Macrophage expression of tartrate-resistant acid phosphatase as a prognostic indicator in colon cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-08

AUTHORS

Joan How, Jason R. Brown, Sasha Saylor, David L. Rimm

ABSTRACT

Recent research has indicated that separate populations of macrophages are associated with differing outcomes in cancer survival. In our study, we examine macrophage expression of tartrate-resistant acid phosphatase (TRAP) and its effect on survival in colon cancer. Immunohistochemical analysis on colorectal adenocarcinomas confirmed macrophage expression of TRAP. Co-localization of TRAP with CD68, a pan-macrophage marker, revealed that TRAP is present in some but not all sub-populations of macrophages. Further co-localization of TRAP with CD163, an M2 marker, revealed that TRAP is expressed by both M2 and non-M2 macrophages. TRAP expression was then measured using the AQUA method of quantitative immunofluorescence in a tissue microarray consisting of 233 colorectal cancer patients seen at Yale-New Haven Hospital. Survival analysis revealed that patients with high TRAP expression have a 22 % increase in 5-year survival (uncorrected log-rank p = 0.025) and a 47 % risk reduction in disease-specific death (p = 0.02). This finding was validated in a second cohort of older cases consisting of 505 colorectal cancer patients. Patients with high TRAP expression in the validation set had a 19 % increase in 5-year survival (log-rank p = 0.0041) and a 52 % risk reduction in death (p = 0.0019). These results provide evidence that macrophage expression of TRAP is associated with improved outcome and implicates TRAP as a potential biomarker in colon cancer. More... »

PAGES

195-204

References to SciGraph publications

  • 2009-12. Biology and Clinical Significance of Tartrate-Resistant Acid Phosphatases: New Perspectives on an Old Enzyme in CALCIFIED TISSUE INTERNATIONAL
  • 2002-11. Automated subcellular localization and quantification of protein expression in tissue microarrays in NATURE MEDICINE
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  • 2012-12. The presence of tumor associated macrophages in tumor stroma as a prognostic marker for breast cancer patients in BMC CANCER
  • 2012-09. Characterisation of tumour-infiltrating macrophages: impact on response and survival in patients receiving primary chemotherapy for breast cancer in BREAST CANCER RESEARCH AND TREATMENT
  • 2007-12. Inflammatory cell infiltration of tumors: Jekyll or Hyde in CANCER AND METASTASIS REVIEWS
  • 1998-05. Different patterns of stromal and cancer cell thymidine phosphorylase reactivity in non-small-cell lung cancer: impact on tumour neoangiogenesis and survival in BRITISH JOURNAL OF CANCER
  • 1997-02. Infiltration of mononuclear inflammatory cells into primary colorectal carcinomas: an immunohistological analysis in BRITISH JOURNAL OF CANCER
  • 2007-12. Tumor-infiltrating macrophages and dendritic cells in human colorectal cancer: relation to local regulatory T cells, systemic T-cell response against tumor-associated antigens and survival in JOURNAL OF TRANSLATIONAL MEDICINE
  • 2006-12. Increased tartrate-resistant acid phosphatase (TRAP) expression in malignant breast, ovarian and melanoma tissue: an investigational study in BMC CANCER
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00418-014-1181-6

    DOI

    http://dx.doi.org/10.1007/s00418-014-1181-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1045521578

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24429833


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    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

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    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00418-014-1181-6'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00418-014-1181-6'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00418-014-1181-6'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00418-014-1181-6'


     

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