SMAD7 deficiency stimulates Müller progenitor cell proliferation during the development of the mammalian retina View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-03-03

AUTHORS

Martina Kugler, Anja Schlecht, Rudolf Fuchshofer, Sabrina I. Schmitt, Ingo Kleiter, Ludwig Aigner, Ernst R. Tamm, Barbara M. Braunger

ABSTRACT

The transforming growth factor-β (TGF-β) pathway contributes to maintain the quiescence of adult neural stem and progenitor cells in the brain. In the retina, Müller cells are discussed to represent a glial cell population with progenitor-like characteristics. Here, we aimed to investigate if elevated TGF-β signaling modulates the proliferation of Müller cells during retinal development. We generated mutant mice with a systemic, heterozygous up-regulation of TGF-β signaling by deleting its inhibitor SMAD7. We investigated apoptosis, proliferation, and differentiation of Müller cells in the developing retina. We show that a heterozygous deletion of SMAD7 results in an increased proliferation of Müller cell progenitors in the central retina at postnatal day 4, the time window when Müller cells differentiate in the mouse retina. This in turn results in a thickened retina and inner nuclear layer and a higher number of differentiated Müller cells in the more developed retina. Müller cells in mutant mice contain higher amounts of nestin than those of control animals which indicates that the increase in TGF-β signaling activity during retinal development contribute to maintain some progenitor-like characteristics in Müller cells even after their differentiation period. We conclude that TGF-β signaling influences Müller cell proliferation and differentiation during retinal development. More... »

PAGES

21-32

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00418-017-1549-5

DOI

http://dx.doi.org/10.1007/s00418-017-1549-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084021762

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28258388


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Differentiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Knockout", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retina", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Smad7 Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stem Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transforming Growth Factor beta", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Institute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.7727.5", 
          "name": [
            "Institute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kugler", 
        "givenName": "Martina", 
        "id": "sg:person.01045166735.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045166735.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.7727.5", 
          "name": [
            "Institute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schlecht", 
        "givenName": "Anja", 
        "id": "sg:person.0655153371.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655153371.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.7727.5", 
          "name": [
            "Institute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fuchshofer", 
        "givenName": "Rudolf", 
        "id": "sg:person.01245307177.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245307177.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.7727.5", 
          "name": [
            "Institute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schmitt", 
        "givenName": "Sabrina I.", 
        "id": "sg:person.01365406665.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365406665.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Neurology, St. Josef-Hospital, Bochum, Germany", 
          "id": "http://www.grid.ac/institutes/grid.416438.c", 
          "name": [
            "Department of Neurology, St. Josef-Hospital, Bochum, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kleiter", 
        "givenName": "Ingo", 
        "id": "sg:person.01320012301.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320012301.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Molecular Regenerative Medicine, Spinal Cord Injury and Tissue Regeneration Center Salzburg, Paracelsus Medical University, Salzburg, Austria", 
          "id": "http://www.grid.ac/institutes/grid.21604.31", 
          "name": [
            "Institute of Molecular Regenerative Medicine, Spinal Cord Injury and Tissue Regeneration Center Salzburg, Paracelsus Medical University, Salzburg, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aigner", 
        "givenName": "Ludwig", 
        "id": "sg:person.0601706113.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601706113.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.7727.5", 
          "name": [
            "Institute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tamm", 
        "givenName": "Ernst R.", 
        "id": "sg:person.01372502067.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372502067.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.7727.5", 
          "name": [
