Clinical, imaging, and histological presentations and outcomes of stroke related to sarcoidosis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-08-14

AUTHORS

Vincent Jachiet, Raphael Lhote, Pierre Rufat, Micheline Pha, Julien Haroche, Sophie Crozier, Corinne Dupel-Potier, Dimitri Psimaras, Zahir Amoura, Fleur Cohen Aubart

ABSTRACT

ObjectivesClinical involvement of the nervous system is uncommon during sarcoidosis. Cerebrovascular events are rarely reported during sarcoidosis and may be confused with primary angiitis of the central nervous system. The characteristics and outcomes of cerebrovascular events during sarcoidosis have not been well-evaluated.Patients and methodsWe conducted a retrospective case series in our institution with an updated review of the literature from 1962 to 2017 to characterize the clinical presentation, imaging, histology and outcomes of stroke that were thought to be causally related to sarcoidosis.ResultsFifty-one patients (31 men, median age at stroke diagnosis of 41 years) receiving a diagnosis of stroke and sarcoidosis, including 8 new cases from our institution and 43 from the literature review, were included. Stroke was the first manifestation of sarcoidosis in 64%. The stroke was ischemic in 69% and hemorrhagic in 31%. A total of 31% experienced a transient ischemic attack before ischemic stroke. A total of 36% of patients had multiple infarcts or hemorrhages. The median number of cardiovascular risk factors was 0. Concerning histological presentation, vascular or perivascular involvement was present in all cases. After a median follow-up of 12 months (after stroke), up to 50% of patients had developed a permanent neurological impairment, 16% had a recurrence of stroke, and 23% died.ConclusionsCerebrovascular events may be the first manifestation of neurosarcoidosis, and have a prognosis impact in such patients, leading to death and permanent neurological impairment. More... »

PAGES

2333-2341

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00415-018-9001-x

DOI

http://dx.doi.org/10.1007/s00415-018-9001-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1106150101

