A long-term study on female mice fed on a genetically modified soybean: effects on liver ageing View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-11

AUTHORS

Manuela Malatesta, Federica Boraldi, Giulia Annovi, Beatrice Baldelli, Serafina Battistelli, Marco Biggiogera, Daniela Quaglino

ABSTRACT

Liver represents a suitable model for monitoring the effects of a diet, due to its key role in controlling the whole metabolism. Although no direct evidence has been reported so far that genetically modified (GM) food may affect health, previous studies on hepatocytes from young female mice fed on GM soybean demonstrated nuclear modifications involving transcription and splicing pathways. In this study, the effects of this diet were studied on liver of old female mice in order to elucidate possible interference with ageing. The morpho-functional characteristics of the liver of 24-month-old mice, fed from weaning on control or GM soybean, were investigated by combining a proteomic approach with ultrastructural, morphometrical and immunoelectron microscopical analyses. Several proteins belonging to hepatocyte metabolism, stress response, calcium signalling and mitochondria were differentially expressed in GM-fed mice, indicating a more marked expression of senescence markers in comparison to controls. Moreover, hepatocytes of GM-fed mice showed mitochondrial and nuclear modifications indicative of reduced metabolic rate. This study demonstrates that GM soybean intake can influence some liver features during ageing and, although the mechanisms remain unknown, underlines the importance to investigate the long-term consequences of GM-diets and the potential synergistic effects with ageing, xenobiotics and/or stress conditions. More... »

PAGES

967-977

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00418-008-0476-x

DOI

http://dx.doi.org/10.1007/s00418-008-0476-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029876917

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18648843


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Age Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animal Feed", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animal Nutritional Physiological Phenomena", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Nucleus Shape", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Size", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Food, Genetically Modified", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microscopy, Immunoelectron", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Plants, Genetically Modified", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteomics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Soybeans", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Verona", 
          "id": "https://www.grid.ac/institutes/grid.5611.3", 
          "name": [
            "Dipartimento di Scienze Morfologico-Biomediche, Sezione di Anatomia e Istologia, University of Verona, strada Le Grazie 8, 37134, Verona, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Malatesta", 
        "givenName": "Manuela", 
        "id": "sg:person.0735555401.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735555401.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Modena and Reggio Emilia", 
          "id": "https://www.grid.ac/institutes/grid.7548.e", 
          "name": [
            "Department of Biomedical Sciences, University of Modena e Reggio Emilia, 41100, Modena, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boraldi", 
        "givenName": "Federica", 
        "id": "sg:person.01214675104.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214675104.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Modena and Reggio Emilia", 
          "id": "https://www.grid.ac/institutes/grid.7548.e", 
          "name": [
            "Department of Biomedical Sciences, University of Modena e Reggio Emilia, 41100, Modena, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Annovi", 
        "givenName": "Giulia", 
        "id": "sg:person.01035567372.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035567372.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Urbino", 
          "id": "https://www.grid.ac/institutes/grid.12711.34", 
          "name": [
            "Istituto di Istologia e Analisi di Laboratorio, University of Urbino, 61029, Urbino (PU), Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Baldelli", 
        "givenName": "Beatrice", 
        "id": "sg:person.01306004113.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306004113.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Urbino", 
          "id": "https://www.grid.ac/institutes/grid.12711.34", 
          "name": [
            "Istituto di Istologia e Analisi di Laboratorio, University of Urbino, 61029, Urbino (PU), Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Battistelli", 
        "givenName": "Serafina", 
        "id": "sg:person.01266772772.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266772772.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pavia", 
          "id": "https://www.grid.ac/institutes/grid.8982.b", 
          "name": [
            "Dipartimento di Biologia Animale, Laboratorio di Biologia Cellulare e Neurobiologia, University of Pavia, 27100, Pavia, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Biggiogera", 
        "givenName": "Marco", 
        "id": "sg:person.01110135410.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110135410.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Modena and Reggio Emilia", 
          "id": "https://www.grid.ac/institutes/grid.7548.e", 
          "name": [
            "Department of Biomedical Sciences, University of Modena e Reggio Emilia, 41100, Modena, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Quaglino", 
        "givenName": "Daniela", 
        "id": "sg:person.01231267762.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231267762.37"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1074/mcp.m500415-mcp200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000702210"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpcell.00035.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002473695"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000065506", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002650033"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/pl00012511", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003092062", 
