A comparative investigation of FK506 and cyclosporin A in murine corneal transplantation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1998-09

AUTHORS

A. Reis, Thomas Reinhard, Rainer Sundmacher, Stefan Braunstein, Erhard Godehardt

ABSTRACT

· Background: Acute rejection is the cause of over 50% of transplant opacifications in some immunological high-risk groups. More potent immunomodulating substances must be found in order to allow extended or individualised therapeutic options for combating rejection. · Methods: Rats of the inbred strains Brown Norway and Lewis were used as donors and recipients, respectively. FK506 (Prograf) was administered intraperitoneally for 14 days in a dosage of 0.3 mg/kg bw, and cyclosporin A (CSA; Sandimmun) was administered, likewise for 14 days, in an intramuscular dosage of 10 mg/kg bw. The transplants were examined every 3rd day by slit-lamp microscopy. Every transplant was subjected to histological or immunohistological evaluation. · Results: The average transplant survival period in the allogeneic strain combination was 7.9 days (SEM=1.1). Therapy with FK506 led to a statistically significant prolongation of transplant survival to 17.1 days (SEM=1.5, P<0.05). Therapy with CSA delayed transplant rejection to 21 days (SEM=0.0, P<0.05). No statistically significant difference was found between the two therapeutic regimens. There were no significant histomorphologic differences in rejected grafts in the FK506- and CSA-treated animals. · Conclusions: In this study we have shown that FK506 is able to delay corneal allograft rejection at a much lower dosage than CSA without a higher incidence of side effects related to toxicity or overimmunosuppression. More... »

PAGES

785-789

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s004170050159

DOI

http://dx.doi.org/10.1007/s004170050159

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004436608

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9801895


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