            "Institute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Braunger", 
        "givenName": "Barbara M.", 
        "id": "sg:person.01365727053.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365727053.90"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00418-015-1354-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013579913", 
          "https://doi.org/10.1007/s00418-015-1354-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00495015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025773109", 
          "https://doi.org/10.1007/bf00495015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/78774", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053190186", 
          "https://doi.org/10.1038/78774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-213x-6-36", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028335167", 
          "https://doi.org/10.1186/1471-213x-6-36"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-03-03", 
    "datePublishedReg": "2017-03-03", 
    "description": "The transforming growth factor-\u03b2 (TGF-\u03b2) pathway contributes to maintain the quiescence of adult neural stem and progenitor cells in the brain. In the retina, M\u00fcller cells are discussed to represent a glial cell population with progenitor-like characteristics. Here, we aimed to investigate if elevated TGF-\u03b2 signaling modulates the proliferation of M\u00fcller cells during retinal development. We generated mutant mice with a systemic, heterozygous up-regulation of TGF-\u03b2 signaling by deleting its inhibitor SMAD7. We investigated apoptosis, proliferation, and differentiation of M\u00fcller cells in the developing retina. We show that a heterozygous deletion of SMAD7 results in an increased proliferation of M\u00fcller cell progenitors in the central retina at postnatal day 4, the time window when M\u00fcller cells differentiate in the mouse retina. This in turn results in a thickened retina and inner nuclear layer and a higher number of differentiated M\u00fcller cells in the more developed retina. M\u00fcller cells in mutant mice contain higher amounts of nestin than those of control animals which indicates that the increase in TGF-\u03b2 signaling activity during retinal development contribute to maintain some progenitor-like characteristics in M\u00fcller cells even after their differentiation period. We conclude that TGF-\u03b2 signaling influences M\u00fcller cell proliferation and differentiation during retinal development.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00418-017-1549-5", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1294817", 
        "issn": [
          "0948-6143", 
          "1432-119X"
        ], 
        "name": "Histochemistry and Cell Biology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "148"
      }
    ], 
    "keywords": [
      "M\u00fcller cells", 
      "progenitor-like characteristics", 
      "retinal development", 
      "mutant mice", 
      "glial cell populations", 
      "postnatal day 4", 
      "inner nuclear layer", 
      "cell proliferation", 
      "M\u00fcller cell proliferation", 
      "adult neural stem", 
      "Smad7 deficiency", 
      "progenitor cell proliferation", 
      "central retina", 
      "nuclear layer", 
      "control animals", 
      "mammalian retina", 
      "mouse retina", 
      "day 4", 
      "retina", 
      "inhibitor Smad7", 
      "neural stem", 
      "progenitor cells", 
      "cell populations", 
      "heterozygous deletion", 
      "cell progenitors", 
      "proliferation", 
      "TGF", 
      "mice", 
      "cells", 
      "differentiation period", 
      "higher number", 
      "nestin", 
      "brain", 
      "Smad7", 
      "differentiation", 
      "apoptosis", 
      "deficiency", 
      "animals", 
      "population", 
      "development", 
      "high amounts", 
      "progenitors", 
      "time window", 
      "period", 
      "deletion", 
      "activity", 
      "quiescence", 
      "regulation", 
      "increase", 
      "stem", 
      "characteristics", 
      "growth", 
      "number", 
      "results", 
      "amount", 
      "window", 
      "turn", 
      "layer"
    ], 
    "name": "SMAD7 deficiency stimulates M\u00fcller progenitor cell proliferation during the development of the mammalian retina", 
    "pagination": "21-32", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1084021762"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00418-017-1549-5"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28258388"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00418-017-1549-5", 
      "https://app.dimensions.ai/details/publication/pub.1084021762"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:36", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_719.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00418-017-1549-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00418-017-1549-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00418-017-1549-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00418-017-1549-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00418-017-1549-5'


