Neurological manifestations of Behçet’s disease in Japan: a study of 54 patients View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-02-03

AUTHORS

Haruko Ideguchi, Akiko Suda, Mitsuhiro Takeno, Yohei Kirino, Atsushi Ihata, Atsuhisa Ueda, Shigeru Ohno, Yasuhisa Baba, Yoshiyuki Kuroiwa, Yoshiaki Ishigatsubo

ABSTRACT

The type and frequency of neurological manifestations of Behçet’s disease (BD) vary with ethnicity. We analyzed the neurological manifestations of BD in Japanese patients. All patients undergoing treatment at one of the two Yokohama City University hospitals from July 1991 to December 2007 and who fulfilled the Japanese criteria for BD revised in 1987 were studied retrospectively by chart review. Patients had been neurologically assessed by neurologists. We recorded neurological signs and symptoms, magnetic resonance imaging or computed tomography findings, and results of cerebrospinal fluid examinations from the records of each patient. We studied 412 patients with BD, of whom 54 (13%) had neurological involvement (neuro-Behçet’s disease: NB). NB patients included a significantly higher proportion of males (61%) than non-NB patients (42%, P = 0.009). The majority of patients (n = 38, 70%) had acute parenchymal NB, 15 (28%) had chronic progressive parenchymal NB, and 1 (2%) had the non-parenchymal type. Headache and fever were more frequently reported by patients with acute parenchymal NB. Personality changes, sphincter disturbances, involuntary movements, and ataxia occurred predominantly in patients with chronic progressive parenchymal NB. Lesions were distributed throughout the CNS, but mainly in the brainstem, white matter, and basal ganglia. Analysis of end-point clinical outcomes revealed a poor prognosis for patients with chronic progressive NB. In Japan, most NB patients have the parenchymal type, and male gender is a predisposing factor. Because of the unfavorable prognosis associated with chronic progressive NB, development of effective therapies are urgently needed. More... »

PAGES

1012-1020

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00415-010-5454-2

DOI

http://dx.doi.org/10.1007/s00415-010-5454-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010270777

