Neuroprotective properties of ciliary neurotrophic factor for cultured adult rat dorsal root ganglion neurons View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-08-05

AUTHORS

Kazunori Sango, Hiroko Yanagisawa, Yukari Komuta, Yang Si, Hitoshi Kawano

ABSTRACT

We observed that recombinant ciliary neurotrophic factor (CNTF) enhanced survival and neurite outgrowth of cultured adult rat dorsal root ganglion (DRG) neurons. Among other neurotrophic factors (NGF and GDNF) and interleukin (IL)-6 cytokine members [IL-6, LIF, cardiotrophin-1, and oncostatin M (OSM)] at the same concentration (50 ng/ml), CNTF, as well as LIF and OSM, displayed high efficacy for the promotion of the number of viable neurons and neurite-bearing cells. CNTF enhanced the number of neurite-bearing cells in both small neurons (soma diameter <30 μm) and large neurons (soma diameter ≥30 μm), whereas NGF and GDNF promoted that in only small neurons. Western blot analysis revealed that CNTF induced phosphorylation of STAT3, Akt, and ERK1/2 in the neurons. Furthermore, the neurite outgrowth-promoting activity of CNTF was diminished by co-treatment with Janus kinase (JAK) 2 inhibitor, AG490; STAT3 inhibitor, STA-21; phosphatidyl inositol-3′-phosphate-kinase (PI3K) inhibitor, LY294002; and mitogen-activated protein kinase kinase (MEK) inhibitor, PD98059, in a concentration-dependent manner. Its survival-promoting activity was also affected by AG490, STA-21, and LY294002 at higher concentrations, but not by PD98059. These findings suggest the involvement of JAK2/STAT3, PI3K/Akt, and MEK/ERK signaling pathways in CNTF-induced neurite outgrowth, where the former two pathways are thought to play major roles in mediating the survival response of neurons to CNTF. More... »

PAGES

669-679

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00418-008-0484-x

DOI

http://dx.doi.org/10.1007/s00418-008-0484-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024683471

