Ontology type: schema:ScholarlyArticle
2007-11-06
AUTHORSUrs A. Leuenberger, Douglas Johnson, Joseph Loomis, Kristen S. Gray, David A. MacLean
ABSTRACTSystemic hypoxia leads to peripheral vasodilation that serves to counteract the decrease in peripheral oxygen (O2) delivery. Skeletal muscle vasodilation associated with hypoxia is due to release of vasodilator substances such as adenosine and/or nitric oxide (NO). We hypothesized that skeletal muscle may act as a source of NO during exposure to hypoxia. Therefore, we measured NO in forearm venous plasma and in skeletal muscle interstitial dialysate in seven healthy young men during exposure to simulated altitude of 2,438 and 4,877 m (20 min at each level) in a hypobaric chamber. O2 saturation (mean ± SEM) fell from 98.0 ± 0.2% at ambient conditions to 91.0 ± 0.4% at 2,438 m and to 73.2 ± 4.4% at 4,877 m (P < 0.05). While blood pressure remained unchanged, heart rate increased in a graded fashion (P < 0.05). Plasma NO (chemiluminescence method) rose from 11.6 ± 1.3 to 16.9 ± 2.9 μM at 2,438 m (P < 0.05) but remained similar at 16.4 ± 2.3 μM at 4,877 m (NS). In contrast, skeletal muscle microdialysate NO levels were lower than plasma NO (P < 0.01) and did not change during simulated altitude. Thus, hypoxia produced by simulated high altitude exposure leads to an increase in plasma but not skeletal muscle interstitial NO. These data support an important role of NO in the peripheral vascular responses to hypoxia. The differential responses of plasma vs. interstitial NO during hypoxia suggest an endothelial or intravascular source of NO. More... »
PAGES457-461
http://scigraph.springernature.com/pub.10.1007/s00421-007-0601-x
DOIhttp://dx.doi.org/10.1007/s00421-007-0601-x
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1053668604
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/17985154
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1116",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical Physiology",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adult",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Altitude",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Atmosphere Exposure Chambers",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Extracellular Fluid",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Forearm",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Hypoxia",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Microdialysis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Muscle, Skeletal",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Nitric Oxide",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Oxygen",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Vasodilation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Veins",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Penn State Heart and Vascular Institute, H047, Pennsylvania State University College of Medicine, 500 University Drive, P.O. Box 850, 17033, Hershey, PA, USA",
"id": "http://www.grid.ac/institutes/grid.29857.31",
"name": [
"Penn State Heart and Vascular Institute, H047, Pennsylvania State University College of Medicine, 500 University Drive, P.O. Box 850, 17033, Hershey, PA, USA"
],
"type": "Organization"
},
"familyName": "Leuenberger",
"givenName": "Urs A.",
"id": "sg:person.0670447005.52",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670447005.52"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Noll Physiological Research Laboratory, Pennsylvania State University, Hershey, PA, USA",
"id": "http://www.grid.ac/institutes/grid.29857.31",
"name": [
"Noll Physiological Research Laboratory, Pennsylvania State University, Hershey, PA, USA"
],
"type": "Organization"
},
"familyName": "Johnson",
"givenName": "Douglas",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Noll Physiological Research Laboratory, Pennsylvania State University, Hershey, PA, USA",
"id": "http://www.grid.ac/institutes/grid.29857.31",
"name": [
"Noll Physiological Research Laboratory, Pennsylvania State University, Hershey, PA, USA"
],
"type": "Organization"
},
"familyName": "Loomis",
"givenName": "Joseph",
"id": "sg:person.01037273204.85",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037273204.85"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Penn State Heart and Vascular Institute, H047, Pennsylvania State University College of Medicine, 500 University Drive, P.O. Box 850, 17033, Hershey, PA, USA",
"id": "http://www.grid.ac/institutes/grid.29857.31",
"name": [
"Penn State Heart and Vascular Institute, H047, Pennsylvania State University College of Medicine, 500 University Drive, P.O. Box 850, 17033, Hershey, PA, USA"
],
"type": "Organization"
},
"familyName": "Gray",
"givenName": "Kristen S.",
"id": "sg:person.016352451202.59",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016352451202.59"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Medical Sciences, Northern Ontario School of Medicine, Sudbury & Thunder Bay, ON, Canada",
"id": "http://www.grid.ac/institutes/grid.436533.4",
"name": [
