Runx2, an inducer of osteoblast and chondrocyte differentiation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-01-22

AUTHORS

Toshihisa Komori

ABSTRACT

Runx2 is a transcription factor that is essential for osteoblast differentiation and chondrocyte maturation. Ihh, expressed in prehypertrophic and hypertrophic chondrocytes, is required for the specification of Runx2+ osteoprogenitors in endochondral bone development. Runx2 induces Sp7, an essential transcription factor for osteoblast differentiation. Canonical Wnt signaling is also required for osteoblast differentiation. Runx2+ osteoprogenitors retain the capacity to differentiate into chondrocytes, and Sp7 and canonical Wnt signaling direct cells to osteoblasts, thereby inhibiting chondrocyte differentiation. The function of Runx2 after the commitment to osteoblasts remains controversial. Runx3 has a redundant function with Runx2 in chondrocyte maturation. Runx2 regulates the expression of Ihh, Col10a1, Spp1, Ibsp, Mmp13, and Vegfa in the respective layers in growth plates. Runx2 enhances chondrocyte proliferation through the induction of Ihh. Ihh induces Pthlh, which inhibits Runx2 and chondrocyte maturation, forming a negative feedback loop for chondrocyte maturation. Runx2 is one of the genes responsible for the pathogenesis of osteoarthritis (OA) because RUNX2 is up-regulated in chondrocytes in OA cartilage and a germline haplodeficiency or deletion of Runx2 in articular chondrocytes decelerates OA progression. Runx2 plays an important role in the bone metastasis of breast and prostate cancers by up-regulating Spp1, Ibsp, Mmp9, Mmp13, Vegfa, Tnfsf11, and Ihh expression and down-regulating Tnfrsf11b expression. Cbfb forms a heterodimer with Runx2 and is required for the efficient DNA binding of Runx2. Cbfb stabilizes Runx proteins at different levels among Runx family proteins by inhibiting their ubiquitination-mediated degradation. Cbfb plays more important roles in endochondral ossification than in intramembranous ossification. More... »

PAGES

313-323

References to SciGraph publications

  • 2006-12-13. Regulatory roles of Runx2 in metastatic tumor and cancer cell interactions with bone in CANCER AND METASTASIS REVIEWS
  • 2017-03-16. Roles of Runx2 in Skeletal Development in RUNX PROTEINS IN DEVELOPMENT AND CANCER
  • 1997-07. Missense mutations abolishing DNA binding of the osteoblast-specific transcription factor OSF2/CBFA1 in cleidocranial dysplasia in NATURE GENETICS
  • 2009-09-30. Regulation of Osteoblast Differentiation by Runx2 in OSTEOIMMUNOLOGY
  • 2009-08-01. Regulation of bone development and extracellular matrix protein genes by RUNX2 in CELL AND TISSUE RESEARCH
  • 2013-03-08. Clinical significance of RUNX2 expression in patients with nonsmall cell lung cancer: a 5-year follow-up study in TUMOR BIOLOGY
  • 2017-05-24. Deletion of Runx2 in Articular Chondrocytes Decelerates the Progression of DMM-Induced Osteoarthritis in Adult Mice in SCIENTIFIC REPORTS
  • 2002-11-18. Core-binding factor β interacts with Runx2 and is required for skeletal development in NATURE GENETICS
  • 2014-11-26. Decreased histone deacetylase 4 is associated with human osteoarthritis cartilage degeneration by releasing histone deacetylase 4 inhibition of runt-related transcription factor-2 and increasing osteoarthritis-related genes: a novel mechanism of human osteoarthritis cartilage degeneration in ARTHRITIS RESEARCH & THERAPY
  • 2002-11-18. The core-binding factor β subunit is required for bone formation and hematopoietic maturation in NATURE GENETICS
  • 1998-09-22. Transcriptional regulation of osteopontin gene in vivo by PEBP2αA/CBFA1 and ETS1 in the skeletal tissues in ONCOGENE
  • 1999-01-21. Both AP-1 and Cbfa1-like factors are required for the induction of interstitial collagenase by parathyroid hormone in ONCOGENE
  • 2008-02-24. Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation in NATURE MEDICINE
  • 2009-11-30. Runx2 regulates survivin expression in prostate cancer cells in LABORATORY INVESTIGATION
  • 2009-11-16. Runx2 association with progression of prostate cancer in patients: mechanisms mediating bone osteolysis and osteoblastic metastatic lesions in ONCOGENE
  • 2007-01-09. Characterization of the human ADAMTS-5 (aggrecanase-2) gene promoter in MOLECULAR BIOLOGY REPORTS
  • 2008-02-24. Dimorphic effects of Notch signaling in bone homeostasis in NATURE MEDICINE
  • 2017-08-10. DNA methylation of the RUNX2 P1 promoter mediates MMP13 transcription in chondrocytes in SCIENTIFIC REPORTS
  • 2002-11-18. Cbfβ interacts with Runx2 and has a critical role in bone development in NATURE GENETICS
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    http://scigraph.springernature.com/pub.10.1007/s00418-018-1640-6

    DOI

    http://dx.doi.org/10.1007/s00418-018-1640-6

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29356961


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