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30109479


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain Ischemia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Central Nervous System Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cerebral Hemorrhage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sarcoidosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stroke", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Service de M\u00e9decine Interne 2, Institut e3m, Centre National de R\u00e9f\u00e9rence Maladies Syst\u00e9miques Rares, Sorbonne Universit\u00e9, Facult\u00e9 de M\u00e9decine, Assistance Publique H\u00f4pitaux de Paris, H\u00f4pital de la Piti\u00e9-Salp\u00eatri\u00e8re, 47-83 Boulevard de l\u2019h\u00f4pital, 75651, Paris Cedex 13, France", 
          "id": "http://www.grid.ac/institutes/grid.411439.a", 
          "name": [
            "Service de M\u00e9decine Interne 2, Institut e3m, Centre National de R\u00e9f\u00e9rence Maladies Syst\u00e9miques Rares, Sorbonne Universit\u00e9, Facult\u00e9 de M\u00e9decine, Assistance Publique H\u00f4pitaux de Paris, H\u00f4pital de la Piti\u00e9-Salp\u00eatri\u00e8re, 47-83 Boulevard de l\u2019h\u00f4pital, 75651, Paris Cedex 13, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jachiet", 
        "givenName": "Vincent", 
        "id": "sg:person.015267247133.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015267247133.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de M\u00e9decine Interne 2, Institut e3m, Centre National de R\u00e9f\u00e9rence Maladies Syst\u00e9miques Rares, Sorbonne Universit\u00e9, Facult\u00e9 de M\u00e9decine, Assistance Publique H\u00f4pitaux de Paris, H\u00f4pital de la Piti\u00e9-Salp\u00eatri\u00e8re, 47-83 Boulevard de l\u2019h\u00f4pital, 75651, Paris Cedex 13, France", 
          "id": "http://www.grid.ac/institutes/grid.411439.a", 
          "name": [
            "Service de M\u00e9decine Interne 2, Institut e3m, Centre National de R\u00e9f\u00e9rence Maladies Syst\u00e9miques Rares, Sorbonne Universit\u00e9, Facult\u00e9 de M\u00e9decine, Assistance Publique H\u00f4pitaux de Paris, H\u00f4pital de la Piti\u00e9-Salp\u00eatri\u00e8re, 47-83 Boulevard de l\u2019h\u00f4pital, 75651, Paris Cedex 13, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lhote", 
        "givenName": "Raphael", 
        "id": "sg:person.01047153417.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047153417.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "D\u00e9partement Biostatistiques, Assistance Publique H\u00f4pitaux de Paris, H\u00f4pital de la Piti\u00e9-Salp\u00eatri\u00e8re, 75013, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.411439.a", 
          "name": [
            "D\u00e9partement Biostatistiques, Assistance Publique H\u00f4pitaux de Paris, H\u00f4pital de la Piti\u00e9-Salp\u00eatri\u00e8re, 75013, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rufat", 
        "givenName": "Pierre", 
        "id": "sg:person.0654317437.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654317437.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de M\u00e9decine Interne 2, Institut e3m, Centre National de R\u00e9f\u00e9rence Maladies Syst\u00e9miques Rares, Sorbonne Universit\u00e9, Facult\u00e9 de M\u00e9decine, Assistance Publique H\u00f4pitaux de Paris, H\u00f4pital de la Piti\u00e9-Salp\u00eatri\u00e8re, 47-83 Boulevard de l\u2019h\u00f4pital, 75651, Paris Cedex 13, France", 
          "id": "http://www.grid.ac/institutes/grid.411439.a", 
          "name": [
            "Service de M\u00e9decine Interne 2, Institut e3m, Centre National de R\u00e9f\u00e9rence Maladies Syst\u00e9miques Rares, Sorbonne Universit\u00e9, Facult\u00e9 de M\u00e9decine, Assistance Publique H\u00f4pitaux de Paris, H\u00f4pital de la Piti\u00e9-Salp\u00eatri\u00e8re, 47-83 Boulevard de l\u2019h\u00f4pital, 75651, Paris Cedex 13, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pha", 
        "givenName": "Micheline", 
        "id": "sg:person.015010512031.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015010512031.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de M\u00e9decine Interne 2, Institut e3m, Centre National de R\u00e9f\u00e9rence Maladies Syst\u00e9miques Rares, Sorbonne Universit\u00e9, Facult\u00e9 de M\u00e9decine, Assistance Publique H\u00f4pitaux de Paris, H\u00f4pital de la Piti\u00e9-Salp\u00eatri\u00e8re, 47-83 Boulevard de l\u2019h\u00f4pital, 75651, Paris Cedex 13, France", 