 

This table displays all metadata directly associated to this object as RDF triples.

234 TRIPLES      21 PREDICATES      98 URIs      84 LITERALS      16 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00418-017-1549-5 schema:about N08e83e54d10f43dea8e144a16a2e89a3
2 N1bd2009738354c958624a63abea72298
3 N2ca47c1bf6de49f98773e2a98ea85255
4 N7347714834e64e1d87ea006ed5b743f1
5 Na5f22f78e7ea45e6a981534bee1a8972
6 Nb0d51fb75d3e4dcab16beff7c365fd59
7 Ncc4c2ac95e9b4375a0484463eeae3b8a
8 Ne12b884c18f547aa838fd2d6debf20ef
9 Neae926c078b14b4b89bb2a09f8fcad0c
10 anzsrc-for:06
11 anzsrc-for:0601
12 anzsrc-for:11
13 anzsrc-for:1109
14 schema:author N03681518019f427d8a71f6d9bc9de68d
15 schema:citation sg:pub.10.1007/bf00495015
16 sg:pub.10.1007/s00418-015-1354-y
17 sg:pub.10.1038/78774
18 sg:pub.10.1186/1471-213x-6-36
19 schema:datePublished 2017-03-03
20 schema:datePublishedReg 2017-03-03
21 schema:description The transforming growth factor-β (TGF-β) pathway contributes to maintain the quiescence of adult neural stem and progenitor cells in the brain. In the retina, Müller cells are discussed to represent a glial cell population with progenitor-like characteristics. Here, we aimed to investigate if elevated TGF-β signaling modulates the proliferation of Müller cells during retinal development. We generated mutant mice with a systemic, heterozygous up-regulation of TGF-β signaling by deleting its inhibitor SMAD7. We investigated apoptosis, proliferation, and differentiation of Müller cells in the developing retina. We show that a heterozygous deletion of SMAD7 results in an increased proliferation of Müller cell progenitors in the central retina at postnatal day 4, the time window when Müller cells differentiate in the mouse retina. This in turn results in a thickened retina and inner nuclear layer and a higher number of differentiated Müller cells in the more developed retina. Müller cells in mutant mice contain higher amounts of nestin than those of control animals which indicates that the increase in TGF-β signaling activity during retinal development contribute to maintain some progenitor-like characteristics in Müller cells even after their differentiation period. We conclude that TGF-β signaling influences Müller cell proliferation and differentiation during retinal development.
22 schema:genre article
23 schema:isAccessibleForFree false
24 schema:isPartOf N015b7449ef964ee48cec6a942c92836f
25 N63e9b146b6914518b21d821ae91a85c2
26 sg:journal.1294817
27 schema:keywords Müller cell proliferation
28 Müller cells
29 Smad7
30 Smad7 deficiency
31 TGF
32 activity
33 adult neural stem
34 amount
35 animals
36 apoptosis
37 brain
38 cell populations
39 cell progenitors
40 cell proliferation
41 cells
42 central retina
43 characteristics
44 control animals
45 day 4
46 deficiency
47 deletion
48 development
49 differentiation
50 differentiation period
51 glial cell populations
52 growth
53 heterozygous deletion
54 high amounts
55 higher number
56 increase
57 inhibitor Smad7
58 inner nuclear layer
59 layer
60 mammalian retina
61 mice
62 mouse retina
63 mutant mice
64 nestin
65 neural stem
66 nuclear layer
67 number
68 period
69 population
70 postnatal day 4
71 progenitor cell proliferation
72 progenitor cells
73 progenitor-like characteristics
74 progenitors
75 proliferation
76 quiescence
77 regulation
78 results
79 retina
80 retinal development
81 stem
82 time window
83 turn
84 window
85 schema:name SMAD7 deficiency stimulates Müller progenitor cell proliferation during the development of the mammalian retina
86 schema:pagination 21-32
87 schema:productId N2573c5a37eae48628c096ec67c28fd4a
88 N25ab1a28527345ffa411ec5c39da634f
89 Nf80adfa2ff29470587482e92f1c1813c
90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084021762
91 https://doi.org/10.1007/s00418-017-1549-5
92 schema:sdDatePublished 2022-12-01T06:36
93 schema:sdLicense https://scigraph.springernature.com/explorer/license/
94 schema:sdPublisher N647713f64eab485d8f2f0ccba8ccb090
95 schema:url https://doi.org/10.1007/s00418-017-1549-5
96 sgo:license sg:explorer/license/
97 sgo:sdDataset articles
98 rdf:type schema:ScholarlyArticle
99 N015b7449ef964ee48cec6a942c92836f schema:volumeNumber 148
100 rdf:type schema:PublicationVolume
101 N03681518019f427d8a71f6d9bc9de68d rdf:first sg:person.01045166735.43
102 rdf:rest Na5829f260d9c478b9ab4fd0ebcdcc987
103 N08e83e54d10f43dea8e144a16a2e89a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Cell Proliferation
105 rdf:type schema:DefinedTerm
106 N1bd2009738354c958624a63abea72298 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Cell Differentiation
108 rdf:type schema:DefinedTerm
109 N2573c5a37eae48628c096ec67c28fd4a schema:name doi
110 schema:value 10.1007/s00418-017-1549-5
111 rdf:type schema:PropertyValue
112 N25ab1a28527345ffa411ec5c39da634f schema:name pubmed_id
113 schema:value 28258388
114 rdf:type schema:PropertyValue
115 N2ca47c1bf6de49f98773e2a98ea85255 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Mice, Knockout
117 rdf:type schema:DefinedTerm
118 N379adf40cf4d4d59a4aebadacca26b17 rdf:first sg:person.0601706113.38
119 rdf:rest Ne70bd6250697466785cdd4ba9aaae1e5
120 N594a7c1596e84eaa9746f0d21c0674fb rdf:first sg:person.01245307177.58
121 rdf:rest N8b4c51f813d148baa27ff2ab1ded975a
122 N63e9b146b6914518b21d821ae91a85c2 schema:issueNumber 1
123 rdf:type schema:PublicationIssue
124 N647713f64eab485d8f2f0ccba8ccb090 schema:name Springer Nature - SN SciGraph project
125 rdf:type schema:Organization
126 N69eb21f3c926424f8446f55b034f488f rdf:first sg:person.01320012301.66