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20127350


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Asians", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Behcet Syndrome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chronic Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cranial Nerves", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Progression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Japan", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nervous System Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prevalence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogenes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radiography", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sex Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Spinal Cord", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Center for Rheumatic Diseases, Yokohama City University Medical Center, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.413045.7", 
          "name": [
            "Center for Rheumatic Diseases, Yokohama City University Medical Center, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ideguchi", 
        "givenName": "Haruko", 
        "id": "sg:person.01324761473.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324761473.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-Ku, 236-0004, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.268441.d", 
          "name": [
            "Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-Ku, 236-0004, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Suda", 
        "givenName": "Akiko", 
        "id": "sg:person.0645117456.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645117456.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-Ku, 236-0004, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.268441.d", 
          "name": [
            "Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-Ku, 236-0004, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takeno", 
        "givenName": "Mitsuhiro", 
        "id": "sg:person.01027461256.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027461256.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-Ku, 236-0004, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.268441.d", 
          "name": [
            "Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-Ku, 236-0004, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kirino", 
        "givenName": "Yohei", 
        "id": "sg:person.01205656516.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205656516.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-Ku, 236-0004, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.268441.d", 
          "name": [
            "Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-Ku, 236-0004, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ihata", 
        "givenName": "Atsushi", 
        "id": "sg:person.01364010267.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364010267.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-Ku, 236-0004, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.268441.d", 
          "name": [
            "Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-Ku, 236-0004, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ueda", 
        "givenName": "Atsuhisa", 
        "id": "sg:person.01032032373.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032032373.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Center for Rheumatic Diseases, Yokohama City University Medical Center, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.413045.7", 
          "name": [
            "Center for Rheumatic Diseases, Yokohama City University Medical Center, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ohno", 
        "givenName": "Shigeru", 
        "id": "sg:person.013722512012.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013722512012.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Neurology, Yokohama City University Graduate School of Medicine, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.268441.d", 
          "name": [
            "Department of Neurology, Yokohama City University Graduate School of Medicine, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Baba", 
        "givenName": "Yasuhisa", 
        "id": "sg:person.01111044433.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111044433.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Neurology, Yokohama City University Graduate School of Medicine, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.268441.d", 
          "name": [
            "Department of Neurology, Yokohama City University Graduate School of Medicine, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kuroiwa", 
        "givenName": "Yoshiyuki", 
        "id": "sg:person.0672736216.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672736216.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-Ku, 236-0004, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.268441.d", 
          "name": [
            "Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-Ku, 236-0004, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ishigatsubo", 
        "givenName": "Yoshiaki", 
        "id": "sg:person.01125133646.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125133646.44"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/369064a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024264501", 
          "https://doi.org/10.1038/369064a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10165-006-0541-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048952731", 
          "https://doi.org/10.1007/s10165-006-0541-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004150170242", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025735470", 
          "https://doi.org/10.1007/s004150170242"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004150050205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046203485", 
          "https://doi.org/10.1007/s004150050205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004150200031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000844966", 
          "https://doi.org/10.1007/s004150200031"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncprheum0436", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026455512", 
          "https://doi.org/10.1038/ncprheum0436"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/0-306-48382-3_75", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050086953", 
          "https://doi.org/10.1007/0-306-48382-3_75"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/ar757", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031502948", 
          "https://doi.org/10.1186/ar757"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00296-006-0149-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009099100", 
          "https://doi.org/10.1007/s00296-006-0149-9"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-02-03", 
    "datePublishedReg": "2010-02-03", 
    "description": "The type and frequency of neurological manifestations of Beh\u00e7et\u2019s disease (BD) vary with ethnicity. We analyzed the neurological manifestations of BD in Japanese patients. All patients undergoing treatment at one of the two Yokohama City University hospitals from July 1991 to December 2007 and who fulfilled the Japanese criteria for BD revised in 1987 were studied retrospectively by chart review. Patients had been neurologically assessed by neurologists. We recorded neurological signs and symptoms, magnetic resonance imaging or computed tomography findings, and results of cerebrospinal fluid examinations from the records of each patient. We studied 412 patients with BD, of whom 54 (13%) had neurological involvement (neuro-Beh\u00e7et\u2019s disease: NB). NB patients included a significantly higher proportion of males (61%) than non-NB patients (42%, P\u00a0=\u00a00.009). The majority of patients (n\u00a0=\u00a038, 70%) had acute parenchymal NB, 15 (28%) had chronic progressive parenchymal NB, and 1 (2%) had the non-parenchymal type. Headache and fever were more frequently reported by patients with acute parenchymal NB. Personality changes, sphincter disturbances, involuntary movements, and ataxia occurred predominantly in patients with chronic progressive parenchymal NB. Lesions were distributed throughout the CNS, but mainly in the brainstem, white matter, and basal ganglia. Analysis of end-point clinical outcomes revealed a poor prognosis for patients with chronic progressive NB. In Japan, most NB patients have the parenchymal type, and male gender is a predisposing factor. Because of the unfavorable prognosis associated with chronic progressive NB, development of effective therapies are urgently needed.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00415-010-5454-2", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1014525", 
        "issn": [
          "0340-5354", 
          "1432-1459"
        ], 
        "name": "Journal of Neurology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "257"
      }
    ], 
    "keywords": [
      "Beh\u00e7et's disease", 
      "neurological manifestations", 
      "NB patients", 
      "Yokohama City University Hospital", 
      "cerebrospinal fluid examination", 
      "majority of patients", 
      "City University Hospital", 
      "magnetic resonance imaging", 
      "parenchymal type", 
      "tomography findings", 
      "sphincter disturbances", 
      "chart review", 
      "fluid examination", 
      "neurological involvement", 
      "clinical outcomes", 
      "poor prognosis", 
      "neurological signs", 
      "unfavorable prognosis", 
      "University Hospital", 
      "basal ganglia", 
      "male gender", 
      "Japanese patients", 
      "effective therapy", 
      "Japanese criteria", 
      "involuntary movements", 
      "patients", 
      "white matter", 
      "resonance imaging", 
      "disease", 
      "personality changes", 
      "prognosis", 
      "manifestations", 
      "higher proportion", 
      "headache", 
      "brainstem", 
      "fever", 
      "ganglia", 
      "hospital", 
      "neurologists", 
      "therapy", 
      "symptoms", 
      "lesions", 
      "ataxia", 
      "outcomes", 
      "treatment", 
      "males", 
      "examination", 
      "signs", 
      "involvement", 
      "ethnicity", 
      "imaging", 
      "gender", 
      "review", 
      "majority", 
      "findings", 
      "proportion", 
      "CN", 
      "types", 
      "factors", 
      "records", 
      "criteria", 
      "study", 
      "Japan", 
      "disturbances", 
      "changes", 
      "frequency", 
      "development", 
      "analysis", 
      "movement", 
      "results", 
      "matter", 
      "Nb"
    ], 
    "name": "Neurological manifestations of Beh\u00e7et\u2019s disease in Japan: a study of 54 patients", 
    "pagination": "1012-1020", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1010270777"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00415-010-5454-2"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "20127350"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00415-010-5454-2", 
      "https://app.dimensions.ai/details/publication/pub.1010270777"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-20T07:26", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_509.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00415-010-5454-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00415-010-5454-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00415-010-5454-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00415-010-5454-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00415-010-5454-2'


