Induced transcription results in local changes in chromatin structure, replication timing, and DNA polytenization in a site of intercalary heterochromatin View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-12

AUTHORS

Dmitry E. Koryakov, Galina V. Pokholkova, Daniil A. Maksimov, Stepan N. Belyakin, Elena S. Belyaeva, Igor F. Zhimulev

ABSTRACT

In salivary gland polytene chromosomes of Drosophila melanogaster, the regions of intercalary heterochromatin are characterized by late replication, under-replication, and genetic silencing. Using Gal4/UAS system, we induced transcription of sequences adjacent to transgene insertions in the band 11A6-9. This activation resulted in a loss of "silent" and appearance of "active" epigenetic marks, recruitment of RNA polymerase II, and formation of a puff. The activated region is now early replicating and shows increased level of DNA polytenization. Notably, all these changes are restricted to the area around the inserts, whereas the rest of the band remains inactive and late replicating. Although only a short area near the insertion site is transcribed, it results in an "open" chromatin conformation in a much broader region. We conclude that regions of intercalary heterochromatin do not form stand-alone units of late replication and under-replication. Every part of such regions can be activated and polytenized independently of other parts. More... »

PAGES

573-583

References to SciGraph publications

  • 2007-06. Using FlyAtlas to identify better Drosophila melanogaster models of human disease in NATURE GENETICS
  • 2003-03. Influence of the SuUR gene on intercalary heterochromatin in Drosophila melanogaster polytene chromosomes in CHROMOSOMA
  • 2010-12. Paucity and preferential suppression of transgenes in late replication domains of the D. melanogaster genome in BMC GENOMICS
  • 2011-03. The developmental transcriptome of Drosophila melanogaster in NATURE
  • 2010-01. Domain-wide regulation of DNA replication timing during mammalian development in CHROMOSOME RESEARCH
  • 2005-04. A genomic view of eukaryotic DNA replication in CHROMOSOME RESEARCH
  • 1974-12. Initial phases of DNA synthesis in Drosophila melanogaster in CHROMOSOMA
  • 1972-09. DNS-Replikation und die Natur der spät replizierenden Orte im X-Chromosom von Drosophila melanogaster in CHROMOSOMA
  • 2008-09. Local DNA underreplication correlates with accumulation of phosphorylated H2Av in the Drosophila melanogaster polytene chromosomes in CHROMOSOME RESEARCH
  • 2004-07. Chromatin regulates origin activity in Drosophila follicle cells in NATURE
  • 2008-10. Intercalary heterochromatin in polytene chromosomes of Drosophila melanogaster in CHROMOSOMA
  • 2006-10. DNA underreplication in intercalary heterochromatin regions in polytene chromosomes of Drosophila melanogaster correlates with the formation of partial chromosomal aberrations and ectopic pairing in CHROMOSOMA
  • 2010-12. Gene density profile reveals the marking of late replicated domains in the Drosophila melanogaster genome in CHROMOSOMA
  • 1976-03. Correspondence of banding patterns to 3H-thymidine labeling patterns in polytene chromosomes in CHROMOSOMA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00412-012-0382-9

    DOI

    http://dx.doi.org/10.1007/s00412-012-0382-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1000633926

