Distribution of vitamin D binding protein expressing neurons in the rat hypothalamus View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-11-26

AUTHORS

Gustav F. Jirikowski, Ulrike W. Kauntzer, Abeer El Emmam Dief, Jack D. Caldwell

ABSTRACT

We observed immunostaining for vitamin D binding protein (DBP) in rat hypothalamus. Part of the supraoptic and of the paraventricular neurons showed DBP immunoreactivity, in part colocalized with Arg-vasopressin. DBP was also observed in widespread axonal projections throughout the lateral hypothalamus, the median eminence and the posterior pituitary lobe. A portion of ependymal cells, the choroids plexus epithelium and some of the endocrine cells in the anterior pituitary lobe contained DBP immunoreactivity. In situ hybridization of semithin sections with a synthetic oligonucleotide probe to DBP mRNA resulted in staining of magnocellular hypothalamic neurons, but not of ependymal cells or anterior lobe cells. Our observations indicate an intrinsic expression of DBP in the rat hypothalamus. DBP may be synthesized and transported along with the classical neurohypophyseal hormones. The multiple locations of DBP-expressing neurons indicate multiple functional properties: DBP may be released from in the posterior lobe, it may act as a hypophyseotropic factor and as a central neuroactive substance. More... »

PAGES

365

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00418-008-0540-6

DOI

http://dx.doi.org/10.1007/s00418-008-0540-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046276441

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19034485


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypothalamus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "In Situ Hybridization", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neurons", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tissue Distribution", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vitamin D-Binding Protein", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Institute of F\u00fcr Anatomie II, Klinium der FSU, Teichgraben 7, 07749, Jena, Germany", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Anatomy II, Friedrich Schiller Universit\u00e4t Jena, PF, Jena, Germany", 
            "Institute of F\u00fcr Anatomie II, Klinium der FSU, Teichgraben 7, 07749, Jena, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jirikowski", 
        "givenName": "Gustav F.", 
        "id": "sg:person.01321665663.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321665663.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratory of Neuroendocrinology, Rockefeller University, New York, NY, USA", 
          "id": "http://www.grid.ac/institutes/grid.134907.8", 
          "name": [
            "Laboratory of Neuroendocrinology, Rockefeller University, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kauntzer", 
        "givenName": "Ulrike W.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Physiology, University of Alexandria, Alexandria, Egypt", 
          "id": "http://www.grid.ac/institutes/grid.7155.6", 
          "name": [
            "Department of Physiology, University of Alexandria, Alexandria, Egypt"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dief", 
        "givenName": "Abeer El Emmam", 
        "id": "sg:person.01045161652.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045161652.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Lake Erie College of Osteopathic Medicine, Erie, PA, USA", 
          "id": "http://www.grid.ac/institutes/grid.419183.6", 
          "name": [
            "Lake Erie College of Osteopathic Medicine, Erie, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Caldwell", 
        "givenName": "Jack D.", 
        "id": "sg:person.01176672271.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176672271.66"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf00501911", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042683652", 
          "https://doi.org/10.1007/bf00501911"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10571-008-9312-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044727674", 
