Kinetics and collagenolytic role of eosinophils in chronic gastric ulcer in the rat View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-07

AUTHORS

N. Ohmiya, Shinsuke Saga, Masaharu Ohbayashi, Ken-ichi Kozaki, Osamu Miyaishi, Miya Kobayashi, Shiro Kasuya, Tomiyasu Arisawa, Hidemi Goto, Tetsuo Hayakawa

ABSTRACT

An association between eosinophils and tissue damage has been observed in numerous disorders. However, few reports have addressed the role of infiltrating eosinophils in gastric ulcer healing. The aim of this study was to investigate the kinetics and role of eosinophils infiltrating experimental chronic gastric ulcers in the rat. We developed a monoclonal antibody against human matrix metalloproteinase 1 (MMP1) purified from conditioned culture medium of human skin fibroblasts. Acetic acid-induced gastric ulcers were resected from rats on days 1, 3, 5, 10, 20, 40, and 180 after the days of induction (day 0). Tissue specimens were immunostained with this antibody and examined with an electron microscope. Few eosinophils were observed in the granulation tissue until day 20. By days 40 and 180, MMP1-positive eosinophils had increased in the granulation tissue of open ulcers. Azan staining revealed dispersed collagen fibers around infiltrating eosinophils. In contrast, scars demonstrated few eosinophils in fibrous tissue on days 40 and 180. Eosinophils which express MMP1 infiltrate granulation tissue at the chronic stage of gastric ulceration. The results suggest that eosinophils may play a role in tissue remodeling and deterioration of ulceration. More... »

PAGES

27-34

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s004180050143

DOI

http://dx.doi.org/10.1007/s004180050143

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007786242

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9377222


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