          "id": "http://www.grid.ac/institutes/grid.411439.a", 
          "name": [
            "Service de M\u00e9decine Interne 2, Institut e3m, Centre National de R\u00e9f\u00e9rence Maladies Syst\u00e9miques Rares, Sorbonne Universit\u00e9, Facult\u00e9 de M\u00e9decine, Assistance Publique H\u00f4pitaux de Paris, H\u00f4pital de la Piti\u00e9-Salp\u00eatri\u00e8re, 47-83 Boulevard de l\u2019h\u00f4pital, 75651, Paris Cedex 13, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Haroche", 
        "givenName": "Julien", 
        "id": "sg:person.0616657632.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616657632.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de Neurologie Vasculaire, Assistance Publique H\u00f4pitaux de Paris, H\u00f4pital de la Piti\u00e9-Salp\u00eatri\u00e8re, 75013, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.411439.a", 
          "name": [
            "Service de Neurologie Vasculaire, Assistance Publique H\u00f4pitaux de Paris, H\u00f4pital de la Piti\u00e9-Salp\u00eatri\u00e8re, 75013, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Crozier", 
        "givenName": "Sophie", 
        "id": "sg:person.0761545607.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761545607.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de Neurologie, H\u00f4pital de Pontoise, 95000, Pontoise, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Service de Neurologie, H\u00f4pital de Pontoise, 95000, Pontoise, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dupel-Potier", 
        "givenName": "Corinne", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de Neurologie, Assistance Publique H\u00f4pitaux de Paris, H\u00f4pital de la Piti\u00e9-Salp\u00eatri\u00e8re, 75013, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.411439.a", 
          "name": [
            "Service de Neurologie, Assistance Publique H\u00f4pitaux de Paris, H\u00f4pital de la Piti\u00e9-Salp\u00eatri\u00e8re, 75013, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Psimaras", 
        "givenName": "Dimitri", 
        "id": "sg:person.01121456021.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121456021.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de M\u00e9decine Interne 2, Institut e3m, Centre National de R\u00e9f\u00e9rence Maladies Syst\u00e9miques Rares, Sorbonne Universit\u00e9, Facult\u00e9 de M\u00e9decine, Assistance Publique H\u00f4pitaux de Paris, H\u00f4pital de la Piti\u00e9-Salp\u00eatri\u00e8re, 47-83 Boulevard de l\u2019h\u00f4pital, 75651, Paris Cedex 13, France", 
          "id": "http://www.grid.ac/institutes/grid.411439.a", 
          "name": [
            "Service de M\u00e9decine Interne 2, Institut e3m, Centre National de R\u00e9f\u00e9rence Maladies Syst\u00e9miques Rares, Sorbonne Universit\u00e9, Facult\u00e9 de M\u00e9decine, Assistance Publique H\u00f4pitaux de Paris, H\u00f4pital de la Piti\u00e9-Salp\u00eatri\u00e8re, 47-83 Boulevard de l\u2019h\u00f4pital, 75651, Paris Cedex 13, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Amoura", 
        "givenName": "Zahir", 
        "id": "sg:person.01163563232.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163563232.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de M\u00e9decine Interne 2, Institut e3m, Centre National de R\u00e9f\u00e9rence Maladies Syst\u00e9miques Rares, Sorbonne Universit\u00e9, Facult\u00e9 de M\u00e9decine, Assistance Publique H\u00f4pitaux de Paris, H\u00f4pital de la Piti\u00e9-Salp\u00eatri\u00e8re, 47-83 Boulevard de l\u2019h\u00f4pital, 75651, Paris Cedex 13, France", 
          "id": "http://www.grid.ac/institutes/grid.411439.a", 
          "name": [
            "Service de M\u00e9decine Interne 2, Institut e3m, Centre National de R\u00e9f\u00e9rence Maladies Syst\u00e9miques Rares, Sorbonne Universit\u00e9, Facult\u00e9 de M\u00e9decine, Assistance Publique H\u00f4pitaux de Paris, H\u00f4pital de la Piti\u00e9-Salp\u00eatri\u00e8re, 47-83 Boulevard de l\u2019h\u00f4pital, 75651, Paris Cedex 13, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cohen Aubart", 
        "givenName": "Fleur", 
        "id": "sg:person.0724302255.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724302255.43"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/s12883-016-0741-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028636305", 
          "https://doi.org/10.1186/s12883-016-0741-x"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-08-14", 
    "datePublishedReg": "2018-08-14", 
