spn-A/rad51 mutant exhibits enhanced genomic damage, cell death and low temperature sensitivity in somatic tissues View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2020-11-22

AUTHORS

Chaitali Khan, Sonia Muliyil, Champakali Ayyub, B. J. Rao

ABSTRACT

Homologous recombination (HR) is one of the key pathways to repair double-strand breaks (DSBs). Rad51 serves an important function of catalysing strand exchange between two homologous sequences in the HR pathway. In higher organisms, rad51 function is indispensable with its absence leading to early embryonic lethality, thus precluding any mechanistic probing of the system. In contrast, the absence of Drosophila rad51 (spn-A/rad51) has been associated with defects in the germline, without any reported detrimental consequences to Drosophila somatic tissues. In this study, we have performed a systematic analysis of developmental defects in somatic tissues of spn-A mutant flies by using genetic complementation between multiple spn-A alleles. Our current study, for the first time, uncovers a requirement for spn-A in somatic tissue maintenance during both larval and pupal stages. Also, we show that spn-A mutant exhibits patterning defects in abdominal cuticle in the stripes and bristles, while there appear to be only subtle defects in the adult wing and eye. Interestingly, spn-A mutant shows a discernible phenotype of low temperature sensitivity, suggesting a role of spn-A in temperature sensitive cellular processes. In summary, our study describes the important role played by spn-A/rad51 in Drosophila somatic tissues. More... »

PAGES

3-14

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00412-020-00746-5

DOI

http://dx.doi.org/10.1007/s00412-020-00746-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1132841010

