Effects of ageing on the fine distribution of the circadian CLOCK protein in reticular formation neurons View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-06

AUTHORS

Manuela Malatesta, Patrizia Fattoretti, Beatrice Baldelli, Serafina Battistelli, Marta Balietti, Carlo Bertoni-Freddari

ABSTRACT

Many biochemical, physiological and behavioural processes, from bacteria to human, exhibit roughly 24 h cyclic oscillations defined as circadian rhythms. However, during ageing, numerous aspects of the circadian biology undergo alterations; in particular, the sleep pattern changes, with more frequent awakenings and shorter sleep time. The basic mechanism of the circadian clock relies on intracellular molecular pathways involving interlocking transcriptional/translational feedback loops, and CLOCK protein, a transcription factor, is essential for normal circadian rhythms. In this study, the fine distribution of CLOCK protein has been analysed, in adult and old rats, at different phases of the daily cycle in the neurons of the medullary reticular formation, involved in the control of the sleep-wake cycle. The results demonstrate quali-quantitative modifications of CLOCK protein in the neurons of old animals, suggesting that such a deregulation of the intracellular clock mechanism may play some role in the degeneration of the sleep-wake circadian cycle. More... »

PAGES

641-647

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00418-007-0284-8

DOI

http://dx.doi.org/10.1007/s00418-007-0284-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035568778

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17415583


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00418-007-0284-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00418-007-0284-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00418-007-0284-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00418-007-0284-8'


 

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