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18679704


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromones", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ciliary Neurotrophic Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dose-Response Relationship, Drug", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Flavonoids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ganglia, Spinal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitogen-Activated Protein Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Morpholines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neurons", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neuroprotective Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphorylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polycyclic Compounds", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins c-akt", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Wistar", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "STAT3 Transcription Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tyrphostins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Division of Neural Development and Regeneration, Department of Developmental Morphology, Tokyo Metropolitan Institute for Neuroscience, 2-6 Musashidai, Fuchu, 183-8526, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272456.0", 
          "name": [
            "Division of Neural Development and Regeneration, Department of Developmental Morphology, Tokyo Metropolitan Institute for Neuroscience, 2-6 Musashidai, Fuchu, 183-8526, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sango", 
        "givenName": "Kazunori", 
        "id": "sg:person.0737564767.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737564767.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Neural Development and Regeneration, Department of Developmental Morphology, Tokyo Metropolitan Institute for Neuroscience, 2-6 Musashidai, Fuchu, 183-8526, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272456.0", 
          "name": [
            "Division of Neural Development and Regeneration, Department of Developmental Morphology, Tokyo Metropolitan Institute for Neuroscience, 2-6 Musashidai, Fuchu, 183-8526, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yanagisawa", 
        "givenName": "Hiroko", 
        "id": "sg:person.0744057267.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744057267.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Neural Development and Regeneration, Department of Developmental Morphology, Tokyo Metropolitan Institute for Neuroscience, 2-6 Musashidai, Fuchu, 183-8526, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272456.0", 
          "name": [
            "Division of Neural Development and Regeneration, Department of Developmental Morphology, Tokyo Metropolitan Institute for Neuroscience, 2-6 Musashidai, Fuchu, 183-8526, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Komuta", 
        "givenName": "Yukari", 
        "id": "sg:person.01321220777.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321220777.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Neural Development and Regeneration, Department of Developmental Morphology, Tokyo Metropolitan Institute for Neuroscience, 2-6 Musashidai, Fuchu, 183-8526, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272456.0", 
          "name": [
            "Division of Neural Development and Regeneration, Department of Developmental Morphology, Tokyo Metropolitan Institute for Neuroscience, 2-6 Musashidai, Fuchu, 183-8526, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Si", 
        "givenName": "Yang", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Neural Development and Regeneration, Department of Developmental Morphology, Tokyo Metropolitan Institute for Neuroscience, 2-6 Musashidai, Fuchu, 183-8526, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272456.0", 
          "name": [
            "Division of Neural Development and Regeneration, Department of Developmental Morphology, Tokyo Metropolitan Institute for Neuroscience, 2-6 Musashidai, Fuchu, 183-8526, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kawano", 
        "givenName": "Hitoshi", 
        "id": "sg:person.01204772377.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204772377.08"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/35046558", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018577936", 
          "https://doi.org/10.1038/35046558"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00418-007-0290-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002395218", 
          "https://doi.org/10.1007/s00418-007-0290-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-0-387-30381-9_3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020270470", 
          "https://doi.org/10.1007/978-0-387-30381-9_3"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008-08-05", 
