Hemodynamic and neurohumoral responses to the restriction of femoral blood flow by KAATSU in healthy subjects View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-03-07

AUTHORS

Haruko Iida, Miwa Kurano, Haruhito Takano, Nami Kubota, Toshihiro Morita, Kentaro Meguro, Yoshiaki Sato, Takashi Abe, Yoshihisa Yamazaki, Kansei Uno, Katsu Takenaka, Ken Hirose, Toshiaki Nakajima

ABSTRACT

The application of an orthostatic stress such as lower body negative pressure (LBNP) has been proposed to minimize the effects of weightlessness on the cardiovascular system and subsequently to reduce the cardiovascular deconditioning. The KAATSU training is a novel method to induce muscle strength and hypertrophy with blood pooling in capacitance vessels by restricting venous return. Here, we studied the hemodynamic, autonomic nervous and hormonal responses to the restriction of femoral blood flow by KAATSU in healthy male subjects, using the ultrasonography and impedance cardiography. The pressurization on both thighs induced pooling of blood into the legs with pressure-dependent reduction of femoral arterial blood flow. The application of 200 mmHg KAATSU significantly decreased left ventricular diastolic dimension (LVDd), cardiac output (CO) and diameter of inferior vena cava (IVC). Similarly, 200 mmHg KAATSU also decreased stroke volume (SV), which was almost equal to the value in standing. Heart rate (HR) and total peripheral resistance (TPR) increased in a similar manner to standing with slight change of mean blood pressure (mBP). High-frequency power (HFRR) decreased during both 200 mmHg KAATSU and standing, while low-frequency/high-frequency power (LFRR/HFRR) increased significantly. During KAATSU and standing, the concentration of noradrenaline (NA) and vasopressin (ADH) and plasma renin activity (PRA) increased. These results indicate that KAATSU in supine subjects reproduces the effects of standing on HR, SV, TPR, etc., thus stimulating an orthostatic stimulus. And, KAATSU training appears to be a useful method for potential countermeasure like LBNP against orthostatic intolerance after spaceflight. More... »

PAGES

275-285

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00421-007-0430-y

DOI

http://dx.doi.org/10.1007/s00421-007-0430-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042714485

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17342543


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28 schema:description The application of an orthostatic stress such as lower body negative pressure (LBNP) has been proposed to minimize the effects of weightlessness on the cardiovascular system and subsequently to reduce the cardiovascular deconditioning. The KAATSU training is a novel method to induce muscle strength and hypertrophy with blood pooling in capacitance vessels by restricting venous return. Here, we studied the hemodynamic, autonomic nervous and hormonal responses to the restriction of femoral blood flow by KAATSU in healthy male subjects, using the ultrasonography and impedance cardiography. The pressurization on both thighs induced pooling of blood into the legs with pressure-dependent reduction of femoral arterial blood flow. The application of 200 mmHg KAATSU significantly decreased left ventricular diastolic dimension (LVDd), cardiac output (CO) and diameter of inferior vena cava (IVC). Similarly, 200 mmHg KAATSU also decreased stroke volume (SV), which was almost equal to the value in standing. Heart rate (HR) and total peripheral resistance (TPR) increased in a similar manner to standing with slight change of mean blood pressure (mBP). High-frequency power (HFRR) decreased during both 200 mmHg KAATSU and standing, while low-frequency/high-frequency power (LFRR/HFRR) increased significantly. During KAATSU and standing, the concentration of noradrenaline (NA) and vasopressin (ADH) and plasma renin activity (PRA) increased. These results indicate that KAATSU in supine subjects reproduces the effects of standing on HR, SV, TPR, etc., thus stimulating an orthostatic stimulus. And, KAATSU training appears to be a useful method for potential countermeasure like LBNP against orthostatic intolerance after spaceflight.
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36 activity
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38 arterial blood flow
39 blood
40 blood flow
41 blood pooling
42 blood pressure
43 body negative pressure
44 capacitance vessels
45 cardiac output
46 cardiography
47 cardiovascular deconditioning
48 cardiovascular system
49 cava
50 changes
51 concentration
52 concentrations of noradrenaline
53 countermeasures
54 deconditioning
55 diameter
56 diastolic dimension
57 dimensions
58 effect
59 effects of weightlessness
60 femoral arterial blood flow
61 femoral blood flow
62 flow
63 healthy male subjects
64 healthy subjects
65 heart rate
66 high-frequency power
67 hormonal responses
68 hypertrophy
69 impedance cardiography
70 inferior vena cava
71 intolerance
72 leg
73 lower body negative pressure
74 male subjects
75 manner
76 mean blood pressure
77 method
78 muscle strength
79 negative pressure
80 neurohumoral responses
81 noradrenaline
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83 orthostatic intolerance
84 orthostatic stimulus
85 orthostatic stress
86 output
87 peripheral resistance
88 plasma renin activity
89 pooling
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91 potential countermeasures
92 power
93 pressure
94 pressure-dependent reduction
95 pressurization
96 rate
97 reduction
98 renin activity
99 resistance
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102 results
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