          "https://doi.org/10.1007/pl00012511"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1289/ehp.7728", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005577348"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.fct.2004.02.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007594397"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/47528", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009901905", 
          "https://doi.org/10.1038/47528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/47528", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009901905", 
          "https://doi.org/10.1038/47528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1020822610085", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010600371", 
          "https://doi.org/10.1023/a:1020822610085"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1248/bpb.27.1444", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010824071"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.livsci.2007.03.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011327408"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1005932915429", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012058979", 
          "https://doi.org/10.1023/a:1005932915429"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jemt.1060140205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013503674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.taap.2004.07.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013627957"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-291x(02)00492-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017695636"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1247/csf.27.173", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017934600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-642-67503-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018337156", 
          "https://doi.org/10.1007/978-3-642-67503-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-642-67503-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018337156", 
          "https://doi.org/10.1007/978-3-642-67503-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/0265203031000109477", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019372097"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/00498250701830267", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019565255"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00185894", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020377992", 
          "https://doi.org/10.1007/bf00185894"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pmic.200300534", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020495406"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0141-1136(00)00088-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021643571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/toxsci/kfj192", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021734032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00244-006-0149-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023817964", 
          "https://doi.org/10.1007/s00244-006-0149-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bies.20075", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023970513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00187008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024428374", 
          "https://doi.org/10.1007/bf00187008"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1189/jlb.0306167", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024663760"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0003-2697(76)90527-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025529346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1196/annals.1297.067", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026623334"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-2952(95)02407-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026714541"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4081/920", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027067811"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1522-2683(19990301)20:3<601::aid-elps601>3.0.co;2-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028608211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1522-2683(19990301)20:3<601::aid-elps601>3.0.co;2-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028608211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(98)05860-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030132545"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0047-6374(02)00117-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030162209"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0047-6374(02)00117-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030162209"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.0021-8782.2002.00103.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032425790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mam.2004.02.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032924194"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/pr.55.2.1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032944188"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1020155502734", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033013261", 
          "https://doi.org/10.1023/a:1020155502734"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0531-5565(84)90038-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033596501"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0531-5565(84)90038-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033596501"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.chemosphere.2005.03.044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033977501"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.fct.2007.08.033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034625080"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4103/0022-3859.33869", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035187039"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.1998.9841", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035551884"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpcell.00248.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036925804"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/b:bgen.0000038024.58911.6e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037145351", 
