Coordination and timing deficits in speech and swallowing in autosomal recessive spastic ataxia of Charlevoix–Saguenay (ARSACS) View Full Text


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Article Info

DATE

2018-09

AUTHORS

Adam P. Vogel, Natalie Rommel, Andreas Oettinger, Lisa H. Stoll, Eva-Maria Kraus, Cynthia Gagnon, Marius Horger, Patrick Krumm, Dagmar Timmann, Elsdon Storey, Ludger Schöls, Matthis Synofzik

ABSTRACT

BACKGROUND: Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is a rare early onset neurodegenerative disease that typically results in ataxia, upper motor neuron dysfunction and sensorimotor peripheral neuropathy. Dysarthria and dysphagia are anecdotally described as key features of ARSACS but the nature, severity and impact of these deficits in ARSACS are not known. A comprehensive quantitative and qualitative characterization of speech and swallowing function will support diagnostics, provide insights into the underlying pathology, and guide day-to-day clinical management. METHODS: 11 consecutive non-Quebec ARSACS patients were recruited, and compared to healthy participants from several published and unpublished cohorts. A comprehensive behavioural assessment including objective acoustic analysis and expert perceptual ratings of motor speech, the Clinical Assessment of Dysphagia in Neurodegeneration (CADN), videofluoroscopy and standardized tests of dysarthria and swallowing related quality of life was conducted. RESULTS: Speech in this ARSACS cohort is characterized by pitch breaks, prosodic deficits including reduced rate and prolonged intervals, and articulatory deficits. The swallowing profile was characterized by delayed initiation of the swallowing reflex and late epiglottic closure. Four out of ten patients were observed aspirating thin liquids on videofluoroscopy. Patients report that they regularly cough or choke on thin liquids and solids during mealtimes. Swallowing and speech-related quality of life was worse than healthy controls on all domains except sleep. CONCLUSIONS: The dysphagia and dysarthria profile of this ARSACS cohort reflects impaired coordination and timing. Dysphagia contributes to a significant impairment in functional quality of life in ARSACS, and appears to manifest distinctly from other ARSACS dysfunctions such as ataxia or spasticity. More... »

PAGES

2060-2070

References to SciGraph publications

  • 2017-06. Clinical assessment of dysphagia in neurodegeneration (CADN): development, validity and reliability of a bedside tool for dysphagia assessment in JOURNAL OF NEUROLOGY
  • 2014-02. Dysphagia and swallowing-related quality of life in Friedreich ataxia in JOURNAL OF NEUROLOGY
  • 2013-12. Autosomal recessive spastic ataxia of Charlevoix Saguenay (ARSACS): expanding the genetic, clinical and imaging spectrum in ORPHANET JOURNAL OF RARE DISEASES
  • 2008-07. ARSACS in the Dutch population: a frequent cause of early-onset cerebellar ataxia in NEUROGENETICS
  • 2010-09. The Impact of Dysphagia on Quality of Life in Ageing and Parkinson’s Disease as Measured by the Swallowing Quality of Life (SWAL-QOL) Questionnaire in DYSPHAGIA
  • 1994-12. Videofluoroscopic evidence of aspiration predicts pneumonia and death but not dehydration following stroke in DYSPHAGIA
  • 2017-10. Dysphagia in Friedreich Ataxia in DYSPHAGIA
  • 2012-11. Longitudinal change in dysarthria associated with Friedreich ataxia: a potential clinical endpoint in JOURNAL OF NEUROLOGY
  • 1996-03. A penetration-aspiration scale in DYSPHAGIA
  • 2000-02. ARSACS, a spastic ataxia common in northeastern Québec, is caused by mutations in a new gene encoding an 11.5-kb ORF in NATURE GENETICS
  • 2015-02. A Systematic Review of Self-reported Swallowing Assessments in Progressive Neurological Disorders in DYSPHAGIA
  • 2014-06. Consensus Paper: Language and the Cerebellum: an Ongoing Enigma in THE CEREBELLUM
  • 2006-07. Clinical Validity of the SWAL-QOL and SWAL-CARE Outcome Tools with Respect to Bolus Flow Measures in DYSPHAGIA
  • 2018-08. Validation and Psychometric Properties of the German Version of the SWAL-QOL in DYSPHAGIA
  • 1998-08. A Study of Interrater Reliability when Using Videofluoroscopy as an Assessment of Swallowing in DYSPHAGIA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00415-018-8950-4

    DOI

    http://dx.doi.org/10.1007/s00415-018-8950-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1105260387

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29968200


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