"Division of Medical Sciences, Northern Ontario School of Medicine, Sudbury & Thunder Bay, ON, Canada"
],
"type": "Organization"
},
"familyName": "MacLean",
"givenName": "David A.",
"id": "sg:person.015751122332.99",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015751122332.99"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/nm718",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027225240",
"https://doi.org/10.1038/nm718"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nm954",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029048023",
"https://doi.org/10.1038/nm954"
],
"type": "CreativeWork"
}
],
"datePublished": "2007-11-06",
"datePublishedReg": "2007-11-06",
"description": "Systemic hypoxia leads to peripheral vasodilation that serves to counteract the decrease in peripheral oxygen (O2) delivery. Skeletal muscle vasodilation associated with hypoxia is due to release of vasodilator substances such as adenosine and/or nitric oxide (NO). We hypothesized that skeletal muscle may act as a source of NO during exposure to hypoxia. Therefore, we measured NO in forearm venous plasma and in skeletal muscle interstitial dialysate in seven healthy young men during exposure to simulated altitude of 2,438 and 4,877\u00a0m (20\u00a0min at each level) in a hypobaric chamber. O2 saturation (mean\u00a0\u00b1\u00a0SEM) fell from 98.0\u00a0\u00b1\u00a00.2% at ambient conditions to 91.0\u00a0\u00b1\u00a00.4% at 2,438\u00a0m and to 73.2\u00a0\u00b1\u00a04.4% at 4,877\u00a0m (P\u00a0<\u00a00.05). While blood pressure remained unchanged, heart rate increased in a graded fashion (P\u00a0<\u00a00.05). Plasma NO (chemiluminescence method) rose from 11.6\u00a0\u00b1\u00a01.3 to 16.9\u00a0\u00b1\u00a02.9\u00a0\u03bcM at 2,438\u00a0m (P\u00a0<\u00a00.05) but remained similar at 16.4\u00a0\u00b1\u00a02.3\u00a0\u03bcM at 4,877\u00a0m (NS). In contrast, skeletal muscle microdialysate NO levels were lower than plasma NO (P\u00a0<\u00a00.01) and did not change during simulated altitude. Thus, hypoxia produced by simulated high altitude exposure leads to an increase in plasma but not skeletal muscle interstitial NO. These data support an important role of NO in the peripheral vascular responses to hypoxia. The differential responses of plasma vs. interstitial NO during hypoxia suggest an endothelial or intravascular source of NO.",
"genre": "article",
"id": "sg:pub.10.1007/s00421-007-0601-x",
"isAccessibleForFree": false,
"isFundedItemOf": [
{
"id": "sg:grant.2437017",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2538284",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2350781",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2424045",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1319730",
"issn": [
"1439-6319",
"1432-1025"
],
"name": "European Journal of Applied Physiology",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "4",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "102"
}
],
"keywords": [
"nitric oxide",
"interstitial nitric oxide",
"muscle interstitial",
"forearm venous plasma",
"peripheral oxygen delivery",
"skeletal muscle vasodilation",
"plasma nitric oxide",
"peripheral vascular responses",
"healthy young men",
"high-altitude exposure",
"vasodilator substances",
"muscle vasodilation",
"systemic hypoxia",
"peripheral vasodilation",
"blood pressure",
"vascular responses",
"venous plasma",
"muscle microdialysate",
"hypobaric hypoxia",
"altitude exposure",
"oxygen delivery",
"heart rate",
"hypobaric chamber",
"O2 saturation",
"intravascular source",
"hypoxia",
"skeletal muscle",
"young men",
"graded fashion",
"vasodilation",
"exposure",
"differential response",
"plasma",
"important role",
"response",
"muscle",
"microdialysates",
"men",
"adenosine",
"delivery",
"\u03bcM",
"release",
"levels",
"decrease",
"substances",
"role",
"rate",
"contrast",
"increase",
"pressure",
"fashion",
"data",
"saturation",
"interstitials",
"chamber",
"oxide",
"conditions",
"source",
"altitude",
"ambient conditions"
],
"name": "Venous but not skeletal muscle interstitial nitric oxide is increased during hypobaric hypoxia",
"pagination": "457-461",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1053668604"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s00421-007-0601-x"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"17985154"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s00421-007-0601-x",
"https://app.dimensions.ai/details/publication/pub.1053668604"
],
"sdDataset": "articles",
"sdDatePublished": "2022-08-04T16:55",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_439.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1007/s00421-007-0601-x"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00421-007-0601-x'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00421-007-0601-x'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00421-007-0601-x'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00421-007-0601-x'
This table displays all metadata directly associated to this object as RDF triples.
225 TRIPLES
21 PREDICATES
101 URIs
91 LITERALS
21 BLANK NODES