          "https://doi.org/10.1023/b:bgen.0000038024.58911.6e"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1524-475x.2003.11605.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037931872"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1464-410x.2007.06860.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039001933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00075197-200111000-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039643855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00075197-200111000-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039643855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0003-2697(88)90208-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042333107"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/3-540-29717-0_12", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043702810", 
          "https://doi.org/10.1007/3-540-29717-0_12"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-5320(69)80016-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044705657"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1440-1681.2007.04638.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045161782"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1440-1681.2007.04638.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045161782"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/10_2007_048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045605663", 
          "https://doi.org/10.1007/10_2007_048"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/elps.11501401209", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045867174"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/elps.11501401209", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045867174"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0531-5565(00)00215-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051579599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mehy.2004.01.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053121801"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ac950914h", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055072376"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ac950914h", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055072376"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/pr7008059", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056294221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/tx0340302", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056297708"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/tx0340302", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056297708"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1079/asc200530", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058251670"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1079/asc200530", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058251670"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpheart.01000.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063194794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/japplphysiol.00733.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063198895"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2135/cropsci1995.0011183x003500050032x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069024817"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/1389557043403305", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069182400"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2741/2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070914297"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijmm.12.4.577", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071505526"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijmm.15.3.371", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071505957"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.170.2.719", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075214779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4081/851", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076620714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076839875", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077125167", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s175173111700091x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084864353"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008-11", 
    "datePublishedReg": "2008-11-01", 
    "description": "Liver represents a suitable model for monitoring the effects of a diet, due to its key role in controlling the whole metabolism. Although no direct evidence has been reported so far that genetically modified (GM) food may affect health, previous studies on hepatocytes from young female mice fed on GM soybean demonstrated nuclear modifications involving transcription and splicing pathways. In this study, the effects of this diet were studied on liver of old female mice in order to elucidate possible interference with ageing. The morpho-functional characteristics of the liver of 24-month-old mice, fed from weaning on control or GM soybean, were investigated by combining a proteomic approach with ultrastructural, morphometrical and immunoelectron microscopical analyses. Several proteins belonging to hepatocyte metabolism, stress response, calcium signalling and mitochondria were differentially expressed in GM-fed mice, indicating a more marked expression of senescence markers in comparison to controls. Moreover, hepatocytes of GM-fed mice showed mitochondrial and nuclear modifications indicative of reduced metabolic rate. This study demonstrates that GM soybean intake can influence some liver features during ageing and, although the mechanisms remain unknown, underlines the importance to investigate the long-term consequences of GM-diets and the potential synergistic effects with ageing, xenobiotics and/or stress conditions.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00418-008-0476-x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1294817", 
        "issn": [
          "0948-6143", 
          "1432-119X"
        ], 
        "name": "Histochemistry and Cell Biology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "130"
      }
    ], 
    "name": "A long-term study on female mice fed on a genetically modified soybean: effects on liver ageing", 