 

This table displays all metadata directly associated to this object as RDF triples.

318 TRIPLES      22 PREDICATES      127 URIs      109 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00415-010-5454-2 schema:about N14e2058f468b4c64af8f71029f5ffcd3
2 N1a8438406fdd4816939f5225fe31c124
3 N433e8974b4c94ba7aff64814838de197
4 N491cf9dcb3424dc78c6e2af2a3f051c4
5 N4a7c5283a6444812938cf62736655b2d
6 N62c06d13a81b4395922057b3057031f5
7 N8440b531ff9741e1a7b4f833fa0e8a72
8 N858322c8603b491d8bc9630327e2bc88
9 N8b8b4d9e43d74f849323dae2c8bd90ca
10 N9d547493cd7b41558c73a263b58bb152
11 Nb53c489add1b4dadbe41d1143490ef68
12 Nc2379edf539f46399d82ce9acfbb1866
13 Ncaf3a5f7ff7942acbb599c38ccce64a3
14 Nd3b9694407be4308ae609a5a03708107
15 Nd3fc703f6fd640769d671ba5df8d19ff
16 Ndb1eebac363146ebb1c5250e8882b52d
17 Ne8861a9be3d9485a82674ebe74be64d7
18 Nf994b399f83c4bb0a60ae041757a124b
19 Nfcc7094b6f9042bc8814305adf269f5b
20 anzsrc-for:11
21 anzsrc-for:1103
22 anzsrc-for:1109
23 schema:author N03eebcbd4dd842cda0c7eb6b6d898e45
24 schema:citation sg:pub.10.1007/0-306-48382-3_75
25 sg:pub.10.1007/s00296-006-0149-9
26 sg:pub.10.1007/s004150050205
27 sg:pub.10.1007/s004150170242
28 sg:pub.10.1007/s004150200031
29 sg:pub.10.1007/s10165-006-0541-z
30 sg:pub.10.1038/369064a0
31 sg:pub.10.1038/ncprheum0436
32 sg:pub.10.1186/ar757
33 schema:datePublished 2010-02-03
34 schema:datePublishedReg 2010-02-03
35 schema:description The type and frequency of neurological manifestations of Behçet’s disease (BD) vary with ethnicity. We analyzed the neurological manifestations of BD in Japanese patients. All patients undergoing treatment at one of the two Yokohama City University hospitals from July 1991 to December 2007 and who fulfilled the Japanese criteria for BD revised in 1987 were studied retrospectively by chart review. Patients had been neurologically assessed by neurologists. We recorded neurological signs and symptoms, magnetic resonance imaging or computed tomography findings, and results of cerebrospinal fluid examinations from the records of each patient. We studied 412 patients with BD, of whom 54 (13%) had neurological involvement (neuro-Behçet’s disease: NB). NB patients included a significantly higher proportion of males (61%) than non-NB patients (42%, P = 0.009). The majority of patients (n = 38, 70%) had acute parenchymal NB, 15 (28%) had chronic progressive parenchymal NB, and 1 (2%) had the non-parenchymal type. Headache and fever were more frequently reported by patients with acute parenchymal NB. Personality changes, sphincter disturbances, involuntary movements, and ataxia occurred predominantly in patients with chronic progressive parenchymal NB. Lesions were distributed throughout the CNS, but mainly in the brainstem, white matter, and basal ganglia. Analysis of end-point clinical outcomes revealed a poor prognosis for patients with chronic progressive NB. In Japan, most NB patients have the parenchymal type, and male gender is a predisposing factor. Because of the unfavorable prognosis associated with chronic progressive NB, development of effective therapies are urgently needed.
36 schema:genre article
37 schema:inLanguage en
38 schema:isAccessibleForFree false
39 schema:isPartOf N90ba9ff68bf74d77b2b0916c73127c51
40 Nad5cb602df1b457a9e8608fb2a5ce96c
41 sg:journal.1014525
42 schema:keywords Behçet's disease
43 CN
44 City University Hospital
45 Japan
46 Japanese criteria
47 Japanese patients
48 NB patients
49 Nb
50 University Hospital
51 Yokohama City University Hospital
52 analysis
53 ataxia
54 basal ganglia
55 brainstem
56 cerebrospinal fluid examination
57 changes
58 chart review
59 clinical outcomes
60 criteria
61 development
62 disease
63 disturbances