    "description": "ObjectivesClinical involvement of the nervous system is uncommon during sarcoidosis. Cerebrovascular events are rarely reported during sarcoidosis and may be confused with primary angiitis of the central nervous system. The characteristics and outcomes of cerebrovascular events during sarcoidosis have not been well-evaluated.Patients and methodsWe conducted a retrospective case series in our institution with an updated review of the literature from 1962 to 2017 to characterize the clinical presentation, imaging, histology and outcomes of stroke that were thought to be causally related to sarcoidosis.ResultsFifty-one patients (31 men, median age at stroke diagnosis of 41\u00a0years) receiving a diagnosis of stroke and sarcoidosis, including 8 new cases from our institution and 43 from the literature review, were included. Stroke was the first manifestation of sarcoidosis in 64%. The stroke was ischemic in 69% and hemorrhagic in 31%. A total of 31% experienced a transient ischemic attack before ischemic stroke. A total of 36% of patients had multiple infarcts or hemorrhages. The median number of cardiovascular risk factors was 0. Concerning histological presentation, vascular or perivascular involvement was present in all cases. After a median follow-up of 12\u00a0months (after stroke), up to 50% of patients had developed a permanent neurological impairment, 16% had a recurrence of stroke, and 23% died.ConclusionsCerebrovascular events may be the first manifestation of neurosarcoidosis, and have a prognosis impact in such patients, leading to death and permanent neurological impairment.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00415-018-9001-x", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1014525", 
        "issn": [
          "0340-5354", 
          "1432-1459"
        ], 
        "name": "Journal of Neurology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "10", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "265"
      }
    ], 
    "keywords": [
      "outcome of stroke", 
      "permanent neurological impairment", 
      "cerebrovascular events", 
      "histological presentation", 
      "neurological impairment", 
      "first manifestation", 
      "nervous system", 
      "transient ischemic attack", 
      "cardiovascular risk factors", 
      "recurrence of stroke", 
      "retrospective case series", 
      "diagnosis of stroke", 
      "central nervous system", 
      "perivascular involvement", 
      "primary angiitis", 
      "ischemic attack", 
      "ischemic stroke", 
      "multiple infarcts", 
      "prognosis impact", 
      "such patients", 
      "case series", 
      "clinical presentation", 
      "risk factors", 
      "median number", 
      "sarcoidosis", 
      "patients", 
      "new cases", 
      "stroke", 
      "outcomes", 
      "impairment", 
      "presentation", 
      "manifestations", 
      "literature review", 
      "total", 
      "involvement", 
      "angiitis", 
      "neurosarcoidosis", 
      "hemorrhage", 
      "infarcts", 
      "review", 
      "recurrence", 
      "hemorrhagic", 
      "MethodsWe", 
      "histology", 
      "ResultsFifty", 
      "diagnosis", 
      "months", 
      "death", 
      "events", 
      "cases", 
      "imaging", 
      "institutions", 
      "factors", 
      "literature", 
      "number", 
      "impact", 
      "series", 
      "attacks", 
      "characteristics", 
      "system", 
      "ObjectivesClinical involvement", 
      "ConclusionsCerebrovascular events"
    ], 
    "name": "Clinical, imaging, and histological presentations and outcomes of stroke related to sarcoidosis", 
    "pagination": "2333-2341", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1106150101"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00415-018-9001-x"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30109479"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00415-018-9001-x", 
      "https://app.dimensions.ai/details/publication/pub.1106150101"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:47", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_766.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00415-018-9001-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00415-018-9001-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00415-018-9001-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00415-018-9001-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00415-018-9001-x'