    "pagination": "967-977", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "8e55032d8c1e57e654699d148f36469a1143d54c03da4796640b414f3f03b4a1"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "18648843"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9506663"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00418-008-0476-x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1029876917"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00418-008-0476-x", 
      "https://app.dimensions.ai/details/publication/pub.1029876917"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T14:32", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000373_0000000373/records_13099_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs00418-008-0476-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00418-008-0476-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00418-008-0476-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00418-008-0476-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00418-008-0476-x'


 

This table displays all metadata directly associated to this object as RDF triples.

411 TRIPLES      21 PREDICATES      117 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00418-008-0476-x schema:about N027d44062b104fd5acd5fa0ce293f19c
2 N0716695ce375456b9f85145bb07b851b
3 N18cfdb92e21f4c94b821e2b00a02532d
4 N1accc44a28534bfeb74bc54a143e8707
5 N51d3aa74f26c4d75934e80fd35a205f6
6 N6bb26d6e08064e4ebecfa9aa292ad71d
7 N74acd6d831464b4c9d934c3b3d21f651
8 N74c314a6e34b44c6b3cc32a1b41358ff
9 N891c6f00ad634084bb534bc3be7a5ee8
10 N921e9ebc04204519b921946e5f0d8eca
11 N93909c9762864a2d918d7c3f0f52e912
12 N944dc1f673a044edbd7aade7682bb873
13 Na50590120db84db197129550c0d4a1cc
14 Nbae23688cd9745378c8cc3efd7a2644d
15 Nccbbddacdb17455191ffd7a0ea0f2764
16 Neebac4f39760451eb78aa083090594f8
17 Nefbe79693fae4b0ba020709ad0826bf5
18 anzsrc-for:11
19 anzsrc-for:1103
20 schema:author N5adcaedad9aa4aed93cf8f0d5286ef7b
21 schema:citation sg:pub.10.1007/10_2007_048
22 sg:pub.10.1007/3-540-29717-0_12
23 sg:pub.10.1007/978-3-642-67503-4
24 sg:pub.10.1007/bf00185894
25 sg:pub.10.1007/bf00187008
26 sg:pub.10.1007/pl00012511
27 sg:pub.10.1007/s00244-006-0149-5
28 sg:pub.10.1023/a:1005932915429
29 sg:pub.10.1023/a:1020155502734
30 sg:pub.10.1023/a:1020822610085
31 sg:pub.10.1023/b:bgen.0000038024.58911.6e
32 sg:pub.10.1038/47528
33 https://app.dimensions.ai/details/publication/pub.1076839875
34 https://app.dimensions.ai/details/publication/pub.1077125167
35 https://doi.org/10.1002/(sici)1522-2683(19990301)20:3<601::aid-elps601>3.0.co;2-6
36 https://doi.org/10.1002/bies.20075
37 https://doi.org/10.1002/elps.11501401209
38 https://doi.org/10.1002/jemt.1060140205
39 https://doi.org/10.1002/pmic.200300534
40 https://doi.org/10.1006/bbrc.1998.9841
41 https://doi.org/10.1016/0003-2697(76)90527-3
42 https://doi.org/10.1016/0003-2697(88)90208-4
43 https://doi.org/10.1016/0006-2952(95)02407-7
44 https://doi.org/10.1016/0531-5565(84)90038-x
45 https://doi.org/10.1016/j.chemosphere.2005.03.044
46 https://doi.org/10.1016/j.fct.2004.02.004
47 https://doi.org/10.1016/j.fct.2007.08.033
48 https://doi.org/10.1016/j.livsci.2007.03.009
49 https://doi.org/10.1016/j.mam.2004.02.008
50 https://doi.org/10.1016/j.mehy.2004.01.021
51 https://doi.org/10.1016/j.taap.2004.07.014
52 https://doi.org/10.1016/s0006-291x(02)00492-8
53 https://doi.org/10.1016/s0022-5320(69)80016-x
54 https://doi.org/10.1016/s0047-6374(02)00117-3
55 https://doi.org/10.1016/s0140-6736(98)05860-7
56 https://doi.org/10.1016/s0141-1136(00)00088-x
57 https://doi.org/10.1016/s0531-5565(00)00215-1
58 https://doi.org/10.1017/s175173111700091x
59 https://doi.org/10.1021/ac950914h
60 https://doi.org/10.1021/pr7008059
61 https://doi.org/10.1021/tx0340302
62 https://doi.org/10.1046/j.0021-8782.2002.00103.x
63 https://doi.org/10.1046/j.1524-475x.2003.11605.x
64 https://doi.org/10.1074/mcp.m500415-mcp200
65 https://doi.org/10.1079/asc200530
66 https://doi.org/10.1080/00498250701830267
67 https://doi.org/10.1080/0265203031000109477
68 https://doi.org/10.1093/toxsci/kfj192
69 https://doi.org/10.1097/00075197-200111000-00005
70 https://doi.org/10.1111/j.1440-1681.2007.04638.x
71 https://doi.org/10.1111/j.1464-410x.2007.06860.x
72 https://doi.org/10.1124/pr.55.2.1
73 https://doi.org/10.1152/ajpcell.00035.2005
74 https://doi.org/10.1152/ajpcell.00248.2006
75 https://doi.org/10.1152/ajpheart.01000.2002
76 https://doi.org/10.1152/japplphysiol.00733.2001
77 https://doi.org/10.1159/000065506
78 https://doi.org/10.1189/jlb.0306167
79 https://doi.org/10.1196/annals.1297.067
80 https://doi.org/10.1247/csf.27.173
81 https://doi.org/10.1248/bpb.27.1444
82 https://doi.org/10.1289/ehp.7728
83 https://doi.org/10.2135/cropsci1995.0011183x003500050032x
84 https://doi.org/10.2174/1389557043403305
85 https://doi.org/10.2741/2002
86 https://doi.org/10.3892/ijmm.12.4.577
87 https://doi.org/10.3892/ijmm.15.3.371
88 https://doi.org/10.4049/jimmunol.170.2.719
89 https://doi.org/10.4081/851
90 https://doi.org/10.4081/920
91 https://doi.org/10.4103/0022-3859.33869
92 schema:datePublished 2008-11
93 schema:datePublishedReg 2008-11-01
94 schema:description Liver represents a suitable model for monitoring the effects of a diet, due to its key role in controlling the whole metabolism. Although no direct evidence has been reported so far that genetically modified (GM) food may affect health, previous studies on hepatocytes from young female mice fed on GM soybean demonstrated nuclear modifications involving transcription and splicing pathways. In this study, the effects of this diet were studied on liver of old female mice in order to elucidate possible interference with ageing. The morpho-functional characteristics of the liver of 24-month-old mice, fed from weaning on control or GM soybean, were investigated by combining a proteomic approach with ultrastructural, morphometrical and immunoelectron microscopical analyses. Several proteins belonging to hepatocyte metabolism, stress response, calcium signalling and mitochondria were differentially expressed in GM-fed mice, indicating a more marked expression of senescence markers in comparison to controls. Moreover, hepatocytes of GM-fed mice showed mitochondrial and nuclear modifications indicative of reduced metabolic rate. This study demonstrates that GM soybean intake can influence some liver features during ageing and, although the mechanisms remain unknown, underlines the importance to investigate the long-term consequences of GM-diets and the potential synergistic effects with ageing, xenobiotics and/or stress conditions.
