1007%2Fs00421-017-3604-2
66 sgo:license sg:explorer/license/
67 sgo:sdDataset articles
68 rdf:type schema:ScholarlyArticle
69 N009f7ff158d34430a5870aea227f23b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
70 schema:name Male
71 rdf:type schema:DefinedTerm
72 N10aad06eb8f54ae4a474813df20196ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Adult
74 rdf:type schema:DefinedTerm
75 N154e44b6a2fb41889582ebbea543e9ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Enzyme Inhibitors
77 rdf:type schema:DefinedTerm
78 N23e81f873f87484c865a52cbfbe084c4 schema:volumeNumber 117
79 rdf:type schema:PublicationVolume
80 N2bd7b013781446838adaa214d94d9369 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name omega-N-Methylarginine
82 rdf:type schema:DefinedTerm
83 N34bb9e8e97ec49c6a3d50715117f8dd2 schema:name dimensions_id
84 schema:value pub.1085038290
85 rdf:type schema:PropertyValue
86 N40f6e0ebe13f4c30a0d1850d0bc237c7 rdf:first sg:person.0626445044.37
87 rdf:rest Nc9052a6daa494f26bfa11852b41a6fc8
88 N59bed75f39c34550acb800e387ae4269 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Muscle, Skeletal
90 rdf:type schema:DefinedTerm
91 N76172c6c32cf4cf8835722002bf7ed0a schema:name nlm_unique_id
92 schema:value 100954790
93 rdf:type schema:PropertyValue
94 N7c2127078c104d559a54088e47d76496 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Nitric Oxide Synthase
96 rdf:type schema:DefinedTerm
97 N7f454f801cf8474a9dc0d6ab1ccc45c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Humans
99 rdf:type schema:DefinedTerm
100 N8afa5004c5da4412a98b45b0e8d5b2b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Exercise
102 rdf:type schema:DefinedTerm
103 N8d1cc3cc071b410d8a24d0a91b0d71a2 schema:name doi
104 schema:value 10.1007/s00421-017-3604-2
105 rdf:type schema:PropertyValue
106 N9724e58ad0594f57ad2a6c037fa50fae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Regional Blood Flow
108 rdf:type schema:DefinedTerm
109 Na9ee9813de884a1782c1ec3ca02adea5 rdf:first sg:person.01036617440.17
110 rdf:rest N40f6e0ebe13f4c30a0d1850d0bc237c7
111 Nbcdff5b26e49401889304e1c495972dd schema:name Springer Nature - SN SciGraph project
112 rdf:type schema:Organization
113 Nc9052a6daa494f26bfa11852b41a6fc8 rdf:first sg:person.0731746535.38
114 rdf:rest Nd0cb38b3048f4639a1394d1b8c9edbbe
115 Nd0cb38b3048f4639a1394d1b8c9edbbe rdf:first sg:person.01210110752.34
116 rdf:rest rdf:nil
117 Nd34916c233d14aaaa548020f7cc2bf2a schema:issueNumber 6
118 rdf:type schema:PublicationIssue
119 Ndf118d0f851e4b09bd5f1b72a6553cf7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Prostaglandin Antagonists
121 rdf:type schema:DefinedTerm
122 Ne303659167a246c5b5138a5babaea1eb schema:name pubmed_id
123 schema:value 28432421
124 rdf:type schema:PropertyValue
125 Nfe03ebfeac784b5e8eb850967440a02f schema:name readcube_id
126 schema:value d0129b36a2bd9376df3a6aea02cddb19d65d315d05d795120b287a601fb5117f
127 rdf:type schema:PropertyValue
128 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
129 schema:name Medical and Health Sciences
130 rdf:type schema:DefinedTerm
131 anzsrc-for:1106 schema:inDefinedTermSet anzsrc-for:
132 schema:name Human Movement and Sports Science
133 rdf:type schema:DefinedTerm
134 sg:journal.1319730 schema:issn 1432-1025
135 1439-6319
136 schema:name European Journal of Applied Physiology
137 rdf:type schema:Periodical
138 sg:person.01036617440.17 schema:affiliation https://www.grid.ac/institutes/grid.5645.2
139 schema:familyName Heinonen
140 schema:givenName Ilkka
141 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036617440.17
142 rdf:type schema:Person
143 sg:person.01210110752.34 schema:affiliation https://www.grid.ac/institutes/grid.470895.7
144 schema:familyName Kalliokoski
145 schema:givenName Kari K.