 

This table displays all metadata directly associated to this object as RDF triples.

255 TRIPLES      22 PREDICATES      103 URIs      94 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00415-018-9001-x schema:about N1232f43958a747a0b8fdc86519064d91
2 N1ff3b060df4f46899e33cba7553206dd
3 N26ce0563207140eeb30088069b153818
4 N3e91f3ddecdf427eb2a27fde12a645b9
5 N5a4af8c117094cb1a4b65d415293a9b0
6 N620ebf4a2eb14093bdf13c593de131f2
7 N75dba395e7d74fca82bbf8465fccabaa
8 N839050e1947045d69db5aa4a0fb95f12
9 N94138c9cfadc4bc29133930bf43e4917
10 Nb162a996751549db967b4596dbe45a43
11 Nb28cfe20ea914cce828d22159429ae7d
12 Nb2c726c97ea147459e7ba1cecc8c47b9
13 Nc3c98084f8ac4996b2556362a7b62b99
14 Nd3440a37fdcf4c709e3ffd583bf5d276
15 anzsrc-for:11
16 anzsrc-for:1109
17 schema:author Nd0f4cfbd68194c0eb8292cb1e0cdda18
18 schema:citation sg:pub.10.1186/s12883-016-0741-x
19 schema:datePublished 2018-08-14
20 schema:datePublishedReg 2018-08-14
21 schema:description ObjectivesClinical involvement of the nervous system is uncommon during sarcoidosis. Cerebrovascular events are rarely reported during sarcoidosis and may be confused with primary angiitis of the central nervous system. The characteristics and outcomes of cerebrovascular events during sarcoidosis have not been well-evaluated.Patients and methodsWe conducted a retrospective case series in our institution with an updated review of the literature from 1962 to 2017 to characterize the clinical presentation, imaging, histology and outcomes of stroke that were thought to be causally related to sarcoidosis.ResultsFifty-one patients (31 men, median age at stroke diagnosis of 41 years) receiving a diagnosis of stroke and sarcoidosis, including 8 new cases from our institution and 43 from the literature review, were included. Stroke was the first manifestation of sarcoidosis in 64%. The stroke was ischemic in 69% and hemorrhagic in 31%. A total of 31% experienced a transient ischemic attack before ischemic stroke. A total of 36% of patients had multiple infarcts or hemorrhages. The median number of cardiovascular risk factors was 0. Concerning histological presentation, vascular or perivascular involvement was present in all cases. After a median follow-up of 12 months (after stroke), up to 50% of patients had developed a permanent neurological impairment, 16% had a recurrence of stroke, and 23% died.ConclusionsCerebrovascular events may be the first manifestation of neurosarcoidosis, and have a prognosis impact in such patients, leading to death and permanent neurological impairment.
22 schema:genre article
23 schema:inLanguage en
24 schema:isAccessibleForFree true
25 schema:isPartOf N33f80db36ed4416b9b5eae5e79cb7cbc
26 N6770198e83a94794a8c737817e65061c
27 sg:journal.1014525
28 schema:keywords ConclusionsCerebrovascular events
29 MethodsWe
30 ObjectivesClinical involvement
31 ResultsFifty
32 angiitis
33 attacks
34 cardiovascular risk factors
35 case series
36 cases
37 central nervous system
38 cerebrovascular events
39 characteristics
40 clinical presentation
41 death
42 diagnosis
43 diagnosis of stroke
44 events
45 factors
46 first manifestation
47 hemorrhage
48 hemorrhagic
49 histological presentation
50 histology
51 imaging
52 impact
53 impairment
54 infarcts
55 institutions
56 involvement
57 ischemic attack
58 ischemic stroke
59 literature
60 literature review
61 manifestations
62 median number
63 months
64 multiple infarcts
65 nervous system
66 neurological impairment
67 neurosarcoidosis
68 new cases
69 number
70 outcome of stroke
71 outcomes
72 patients
73 perivascular involvement
74 permanent neurological impairment
75 presentation
76 primary angiitis
77 prognosis impact
78 recurrence
79 recurrence of stroke
80 retrospective case series
81 review
82 risk factors
83 sarcoidosis
84 series
85 stroke
86 such patients
87 system
88 total
89 transient ischemic attack
90 schema:name Clinical, imaging, and histological presentations and outcomes of stroke related to sarcoidosis
91 schema:pagination 2333-2341
92 schema:productId N2bcc7b58a210465f9d42da6d6fc4b2ca
93 N52c52294e6e5472bb07fedd6bb4ae238
94 Nf646297af01449758608906a755199ba
95 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106150101
96 https://doi.org/10.1007/s00415-018-9001-x
97 schema:sdDatePublished 2022-01-01T18:47