64 effective therapy
65 ethnicity
66 examination
67 factors
68 fever
69 findings
70 fluid examination
71 frequency
72 ganglia
73 gender
74 headache
75 higher proportion
76 hospital
77 imaging
78 involuntary movements
79 involvement
80 lesions
81 magnetic resonance imaging
82 majority
83 majority of patients
84 male gender
85 males
86 manifestations
87 matter
88 movement
89 neurological involvement
90 neurological manifestations
91 neurological signs
92 neurologists
93 outcomes
94 parenchymal type
95 patients
96 personality changes
97 poor prognosis
98 prognosis
99 proportion
100 records
101 resonance imaging
102 results
103 review
104 signs
105 sphincter disturbances
106 study
107 symptoms
108 therapy
109 tomography findings
110 treatment
111 types
112 unfavorable prognosis
113 white matter
114 schema:name Neurological manifestations of Behçet’s disease in Japan: a study of 54 patients
115 schema:pagination 1012-1020
116 schema:productId N4f23e3a2297f46f69dd2d0b0aa588a21
117 Ncf559c30b60e4ad894aa9e0d5d12e7c7
118 Ne93327dcaab549759b3e7c6cd2fd8907
119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010270777
120 https://doi.org/10.1007/s00415-010-5454-2
121 schema:sdDatePublished 2022-05-20T07:26
122 schema:sdLicense https://scigraph.springernature.com/explorer/license/
123 schema:sdPublisher N46c51222580644cab070135a5e7b32a0
124 schema:url https://doi.org/10.1007/s00415-010-5454-2
125 sgo:license sg:explorer/license/
126 sgo:sdDataset articles
127 rdf:type schema:ScholarlyArticle
128 N010eec14a901408abba4479c1cb4a052 rdf:first sg:person.01027461256.90
129 rdf:rest N850eb7a36b2548858d2a6e862b0b8c1c
130 N02d54af1fee84701852e6cc2b3882677 rdf:first sg:person.01125133646.44
131 rdf:rest rdf:nil
132 N03eebcbd4dd842cda0c7eb6b6d898e45 rdf:first sg:person.01324761473.79
133 rdf:rest Ncf9a3619651b443f9aa407eaa7aaf99e
134 N14e2058f468b4c64af8f71029f5ffcd3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Radiography
136 rdf:type schema:DefinedTerm
137 N1a8438406fdd4816939f5225fe31c124 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Adult
139 rdf:type schema:DefinedTerm
140 N3b8e26b0dd5040e3976e492d0c773711 rdf:first sg:person.01032032373.04
141 rdf:rest Nbb2844c10b114ef1a39ed579ba0053b4
142 N41d095da2b3644fc895eb71d8a8ff72d rdf:first sg:person.0672736216.96
143 rdf:rest N02d54af1fee84701852e6cc2b3882677
144 N433e8974b4c94ba7aff64814838de197 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Humans
146 rdf:type schema:DefinedTerm
147 N46c51222580644cab070135a5e7b32a0 schema:name Springer Nature - SN SciGraph project
148 rdf:type schema:Organization
149 N491cf9dcb3424dc78c6e2af2a3f051c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Proto-Oncogenes
151 rdf:type schema:DefinedTerm
152 N4a7c5283a6444812938cf62736655b2d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Chronic Disease
154 rdf:type schema:DefinedTerm
155 N4f23e3a2297f46f69dd2d0b0aa588a21 schema:name dimensions_id
156 schema:value pub.1010270777
157 rdf:type schema:PropertyValue
158 N62c06d13a81b4395922057b3057031f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Female
160 rdf:type schema:DefinedTerm
161 N8440b531ff9741e1a7b4f833fa0e8a72 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Treatment Outcome
163 rdf:type schema:DefinedTerm
164 N850eb7a36b2548858d2a6e862b0b8c1c rdf:first sg:person.01205656516.09
165 rdf:rest Ne35482861ed1482f98e73460ff54568f
166 N858322c8603b491d8bc9630327e2bc88 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Nervous System Diseases
168 rdf:type schema:DefinedTerm
169 N8b8b4d9e43d74f849323dae2c8bd90ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Spinal Cord
171 rdf:type schema:DefinedTerm