146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210110752.34
147 rdf:type schema:Person
148 sg:person.0626445044.37 schema:affiliation https://www.grid.ac/institutes/grid.5254.6
149 schema:familyName Saltin
150 schema:givenName Bengt
151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626445044.37
152 rdf:type schema:Person
153 sg:person.0731746535.38 schema:affiliation https://www.grid.ac/institutes/grid.5254.6
154 schema:familyName Hellsten
155 schema:givenName Ylva
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731746535.38
157 rdf:type schema:Person
158 sg:pub.10.1007/bf01003594 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027604973
159 https://doi.org/10.1007/bf01003594
160 rdf:type schema:CreativeWork
161 sg:pub.10.1007/s00421-012-2329-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009054106
162 https://doi.org/10.1007/s00421-012-2329-5
163 rdf:type schema:CreativeWork
164 sg:pub.10.1186/1743-7075-10-43 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019938111
165 https://doi.org/10.1186/1743-7075-10-43
166 rdf:type schema:CreativeWork
167 https://app.dimensions.ai/details/publication/pub.1083042811 schema:CreativeWork
168 https://doi.org/10.1002/cphy.c100048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010738582
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1002/jlcr.25804401381 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031476084
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1016/0022-510x(73)90023-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008393632
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1016/j.niox.2014.09.157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049808602
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1111/j.1469-7793.2001.0257j.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006715247
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1113/expphysiol.2013.076927 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025990719
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1113/jphysiol.2006.127423 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003360487
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1113/jphysiol.2009.183723 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035544083
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1152/ajpheart.00925.2012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004572118
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1152/ajpheart.00996.2010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024911270
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1152/ajpheart.1999.276.6.h1951 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074473790
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1152/ajpregu.00056.2010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021725323
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1152/ajpregu.00245.2011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052849577
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1152/ajpregu.00631.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023064703
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1152/jappl.1994.77.3.1288 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082400818
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1152/japplphysiol.00567.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006794796
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1152/japplphysiol.00732.2011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038262627
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1152/japplphysiol.00745.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007538471
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1152/physiol.00067.2013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041942887
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1249/jes.0000000000000044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003942172
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1249/jes.0000000000000074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003625680
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1249/mss.0000000000000178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009098944
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1371/journal.pone.0052191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051377132
213 rdf:type schema:CreativeWork
214 https://doi.org/10.2337/diabetes.48.9.1815 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070744282
215 rdf:type schema:CreativeWork
216 https://doi.org/10.2337/diabetes.51.8.2572 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035620962
217 rdf:type schema:CreativeWork
218 https://doi.org/10.3389/fphys.2012.00411 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019508017
219 rdf:type schema:CreativeWork
220 https://www.grid.ac/institutes/grid.470895.7 schema:alternateName Turku PET Centre
221 schema:name Turku PET Centre, University of Turku, PO Box 52, 20521, Turku, Finland
222 rdf:type schema:Organization
223 https://www.grid.ac/institutes/grid.5254.6 schema:alternateName University of Copenhagen
224 schema:name Copenhagen Muscle Research Center, University of Copenhagen, Copenhagen, Denmark
225 Exercise and Sport Sciences, Section of Human Physiology, University of Copenhagen, Copenhagen, Denmark
226 rdf:type schema:Organization
227 https://www.grid.ac/institutes/grid.5645.2 schema:alternateName Erasmus University Medical Center
228 schema:name Department of Clinical Physiology and Nuclear Medicine, University of Turku, Turku, Finland
229 Division of Experimental Cardiology, Thoraxcenter, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
230 Turku PET Centre, University of Turku, PO Box 52, 20521, Turku, Finland
231 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...