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23015267


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals, Genetically Modified", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chromatin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA Replication Timing", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Drosophila Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Drosophila melanogaster", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Endoreduplication", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Epigenesis, Genetic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genes, Reporter", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Heterochromatin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Polytene Chromosomes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA Polymerase II", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transcription, Genetic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transgenes", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "name": [
                "Institute of Molecular and Cellular Biology SB RAS, 630090, Novosibirsk, Russia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Koryakov", 
            "givenName": "Dmitry E.", 
            "id": "sg:person.01117210750.79", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117210750.79"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Institute of Molecular and Cellular Biology SB RAS, 630090, Novosibirsk, Russia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pokholkova", 
            "givenName": "Galina V.", 
            "id": "sg:person.063215502.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.063215502.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Institute of Molecular and Cellular Biology SB RAS, 630090, Novosibirsk, Russia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Maksimov", 
            "givenName": "Daniil A.", 
            "id": "sg:person.01233437350.58", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233437350.58"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Institute of Molecular and Cellular Biology SB RAS, 630090, Novosibirsk, Russia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Belyakin", 
            "givenName": "Stepan N.", 
            "id": "sg:person.01301552550.92", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301552550.92"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Institute of Molecular and Cellular Biology SB RAS, 630090, Novosibirsk, Russia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Belyaeva", 
            "givenName": "Elena S.", 
            "id": "sg:person.01135023306.81", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01135023306.81"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Institute of Molecular and Cellular Biology SB RAS, 630090, Novosibirsk, Russia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhimulev", 
            "givenName": "Igor F.", 
            "id": "sg:person.01203136506.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203136506.00"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1073/pnas.0502702102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001009961"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(01)00281-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002057901"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.292104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002405627"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/molbev/msr178", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003530082"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.511809", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004061649"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2010.09.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006611187"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00412-002-0218-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009725234", 
              "https://doi.org/10.1007/s00412-002-0218-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10577-005-1508-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011155639", 
              "https://doi.org/10.1007/s10577-005-1508-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkf496", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011937384"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tig.2005.05.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013777992"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.25.11.571", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014206963"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2005.10.029", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014310642"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10577-009-9100-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014936006", 
              "https://doi.org/10.1007/s10577-009-9100-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10577-009-9100-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014936006", 
              "https://doi.org/10.1007/s10577-009-9100-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10577-009-9100-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014936006", 
              "https://doi.org/10.1007/s10577-009-9100-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.6276007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015510707"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0030035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015847115"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00412-010-0280-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016839486", 
              "https://doi.org/10.1007/s00412-010-0280-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00412-010-0280-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016839486", 
              "https://doi.org/10.1007/s00412-010-0280-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pcbi.1002225", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020861181"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.201007125", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021100696"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0408170101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021434572"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)81181-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021548250"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00412-008-0163-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023402249", 
              "https://doi.org/10.1007/s00412-008-0163-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00412-008-0163-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023402249", 
              "https://doi.org/10.1007/s00412-008-0163-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00292947", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024910392", 
              "https://doi.org/10.1007/bf00292947"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.114611.110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028065372"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.126003.111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029186812"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00326362", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029537623", 
              "https://doi.org/10.1007/bf00326362"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1246404", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030113964"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00412-006-0063-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031108552", 
              "https://doi.org/10.1007/s00412-006-0063-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00412-006-0063-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031108552", 
              "https://doi.org/10.1007/s00412-006-0063-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09715", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031240109", 
              "https://doi.org/10.1038/nature09715"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2164-11-318", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031269250", 
              "https://doi.org/10.1186/1471-2164-11-318"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.097873.109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036947984"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pcbi.1002322", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039584318"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02694", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040566175", 
              "https://doi.org/10.1038/nature02694"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02694", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040566175", 
              "https://doi.org/10.1038/nature02694"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1534/genetics.104.026427", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043091524"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1534/genetics.104.026427", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043091524"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.116038.110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047024052"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.145.7.1341", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048460927"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00319871", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049651559", 
              "https://doi.org/10.1007/bf00319871"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00319871", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049651559", 
              "https://doi.org/10.1007/bf00319871"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.gde.2006.02.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050200703"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ceb.2011.04.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051072032"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng2049", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051956862", 
              "https://doi.org/10.1038/ng2049"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2008.05.029", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052336087"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10577-008-1244-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052532157", 
              "https://doi.org/10.1007/s10577-008-1244-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10577-008-1244-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052532157", 
              "https://doi.org/10.1007/s10577-008-1244-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/epi.4.2.7772", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072302890"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/fly.5.3.16729", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072303511"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075016600", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079817085", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/oxfordjournals.jhered.a104022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083617386"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2012-12", 
        "datePublishedReg": "2012-12-01", 
        "description": "In salivary gland polytene chromosomes of Drosophila melanogaster, the regions of intercalary heterochromatin are characterized by late replication, under-replication, and genetic silencing. Using Gal4/UAS system, we induced transcription of sequences adjacent to transgene insertions in the band 11A6-9. This activation resulted in a loss of \"silent\" and appearance of \"active\" epigenetic marks, recruitment of RNA polymerase II, and formation of a puff. The activated region is now early replicating and shows increased level of DNA polytenization. Notably, all these changes are restricted to the area around the inserts, whereas the rest of the band remains inactive and late replicating. Although only a short area near the insertion site is transcribed, it results in an \"open\" chromatin conformation in a much broader region. We conclude that regions of intercalary heterochromatin do not form stand-alone units of late replication and under-replication. Every part of such regions can be activated and polytenized independently of other parts.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s00412-012-0382-9", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.5335796", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1312277", 
            "issn": [
              "0009-5915", 
              "1432-0886"
            ], 
            "name": "Chromosoma", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "6", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "121"
          }
        ], 
        "name": "Induced transcription results in local changes in chromatin structure, replication timing, and DNA polytenization in a site of intercalary heterochromatin", 
        "pagination": "573-583", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "0304bd29ce2f99a2522bde18fa5a8988b85074bd1c8241d2579e7b8371e01e74"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "23015267"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "2985138R"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00412-012-0382-9"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1000633926"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00412-012-0382-9", 
          "https://app.dimensions.ai/details/publication/pub.1000633926"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T21:30", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000485.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1007/s00412-012-0382-9"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00412-012-0382-9'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00412-012-0382-9'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00412-012-0382-9'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00412-012-0382-9'


     

    This table displays all metadata directly associated to this object as RDF triples.