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/33222024


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Body Patterning", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Death", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Damage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drosophila Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drosophila melanogaster", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Developmental", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Germ Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Homologous Recombination", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Meiosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phenotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rad51 Recombinase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Temperature", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, NY, USA", 
          "id": "http://www.grid.ac/institutes/grid.251993.5", 
          "name": [
            "Department of Biological Sciences, Tata Institute of Fundamental Research, Colaba, 400005, Mumbai, India", 
            "Department of Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Khan", 
        "givenName": "Chaitali", 
        "id": "sg:person.010041415317.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010041415317.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sir William Dunn School of Pathology, University of Oxford, South Parks Road, OX1 3RE, Oxford, UK", 
          "id": "http://www.grid.ac/institutes/grid.4991.5", 
          "name": [
            "Department of Biological Sciences, Tata Institute of Fundamental Research, Colaba, 400005, Mumbai, India", 
            "Sir William Dunn School of Pathology, University of Oxford, South Parks Road, OX1 3RE, Oxford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Muliyil", 
        "givenName": "Sonia", 
        "id": "sg:person.01134672210.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134672210.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biological Sciences, Tata Institute of Fundamental Research, Colaba, 400005, Mumbai, India", 
          "id": "http://www.grid.ac/institutes/grid.22401.35", 
          "name": [
            "Department of Biological Sciences, Tata Institute of Fundamental Research, Colaba, 400005, Mumbai, India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ayyub", 
        "givenName": "Champakali", 
        "id": "sg:person.0760716567.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760716567.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Indian Institute of Science Education and Research (IISER) Tirupati, Transit Campus, Sree Rama Engineering College, Tirupati, India", 
          "id": "http://www.grid.ac/institutes/grid.494635.9", 
          "name": [
            "Department of Biological Sciences, Tata Institute of Fundamental Research, Colaba, 400005, Mumbai, India", 
            "Indian Institute of Science Education and Research (IISER) Tirupati, Transit Campus, Sree Rama Engineering College, Tirupati, India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rao", 
        "givenName": "B. J.", 
        "id": "sg:person.01236072700.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236072700.11"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf00848779", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048323153", 
          "https://doi.org/10.1007/bf00848779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb0104-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030880261", 
          "https://doi.org/10.1038/nsmb0104-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1210868", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044587952", 
          "https://doi.org/10.1038/sj.onc.1210868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1210881", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031474067", 
          "https://doi.org/10.1038/sj.onc.1210881"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg3729", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045403173", 
          "https://doi.org/10.1038/nrg3729"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2020-11-22", 
    "datePublishedReg": "2020-11-22", 
    "description": "Homologous recombination (HR) is one of the key pathways to repair double-strand breaks (DSBs). Rad51 serves an important function of catalysing strand exchange between two homologous sequences in the HR pathway. In higher organisms, rad51 function is indispensable with its absence leading to early embryonic lethality, thus precluding any mechanistic probing of the system. In contrast, the absence of Drosophila rad51 (spn-A/rad51) has been associated with defects in the germline, without any reported detrimental consequences to Drosophila somatic tissues. In this study, we have performed a systematic analysis of developmental defects in somatic tissues of spn-A mutant flies by using genetic complementation between multiple spn-A alleles. Our current study, for the first time, uncovers a requirement for spn-A in somatic tissue maintenance during both larval and pupal stages. Also, we show that spn-A mutant exhibits patterning defects in abdominal cuticle in the stripes and bristles, while there appear to be only subtle defects in the adult wing and eye. Interestingly, spn-A mutant shows a discernible phenotype of low temperature sensitivity, suggesting a role of spn-A in temperature sensitive cellular processes. In summary, our study describes the important role played by spn-A/rad51 in Drosophila somatic tissues.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00412-020-00746-5", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1312277", 
        "issn": [
          "0009-5915", 
          "1432-0886"
        ], 
        "name": "Chromosoma", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "130"
      }
    ], 
    "keywords": [
      "Drosophila somatic tissues", 
      "double-strand breaks", 
      "somatic tissues", 
      "homologous recombination", 
      "sensitive cellular processes", 
      "early embryonic lethality", 
      "Drosophila Rad51", 
      "role of Spn", 
      "rad51 mutants", 
      "RAD51 function", 
      "discernible phenotype", 
      "genetic complementation", 
      "higher organisms", 
      "mutant flies", 
      "embryonic lethality", 
      "cellular processes", 
      "adult wing", 
      "HR pathway", 
      "homologous sequences", 
      "strand exchange", 
      "tissue maintenance", 
      "developmental defects", 
      "pupal stage", 
      "RAD51", 
      "cell death", 
      "genomic damage", 
      "key pathways", 
      "abdominal cuticle", 
      "important functions", 
      "mutants", 
      "mechanistic probing", 
      "subtle defects", 
      "temperature sensitivity", 
      "pathway", 
      "important role", 
      "complementation", 
      "tissue", 
      "germline", 
      "larval", 
      "organisms", 
      "flies", 
      "cuticle", 
      "phenotype", 
      "bristles", 
      "systematic analysis", 
      "lethality", 
      "detrimental consequences", 
      "alleles", 
      "low temperature sensitivity", 
      "recombination", 
      "defects", 
      "first time", 
      "role", 
      "sequence", 
      "absence", 
      "function", 
      "maintenance", 
      "SPN", 
      "breaks", 
      "probing", 
      "wing", 
      "current study", 
      "contrast", 
      "stage", 
      "damage", 
      "study", 
      "death", 
      "consequences", 
      "summary", 
      "stripes", 
      "exchange", 
      "sensitivity", 
      "analysis", 
      "process", 
      "system", 
      "requirements", 
      "time", 
      "eyes", 
      "somatic tissue maintenance", 
      "temperature sensitive cellular processes"
    ], 
    "name": "spn-A/rad51 mutant exhibits enhanced genomic damage, cell death and low temperature sensitivity in somatic tissues", 
    "pagination": "3-14", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1132841010"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00412-020-00746-5"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "33222024"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00412-020-00746-5", 
      "https://app.dimensions.ai/details/publication/pub.1132841010"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:56", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_857.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00412-020-00746-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00412-020-00746-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00412-020-00746-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00412-020-00746-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00412-020-00746-5'


 

This table displays all metadata directly associated to this object as RDF triples.