    "datePublishedReg": "2008-08-05", 
    "description": "We observed that recombinant ciliary neurotrophic factor (CNTF) enhanced survival and neurite outgrowth of cultured adult rat dorsal root ganglion (DRG) neurons. Among other neurotrophic factors (NGF and GDNF) and interleukin (IL)-6 cytokine members [IL-6, LIF, cardiotrophin-1, and oncostatin M (OSM)] at the same concentration (50\u00a0ng/ml), CNTF, as well as LIF and OSM, displayed high efficacy for the promotion of the number of viable neurons and neurite-bearing cells. CNTF enhanced the number of neurite-bearing cells in both small neurons (soma diameter <30\u00a0\u03bcm) and large neurons (soma diameter \u226530\u00a0\u03bcm), whereas NGF and GDNF promoted that in only small neurons. Western blot analysis revealed that CNTF induced phosphorylation of STAT3, Akt, and ERK1/2 in the neurons. Furthermore, the neurite outgrowth-promoting activity of CNTF was diminished by co-treatment with Janus kinase (JAK) 2 inhibitor, AG490; STAT3 inhibitor, STA-21; phosphatidyl inositol-3\u2032-phosphate-kinase (PI3K) inhibitor, LY294002; and mitogen-activated protein kinase kinase (MEK) inhibitor, PD98059, in a concentration-dependent manner. Its survival-promoting activity was also affected by AG490, STA-21, and LY294002 at higher concentrations, but not by PD98059. These findings suggest the involvement of JAK2/STAT3, PI3K/Akt, and MEK/ERK signaling pathways in CNTF-induced neurite outgrowth, where the former two pathways are thought to play major roles in mediating the survival response of neurons to CNTF.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00418-008-0484-x", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1294817", 
        "issn": [
          "0948-6143", 
          "1432-119X"
        ], 
        "name": "Histochemistry and Cell Biology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "130"
      }
    ], 
    "keywords": [
      "neurite-bearing cells", 
      "ciliary neurotrophic factor", 
      "cultured adult rat dorsal root ganglion neurons", 
      "mitogen-activated protein kinase kinase inhibitor", 
      "protein kinase kinase inhibitor", 
      "neurite outgrowth", 
      "kinase kinase inhibitor", 
      "MEK/ERK", 
      "kinase inhibitors", 
      "STA-21", 
      "phosphorylation of STAT3", 
      "PI3K/Akt", 
      "Janus kinase 2 inhibitor", 
      "kinase 2 inhibitor", 
      "neurite outgrowth-promoting activity", 
      "JAK2/STAT3", 
      "survival-promoting activity", 
      "Western blot analysis", 
      "outgrowth-promoting activity", 
      "STAT3 inhibitor", 
      "survival response", 
      "recombinant ciliary neurotrophic factor", 
      "blot analysis", 
      "dorsal root ganglion neurons", 
      "PD98059", 
      "LY294002", 
      "concentration-dependent manner", 
      "Akt", 
      "STAT3", 
      "pathway", 
      "inhibitors", 
      "outgrowth", 
      "rat dorsal root ganglion neurons", 
      "neurotrophic factor", 
      "ganglion neurons", 
      "cells", 
      "major role", 
      "phosphorylation", 
      "adult rat dorsal root ganglion neurons", 
      "ERK", 
      "AG490", 
      "ERK1/2", 
      "neurons", 
      "phosphatidyl", 
      "activity", 
      "high concentrations", 
      "cytokine member", 
      "same concentration", 
      "GDNF", 
      "NGF", 
      "members", 
      "factors", 
      "role", 
      "survival", 
      "manner", 
      "large neurons", 
      "OSM", 
      "number", 
      "response", 
      "viable neurons", 
      "small neurons", 
      "concentration", 
      "involvement", 
      "analysis", 
      "neuroprotective properties", 
      "high efficacy", 
      "interleukin", 
      "findings", 
      "promotion", 
      "LiF", 
      "properties", 
      "efficacy", 
      "root ganglion (DRG) neurons", 
      "only small neurons", 
      "CNTF-induced neurite outgrowth"
    ], 
    "name": "Neuroprotective properties of ciliary neurotrophic factor for cultured adult rat dorsal root ganglion neurons", 
    "pagination": "669-679", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1024683471"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00418-008-0484-x"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "18679704"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00418-008-0484-x", 
      "https://app.dimensions.ai/details/publication/pub.1024683471"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:19", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_474.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00418-008-0484-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00418-008-0484-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00418-008-0484-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00418-008-0484-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00418-008-0484-x'