127 rdf:rest N379adf40cf4d4d59a4aebadacca26b17
128 N7347714834e64e1d87ea006ed5b743f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Transforming Growth Factor beta
130 rdf:type schema:DefinedTerm
131 N8b4c51f813d148baa27ff2ab1ded975a rdf:first sg:person.01365406665.27
132 rdf:rest N69eb21f3c926424f8446f55b034f488f
133 Na5829f260d9c478b9ab4fd0ebcdcc987 rdf:first sg:person.0655153371.62
134 rdf:rest N594a7c1596e84eaa9746f0d21c0674fb
135 Na5f22f78e7ea45e6a981534bee1a8972 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Mice
137 rdf:type schema:DefinedTerm
138 Nb0d51fb75d3e4dcab16beff7c365fd59 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Smad7 Protein
140 rdf:type schema:DefinedTerm
141 Nb6df1e25fadd41c8a629ab5192a3f569 rdf:first sg:person.01365727053.90
142 rdf:rest rdf:nil
143 Ncc4c2ac95e9b4375a0484463eeae3b8a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Retina
145 rdf:type schema:DefinedTerm
146 Ne12b884c18f547aa838fd2d6debf20ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Stem Cells
148 rdf:type schema:DefinedTerm
149 Ne70bd6250697466785cdd4ba9aaae1e5 rdf:first sg:person.01372502067.06
150 rdf:rest Nb6df1e25fadd41c8a629ab5192a3f569
151 Neae926c078b14b4b89bb2a09f8fcad0c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Animals
153 rdf:type schema:DefinedTerm
154 Nf80adfa2ff29470587482e92f1c1813c schema:name dimensions_id
155 schema:value pub.1084021762
156 rdf:type schema:PropertyValue
157 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
158 schema:name Biological Sciences
159 rdf:type schema:DefinedTerm
160 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
161 schema:name Biochemistry and Cell Biology
162 rdf:type schema:DefinedTerm
163 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
164 schema:name Medical and Health Sciences
165 rdf:type schema:DefinedTerm
166 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
167 schema:name Neurosciences
168 rdf:type schema:DefinedTerm
169 sg:journal.1294817 schema:issn 0948-6143
170 1432-119X
171 schema:name Histochemistry and Cell Biology
172 schema:publisher Springer Nature
173 rdf:type schema:Periodical
174 sg:person.01045166735.43 schema:affiliation grid-institutes:grid.7727.5
175 schema:familyName Kugler
176 schema:givenName Martina
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045166735.43
178 rdf:type schema:Person
179 sg:person.01245307177.58 schema:affiliation grid-institutes:grid.7727.5
180 schema:familyName Fuchshofer
181 schema:givenName Rudolf
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245307177.58
183 rdf:type schema:Person
184 sg:person.01320012301.66 schema:affiliation grid-institutes:grid.416438.c
185 schema:familyName Kleiter
186 schema:givenName Ingo
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320012301.66
188 rdf:type schema:Person
189 sg:person.01365406665.27 schema:affiliation grid-institutes:grid.7727.5
190 schema:familyName Schmitt
191 schema:givenName Sabrina I.
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365406665.27
193 rdf:type schema:Person
194 sg:person.01365727053.90 schema:affiliation grid-institutes:grid.7727.5
195 schema:familyName Braunger
196 schema:givenName Barbara M.
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365727053.90
198 rdf:type schema:Person
199 sg:person.01372502067.06 schema:affiliation grid-institutes:grid.7727.5
200 schema:familyName Tamm
201 schema:givenName Ernst R.
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372502067.06
203 rdf:type schema:Person
204 sg:person.0601706113.38 schema:affiliation grid-institutes:grid.21604.31
205 schema:familyName Aigner
206 schema:givenName Ludwig
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601706113.38
208 rdf:type schema:Person
209 sg:person.0655153371.62 schema:affiliation grid-institutes:grid.7727.5
210 schema:familyName Schlecht
211 schema:givenName Anja
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655153371.62
213 rdf:type schema:Person
214 sg:pub.10.1007/bf00495015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025773109
215 https://doi.org/10.1007/bf00495015
216 rdf:type schema:CreativeWork
217 sg:pub.10.1007/s00418-015-1354-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1013579913
218 https://doi.org/10.1007/s00418-015-1354-y
219 rdf:type schema:CreativeWork
220 sg:pub.10.1038/78774 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053190186
221 https://doi.org/10.1038/78774
222 rdf:type schema:CreativeWork
223 sg:pub.10.1186/1471-213x-6-36 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028335167
224 https://doi.org/10.1186/1471-213x-6-36
225 rdf:type schema:CreativeWork
226 grid-institutes:grid.21604.31 schema:alternateName Institute of Molecular Regenerative Medicine, Spinal Cord Injury and Tissue Regeneration Center Salzburg, Paracelsus Medical University, Salzburg, Austria
227 schema:name Institute of Molecular Regenerative Medicine, Spinal Cord Injury and Tissue Regeneration Center Salzburg, Paracelsus Medical University, Salzburg, Austria
228 rdf:type schema:Organization
229 grid-institutes:grid.416438.c schema:alternateName Department of Neurology, St. Josef-Hospital, Bochum, Germany
230 schema:name Department of Neurology, St. Josef-Hospital, Bochum, Germany
231 rdf:type schema:Organization
232 grid-institutes:grid.7727.5 schema:alternateName Institute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany
233 schema:name Institute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany
234 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...