95 schema:genre research_article
96 schema:inLanguage en
97 schema:isAccessibleForFree false
98 schema:isPartOf N2988a757076742da83f0bc58a2b46eb8
99 N58c9ff44bfd8435998543d49616d9060
100 sg:journal.1294817
101 schema:name A long-term study on female mice fed on a genetically modified soybean: effects on liver ageing
102 schema:pagination 967-977
103 schema:productId N3cf2ef9553104cd7ae346c531d40c8e9
104 N6313d92ec356437eb136a5976ef8aaa1
105 N763d25e1e5d643f9a6376887df758a04
106 Nb5d5b6fc241c4378adcda6b16dea1fd5
107 Nc9ef8f747816437c921c76df1f6297dc
108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029876917
109 https://doi.org/10.1007/s00418-008-0476-x
110 schema:sdDatePublished 2019-04-11T14:32
111 schema:sdLicense https://scigraph.springernature.com/explorer/license/
112 schema:sdPublisher Nb664ef3620814bce8667f319547776bf
113 schema:url http://link.springer.com/10.1007%2Fs00418-008-0476-x
114 sgo:license sg:explorer/license/
115 sgo:sdDataset articles
116 rdf:type schema:ScholarlyArticle
117 N027d44062b104fd5acd5fa0ce293f19c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Proteins
119 rdf:type schema:DefinedTerm
120 N0716695ce375456b9f85145bb07b851b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Age Factors
122 rdf:type schema:DefinedTerm
123 N18cfdb92e21f4c94b821e2b00a02532d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Soybeans
125 rdf:type schema:DefinedTerm
126 N1accc44a28534bfeb74bc54a143e8707 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Proteomics
128 rdf:type schema:DefinedTerm
129 N2988a757076742da83f0bc58a2b46eb8 schema:issueNumber 5
130 rdf:type schema:PublicationIssue
131 N3cf2ef9553104cd7ae346c531d40c8e9 schema:name doi
132 schema:value 10.1007/s00418-008-0476-x
133 rdf:type schema:PropertyValue
134 N51d3aa74f26c4d75934e80fd35a205f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Food, Genetically Modified
136 rdf:type schema:DefinedTerm
137 N58c9ff44bfd8435998543d49616d9060 schema:volumeNumber 130
138 rdf:type schema:PublicationVolume
139 N5adcaedad9aa4aed93cf8f0d5286ef7b rdf:first sg:person.0735555401.07
140 rdf:rest N5fbb9e5944ea4e4fbd8fd0e160d30c58
141 N5c9168cf53a04f23a3f117e68f2e84f9 rdf:first sg:person.01110135410.05
142 rdf:rest Nd65bc3a9612e461cb6995fc9c042da19
143 N5fbb9e5944ea4e4fbd8fd0e160d30c58 rdf:first sg:person.01214675104.50
144 rdf:rest N66474dacdbb8416b807bdf5601c20719
145 N6313d92ec356437eb136a5976ef8aaa1 schema:name pubmed_id
146 schema:value 18648843
147 rdf:type schema:PropertyValue
148 N66474dacdbb8416b807bdf5601c20719 rdf:first sg:person.01035567372.39
149 rdf:rest Nfdce0b1fcfe3474c99f42cf2acb30121
150 N6bb26d6e08064e4ebecfa9aa292ad71d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Cell Nucleus Shape
152 rdf:type schema:DefinedTerm
153 N74acd6d831464b4c9d934c3b3d21f651 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Female
155 rdf:type schema:DefinedTerm
156 N74c314a6e34b44c6b3cc32a1b41358ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Mice
158 rdf:type schema:DefinedTerm
159 N763d25e1e5d643f9a6376887df758a04 schema:name readcube_id
160 schema:value 8e55032d8c1e57e654699d148f36469a1143d54c03da4796640b414f3f03b4a1
161 rdf:type schema:PropertyValue
162 N891c6f00ad634084bb534bc3be7a5ee8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Aging
164 rdf:type schema:DefinedTerm
165 N921e9ebc04204519b921946e5f0d8eca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Animal Feed
167 rdf:type schema:DefinedTerm
168 N93909c9762864a2d918d7c3f0f52e912 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Microscopy, Immunoelectron
170 rdf:type schema:DefinedTerm
171 N944dc1f673a044edbd7aade7682bb873 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Cell Size
173 rdf:type schema:DefinedTerm
174 Na50590120db84db197129550c0d4a1cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Liver
176 rdf:type schema:DefinedTerm
177 Nb5d5b6fc241c4378adcda6b16dea1fd5 schema:name dimensions_id
178 schema:value pub.1029876917
179 rdf:type schema:PropertyValue
180 Nb664ef3620814bce8667f319547776bf schema:name Springer Nature - SN SciGraph project
181 rdf:type schema:Organization
182 Nbae23688cd9745378c8cc3efd7a2644d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Immunohistochemistry
184 rdf:type schema:DefinedTerm
185 Nc9ef8f747816437c921c76df1f6297dc schema:name nlm_unique_id
186 schema:value 9506663
187 rdf:type schema:PropertyValue
188 Nccbbddacdb17455191ffd7a0ea0f2764 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Animal Nutritional Physiological Phenomena
190 rdf:type schema:DefinedTerm
191 Nd65bc3a9612e461cb6995fc9c042da19 rdf:first sg:person.01231267762.37
192 rdf:rest rdf:nil
