Ontology type: schema:ScholarlyArticle
2013-06
AUTHORSJames Pearson, Kameljit K. Kalsi, Eric J. Stöhr, David A. Low, Horace Barker, Leena Ali, José González-Alonso
ABSTRACTDehydration and hyperthermia reduces leg blood flow (LBF), cardiac output ([Formula: see text]) and arterial pressure during whole-body exercise. It is unknown whether the reductions in blood flow are associated with dehydration-induced alterations in arterial blood oxygen content (C aO2) and O2-dependent signalling. This study investigated the impact of dehydration and concomitant alterations in C aO2 upon LBF and [Formula: see text]. Haemodynamics, arterial and femoral venous blood parameters and plasma [ATP] were measured at rest and during one-legged knee-extensor exercise in 7 males in four conditions: (1) control, (2) mild dehydration, (3) moderate dehydration, and (4) rehydration. Relative to control, C aO2 and LBF increased with dehydration at rest and during exercise (C aO2: from 199 ± 1 to 208 ± 2, and 202 ± 2 to 210 ± 2 ml L(-1) and LBF: from 0.38 ± 0.04 to 0.77 ± 0.09, and 1.64 ± 0.09 to 1.88 ± 0.1 L min(-1), respectively). Similarly, [Formula: see text] was unchanged or increased with dehydration at rest and during exercise, whereas arterial and leg perfusion pressures declined. Following rehydration, C aO2 declined (to 193 ± 2 mL L(-1)) but LBF remained elevated. Alterations in LBF were unrelated to C aO2 (r (2) = 0.13-0.27, P = 0.48-0.64) and plasma [ATP]. These findings suggest dehydration and concomitant alterations in C aO2 do not compromise LBF despite reductions in plasma [ATP]. While an additive or synergistic effect cannot be excluded, reductions in LBF during exercise with dehydration may not necessarily be associated with alterations in C aO2 and/or intravascular [ATP]. More... »
PAGES1499-1509
http://scigraph.springernature.com/pub.10.1007/s00421-012-2579-2
DOIhttp://dx.doi.org/10.1007/s00421-012-2579-2
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curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00421-012-2579-2'
This table displays all metadata directly associated to this object as RDF triples.
311 TRIPLES
21 PREDICATES
88 URIs
33 LITERALS
21 BLANK NODES