Ontology type: schema:ScholarlyArticle
1999-05
AUTHORSA. Résibois, Laetitia Cuvelier, Michal Svoboda, Claus W. Heizmann, Beat Thöny
ABSTRACTThe bifunctional protein PCD/DCoH is both a pterin-4alpha-carbinolamine dehydratase (PCD) involved in the recycling of tetrahydrobiopterin (BH4) and a dimerisation cofactor (DCoH) of the hepatic nuclear factor 1alpha (HNF-1alpha). An antiserum raised against rat PCD/DCoH was used to localise the protein in peripheral organs. In liver, all the hepatocytes but not the other cell types are immunoreactive. In kidney, the protein is prevalent in the proximal and distal convoluted tubules. In adrenals, all the cells of the medulla are labelled. Positive nerve cells occur in myenteric ganglia of the whole gastrointestinal tract and in the intestinal submucous ganglia. Many positive endocrine cells are present in the epithelium. The immunoreactivity is either cytoplasmic (hepatocytes, convoluted tubules of the kidney and part of the gastrointestinal endocrine cells) or prominently nuclear (kidney collecting tubules, adrenals, intestinal neural plexuses and part of the gastrointestinal endocrine cells). Our results show that PCD/DCoH is present in cells expressing enzymes that use BH4 as a cofactor and/or HNF-1alpha. In addition, PCD/DCoH is present in other cells, for example, neurons in the submucosal plexus. This fact and the prominent nuclear immunoreactivity found in all the positive cells derived from the neural crests argue in favour of a new, still unknown function for the protein. More... »
PAGES381-390
http://scigraph.springernature.com/pub.10.1007/s004180050371
DOIhttp://dx.doi.org/10.1007/s004180050371
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1011856108
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/10403117
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biochemistry and Cell Biology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adrenal Cortex",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antibody Specificity",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Digestive System",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Gastric Fundus",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Hydro-Lyases",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Kidney",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Liver",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Rabbits",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Rats",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Rats, Wistar",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Tissue Distribution",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Universit\u00e9 Libre de Bruxelles",
"id": "https://www.grid.ac/institutes/grid.4989.c",
"name": [
"Laboratoire d\u2019Histologie, Facult\u00e9 de M\u00e9decine CP620, Universit\u00e9 Libre de Bruxelles, 808 route de Lennik, B-1070 Brussels, Belgium e-mail: aresiboi@med.ac.be Tel.: 322-5556383 Fax: 322-5556285, BE"
],
"type": "Organization"
},
"familyName": "R\u00e9sibois",
"givenName": "A.",
"id": "sg:person.01065501132.55",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065501132.55"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Universit\u00e9 Libre de Bruxelles",
"id": "https://www.grid.ac/institutes/grid.4989.c",
"name": [
"Laboratoire d\u2019Histologie, Facult\u00e9 de M\u00e9decine CP620, Universit\u00e9 Libre de Bruxelles, 808 route de Lennik, B-1070 Brussels, Belgium e-mail: aresiboi@med.ac.be Tel.: 322-5556383 Fax: 322-5556285, BE"
],
"type": "Organization"
},
"familyName": "Cuvelier",
"givenName": "Laetitia",
"id": "sg:person.01016571452.05",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016571452.05"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Universit\u00e9 Libre de Bruxelles",
"id": "https://www.grid.ac/institutes/grid.4989.c",
"name": [
"Laboratoire de Biochimie et de la Nutrition, Universit\u00e9 Libre de Bruxelles, 808 route de Lennik, B-1070 Brussels, Belgium, BE"
],
"type": "Organization"
},
"familyName": "Svoboda",
"givenName": "Michal",
"id": "sg:person.0610551417.85",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610551417.85"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Zurich",
"id": "https://www.grid.ac/institutes/grid.7400.3",
"name": [
"Division of Clinical Chemistry and Biochemistry, Department of Pediatrics, University of Z\u00fcrich, Z\u00fcrich, Switzerland, CH"
],
"type": "Organization"
},
"familyName": "Heizmann",
"givenName": "Claus W.",
"id": "sg:person.01257747106.47",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257747106.47"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Zurich",
"id": "https://www.grid.ac/institutes/grid.7400.3",
"name": [
"Division of Clinical Chemistry and Biochemistry, Department of Pediatrics, University of Z\u00fcrich, Z\u00fcrich, Switzerland, CH"
],
"type": "Organization"
},
"familyName": "Th\u00f6ny",
"givenName": "Beat",
"id": "sg:person.0762173044.42",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762173044.42"
],
"type": "Person"
}
],
"datePublished": "1999-05",
"datePublishedReg": "1999-05-01",
"description": "The bifunctional protein PCD/DCoH is both a pterin-4alpha-carbinolamine dehydratase (PCD) involved in the recycling of tetrahydrobiopterin (BH4) and a dimerisation cofactor (DCoH) of the hepatic nuclear factor 1alpha (HNF-1alpha). An antiserum raised against rat PCD/DCoH was used to localise the protein in peripheral organs. In liver, all the hepatocytes but not the other cell types are immunoreactive. In kidney, the protein is prevalent in the proximal and distal convoluted tubules. In adrenals, all the cells of the medulla are labelled. Positive nerve cells occur in myenteric ganglia of the whole gastrointestinal tract and in the intestinal submucous ganglia. Many positive endocrine cells are present in the epithelium. The immunoreactivity is either cytoplasmic (hepatocytes, convoluted tubules of the kidney and part of the gastrointestinal endocrine cells) or prominently nuclear (kidney collecting tubules, adrenals, intestinal neural plexuses and part of the gastrointestinal endocrine cells). Our results show that PCD/DCoH is present in cells expressing enzymes that use BH4 as a cofactor and/or HNF-1alpha. In addition, PCD/DCoH is present in other cells, for example, neurons in the submucosal plexus. This fact and the prominent nuclear immunoreactivity found in all the positive cells derived from the neural crests argue in favour of a new, still unknown function for the protein.",
"genre": "research_article",
"id": "sg:pub.10.1007/s004180050371",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1294817",
"issn": [
"0948-6143",
"1432-119X"
],
"name": "Histochemistry and Cell Biology",
"type": "Periodical"
},
{
"issueNumber": "5",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "111"
}
],
"name": "Immunohistochemical localisation of pterin-4\u03b1-carbinolamine dehydratase in rat peripheral organs",
"pagination": "381-390",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"387d089d9d32d30d14b2b42789d744eb51a39a0e259f1d796b80046ae5979205"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"10403117"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"9506663"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s004180050371"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1011856108"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s004180050371",
"https://app.dimensions.ai/details/publication/pub.1011856108"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T13:16",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000511.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1007%2Fs004180050371"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s004180050371'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s004180050371'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s004180050371'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s004180050371'
This table displays all metadata directly associated to this object as RDF triples.
157 TRIPLES
20 PREDICATES
43 URIs
35 LITERALS
23 BLANK NODES