263 TRIPLES      22 PREDICATES      128 URIs      114 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00412-020-00746-5 schema:about N01b3ecba9f884f56a6b398b910d7c4d3
2 N0669a190a8b64c4aa0ad58fc252f25dd
3 N372a492761e045ca8ce8fad5f16a7bf7
4 N50f8b8eb1c654858920eb1971a51cd80
5 N54bbc0f92e734bccad5c8995de079e3d
6 N6d2ff6d717c244f6afa0da8f0ab30e8f
7 N7726a79cc27b4cd2be2518774f8f003c
8 N8da780369b3e47a0a01eb1d831c3a02c
9 N9830a955b28f4f55a6fb6897c206085f
10 N9ba8fa0722264c7989cc1f8ecadcb62f
11 Naac4d1bba1774fe5a82a8d51033fa9c5
12 Nb4047db8790049a998f6aa3e2bab89bb
13 Nc933521a20a64d28b20568371174c7f4
14 Nd52aeaaaa8474bb9b7d3b217e26f22ac
15 Nddee956159d14413ae97be4405a2862c
16 Ne78cf201e1764ad9a7ba751585647a22
17 anzsrc-for:06
18 anzsrc-for:0601
19 anzsrc-for:0604
20 schema:author Ne3783c2d7ad74351b5cd5f7ba18e7a9c
21 schema:citation sg:pub.10.1007/bf00848779
22 sg:pub.10.1038/nrg3729
23 sg:pub.10.1038/nsmb0104-9
24 sg:pub.10.1038/sj.onc.1210868
25 sg:pub.10.1038/sj.onc.1210881
26 schema:datePublished 2020-11-22
27 schema:datePublishedReg 2020-11-22
28 schema:description Homologous recombination (HR) is one of the key pathways to repair double-strand breaks (DSBs). Rad51 serves an important function of catalysing strand exchange between two homologous sequences in the HR pathway. In higher organisms, rad51 function is indispensable with its absence leading to early embryonic lethality, thus precluding any mechanistic probing of the system. In contrast, the absence of Drosophila rad51 (spn-A/rad51) has been associated with defects in the germline, without any reported detrimental consequences to Drosophila somatic tissues. In this study, we have performed a systematic analysis of developmental defects in somatic tissues of spn-A mutant flies by using genetic complementation between multiple spn-A alleles. Our current study, for the first time, uncovers a requirement for spn-A in somatic tissue maintenance during both larval and pupal stages. Also, we show that spn-A mutant exhibits patterning defects in abdominal cuticle in the stripes and bristles, while there appear to be only subtle defects in the adult wing and eye. Interestingly, spn-A mutant shows a discernible phenotype of low temperature sensitivity, suggesting a role of spn-A in temperature sensitive cellular processes. In summary, our study describes the important role played by spn-A/rad51 in Drosophila somatic tissues.
29 schema:genre article
30 schema:inLanguage en
31 schema:isAccessibleForFree false
32 schema:isPartOf N8890f91f2d964bed9e23d3c3e4a5c904
33 Nc5fe4cc90e814a7893404b004dc102a4
34 sg:journal.1312277
35 schema:keywords Drosophila Rad51
36 Drosophila somatic tissues
37 HR pathway
38 RAD51
39 RAD51 function
40 SPN
41 abdominal cuticle
42 absence
43 adult wing
44 alleles
45 analysis
46 breaks
47 bristles
48 cell death
49 cellular processes
50 complementation
51 consequences
52 contrast
53 current study
54 cuticle
55 damage
56 death
57 defects
58 detrimental consequences
59 developmental defects
60 discernible phenotype
61 double-strand breaks
62 early embryonic lethality
63 embryonic lethality
64 exchange
65 eyes
66 first time
67 flies
68 function
69 genetic complementation
70 genomic damage
71 germline
72 higher organisms
73 homologous recombination
74 homologous sequences
75 important functions
76 important role
77 key pathways
78 larval
79 lethality
80 low temperature sensitivity
81 maintenance
82 mechanistic probing
83 mutant flies
84 mutants
85 organisms
86 pathway
87 phenotype
88 probing
89 process
90 pupal stage
91 rad51 mutants
92 recombination
93 requirements
94 role
95 role of Spn
96 sensitive cellular processes
97 sensitivity
98 sequence
99 somatic tissue maintenance
100 somatic tissues
101 stage
102 strand exchange
103 stripes
104 study
105 subtle defects
106 summary
107 system
108 systematic analysis
109 temperature sensitive cellular processes
110 temperature sensitivity
111 time
112 tissue
113 tissue maintenance
114 wing
