REM sleep behavior disorder in Japanese patients with Parkinson’s disease: a multicenter study using the REM sleep behavior disorder screening ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-01-10

AUTHORS

Yoshihiro Nihei, Kazushi Takahashi, Atsuo Koto, Ban Mihara, Yoko Morita, Kazuo Isozumi, Kouichi Ohta, Kazuhiro Muramatsu, Jun Gotoh, Keiji Yamaguchi, Yutaka Tomita, Hideki Sato, Morinobu Seki, Satoko Iwasawa, Norihiro Suzuki

ABSTRACT

REM sleep behavior disorder (RBD) is known to be observed more frequently in patients with an α-synucleinopathy such as Parkinson’s disease (PD) than in the general population. The precise prevalence of RBD in Japanese PD patients is not known. Therefore, we investigated the prevalence and the clinical characteristics of patients with RBD in a large population of Japanese patients with PD. We investigated various clinical features and employed the Japanese version of the RBD screening questionnaire on 469 non-demented Japanese PD patients in this multicenter study. Probable or possible RBD was detected in 146 patients (31.1%) and was significantly associated with longer PD duration, higher Hoehn and Yahr stage, higher Unified Parkinson’s Disease Rating Scale part III subscale (7 items), more motor fluctuations, and a higher levodopa-equivalent daily dose (p < 0.01). As to the major autonomic dysfunctions, severe constipation was significantly more frequent in PD patients with RBD than in those without it (p < 0.01). The RBD symptoms of 53 patients (39.0%) preceded the onset of PD motor symptoms. The median interval from the onset of RBD symptoms to PD motor symptoms was 17.5 years, and 3 patients had intervals of over 50 years. This large-scale multicenter study revealed that RBD is a frequent non-motor symptom in Japanese patients with PD, which may precede the onset of motor symptoms. Moreover, RBD that increases with the duration and severity of PD may be associated with autonomic dysfunction. More... »

PAGES

1606-1612

Journal

TITLE

Journal of Neurology

ISSUE

8

VOLUME

259

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00415-011-6386-1

DOI

http://dx.doi.org/10.1007/s00415-011-6386-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020528753

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22231870


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21 schema:description REM sleep behavior disorder (RBD) is known to be observed more frequently in patients with an α-synucleinopathy such as Parkinson’s disease (PD) than in the general population. The precise prevalence of RBD in Japanese PD patients is not known. Therefore, we investigated the prevalence and the clinical characteristics of patients with RBD in a large population of Japanese patients with PD. We investigated various clinical features and employed the Japanese version of the RBD screening questionnaire on 469 non-demented Japanese PD patients in this multicenter study. Probable or possible RBD was detected in 146 patients (31.1%) and was significantly associated with longer PD duration, higher Hoehn and Yahr stage, higher Unified Parkinson’s Disease Rating Scale part III subscale (7 items), more motor fluctuations, and a higher levodopa-equivalent daily dose (p < 0.01). As to the major autonomic dysfunctions, severe constipation was significantly more frequent in PD patients with RBD than in those without it (p < 0.01). The RBD symptoms of 53 patients (39.0%) preceded the onset of PD motor symptoms. The median interval from the onset of RBD symptoms to PD motor symptoms was 17.5 years, and 3 patients had intervals of over 50 years. This large-scale multicenter study revealed that RBD is a frequent non-motor symptom in Japanese patients with PD, which may precede the onset of motor symptoms. Moreover, RBD that increases with the duration and severity of PD may be associated with autonomic dysfunction.
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29 III subscale
30 Japanese PD patients
31 Japanese patients
32 Japanese version
33 PD duration
34 PD motor symptoms
35 PD patients
36 Parkinson's disease
37 Parkinson’s Disease Rating Scale part III subscale
38 RBD symptoms
39 REM Sleep Behavior Disorder Screening Questionnaire
40 REM sleep behavior disorder
41 Rating Scale part III subscale
42 Scale part III subscale
43 Screening Questionnaire
44 Unified Parkinson’s Disease Rating Scale part III subscale
45 Yahr stage
46 autonomic dysfunction
47 behavior disorder
48 behavior disorder screening questionnaire
49 characteristics
50 clinical characteristics
51 clinical features
52 constipation
53 daily dose
54 disease
55 disorder screening questionnaire
56 disorders
57 dose
58 duration
59 dysfunction
60 features
61 fluctuations
62 frequent non-motor symptoms
63 general population
64 higher Hoehn
65 higher Unified Parkinson’s Disease Rating Scale part III subscale
66 higher levodopa equivalent daily dose
67 intervals
68 large population
69 large-scale multicenter study
70 levodopa equivalent daily dose
71 longer PD duration
72 major autonomic dysfunctions
73 median interval
74 more motor fluctuations
75 motor fluctuations
76 motor symptoms
77 multicenter study
78 non-demented Japanese PD patients
79 non-motor symptoms
80 onset
81 part III subscale
82 patients
83 population
84 possible REM sleep behavior disorder
85 precise prevalence
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