Preliminary study of the safety and efficacy of medium-chain triglycerides for use as an intraocular tamponading agent in minipigs View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-05-25

AUTHORS

Vincent J. Soler, Camille Laurent, Frédéric Sakr, Alain Regnier, Cyrielle Tricoire, Olivier Cases, Renata Kozyraki, Jean-Yves Douet, Véronique Pagot-Mathis

ABSTRACT

PurposeTo date, only silicone oils and gases have the appropriate characteristics for use in vitreo-retinal surgery as vitreous substitutes with intraocular tamponading properties. This preliminary study evaluated the safety and efficacy of medium-chain triglycerides (MCTs) for use as a tamponading agent in minipigs.MethodsIn 15 minipigs, 15 right eyes underwent vitrectomies followed by injection of MCT tamponade (day 1). Two groups were defined. In Group A (ten eyes), the surgical procedure before MCT injection included induced rhegmatogenous retinal detachment (RRD), retina flattening, and retinopexy. In Group B (five eyes), MCT was injected without inducing RRD; in these eyes, MCT was removed on day 90. Pigs were sacrificed on day 45 (Group A) or 120 (Group B). Eyes were examined on days 1, 5, 15, and 45 in both groups and on days 90 and 120 in Group B. In Group B only, we performed bilateral electroretinography examinations on days 1 and 120, and histological examinations of MCTs and controlateral eyes were performed after sacrifice.ResultsIn Group A eyes (n = 9; one eye was non-assessable), on day 45, the retina was flat in seven eyes and two RRD detachments were observed in insufficiently MCT-filled eyes. In Group B, electroretinography showed no significant differences between MCT eyes and controls on days 1 or 120. Histological analyses revealed no signs of retinal toxicity.ConclusionsThis study showed that MCT tamponade seems to be effective and safe; however, additional studies are needed before it becomes commonly used as a tamponading agent in humans. More... »

PAGES

1593-1604

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00417-017-3695-9

DOI

http://dx.doi.org/10.1007/s00417-017-3695-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1085594438

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28547316


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30 schema:description PurposeTo date, only silicone oils and gases have the appropriate characteristics for use in vitreo-retinal surgery as vitreous substitutes with intraocular tamponading properties. This preliminary study evaluated the safety and efficacy of medium-chain triglycerides (MCTs) for use as a tamponading agent in minipigs.MethodsIn 15 minipigs, 15 right eyes underwent vitrectomies followed by injection of MCT tamponade (day 1). Two groups were defined. In Group A (ten eyes), the surgical procedure before MCT injection included induced rhegmatogenous retinal detachment (RRD), retina flattening, and retinopexy. In Group B (five eyes), MCT was injected without inducing RRD; in these eyes, MCT was removed on day 90. Pigs were sacrificed on day 45 (Group A) or 120 (Group B). Eyes were examined on days 1, 5, 15, and 45 in both groups and on days 90 and 120 in Group B. In Group B only, we performed bilateral electroretinography examinations on days 1 and 120, and histological examinations of MCTs and controlateral eyes were performed after sacrifice.ResultsIn Group A eyes (n = 9; one eye was non-assessable), on day 45, the retina was flat in seven eyes and two RRD detachments were observed in insufficiently MCT-filled eyes. In Group B, electroretinography showed no significant differences between MCT eyes and controls on days 1 or 120. Histological analyses revealed no signs of retinal toxicity.ConclusionsThis study showed that MCT tamponade seems to be effective and safe; however, additional studies are needed before it becomes commonly used as a tamponading agent in humans.
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37 schema:keywords A eyes
38 Additional studies
39 B. In Group B
40 ConclusionsThis study
41 Group A eyes
42 In group B
43 MCT eyes
44 MCT injection
45 MCT tamponade
46 MethodsIn 15 minipigs
47 PurposeTo date
48 RRD detachments
49 ResultsIn Group A eyes
50 agents
51 analysis
52 appropriate characteristics
53 bilateral electroretinography examinations
54 characteristics
55 control
56 controlateral eye
57 date
58 day 1
59 day 45
60 day 90
61 detachment
62 differences
63 efficacy
64 electroretinography
65 electroretinography (ERG) examination
66 examination
67 eyes
68 flattening
69 gases
70 group
71 group A
72 group B
73 group B. In group B
74 histological analysis
75 histological examination
76 humans
77 injection
78 intraocular tamponading agent
79 intraocular tamponading properties
80 medium-chain triglycerides
81 minipigs
82 oil
83 pigs
84 preliminary study
85 procedure
86 properties
87 retina
88 retina flattening
89 retinal detachment
90 retinal toxicity
91 retinopexy
92 rhegmatogenous retinal detachment
93 right eye
94 sacrifice
95 safety
96 significant differences
97 signs
98 silicone oil
99 study
100 substitute
101 surgery
102 surgical procedures
103 tamponade
104 tamponading agent
105 tamponading properties
106 toxicity
107 triglycerides
108 use
109 vitrectomy
110 vitreo-retinal surgery
111 vitreous substitute
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