193 Ne3d5b02e80de48e1a61a29e3833c9d9d rdf:first sg:person.01266772772.91
194 rdf:rest N5c9168cf53a04f23a3f117e68f2e84f9
195 Neebac4f39760451eb78aa083090594f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
196 schema:name Plants, Genetically Modified
197 rdf:type schema:DefinedTerm
198 Nefbe79693fae4b0ba020709ad0826bf5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name Animals
200 rdf:type schema:DefinedTerm
201 Nfdce0b1fcfe3474c99f42cf2acb30121 rdf:first sg:person.01306004113.45
202 rdf:rest Ne3d5b02e80de48e1a61a29e3833c9d9d
203 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
204 schema:name Medical and Health Sciences
205 rdf:type schema:DefinedTerm
206 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
207 schema:name Clinical Sciences
208 rdf:type schema:DefinedTerm
209 sg:journal.1294817 schema:issn 0948-6143
210 1432-119X
211 schema:name Histochemistry and Cell Biology
212 rdf:type schema:Periodical
213 sg:person.01035567372.39 schema:affiliation https://www.grid.ac/institutes/grid.7548.e
214 schema:familyName Annovi
215 schema:givenName Giulia
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035567372.39
217 rdf:type schema:Person
218 sg:person.01110135410.05 schema:affiliation https://www.grid.ac/institutes/grid.8982.b
219 schema:familyName Biggiogera
220 schema:givenName Marco
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110135410.05
222 rdf:type schema:Person
223 sg:person.01214675104.50 schema:affiliation https://www.grid.ac/institutes/grid.7548.e
224 schema:familyName Boraldi
225 schema:givenName Federica
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214675104.50
227 rdf:type schema:Person
228 sg:person.01231267762.37 schema:affiliation https://www.grid.ac/institutes/grid.7548.e
229 schema:familyName Quaglino
230 schema:givenName Daniela
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231267762.37
232 rdf:type schema:Person
233 sg:person.01266772772.91 schema:affiliation https://www.grid.ac/institutes/grid.12711.34
234 schema:familyName Battistelli
235 schema:givenName Serafina
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266772772.91
237 rdf:type schema:Person
238 sg:person.01306004113.45 schema:affiliation https://www.grid.ac/institutes/grid.12711.34
239 schema:familyName Baldelli
240 schema:givenName Beatrice
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306004113.45
242 rdf:type schema:Person
243 sg:person.0735555401.07 schema:affiliation https://www.grid.ac/institutes/grid.5611.3
244 schema:familyName Malatesta
245 schema:givenName Manuela
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735555401.07
247 rdf:type schema:Person
248 sg:pub.10.1007/10_2007_048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045605663
249 https://doi.org/10.1007/10_2007_048
250 rdf:type schema:CreativeWork
251 sg:pub.10.1007/3-540-29717-0_12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043702810
252 https://doi.org/10.1007/3-540-29717-0_12
253 rdf:type schema:CreativeWork
254 sg:pub.10.1007/978-3-642-67503-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018337156
255 https://doi.org/10.1007/978-3-642-67503-4
256 rdf:type schema:CreativeWork
257 sg:pub.10.1007/bf00185894 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020377992
258 https://doi.org/10.1007/bf00185894
259 rdf:type schema:CreativeWork
260 sg:pub.10.1007/bf00187008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024428374
261 https://doi.org/10.1007/bf00187008
262 rdf:type schema:CreativeWork
263 sg:pub.10.1007/pl00012511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003092062
264 https://doi.org/10.1007/pl00012511
265 rdf:type schema:CreativeWork
266 sg:pub.10.1007/s00244-006-0149-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023817964
267 https://doi.org/10.1007/s00244-006-0149-5
268 rdf:type schema:CreativeWork
269 sg:pub.10.1023/a:1005932915429 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012058979
270 https://doi.org/10.1023/a:1005932915429
271 rdf:type schema:CreativeWork
272 sg:pub.10.1023/a:1020155502734 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033013261
273 https://doi.org/10.1023/a:1020155502734
274 rdf:type schema:CreativeWork
275 sg:pub.10.1023/a:1020822610085 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010600371
276 https://doi.org/10.1023/a:1020822610085
277 rdf:type schema:CreativeWork
278 sg:pub.10.1023/b:bgen.0000038024.58911.6e schema:sameAs https://app.dimensions.ai/details/publication/pub.1037145351
279 https://doi.org/10.1023/b:bgen.0000038024.58911.6e
280 rdf:type schema:CreativeWork
281 sg:pub.10.1038/47528 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009901905