          "https://doi.org/10.1007/s10571-008-9312-z"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008-11-26", 
    "datePublishedReg": "2008-11-26", 
    "description": "We observed immunostaining for vitamin D binding protein (DBP) in rat hypothalamus. Part of the supraoptic and of the paraventricular neurons showed DBP immunoreactivity, in part colocalized with Arg-vasopressin. DBP was also observed in widespread axonal projections throughout the lateral hypothalamus, the median eminence and the posterior pituitary lobe. A portion of ependymal cells, the choroids plexus epithelium and some of the endocrine cells in the anterior pituitary lobe contained DBP immunoreactivity. In situ hybridization of semithin sections with a synthetic oligonucleotide probe to DBP mRNA resulted in staining of magnocellular hypothalamic neurons, but not of ependymal cells or anterior lobe cells. Our observations indicate an intrinsic expression of DBP in the rat hypothalamus. DBP may be synthesized and transported along with the classical neurohypophyseal hormones. The multiple locations of DBP-expressing neurons indicate multiple functional properties: DBP may be released from in the posterior lobe, it may act as a hypophyseotropic factor and as a central neuroactive substance.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00418-008-0540-6", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1294817", 
        "issn": [
          "0948-6143", 
          "1432-119X"
        ], 
        "name": "Histochemistry and Cell Biology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "131"
      }
    ], 
    "keywords": [
      "D binding protein", 
      "rat hypothalamus", 
      "pituitary lobe", 
      "ependymal cells", 
      "widespread axonal projections", 
      "vitamin D binding protein", 
      "magnocellular hypothalamic neurons", 
      "anterior pituitary lobe", 
      "anterior lobe cells", 
      "posterior pituitary lobe", 
      "choroid plexus epithelium", 
      "vitamin D", 
      "hypothalamic neurons", 
      "paraventricular neurons", 
      "lateral hypothalamus", 
      "neuroactive substances", 
      "axonal projections", 
      "median eminence", 
      "hypothalamus", 
      "plexus epithelium", 
      "posterior lobe", 
      "endocrine cells", 
      "neurons", 
      "Arg-vasopressin", 
      "neurohypophyseal hormones", 
      "intrinsic expression", 
      "immunoreactivity", 
      "lobe cells", 
      "lobe", 
      "semithin sections", 
      "situ hybridization", 
      "cells", 
      "binding protein", 
      "DBP mRNA", 
      "hormone", 
      "epithelium", 
      "eminence", 
      "staining", 
      "synthetic oligonucleotide probes", 
      "protein", 
      "functional properties", 
      "mRNA", 
      "expression", 
      "multiple functional properties", 
      "oligonucleotide probes", 
      "factors", 
      "substances", 
      "hybridization", 
      "part", 
      "portion", 
      "multiple locations", 
      "projections", 
      "sections", 
      "observations", 
      "location", 
      "probe", 
      "distribution", 
      "properties", 
      "DBP immunoreactivity", 
      "classical neurohypophyseal hormones", 
      "hypophyseotropic factor", 
      "central neuroactive substance"
    ], 
    "name": "Distribution of vitamin D binding protein expressing neurons in the rat hypothalamus", 
    "pagination": "365", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1046276441"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00418-008-0540-6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "19034485"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00418-008-0540-6", 
      "https://app.dimensions.ai/details/publication/pub.1046276441"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:18", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_459.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00418-008-0540-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00418-008-0540-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00418-008-0540-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00418-008-0540-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00418-008-0540-6'