115 schema:name spn-A/rad51 mutant exhibits enhanced genomic damage, cell death and low temperature sensitivity in somatic tissues
116 schema:pagination 3-14
117 schema:productId N953f8187d1c345abb0327fa94608cab4
118 Na96df42e61304b52ac6533c1cb588678
119 Nebe9449ab91344d1b4742800dbbcf01e
120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1132841010
121 https://doi.org/10.1007/s00412-020-00746-5
122 schema:sdDatePublished 2022-01-01T18:56
123 schema:sdLicense https://scigraph.springernature.com/explorer/license/
124 schema:sdPublisher N1ad8813a320d453bb05f6d8ff4b91cd7
125 schema:url https://doi.org/10.1007/s00412-020-00746-5
126 sgo:license sg:explorer/license/
127 sgo:sdDataset articles
128 rdf:type schema:ScholarlyArticle
129 N01b3ecba9f884f56a6b398b910d7c4d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Rad51 Recombinase
131 rdf:type schema:DefinedTerm
132 N0669a190a8b64c4aa0ad58fc252f25dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Body Patterning
134 rdf:type schema:DefinedTerm
135 N1ad8813a320d453bb05f6d8ff4b91cd7 schema:name Springer Nature - SN SciGraph project
136 rdf:type schema:Organization
137 N2870bbcf393e4d52a6b65c9b3bd90a56 rdf:first sg:person.01134672210.73
138 rdf:rest Neb4b5242c20543d3b03c3a8002bbd927
139 N372a492761e045ca8ce8fad5f16a7bf7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Female
141 rdf:type schema:DefinedTerm
142 N4bac564e3ee643e9b2ce78349e8ac01c rdf:first sg:person.01236072700.11
143 rdf:rest rdf:nil
144 N50f8b8eb1c654858920eb1971a51cd80 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Gene Expression Regulation, Developmental
146 rdf:type schema:DefinedTerm
147 N54bbc0f92e734bccad5c8995de079e3d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Drosophila Proteins
149 rdf:type schema:DefinedTerm
150 N6d2ff6d717c244f6afa0da8f0ab30e8f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Cell Death
152 rdf:type schema:DefinedTerm
153 N7726a79cc27b4cd2be2518774f8f003c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Homologous Recombination
155 rdf:type schema:DefinedTerm
156 N8890f91f2d964bed9e23d3c3e4a5c904 schema:issueNumber 1
157 rdf:type schema:PublicationIssue
158 N8da780369b3e47a0a01eb1d831c3a02c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Meiosis
160 rdf:type schema:DefinedTerm
161 N953f8187d1c345abb0327fa94608cab4 schema:name doi
162 schema:value 10.1007/s00412-020-00746-5
163 rdf:type schema:PropertyValue
164 N9830a955b28f4f55a6fb6897c206085f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Germ Cells
166 rdf:type schema:DefinedTerm
167 N9ba8fa0722264c7989cc1f8ecadcb62f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name DNA Damage
169 rdf:type schema:DefinedTerm
170 Na96df42e61304b52ac6533c1cb588678 schema:name dimensions_id
171 schema:value pub.1132841010
172 rdf:type schema:PropertyValue
173 Naac4d1bba1774fe5a82a8d51033fa9c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Drosophila melanogaster
175 rdf:type schema:DefinedTerm
176 Nb4047db8790049a998f6aa3e2bab89bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Mutation
178 rdf:type schema:DefinedTerm
179 Nc5fe4cc90e814a7893404b004dc102a4 schema:volumeNumber 130
180 rdf:type schema:PublicationVolume
181 Nc933521a20a64d28b20568371174c7f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Animals
183 rdf:type schema:DefinedTerm
184 Nd52aeaaaa8474bb9b7d3b217e26f22ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Phenotype
186 rdf:type schema:DefinedTerm
187 Nddee956159d14413ae97be4405a2862c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Male
189 rdf:type schema:DefinedTerm
190 Ne3783c2d7ad74351b5cd5f7ba18e7a9c rdf:first sg:person.010041415317.73
191 rdf:rest N2870bbcf393e4d52a6b65c9b3bd90a56
192 Ne78cf201e1764ad9a7ba751585647a22 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Temperature
194 rdf:type schema:DefinedTerm
195 Neb4b5242c20543d3b03c3a8002bbd927 rdf:first sg:person.0760716567.72
196 rdf:rest N4bac564e3ee643e9b2ce78349e8ac01c