282 https://doi.org/10.1038/47528
283 rdf:type schema:CreativeWork
284 https://app.dimensions.ai/details/publication/pub.1076839875 schema:CreativeWork
285 https://app.dimensions.ai/details/publication/pub.1077125167 schema:CreativeWork
286 https://doi.org/10.1002/(sici)1522-2683(19990301)20:3<601::aid-elps601>3.0.co;2-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028608211
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1002/bies.20075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023970513
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1002/elps.11501401209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045867174
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1002/jemt.1060140205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013503674
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1002/pmic.200300534 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020495406
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1006/bbrc.1998.9841 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035551884
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1016/0003-2697(76)90527-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025529346
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1016/0003-2697(88)90208-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042333107
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1016/0006-2952(95)02407-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026714541
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1016/0531-5565(84)90038-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033596501
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1016/j.chemosphere.2005.03.044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033977501
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1016/j.fct.2004.02.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007594397
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1016/j.fct.2007.08.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034625080
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1016/j.livsci.2007.03.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011327408
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1016/j.mam.2004.02.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032924194
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1016/j.mehy.2004.01.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053121801
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1016/j.taap.2004.07.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013627957
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1016/s0006-291x(02)00492-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017695636
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1016/s0022-5320(69)80016-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044705657
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1016/s0047-6374(02)00117-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030162209
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1016/s0140-6736(98)05860-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030132545
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1016/s0141-1136(00)00088-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021643571
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1016/s0531-5565(00)00215-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051579599
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1017/s175173111700091x schema:sameAs https://app.dimensions.ai/details/publication/pub.1084864353
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1021/ac950914h schema:sameAs https://app.dimensions.ai/details/publication/pub.1055072376
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1021/pr7008059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056294221
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1021/tx0340302 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056297708
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1046/j.0021-8782.2002.00103.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1032425790
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1046/j.1524-475x.2003.11605.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037931872
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1074/mcp.m500415-mcp200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000702210
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1079/asc200530 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058251670