 

This table displays all metadata directly associated to this object as RDF triples.

198 TRIPLES      22 PREDICATES      99 URIs      89 LITERALS      16 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00418-008-0540-6 schema:about N002afb4c1868425eabfbd71dd322c6b2
2 N285e85cde47d41509003c86db6a903b3
3 N32f23ea0e9c644228ff93703e12108dd
4 N3d7f63d3854546a2bca6e0d7ba7571cf
5 N6b01d269f2b341ecb5b6ff3e9e8f44c9
6 N8476951698504479b1f39883eb927c42
7 N86ca6bc4b76d4c07922a3f2e43ffc6b5
8 N9e1eff2273fe401d8bfadf0a1e1fa9f6
9 Nb05ec80a3c834628963522dffe4910f0
10 anzsrc-for:11
11 anzsrc-for:1109
12 schema:author Na7f4ed7c213d49d3a54e1b78789c8623
13 schema:citation sg:pub.10.1007/bf00501911
14 sg:pub.10.1007/s10571-008-9312-z
15 schema:datePublished 2008-11-26
16 schema:datePublishedReg 2008-11-26
17 schema:description We observed immunostaining for vitamin D binding protein (DBP) in rat hypothalamus. Part of the supraoptic and of the paraventricular neurons showed DBP immunoreactivity, in part colocalized with Arg-vasopressin. DBP was also observed in widespread axonal projections throughout the lateral hypothalamus, the median eminence and the posterior pituitary lobe. A portion of ependymal cells, the choroids plexus epithelium and some of the endocrine cells in the anterior pituitary lobe contained DBP immunoreactivity. In situ hybridization of semithin sections with a synthetic oligonucleotide probe to DBP mRNA resulted in staining of magnocellular hypothalamic neurons, but not of ependymal cells or anterior lobe cells. Our observations indicate an intrinsic expression of DBP in the rat hypothalamus. DBP may be synthesized and transported along with the classical neurohypophyseal hormones. The multiple locations of DBP-expressing neurons indicate multiple functional properties: DBP may be released from in the posterior lobe, it may act as a hypophyseotropic factor and as a central neuroactive substance.
18 schema:genre article
19 schema:inLanguage en
20 schema:isAccessibleForFree false
21 schema:isPartOf N23ff1bea22914f179fe69e61c2bcf76f
22 N8011d4b43a8a4e61a3e65a311137772c
23 sg:journal.1294817
24 schema:keywords Arg-vasopressin
25 D binding protein
26 DBP immunoreactivity
27 DBP mRNA
28 anterior lobe cells
29 anterior pituitary lobe
30 axonal projections
31 binding protein
32 cells
33 central neuroactive substance
34 choroid plexus epithelium
35 classical neurohypophyseal hormones
36 distribution
37 eminence
38 endocrine cells
39 ependymal cells
40 epithelium
41 expression
42 factors
43 functional properties
44 hormone
45 hybridization
46 hypophyseotropic factor
47 hypothalamic neurons
48 hypothalamus
49 immunoreactivity
50 intrinsic expression
51 lateral hypothalamus
52 lobe
53 lobe cells
54 location
55 mRNA
56 magnocellular hypothalamic neurons
57 median eminence
58 multiple functional properties
59 multiple locations
60 neuroactive substances
61 neurohypophyseal hormones
62 neurons
63 observations
64 oligonucleotide probes
65 paraventricular neurons
66 part
67 pituitary lobe
68 plexus epithelium
69 portion
70 posterior lobe
71 posterior pituitary lobe
72 probe
73 projections
74 properties
75 protein
76 rat hypothalamus
77 sections
78 semithin sections
79 situ hybridization
80 staining
81 substances
82 synthetic oligonucleotide probes
83 vitamin D
84 vitamin D binding protein
85 widespread axonal projections
86 schema:name Distribution of vitamin D binding protein expressing neurons in the rat hypothalamus
87 schema:pagination 365
88 schema:productId N0c488f3028d9471287784237808a2e84
89 N964af1ac39094952a2e1a0d88ebd61bf
90 Nb39b82d6acbf4e9797976d37b8c0e48b
91 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046276441
92 https://doi.org/10.1007/s00418-008-0540-6
93 schema:sdDatePublished 2022-01-01T18:18
94 schema:sdLicense https://scigraph.springernature.com/explorer/license/
95 schema:sdPublisher N741e34a84ad647548d625d53f7c0cd6f
96 schema:url https://doi.org/10.1007/s00418-008-0540-6
97 sgo:license sg:explorer/license/
98 sgo:sdDataset articles
99 rdf:type schema:ScholarlyArticle
100 N002afb4c1868425eabfbd71dd322c6b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Tissue Distribution
102 rdf:type schema:DefinedTerm
103 N0c488f3028d9471287784237808a2e84 schema:name dimensions_id
104 schema:value pub.1046276441
105 rdf:type schema:PropertyValue
106 N23ff1bea22914f179fe69e61c2bcf76f schema:issueNumber 3
107 rdf:type schema:PublicationIssue
108 N285e85cde47d41509003c86db6a903b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Hypothalamus
110 rdf:type schema:DefinedTerm