172 N90ba9ff68bf74d77b2b0916c73127c51 schema:issueNumber 6
173 rdf:type schema:PublicationIssue
174 N9d547493cd7b41558c73a263b58bb152 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Cranial Nerves
176 rdf:type schema:DefinedTerm
177 Nad5cb602df1b457a9e8608fb2a5ce96c schema:volumeNumber 257
178 rdf:type schema:PublicationVolume
179 Nb53c489add1b4dadbe41d1143490ef68 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Asians
181 rdf:type schema:DefinedTerm
182 Nb99f1dbe7db744ada8a0a12e9fa709ca rdf:first sg:person.01111044433.24
183 rdf:rest N41d095da2b3644fc895eb71d8a8ff72d
184 Nbb2844c10b114ef1a39ed579ba0053b4 rdf:first sg:person.013722512012.55
185 rdf:rest Nb99f1dbe7db744ada8a0a12e9fa709ca
186 Nc2379edf539f46399d82ce9acfbb1866 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Prevalence
188 rdf:type schema:DefinedTerm
189 Ncaf3a5f7ff7942acbb599c38ccce64a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Male
191 rdf:type schema:DefinedTerm
192 Ncf559c30b60e4ad894aa9e0d5d12e7c7 schema:name pubmed_id
193 schema:value 20127350
194 rdf:type schema:PropertyValue
195 Ncf9a3619651b443f9aa407eaa7aaf99e rdf:first sg:person.0645117456.31
196 rdf:rest N010eec14a901408abba4479c1cb4a052
197 Nd3b9694407be4308ae609a5a03708107 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Disease Progression
199 rdf:type schema:DefinedTerm
200 Nd3fc703f6fd640769d671ba5df8d19ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Sex Factors
202 rdf:type schema:DefinedTerm
203 Ndb1eebac363146ebb1c5250e8882b52d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
204 schema:name Brain
205 rdf:type schema:DefinedTerm
206 Ne35482861ed1482f98e73460ff54568f rdf:first sg:person.01364010267.46
207 rdf:rest N3b8e26b0dd5040e3976e492d0c773711
208 Ne8861a9be3d9485a82674ebe74be64d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
209 schema:name Behcet Syndrome
210 rdf:type schema:DefinedTerm
211 Ne93327dcaab549759b3e7c6cd2fd8907 schema:name doi
212 schema:value 10.1007/s00415-010-5454-2
213 rdf:type schema:PropertyValue
214 Nf994b399f83c4bb0a60ae041757a124b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
215 schema:name Japan
216 rdf:type schema:DefinedTerm
217 Nfcc7094b6f9042bc8814305adf269f5b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
218 schema:name Retrospective Studies
219 rdf:type schema:DefinedTerm
220 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
221 schema:name Medical and Health Sciences
222 rdf:type schema:DefinedTerm
223 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
224 schema:name Clinical Sciences
225 rdf:type schema:DefinedTerm
226 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
227 schema:name Neurosciences
228 rdf:type schema:DefinedTerm
229 sg:journal.1014525 schema:issn 0340-5354
230 1432-1459
231 schema:name Journal of Neurology
232 schema:publisher Springer Nature
233 rdf:type schema:Periodical
234 sg:person.01027461256.90 schema:affiliation grid-institutes:grid.268441.d
235 schema:familyName Takeno
236 schema:givenName Mitsuhiro
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027461256.90
238 rdf:type schema:Person
239 sg:person.01032032373.04 schema:affiliation grid-institutes:grid.268441.d
240 schema:familyName Ueda
241 schema:givenName Atsuhisa
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032032373.04
243 rdf:type schema:Person
244 sg:person.01111044433.24 schema:affiliation grid-institutes:grid.268441.d
245 schema:familyName Baba
246 schema:givenName Yasuhisa
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111044433.24
248 rdf:type schema:Person
249 sg:person.01125133646.44 schema:affiliation grid-institutes:grid.268441.d
250 schema:familyName Ishigatsubo
251 schema:givenName Yoshiaki