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1080/00498250701830267 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019565255
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1080/0265203031000109477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019372097
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1093/toxsci/kfj192 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021734032
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1097/00075197-200111000-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039643855
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1111/j.1440-1681.2007.04638.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1045161782
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1111/j.1464-410x.2007.06860.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039001933
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1124/pr.55.2.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032944188
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1152/ajpcell.00035.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002473695
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1152/ajpcell.00248.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036925804
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1152/ajpheart.01000.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063194794
367 rdf:type schema:CreativeWork
368 https://doi.org/10.1152/japplphysiol.00733.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063198895
369 rdf:type schema:CreativeWork
370 https://doi.org/10.1159/000065506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002650033
371 rdf:type schema:CreativeWork
372 https://doi.org/10.1189/jlb.0306167 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024663760
373 rdf:type schema:CreativeWork
374 https://doi.org/10.1196/annals.1297.067 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026623334
375 rdf:type schema:CreativeWork
376 https://doi.org/10.1247/csf.27.173 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017934600
377 rdf:type schema:CreativeWork
378 https://doi.org/10.1248/bpb.27.1444 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010824071
379 rdf:type schema:CreativeWork
380 https://doi.org/10.1289/ehp.7728 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005577348
381 rdf:type schema:CreativeWork
382 https://doi.org/10.2135/cropsci1995.0011183x003500050032x schema:sameAs https://app.dimensions.ai/details/publication/pub.1069024817
383 rdf:type schema:CreativeWork
384 https://doi.org/10.2174/1389557043403305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069182400
385 rdf:type schema:CreativeWork
386 https://doi.org/10.2741/2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070914297
387 rdf:type schema:CreativeWork
388 https://doi.org/10.3892/ijmm.12.4.577 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071505526
389 rdf:type schema:CreativeWork
390 https://doi.org/10.3892/ijmm.15.3.371 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071505957
391 rdf:type schema:CreativeWork
392 https://doi.org/10.4049/jimmunol.170.2.719 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075214779
393 rdf:type schema:CreativeWork
394 https://doi.org/10.4081/851 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076620714
395 rdf:type schema:CreativeWork
396 https://doi.org/10.4081/920 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027067811
397 rdf:type schema:CreativeWork
398 https://doi.org/10.4103/0022-3859.33869 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035187039
399 rdf:type schema:CreativeWork
400 https://www.grid.ac/institutes/grid.12711.34 schema:alternateName University of Urbino
401 schema:name Istituto di Istologia e Analisi di Laboratorio, University of Urbino, 61029, Urbino (PU), Italy
402 rdf:type schema:Organization
403 https://www.grid.ac/institutes/grid.5611.3 schema:alternateName University of Verona
404 schema:name Dipartimento di Scienze Morfologico-Biomediche, Sezione di Anatomia e Istologia, University of Verona, strada Le Grazie 8, 37134, Verona, Italy
405 rdf:type schema:Organization
406 https://www.grid.ac/institutes/grid.7548.e schema:alternateName University of Modena and Reggio Emilia
407 schema:name Department of Biomedical Sciences, University of Modena e Reggio Emilia, 41100, Modena, Italy
408 rdf:type schema:Organization
409 https://www.grid.ac/institutes/grid.8982.b schema:alternateName University of Pavia
410 schema:name Dipartimento di Biologia Animale, Laboratorio di Biologia Cellulare e Neurobiologia, University of Pavia, 27100, Pavia, Italy
411 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...