 

This table displays all metadata directly associated to this object as RDF triples.

264 TRIPLES      22 PREDICATES      126 URIs      115 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00418-008-0484-x schema:about N14893d4e187a4321ae1c7e6ee45419e9
2 N2ac00a2e268f46ceb65416e6f45c03bc
3 N383746e47977458c936487efe309372d
4 N3a888e68b11944258de51d7f006834ac
5 N4842f8d54d69496e93401d43c76412df
6 N4e94782da0df46749a4fd6cdf7421e51
7 N5759ebaf6204418b8d0f484b921388db
8 N578564499e494c018f9933053f278f55
9 N75ec63b5fda0439199d975b0389e1158
10 N7e79295ff9074b65b1cc2769a6a24994
11 N88ffb1908b6643fea455a5990944709d
12 N8a061f207a6d4a6cb80196a3ec28568a
13 N90ffe2488ebc46489666983a7e854d5d
14 Na8fc714f40a14692ade1665baf12a21d
15 Nac163854ac964dfaafb588011de5a7b4
16 Nacf60216c10d4e19b41649b597e8e46d
17 Nada4baf1a8aa40c28a6572af86d8c8cf
18 Nb9ed088ec5314cb4b00f91c76d7d4497
19 Nbb9fbf61591f49c895ec5bdd920537c3
20 Ncc8c218f0f8146458c9b2ea997c900ca
21 Ncdec77f0b8c34b7fb4dec7a9eb59fa16
22 Nf20c39c8cdc642279678ac46bae2fd9c
23 anzsrc-for:06
24 anzsrc-for:0601
25 schema:author Nd73a63dff00a4c0dbd657820a2dcd179
26 schema:citation sg:pub.10.1007/978-0-387-30381-9_3
27 sg:pub.10.1007/s00418-007-0290-x
28 sg:pub.10.1038/35046558
29 schema:datePublished 2008-08-05
30 schema:datePublishedReg 2008-08-05
31 schema:description We observed that recombinant ciliary neurotrophic factor (CNTF) enhanced survival and neurite outgrowth of cultured adult rat dorsal root ganglion (DRG) neurons. Among other neurotrophic factors (NGF and GDNF) and interleukin (IL)-6 cytokine members [IL-6, LIF, cardiotrophin-1, and oncostatin M (OSM)] at the same concentration (50 ng/ml), CNTF, as well as LIF and OSM, displayed high efficacy for the promotion of the number of viable neurons and neurite-bearing cells. CNTF enhanced the number of neurite-bearing cells in both small neurons (soma diameter <30 μm) and large neurons (soma diameter ≥30 μm), whereas NGF and GDNF promoted that in only small neurons. Western blot analysis revealed that CNTF induced phosphorylation of STAT3, Akt, and ERK1/2 in the neurons. Furthermore, the neurite outgrowth-promoting activity of CNTF was diminished by co-treatment with Janus kinase (JAK) 2 inhibitor, AG490; STAT3 inhibitor, STA-21; phosphatidyl inositol-3′-phosphate-kinase (PI3K) inhibitor, LY294002; and mitogen-activated protein kinase kinase (MEK) inhibitor, PD98059, in a concentration-dependent manner. Its survival-promoting activity was also affected by AG490, STA-21, and LY294002 at higher concentrations, but not by PD98059. These findings suggest the involvement of JAK2/STAT3, PI3K/Akt, and MEK/ERK signaling pathways in CNTF-induced neurite outgrowth, where the former two pathways are thought to play major roles in mediating the survival response of neurons to CNTF.
32 schema:genre article
33 schema:inLanguage en
34 schema:isAccessibleForFree false
35 schema:isPartOf N6eb27bded0064444994de2fdca7ad240
36 N967f9b2be61b4e01a68b37b1a40bd78e
37 sg:journal.1294817
38 schema:keywords AG490
39 Akt
40 CNTF-induced neurite outgrowth
41 ERK
42 ERK1/2
43 GDNF
44 JAK2/STAT3
45 Janus kinase 2 inhibitor
46 LY294002
47 LiF
48 MEK/ERK
49 NGF
50 OSM
51 PD98059
52 PI3K/Akt
53 STA-21
54 STAT3
55 STAT3 inhibitor
56 Western blot analysis
57 activity
58 adult rat dorsal root ganglion neurons
59 analysis
60 blot analysis
61 cells
62 ciliary neurotrophic factor
63 concentration
64 concentration-dependent manner
65 cultured adult rat dorsal root ganglion neurons
66 cytokine member
67 dorsal root ganglion neurons
68 efficacy
69 factors
70 findings
71 ganglion neurons
72 high concentrations
73 high efficacy
74 inhibitors
75 interleukin
76 involvement
77 kinase 2 inhibitor
78 kinase inhibitors
79 kinase kinase inhibitor
80 large neurons
81 major role
82 manner
83 members
84 mitogen-activated protein kinase kinase inhibitor
85 neurite outgrowth
86 neurite outgrowth-promoting activity
87 neurite-bearing cells
88 neurons
89 neuroprotective properties
90 neurotrophic factor
91 number
92 only small neurons
