A review of in vivo animal studies in retinal prosthesis research View Full Text


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Article Info

DATE

2008-08-16

AUTHORS

Dimiter R. Bertschinger, Evgueny Beknazar, Manuel Simonutti, Avinoam B. Safran, José A. Sahel, Serge G. Rosolen, Serge Picaud, Joel Salzmann

ABSTRACT

BackgroundThe development of a functional retinal prosthesis for acquired blindness is a great challenge. Rapid progress in the field over the last 15 years would not have been possible without extensive animal experimentation pertaining to device design and fabrication, biocompatibility, stimulation parameters and functional responses. This paper presents an overview of in vivo animal research related to retinal prosthetics, and aims to summarize the relevant studies.MethodsA Pubmed search of the English language literature was performed. The key search terms were: retinal implant, retinal prosthesis, artificial vision, rat, rabbit, cat, dog, sheep, pig, minipig. In addition a manual search was performed based on references quoted in the articles retrieved through Pubmed.ResultsWe identified 50 articles relevant to in vivo animal experimentation directly related to the development of a retinal implant. The highest number of publications related to the cat (n = 18).ConclusionThe contribution of animal models to the development of retinal prosthetic devices has been enormous, and has led to human feasibility studies. Grey areas remain regarding long-term tissue-implant interactions, biomaterials, prosthesis design and neural adaptation. Animals will continue to play a key role in this rapidly evolving field. More... »

PAGES

1505-1517

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00417-008-0891-7

    DOI

    http://dx.doi.org/10.1007/s00417-008-0891-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1018357574

    PUBMED

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