98 schema:sdLicense https://scigraph.springernature.com/explorer/license/
99 schema:sdPublisher N7a79adfd49f24060837a191e3f3f41c9
100 schema:url https://doi.org/10.1007/s00415-018-9001-x
101 sgo:license sg:explorer/license/
102 sgo:sdDataset articles
103 rdf:type schema:ScholarlyArticle
104 N00f54027848746c5886f957c0eebe535 rdf:first sg:person.01121456021.27
105 rdf:rest N8934c1011c6a48f8bfea8e588c7b0aec
106 N0d3b7528dcdc42a183009c2281cd47e0 schema:affiliation grid-institutes:None
107 schema:familyName Dupel-Potier
108 schema:givenName Corinne
109 rdf:type schema:Person
110 N1232f43958a747a0b8fdc86519064d91 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Young Adult
112 rdf:type schema:DefinedTerm
113 N1ff3b060df4f46899e33cba7553206dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Central Nervous System Diseases
115 rdf:type schema:DefinedTerm
116 N26ce0563207140eeb30088069b153818 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Aged
118 rdf:type schema:DefinedTerm
119 N2bcc7b58a210465f9d42da6d6fc4b2ca schema:name pubmed_id
120 schema:value 30109479
121 rdf:type schema:PropertyValue
122 N33f80db36ed4416b9b5eae5e79cb7cbc schema:issueNumber 10
123 rdf:type schema:PublicationIssue
124 N3857380fc89f4d95b0267604f7ac7c01 rdf:first sg:person.0616657632.03
125 rdf:rest Nf8153ebd1d8342cbba8ea0c5934ba9b7
126 N3e91f3ddecdf427eb2a27fde12a645b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Male
128 rdf:type schema:DefinedTerm
129 N44e526bf154a49e59a987c23574e9252 rdf:first sg:person.0654317437.17
130 rdf:rest Nf5dceb1e3b6046959589324daa3c1ca1
131 N52c52294e6e5472bb07fedd6bb4ae238 schema:name doi
132 schema:value 10.1007/s00415-018-9001-x
133 rdf:type schema:PropertyValue
134 N5a4af8c117094cb1a4b65d415293a9b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Female
136 rdf:type schema:DefinedTerm
137 N620ebf4a2eb14093bdf13c593de131f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Retrospective Studies
139 rdf:type schema:DefinedTerm
140 N6770198e83a94794a8c737817e65061c schema:volumeNumber 265
141 rdf:type schema:PublicationVolume
142 N6a93f7b3abea409c9d2dde7435205d9b rdf:first sg:person.01047153417.79
143 rdf:rest N44e526bf154a49e59a987c23574e9252
144 N75dba395e7d74fca82bbf8465fccabaa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Middle Aged
146 rdf:type schema:DefinedTerm
147 N7a79adfd49f24060837a191e3f3f41c9 schema:name Springer Nature - SN SciGraph project
148 rdf:type schema:Organization
149 N839050e1947045d69db5aa4a0fb95f12 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Humans
151 rdf:type schema:DefinedTerm
152 N8934c1011c6a48f8bfea8e588c7b0aec rdf:first sg:person.01163563232.62
153 rdf:rest Nb121165e6a634a6983444a9e6f66f1bf
154 N94138c9cfadc4bc29133930bf43e4917 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Brain Ischemia
156 rdf:type schema:DefinedTerm
157 Nb121165e6a634a6983444a9e6f66f1bf rdf:first sg:person.0724302255.43
158 rdf:rest rdf:nil
159 Nb162a996751549db967b4596dbe45a43 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Sarcoidosis
161 rdf:type schema:DefinedTerm
162 Nb28cfe20ea914cce828d22159429ae7d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Cerebral Hemorrhage
164 rdf:type schema:DefinedTerm
165 Nb2c726c97ea147459e7ba1cecc8c47b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Follow-Up Studies
167 rdf:type schema:DefinedTerm
168 Nc3c98084f8ac4996b2556362a7b62b99 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Adult
170 rdf:type schema:DefinedTerm
171 Nd0f4cfbd68194c0eb8292cb1e0cdda18 rdf:first sg:person.015267247133.07
172 rdf:rest N6a93f7b3abea409c9d2dde7435205d9b
173 Nd179afbe6f164c4aa87be62f4f6aba42 rdf:first N0d3b7528dcdc42a183009c2281cd47e0
174 rdf:rest N00f54027848746c5886f957c0eebe535
175 Nd3440a37fdcf4c709e3ffd583bf5d276 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Stroke
177 rdf:type schema:DefinedTerm
178 Nf5dceb1e3b6046959589324daa3c1ca1 rdf:first sg:person.015010512031.26
179 rdf:rest N3857380fc89f4d95b0267604f7ac7c01
180 Nf646297af01449758608906a755199ba schema:name dimensions_id
181 schema:value pub.1106150101
182 rdf:type schema:PropertyValue
183 Nf8153ebd1d8342cbba8ea0c5934ba9b7 rdf:first sg:person.0761545607.60
184 rdf:rest Nd179afbe6f164c4aa87be62f4f6aba42
185 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