93 outgrowth
94 outgrowth-promoting activity
95 pathway
96 phosphatidyl
97 phosphorylation
98 phosphorylation of STAT3
99 promotion
100 properties
101 protein kinase kinase inhibitor
102 rat dorsal root ganglion neurons
103 recombinant ciliary neurotrophic factor
104 response
105 role
106 root ganglion (DRG) neurons
107 same concentration
108 small neurons
109 survival
110 survival response
111 survival-promoting activity
112 viable neurons
113 schema:name Neuroprotective properties of ciliary neurotrophic factor for cultured adult rat dorsal root ganglion neurons
114 schema:pagination 669-679
115 schema:productId N0738061e679147e39348393c9039acad
116 N938e6849406e4b608b67eccd3d558511
117 N9780f6bd8f624cefb47fd37922cd450c
118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024683471
119 https://doi.org/10.1007/s00418-008-0484-x
120 schema:sdDatePublished 2022-01-01T18:19
121 schema:sdLicense https://scigraph.springernature.com/explorer/license/
122 schema:sdPublisher N332df54dc5de499ab65fe8d063fb18d0
123 schema:url https://doi.org/10.1007/s00418-008-0484-x
124 sgo:license sg:explorer/license/
125 sgo:sdDataset articles
126 rdf:type schema:ScholarlyArticle
127 N0738061e679147e39348393c9039acad schema:name doi
128 schema:value 10.1007/s00418-008-0484-x
129 rdf:type schema:PropertyValue
130 N14893d4e187a4321ae1c7e6ee45419e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Rats
132 rdf:type schema:DefinedTerm
133 N2ac00a2e268f46ceb65416e6f45c03bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Polycyclic Compounds
135 rdf:type schema:DefinedTerm
136 N332df54dc5de499ab65fe8d063fb18d0 schema:name Springer Nature - SN SciGraph project
137 rdf:type schema:Organization
138 N383746e47977458c936487efe309372d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Dose-Response Relationship, Drug
140 rdf:type schema:DefinedTerm
141 N3a888e68b11944258de51d7f006834ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Neuroprotective Agents
143 rdf:type schema:DefinedTerm
144 N4842f8d54d69496e93401d43c76412df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Mitogen-Activated Protein Kinases
146 rdf:type schema:DefinedTerm
147 N4a3fa8aa342f4f809052160f1e7ac7b9 rdf:first Nf4d6f641b1f144d1b522cbadde11d81b
148 rdf:rest N968b9e0299d247bdac6989b37b0584c5
149 N4e94782da0df46749a4fd6cdf7421e51 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Ciliary Neurotrophic Factor
151 rdf:type schema:DefinedTerm
152 N5759ebaf6204418b8d0f484b921388db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Immunohistochemistry
154 rdf:type schema:DefinedTerm
155 N578564499e494c018f9933053f278f55 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Chromones
157 rdf:type schema:DefinedTerm
158 N6eb27bded0064444994de2fdca7ad240 schema:volumeNumber 130
159 rdf:type schema:PublicationVolume
160 N75ec63b5fda0439199d975b0389e1158 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Tyrphostins
162 rdf:type schema:DefinedTerm
163 N7e79295ff9074b65b1cc2769a6a24994 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Animals
165 rdf:type schema:DefinedTerm
166 N88ffb1908b6643fea455a5990944709d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Signal Transduction
168 rdf:type schema:DefinedTerm
169 N8a061f207a6d4a6cb80196a3ec28568a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Phosphorylation
171 rdf:type schema:DefinedTerm
172 N90ffe2488ebc46489666983a7e854d5d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Cell Survival
174 rdf:type schema:DefinedTerm
175 N938e6849406e4b608b67eccd3d558511 schema:name pubmed_id
176 schema:value 18679704
177 rdf:type schema:PropertyValue
178 N967f9b2be61b4e01a68b37b1a40bd78e schema:issueNumber 4
179 rdf:type schema:PublicationIssue
180 N968b9e0299d247bdac6989b37b0584c5 rdf:first sg:person.01204772377.08
181 rdf:rest rdf:nil
182 N9780f6bd8f624cefb47fd37922cd450c schema:name dimensions_id
183 schema:value pub.1024683471
184 rdf:type schema:PropertyValue
185 Na8fc714f40a14692ade1665baf12a21d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Neurons
187 rdf:type schema:DefinedTerm
