Association of ACE ID and ACE G2350A polymorphism with increased blood pressure in persons exposed to different sound levels in ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-02-09

AUTHORS

Syed Kashif Nawaz, Shahida Hasnain

ABSTRACT

PurposeTo investigate the role of ACE ID and ACE G2350A polymorphism in increasing the blood pressure of persons exposed to different sound levels.MethodPersons exposed to normal sound level (≤80 dBA) and noise (>80 dBA) were divided in two categories on the basis of blood pressure. Category A was comprised of the individuals with blood pressure ranges equal or less than that for normotensive persons. Category B was composed of the workers with blood pressure above than that for category A. ACE ID and ACE G2350A polymorphism was detected for analysis of its association with the increased blood pressure considering noise as modifier.ResultsLeast homozygous allele model for ACE ID polymorphism indicates no association of DD allele with the increased blood pressure in persons exposed to normal sound (Odds ratio: 0.831; 95% Confidence interval: 0.340–2.030). Similar findings were noted in persons exposed to noise (Odds ratio: 0.992; 95% Confidence interval: 0.536–1.835). Combining all the samples did not change the results (Odds ratio: 0.948; 95% Confidence interval: 0.580–1.549). For ACE G2350A polymorphism, least common homozygote model revealed that AA allele did not affect the chances of increased blood pressure in normal sound exposed group (Odds ratio: 0.827; 95% Confidence interval: 0.169–4.042) and noise exposed group (Odds ratio: 1.416; 95% Confidence interval: 0.682–2.941). There was no prominent variation in the results on combining all the samples (Odds ratio: 1.529; 95% Confidence interval: 0.807–2.872).ConclusionsNo association was observed between ACE ID/ACE G2350A polymorphism and the increased blood pressure in persons exposed to normal sound and noise in Pakistani population. More... »

PAGES

355-360

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00420-011-0619-6

DOI

http://dx.doi.org/10.1007/s00420-011-0619-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052030931

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21305316


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