186 schema:name Medical and Health Sciences
187 rdf:type schema:DefinedTerm
188 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
189 schema:name Neurosciences
190 rdf:type schema:DefinedTerm
191 sg:journal.1014525 schema:issn 0340-5354
192 1432-1459
193 schema:name Journal of Neurology
194 schema:publisher Springer Nature
195 rdf:type schema:Periodical
196 sg:person.01047153417.79 schema:affiliation grid-institutes:grid.411439.a
197 schema:familyName Lhote
198 schema:givenName Raphael
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047153417.79
200 rdf:type schema:Person
201 sg:person.01121456021.27 schema:affiliation grid-institutes:grid.411439.a
202 schema:familyName Psimaras
203 schema:givenName Dimitri
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121456021.27
205 rdf:type schema:Person
206 sg:person.01163563232.62 schema:affiliation grid-institutes:grid.411439.a
207 schema:familyName Amoura
208 schema:givenName Zahir
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163563232.62
210 rdf:type schema:Person
211 sg:person.015010512031.26 schema:affiliation grid-institutes:grid.411439.a
212 schema:familyName Pha
213 schema:givenName Micheline
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015010512031.26
215 rdf:type schema:Person
216 sg:person.015267247133.07 schema:affiliation grid-institutes:grid.411439.a
217 schema:familyName Jachiet
218 schema:givenName Vincent
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015267247133.07
220 rdf:type schema:Person
221 sg:person.0616657632.03 schema:affiliation grid-institutes:grid.411439.a
222 schema:familyName Haroche
223 schema:givenName Julien
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616657632.03
225 rdf:type schema:Person
226 sg:person.0654317437.17 schema:affiliation grid-institutes:grid.411439.a
227 schema:familyName Rufat
228 schema:givenName Pierre
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654317437.17
230 rdf:type schema:Person
231 sg:person.0724302255.43 schema:affiliation grid-institutes:grid.411439.a
232 schema:familyName Cohen Aubart
233 schema:givenName Fleur
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724302255.43
235 rdf:type schema:Person
236 sg:person.0761545607.60 schema:affiliation grid-institutes:grid.411439.a
237 schema:familyName Crozier
238 schema:givenName Sophie
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761545607.60
240 rdf:type schema:Person
241 sg:pub.10.1186/s12883-016-0741-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028636305
242 https://doi.org/10.1186/s12883-016-0741-x
243 rdf:type schema:CreativeWork
244 grid-institutes:None schema:alternateName Service de Neurologie, Hôpital de Pontoise, 95000, Pontoise, France
245 schema:name Service de Neurologie, Hôpital de Pontoise, 95000, Pontoise, France
246 rdf:type schema:Organization
247 grid-institutes:grid.411439.a schema:alternateName Département Biostatistiques, Assistance Publique Hôpitaux de Paris, Hôpital de la Pitié-Salpêtrière, 75013, Paris, France
248 Service de Médecine Interne 2, Institut e3m, Centre National de Référence Maladies Systémiques Rares, Sorbonne Université, Faculté de Médecine, Assistance Publique Hôpitaux de Paris, Hôpital de la Pitié-Salpêtrière, 47-83 Boulevard de l’hôpital, 75651, Paris Cedex 13, France
249 Service de Neurologie Vasculaire, Assistance Publique Hôpitaux de Paris, Hôpital de la Pitié-Salpêtrière, 75013, Paris, France
250 Service de Neurologie, Assistance Publique Hôpitaux de Paris, Hôpital de la Pitié-Salpêtrière, 75013, Paris, France
251 schema:name Département Biostatistiques, Assistance Publique Hôpitaux de Paris, Hôpital de la Pitié-Salpêtrière, 75013, Paris, France
252 Service de Médecine Interne 2, Institut e3m, Centre National de Référence Maladies Systémiques Rares, Sorbonne Université, Faculté de Médecine, Assistance Publique Hôpitaux de Paris, Hôpital de la Pitié-Salpêtrière, 47-83 Boulevard de l’hôpital, 75651, Paris Cedex 13, France
253 Service de Neurologie Vasculaire, Assistance Publique Hôpitaux de Paris, Hôpital de la Pitié-Salpêtrière, 75013, Paris, France
254 Service de Neurologie, Assistance Publique Hôpitaux de Paris, Hôpital de la Pitié-Salpêtrière, 75013, Paris, France
255 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...