197 Nebe9449ab91344d1b4742800dbbcf01e schema:name pubmed_id
198 schema:value 33222024
199 rdf:type schema:PropertyValue
200 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
201 schema:name Biological Sciences
202 rdf:type schema:DefinedTerm
203 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
204 schema:name Biochemistry and Cell Biology
205 rdf:type schema:DefinedTerm
206 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
207 schema:name Genetics
208 rdf:type schema:DefinedTerm
209 sg:journal.1312277 schema:issn 0009-5915
210 1432-0886
211 schema:name Chromosoma
212 schema:publisher Springer Nature
213 rdf:type schema:Periodical
214 sg:person.010041415317.73 schema:affiliation grid-institutes:grid.251993.5
215 schema:familyName Khan
216 schema:givenName Chaitali
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010041415317.73
218 rdf:type schema:Person
219 sg:person.01134672210.73 schema:affiliation grid-institutes:grid.4991.5
220 schema:familyName Muliyil
221 schema:givenName Sonia
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134672210.73
223 rdf:type schema:Person
224 sg:person.01236072700.11 schema:affiliation grid-institutes:grid.494635.9
225 schema:familyName Rao
226 schema:givenName B. J.
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236072700.11
228 rdf:type schema:Person
229 sg:person.0760716567.72 schema:affiliation grid-institutes:grid.22401.35
230 schema:familyName Ayyub
231 schema:givenName Champakali
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760716567.72
233 rdf:type schema:Person
234 sg:pub.10.1007/bf00848779 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048323153
235 https://doi.org/10.1007/bf00848779
236 rdf:type schema:CreativeWork
237 sg:pub.10.1038/nrg3729 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045403173
238 https://doi.org/10.1038/nrg3729
239 rdf:type schema:CreativeWork
240 sg:pub.10.1038/nsmb0104-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030880261
241 https://doi.org/10.1038/nsmb0104-9
242 rdf:type schema:CreativeWork
243 sg:pub.10.1038/sj.onc.1210868 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044587952
244 https://doi.org/10.1038/sj.onc.1210868
245 rdf:type schema:CreativeWork
246 sg:pub.10.1038/sj.onc.1210881 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031474067
247 https://doi.org/10.1038/sj.onc.1210881
248 rdf:type schema:CreativeWork
249 grid-institutes:grid.22401.35 schema:alternateName Department of Biological Sciences, Tata Institute of Fundamental Research, Colaba, 400005, Mumbai, India
250 schema:name Department of Biological Sciences, Tata Institute of Fundamental Research, Colaba, 400005, Mumbai, India
251 rdf:type schema:Organization
252 grid-institutes:grid.251993.5 schema:alternateName Department of Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, NY, USA
253 schema:name Department of Biological Sciences, Tata Institute of Fundamental Research, Colaba, 400005, Mumbai, India
254 Department of Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, NY, USA
255 rdf:type schema:Organization
256 grid-institutes:grid.494635.9 schema:alternateName Indian Institute of Science Education and Research (IISER) Tirupati, Transit Campus, Sree Rama Engineering College, Tirupati, India
257 schema:name Department of Biological Sciences, Tata Institute of Fundamental Research, Colaba, 400005, Mumbai, India
258 Indian Institute of Science Education and Research (IISER) Tirupati, Transit Campus, Sree Rama Engineering College, Tirupati, India
259 rdf:type schema:Organization
260 grid-institutes:grid.4991.5 schema:alternateName Sir William Dunn School of Pathology, University of Oxford, South Parks Road, OX1 3RE, Oxford, UK
261 schema:name Department of Biological Sciences, Tata Institute of Fundamental Research, Colaba, 400005, Mumbai, India
262 Sir William Dunn School of Pathology, University of Oxford, South Parks Road, OX1 3RE, Oxford, UK
263 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...