2017 revisions of McDonald criteria shorten the time to diagnosis of multiple sclerosis in clinically isolated syndromes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-11

AUTHORS

Lorenzo Gaetani, Luca Prosperini, Andrea Mancini, Paolo Eusebi, Maria Chiara Cerri, Carlo Pozzilli, Paolo Calabresi, Paola Sarchielli, Massimiliano Di Filippo

ABSTRACT

OBJECTIVES: To investigate the impact of the 2017 revisions of McDonald criteria on the diagnosis of multiple sclerosis (MS) in a cohort of patients with clinically isolated syndrome (CIS) and dissemination in space (DIS) of demyelinating lesions. METHODS: We retrospectively analyzed 137 patients with CIS + DIS from two Italian MS centers. RESULTS: Application of the 2017 revisions of McDonald criteria in our cohort led to a diagnosis of MS in 82.5% of the patients who could have not been diagnosed with MS according to the previous criteria at the time of the first demyelinating event. After a follow-up of 3.8 ± 2.9 years, 85.8% of these patients eventually satisfied also the previous (2010) criteria. CONCLUSIONS: Application of the 2017 revisions of McDonald criteria results in an earlier diagnosis of MS in a large percentage of CIS patients destined to convert to MS. More... »

PAGES

2684-2687

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00415-018-9048-8

DOI

http://dx.doi.org/10.1007/s00415-018-9048-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1106894066

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30196327


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