Unravelling HP1 functions: post-transcriptional regulation of stem cell fate View Full Text


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Article Info

DATE

2021-06-15

AUTHORS

Assunta Maria Casale, Ugo Cappucci, Lucia Piacentini

ABSTRACT

Heterochromatin protein 1 (HP1) is a non-histone chromosomal protein first identified in Drosophila as a major component of constitutive heterochromatin, required for stable epigenetic gene silencing in many species including humans. Over the years, several studies have highlighted additional roles of HP1 in different cellular processes including telomere maintenance, DNA replication and repair, chromosome segregation and, surprisingly, positive regulation of gene expression. In this review, we briefly summarize past research and recent results supporting the unexpected and emerging role of HP1 in activating gene expression. In particular, we discuss the role of HP1 in post-transcriptional regulation of mRNA processing because it has proved decisive in the control of germline stem cells homeostasis in Drosophila and has certainly added a new dimension to our understanding on HP1 targeting and functions in epigenetic regulation of stem cell behaviour. More... »

PAGES

103-111

References to SciGraph publications

  • 2014-03-12. Dynamic Phosphorylation of HP1α Regulates Mitotic Progression in Human Cells in NATURE COMMUNICATIONS
  • 2018-09-04. Local enrichment of HP1alpha at telomeres alters their structure and regulation of telomere protection in NATURE COMMUNICATIONS
  • 2002-02-19. Higher-order structure in pericentric heterochromatin involves a distinct pattern of histone modification and an RNA component in NATURE GENETICS
  • 2020-06-05. Various modes of HP1a interactions with the euchromatic chromosome arms in Drosophila ovarian somatic cells in CHROMOSOMA
  • 2019-03-13. Heterochromatin protein 1 (HP1) is intrinsically required for post-transcriptional regulation of Drosophila Germline Stem Cell (GSC) maintenance in SCIENTIFIC REPORTS
  • 2005-10-30. Sex-specific role of Drosophila melanogaster HP1 in regulating chromatin structure and gene transcription in NATURE GENETICS
  • 2017-06-21. Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin in NATURE
  • 1999-08. Localization and phosphorylation of HP1 proteins during the cell cycle in mammalian cells in CHROMOSOMA
  • 2019-10-16. HP1 reshapes the nucleosome core to promote phase separation of heterochromatin in NATURE
  • 2002-02-20. Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9 in NATURE
  • 2006-03-12. Evidence for the existence of an HP1-mediated subcode within the histone code in NATURE CELL BIOLOGY
  • 2017-08-23. A heterochromatin-dependent transcription machinery drives piRNA expression in NATURE
  • 2001-03. Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins in NATURE
  • 2017-06-21. Phase separation drives heterochromatin domain formation in NATURE
  • 2001-03. Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain in NATURE
  • 2019-04-02. Citrullination of HP1γ chromodomain affects association with chromatin in EPIGENETICS & CHROMATIN
  • 2004-12-09. Mutations in the heterochromatin protein 1 (HP1) hinge domain affect HP1 protein interactions and chromosomal distribution in CHROMOSOMA
  • 2004-04. HP1 and the dynamics of heterochromatin maintenance in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2019-12-13. NBS1 interacts with HP1 to ensure genome integrity in CELL DEATH & DISEASE
  • 2014-11-16. Tethering of SUUR and HP1 proteins results in delayed replication of euchromatic regions in Drosophila melanogaster polytene chromosomes in CHROMOSOMA
  • 2009-10-04. DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction in NATURE GENETICS
  • 2003-03. Chromosomal Distribution of Heterochromatin Protein 1 (HP1) in Drosophila: a Cytological Map of Euchromatic HP1 Binding Sites in GENETICA
  • 2018-10-10. Mechanisms Underlying the Regulation of HP1γ by the NGF-PKA Signaling Pathway in SCIENTIFIC REPORTS
  • 2011-02-13. SUMOylation promotes de novo targeting of HP1α to pericentric heterochromatin in NATURE GENETICS
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    URI

    http://scigraph.springernature.com/pub.10.1007/s00412-021-00760-1

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