188 Nac163854ac964dfaafb588011de5a7b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Morpholines
190 rdf:type schema:DefinedTerm
191 Nacf60216c10d4e19b41649b597e8e46d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Proto-Oncogene Proteins c-akt
193 rdf:type schema:DefinedTerm
194 Nada4baf1a8aa40c28a6572af86d8c8cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Cells, Cultured
196 rdf:type schema:DefinedTerm
197 Nb9ed088ec5314cb4b00f91c76d7d4497 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name STAT3 Transcription Factor
199 rdf:type schema:DefinedTerm
200 Nbb9fbf61591f49c895ec5bdd920537c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Flavonoids
202 rdf:type schema:DefinedTerm
203 Nbf175e2667334ec981902c8698e0e4bd rdf:first sg:person.0744057267.04
204 rdf:rest Ne095fde89c554158a99782803b03faf7
205 Ncc8c218f0f8146458c9b2ea997c900ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Ganglia, Spinal
207 rdf:type schema:DefinedTerm
208 Ncdec77f0b8c34b7fb4dec7a9eb59fa16 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
209 schema:name Rats, Wistar
210 rdf:type schema:DefinedTerm
211 Nd73a63dff00a4c0dbd657820a2dcd179 rdf:first sg:person.0737564767.12
212 rdf:rest Nbf175e2667334ec981902c8698e0e4bd
213 Ne095fde89c554158a99782803b03faf7 rdf:first sg:person.01321220777.12
214 rdf:rest N4a3fa8aa342f4f809052160f1e7ac7b9
215 Nf20c39c8cdc642279678ac46bae2fd9c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
216 schema:name Female
217 rdf:type schema:DefinedTerm
218 Nf4d6f641b1f144d1b522cbadde11d81b schema:affiliation grid-institutes:grid.272456.0
219 schema:familyName Si
220 schema:givenName Yang
221 rdf:type schema:Person
222 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
223 schema:name Biological Sciences
224 rdf:type schema:DefinedTerm
225 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
226 schema:name Biochemistry and Cell Biology
227 rdf:type schema:DefinedTerm
228 sg:journal.1294817 schema:issn 0948-6143
229 1432-119X
230 schema:name Histochemistry and Cell Biology
231 schema:publisher Springer Nature
232 rdf:type schema:Periodical
233 sg:person.01204772377.08 schema:affiliation grid-institutes:grid.272456.0
234 schema:familyName Kawano
235 schema:givenName Hitoshi
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204772377.08
237 rdf:type schema:Person
238 sg:person.01321220777.12 schema:affiliation grid-institutes:grid.272456.0
239 schema:familyName Komuta
240 schema:givenName Yukari
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321220777.12
242 rdf:type schema:Person
243 sg:person.0737564767.12 schema:affiliation grid-institutes:grid.272456.0
244 schema:familyName Sango
245 schema:givenName Kazunori
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737564767.12
247 rdf:type schema:Person
248 sg:person.0744057267.04 schema:affiliation grid-institutes:grid.272456.0
249 schema:familyName Yanagisawa
250 schema:givenName Hiroko
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744057267.04
252 rdf:type schema:Person
253 sg:pub.10.1007/978-0-387-30381-9_3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020270470
254 https://doi.org/10.1007/978-0-387-30381-9_3
255 rdf:type schema:CreativeWork
256 sg:pub.10.1007/s00418-007-0290-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002395218
257 https://doi.org/10.1007/s00418-007-0290-x
258 rdf:type schema:CreativeWork
259 sg:pub.10.1038/35046558 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018577936
260 https://doi.org/10.1038/35046558
261 rdf:type schema:CreativeWork
262 grid-institutes:grid.272456.0 schema:alternateName Division of Neural Development and Regeneration, Department of Developmental Morphology, Tokyo Metropolitan Institute for Neuroscience, 2-6 Musashidai, Fuchu, 183-8526, Tokyo, Japan
263 schema:name Division of Neural Development and Regeneration, Department of Developmental Morphology, Tokyo Metropolitan Institute for Neuroscience, 2-6 Musashidai, Fuchu, 183-8526, Tokyo, Japan
264 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...