BPIFB1 (LPLUNC1) is upregulated in cystic fibrosis lung disease View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-11

AUTHORS

Lynne Bingle, Kirsty Wilson, Maslinda Musa, Bianca Araujo, Doris Rassl, William A. Wallace, Elizabeth E. LeClair, Thais Mauad, Zhe Zhou, Marcus A. Mall, Colin D. Bingle

ABSTRACT

Although the biology the PLUNC (recently renamed BPI fold, BPIF) family of secreted proteins is poorly understood, multiple array based studies have suggested that some are differentially expressed in lung diseases. We have examined the expression of BPIFB1 (LPLUNC1), the prototypic two-domain containing family member, in lungs from CF patients and in mouse models of CF lung disease. BPIFB1 was localized in CF lung samples along with BPIFA1, MUC5AC, CD68 and NE and directly compared to histologically normal lung tissues and that of bacterial pneumonia. We generated novel antibodies to mouse BPIF proteins to conduct similar studies on ENaC transgenic (ENaC-Tg) mice, a model for CF-like lung disease. Small airways in CF demonstrated marked epithelial staining of BPIFB1 in goblet cells but staining was absent from alveolar regions. BPIFA1 and BPIFB1 were not co-localised in the diseased lungs. In ENaC-Tg mice there was strong staining of both proteins in the airways and luminal contents. This was most marked for BPIFB1 and was noted within 2 weeks of birth. The two proteins were present in distinct cells within epithelium. BPIFB1 was readily detected in BAL from ENaC-Tg mice but was absent from wild-type mice. Alterations in the expression of BPIF proteins is associated with CF lung disease in humans and mice. It is unclear if this elevation of protein production, which results from phenotypic alteration of the cells within the diseased epithelium, plays a role in the pathogenesis of the disease. More... »

PAGES

749-758

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00418-012-0990-8

DOI

http://dx.doi.org/10.1007/s00418-012-0990-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005802106

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22767025


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