Staging of the intracerebral inclusion body pathology associated with idiopathic Parkinson's disease (preclinical and clinical stages) View Full Text


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Article Info

DATE

2002-10

AUTHORS

Heiko Braak, Kelly Del Tredici, Hansjürgen Bratzke, John Hamm-Clement, Daniele Sandmann-Keil, Udo Rüb

ABSTRACT

. The synucleinopathy known as idiopathic Parkinson's disease (IPD) is a multi-system disorder in the course of which only a few predisposed nerve cell types in specific regions of the human brain become progressively involved. The underlying neuropathological process (formation of proteinaceous intraneuronal inclusion bodies) intracerebrally begins in clearly defined induction sites and advances in a topographically predictable sequence. Components of the autonomic, limbic, and motor systems sustain especially heavy damage. During the presymptomatic stages 1 and 2, the IPD-related inclusion body pathology remains confined to the medulla oblongata and olfactory bulb. In stages 3 and 4, the substantia nigra and other nuclear grays of the midbrain and basal forebrain are the focus of initially subtle and, then, severe changes. The illness reaches its symptomatic phase. In end-stages 5 and 6, the pathological process encroaches upon the telencephalic cortex. IPD manifests itself in all of its dimensions, which under the influence of the supervening cortical pathology are subject to increasing complexity. More... »

PAGES

iii1-iii5

References to SciGraph publications

  • 1997-08. α-Synuclein in Lewy bodies in NATURE
  • 2001-07. Alpha-synuclein and neurodegenerative diseases in NATURE REVIEWS NEUROSCIENCE
  • 2000-04. Pathoanatomy of Parkinson’s disease in JOURNAL OF NEUROLOGY
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    http://scigraph.springernature.com/pub.10.1007/s00415-002-1301-4

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    http://dx.doi.org/10.1007/s00415-002-1301-4

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    https://app.dimensions.ai/details/publication/pub.1044517506

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/12528692


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