111 N32f23ea0e9c644228ff93703e12108dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Vitamin D-Binding Protein
113 rdf:type schema:DefinedTerm
114 N3d7f63d3854546a2bca6e0d7ba7571cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Rats
116 rdf:type schema:DefinedTerm
117 N6b01d269f2b341ecb5b6ff3e9e8f44c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Neurons
119 rdf:type schema:DefinedTerm
120 N741e34a84ad647548d625d53f7c0cd6f schema:name Springer Nature - SN SciGraph project
121 rdf:type schema:Organization
122 N8011d4b43a8a4e61a3e65a311137772c schema:volumeNumber 131
123 rdf:type schema:PublicationVolume
124 N8476951698504479b1f39883eb927c42 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name In Situ Hybridization
126 rdf:type schema:DefinedTerm
127 N86b0aa31def2474f9795c2c265e5c993 rdf:first Ne241b65e4e2e458e9a3380b6c73d4a1b
128 rdf:rest Nbc2d1b8036394055b6872f8ed2f6154c
129 N86ca6bc4b76d4c07922a3f2e43ffc6b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Animals
131 rdf:type schema:DefinedTerm
132 N964af1ac39094952a2e1a0d88ebd61bf schema:name doi
133 schema:value 10.1007/s00418-008-0540-6
134 rdf:type schema:PropertyValue
135 N9e1eff2273fe401d8bfadf0a1e1fa9f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Immunohistochemistry
137 rdf:type schema:DefinedTerm
138 Na7f4ed7c213d49d3a54e1b78789c8623 rdf:first sg:person.01321665663.87
139 rdf:rest N86b0aa31def2474f9795c2c265e5c993
140 Nb05ec80a3c834628963522dffe4910f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name RNA, Messenger
142 rdf:type schema:DefinedTerm
143 Nb39b82d6acbf4e9797976d37b8c0e48b schema:name pubmed_id
144 schema:value 19034485
145 rdf:type schema:PropertyValue
146 Nb3d47d29e2ec4c08acd775b92c4e51c9 rdf:first sg:person.01176672271.66
147 rdf:rest rdf:nil
148 Nbc2d1b8036394055b6872f8ed2f6154c rdf:first sg:person.01045161652.05
149 rdf:rest Nb3d47d29e2ec4c08acd775b92c4e51c9
150 Ne241b65e4e2e458e9a3380b6c73d4a1b schema:affiliation grid-institutes:grid.134907.8
151 schema:familyName Kauntzer
152 schema:givenName Ulrike W.
153 rdf:type schema:Person
154 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
155 schema:name Medical and Health Sciences
156 rdf:type schema:DefinedTerm
157 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
158 schema:name Neurosciences
159 rdf:type schema:DefinedTerm
160 sg:journal.1294817 schema:issn 0948-6143
161 1432-119X
162 schema:name Histochemistry and Cell Biology
163 schema:publisher Springer Nature
164 rdf:type schema:Periodical
165 sg:person.01045161652.05 schema:affiliation grid-institutes:grid.7155.6
166 schema:familyName Dief
167 schema:givenName Abeer El Emmam
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045161652.05
169 rdf:type schema:Person
170 sg:person.01176672271.66 schema:affiliation grid-institutes:grid.419183.6
171 schema:familyName Caldwell
172 schema:givenName Jack D.
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176672271.66
174 rdf:type schema:Person
175 sg:person.01321665663.87 schema:affiliation grid-institutes:None
176 schema:familyName Jirikowski
177 schema:givenName Gustav F.
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321665663.87
179 rdf:type schema:Person
180 sg:pub.10.1007/bf00501911 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042683652
181 https://doi.org/10.1007/bf00501911
182 rdf:type schema:CreativeWork
183 sg:pub.10.1007/s10571-008-9312-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1044727674
184 https://doi.org/10.1007/s10571-008-9312-z
185 rdf:type schema:CreativeWork
186 grid-institutes:None schema:alternateName Institute of Für Anatomie II, Klinium der FSU, Teichgraben 7, 07749, Jena, Germany
187 schema:name Department of Anatomy II, Friedrich Schiller Universität Jena, PF, Jena, Germany
188 Institute of Für Anatomie II, Klinium der FSU, Teichgraben 7, 07749, Jena, Germany
189 rdf:type schema:Organization
190 grid-institutes:grid.134907.8 schema:alternateName Laboratory of Neuroendocrinology, Rockefeller University, New York, NY, USA
191 schema:name Laboratory of Neuroendocrinology, Rockefeller University, New York, NY, USA
192 rdf:type schema:Organization
193 grid-institutes:grid.419183.6 schema:alternateName Lake Erie College of Osteopathic Medicine, Erie, PA, USA
194 schema:name Lake Erie College of Osteopathic Medicine, Erie, PA, USA
195 rdf:type schema:Organization
196 grid-institutes:grid.7155.6 schema:alternateName Department of Physiology, University of Alexandria, Alexandria, Egypt
197 schema:name Department of Physiology, University of Alexandria, Alexandria, Egypt
198 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...