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125133646.44
253 rdf:type schema:Person
254 sg:person.01205656516.09 schema:affiliation grid-institutes:grid.268441.d
255 schema:familyName Kirino
256 schema:givenName Yohei
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205656516.09
258 rdf:type schema:Person
259 sg:person.01324761473.79 schema:affiliation grid-institutes:grid.413045.7
260 schema:familyName Ideguchi
261 schema:givenName Haruko
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324761473.79
263 rdf:type schema:Person
264 sg:person.01364010267.46 schema:affiliation grid-institutes:grid.268441.d
265 schema:familyName Ihata
266 schema:givenName Atsushi
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364010267.46
268 rdf:type schema:Person
269 sg:person.013722512012.55 schema:affiliation grid-institutes:grid.413045.7
270 schema:familyName Ohno
271 schema:givenName Shigeru
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013722512012.55
273 rdf:type schema:Person
274 sg:person.0645117456.31 schema:affiliation grid-institutes:grid.268441.d
275 schema:familyName Suda
276 schema:givenName Akiko
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645117456.31
278 rdf:type schema:Person
279 sg:person.0672736216.96 schema:affiliation grid-institutes:grid.268441.d
280 schema:familyName Kuroiwa
281 schema:givenName Yoshiyuki
282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672736216.96
283 rdf:type schema:Person
284 sg:pub.10.1007/0-306-48382-3_75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050086953
285 https://doi.org/10.1007/0-306-48382-3_75
286 rdf:type schema:CreativeWork
287 sg:pub.10.1007/s00296-006-0149-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009099100
288 https://doi.org/10.1007/s00296-006-0149-9
289 rdf:type schema:CreativeWork
290 sg:pub.10.1007/s004150050205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046203485
291 https://doi.org/10.1007/s004150050205
292 rdf:type schema:CreativeWork
293 sg:pub.10.1007/s004150170242 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025735470
294 https://doi.org/10.1007/s004150170242
295 rdf:type schema:CreativeWork
296 sg:pub.10.1007/s004150200031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000844966
297 https://doi.org/10.1007/s004150200031
298 rdf:type schema:CreativeWork
299 sg:pub.10.1007/s10165-006-0541-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1048952731
300 https://doi.org/10.1007/s10165-006-0541-z
301 rdf:type schema:CreativeWork
302 sg:pub.10.1038/369064a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024264501
303 https://doi.org/10.1038/369064a0
304 rdf:type schema:CreativeWork
305 sg:pub.10.1038/ncprheum0436 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026455512
306 https://doi.org/10.1038/ncprheum0436
307 rdf:type schema:CreativeWork
308 sg:pub.10.1186/ar757 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031502948
309 https://doi.org/10.1186/ar757
310 rdf:type schema:CreativeWork
311 grid-institutes:grid.268441.d schema:alternateName Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-Ku, 236-0004, Yokohama, Japan
312 Department of Neurology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
313 schema:name Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-Ku, 236-0004, Yokohama, Japan
314 Department of Neurology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
315 rdf:type schema:Organization
316 grid-institutes:grid.413045.7 schema:alternateName Center for Rheumatic Diseases, Yokohama City University Medical Center, Yokohama, Japan
317 schema:name Center for Rheumatic Diseases, Yokohama City University Medical Center, Yokohama, Japan
318 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...