Similarities and differences in tissue distribution of DLK1 and DLK2 during E16.5 mouse embryogenesis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03-19

AUTHORS

P. Garcia-Gallastegi, A. Ruiz-García, G. Ibarretxe, S. Rivero-Hinojosa, A. D. González-Siccha, J. Laborda, O. Crende, F. Unda, J. J. García-Ramírez

ABSTRACT

DLK1 and DLK2 are transmembrane proteins belonging to the EGF-like repeat-containing family that function as non-canonical NOTCH inhibitory ligands. DLK1 is usually downregulated after embryo development and its distribution in some adult and embryonic tissues has been described. However, the expression and role of DLK2 in embryo and adult tissues remains unclear. To better understand the relevance of both proteins during embryo development, we analyzed the expression pattern of DLK1 and DLK2 in 16.5-day-old mouse embryos (E16.5) and evaluated the possible relationship between these two proteins in embryo tissues and cell types. We found that DLK1 and DLK2 proteins exhibited a broad distribution pattern, which was detected in developing mouse organs from each of the three germ layers: ectoderm (brain, salivary glands), mesoderm (skeletal muscle, vertebral column, kidney, cartilage), and endoderm (thymus, lung, pancreas, intestine, liver). The expression pattern of DLK1 and DLK2 indicates that both proteins could play a synergistic role during cell differentiation. This study provides additional information for understanding temporal and site-specific effects of DLK1 and DLK2 during embryo morphogenesis and cell differentiation. More... »

PAGES

1-14

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00418-019-01778-4

DOI

http://dx.doi.org/10.1007/s00418-019-01778-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112860965

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30888503


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Download the RDF metadata as:  json-ld nt turtle xml License info

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RDF/XML is a standard XML format for linked data.

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282 schema:name Departamento de Bioquímica, Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, Av. Juan Pablo II s/n, Trujillo, Peru
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284 https://www.grid.ac/institutes/grid.239560.b schema:alternateName Children’s National Health System
285 schema:name Center for Cancer and Immunology Research, Children’s Research Institute, National Health System, 111 Michigan Ave NW, 20010, Washington, DC, USA
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287 https://www.grid.ac/institutes/grid.8048.4 schema:alternateName University of Castile-La Mancha
288 schema:name Department of Inorganic and Organic Chemistry and Biochemistry, Medical School, Regional Center for Biomedical Research, Unidad Asociada de Biomedicina (UCLM-CSIC), University of Castilla-La Mancha, Calle Almansa 14, 02008, Albacete, Spain
289 Department of Inorganic and Organic Chemistry and Biochemistry, Pharmacy School, Regional Center for Biomedical Research, Unidad Asociada de Biomedicina (UCLM-CSIC), University of Castilla-La Mancha, Avda José María Sánchez Ibáñez s/n, 02008, Albacete, Spain
290 rdf:type schema:Organization
 




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