Sostdc1 is expressed in all major compartments of developing and adult mammalian eyes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-09-16

AUTHORS

Maud Valensi, Gabrielle Goldman, Dominique Marchant, Loïc Van Den Berghe, Laurent Jonet, Alejandra Daruich, Matthieu P. Robert, Eric Krejci, Christophe Klein, Frédéric Mascarelli, Claudine Versaux-Botteri, Alexandre Moulin, Marc Putterman, Fabien Guimiot, Thierry Molina, Benoît Terris, Dominique Brémond-Gignac, Francine Behar-Cohen, Marc M. Abitbol

ABSTRACT

PurposeThis study was conducted in order to study Sostdc1 expression in rat and human developing and adult eyes.MethodsUsing the yeast signal sequence trap screening method, we identified the Sostdc1 cDNA encoding a protein secreted by the adult rat retinal pigment epithelium. We determined by in situ hybridization, RT-PCR, immunohistochemistry, and western blot analysis Sostdc1 gene and protein expression in developing and postnatal rat ocular tissue sections. We also investigated Sostdc1 immunohistolocalization in developing and adult human ocular tissues.ResultsWe demonstrated a prominent Sostdc1 gene expression in the developing rat central nervous system (CNS) and eyes at early developmental stages from E10.5 days postconception (dpc) to E13 dpc. Specific Sostdc1 immunostaining was also detected in most adult cells of rat ocular tissue sections. We also identified the rat ocular embryonic compartments characterized by a specific Sostdc1 immunohistostaining and specific Pax6, Sox2, Otx2, and Vsx2 immunohistostaining from embryonic stages E10.5 to E13 dpc. Furthermore, we determined the localization of SOSTDC1 immunoreactivity in ocular tissue sections of developing and adult human eyes. Indeed, we detected SOSTDC1 immunostaining in developing and adult human retinal pigment epithelium (RPE) and neural retina (NR) as well as in several developing and adult human ocular compartments, including the walls of choroidal and scleral vessels. Of utmost importance, we observed a strong SOSTDC1 expression in a pathological ocular specimen of type 2 Peters' anomaly complicated by retinal neovascularization as well in the walls ofother pathological extra-ocular vessels. ConclusionAs rat Sostdc1 and human SOSTDC1 are dual antagonists of the Wnt/β-catenin and BMP signaling pathways, these results underscore the potential crucial roles of these pathways and their antagonists, such as Sostdc1 and SOSTDC1, in developing and adult mammalian normal eyes as well as in syndromic and nonsyndromic congenital eye diseases. More... »

PAGES

2401-2427

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00417-019-04462-4

DOI

http://dx.doi.org/10.1007/s00417-019-04462-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1121043061

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31529323


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