    321 TRIPLES      21 PREDICATES      89 URIs      35 LITERALS      23 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00412-012-0382-9 schema:about N006f621a17324685ab684db36fad18d2
    2 N04aa5ea7d4f242e8b184c70c233dd319
    3 N04c8938a3794429cbd21ad6f8b3aed38
    4 N1dde44eff51f4f668be09c4f9504561c
    5 N2875003996c146dc8b6c52fb91d6d76b
    6 N2b56a8a5a66e428dba4502a1308f751d
    7 N2f478d3e3c59458097d871bc5d24da62
    8 N702c77ca19f14aae81eeda8395f9c8d9
    9 Na6ee2952733a4f279aa9987f84204527
    10 Na874b78c47524e37bacb0d1820bbb64e
    11 Nb15b8408bd41490499ca7530cef417f7
    12 Nc4c9493093da4964bf72732b499a9b24
    13 Ncd2cc81a43b34102a9c6676b9fe83c68
    14 Ndd985dcf32074467bf9c6f0af66a78d6
    15 anzsrc-for:06
    16 anzsrc-for:0604
    17 schema:author Ne4c965e4ef504f839bae638bc2d6d5e1
    18 schema:citation sg:pub.10.1007/bf00292947
    19 sg:pub.10.1007/bf00319871
    20 sg:pub.10.1007/bf00326362
    21 sg:pub.10.1007/s00412-002-0218-0
    22 sg:pub.10.1007/s00412-006-0063-7
    23 sg:pub.10.1007/s00412-008-0163-7
    24 sg:pub.10.1007/s00412-010-0280-y
    25 sg:pub.10.1007/s10577-005-1508-1
    26 sg:pub.10.1007/s10577-008-1244-4
    27 sg:pub.10.1007/s10577-009-9100-8
    28 sg:pub.10.1038/nature02694
    29 sg:pub.10.1038/nature09715
    30 sg:pub.10.1038/ng2049
    31 sg:pub.10.1186/1471-2164-11-318
    32 https://app.dimensions.ai/details/publication/pub.1075016600
    33 https://app.dimensions.ai/details/publication/pub.1079817085
    34 https://doi.org/10.1016/j.ceb.2011.04.004
    35 https://doi.org/10.1016/j.cell.2008.05.029
    36 https://doi.org/10.1016/j.cell.2010.09.009
    37 https://doi.org/10.1016/j.gde.2006.02.007
    38 https://doi.org/10.1016/j.molcel.2005.10.029
    39 https://doi.org/10.1016/j.tig.2005.05.012
    40 https://doi.org/10.1016/s0092-8674(00)81181-2
    41 https://doi.org/10.1016/s0092-8674(01)00281-1
    42 https://doi.org/10.1073/pnas.0408170101
    43 https://doi.org/10.1073/pnas.0502702102
    44 https://doi.org/10.1073/pnas.25.11.571
    45 https://doi.org/10.1083/jcb.145.7.1341
    46 https://doi.org/10.1083/jcb.201007125
    47 https://doi.org/10.1093/molbev/msr178
    48 https://doi.org/10.1093/nar/gkf496
    49 https://doi.org/10.1093/oxfordjournals.jhered.a104022
    50 https://doi.org/10.1101/gad.1246404
    51 https://doi.org/10.1101/gad.292104
    52 https://doi.org/10.1101/gad.511809
    53 https://doi.org/10.1101/gr.097873.109
    54 https://doi.org/10.1101/gr.114611.110
    55 https://doi.org/10.1101/gr.116038.110
    56 https://doi.org/10.1101/gr.126003.111
    57 https://doi.org/10.1101/gr.6276007
    58 https://doi.org/10.1371/journal.pcbi.1002225
    59 https://doi.org/10.1371/journal.pcbi.1002322
    60 https://doi.org/10.1371/journal.pone.0030035
    61 https://doi.org/10.1534/genetics.104.026427
    62 https://doi.org/10.4161/epi.4.2.7772
    63 https://doi.org/10.4161/fly.5.3.16729
    64 schema:datePublished 2012-12
    65 schema:datePublishedReg 2012-12-01
    66 schema:description In salivary gland polytene chromosomes of Drosophila melanogaster, the regions of intercalary heterochromatin are characterized by late replication, under-replication, and genetic silencing. Using Gal4/UAS system, we induced transcription of sequences adjacent to transgene insertions in the band 11A6-9. This activation resulted in a loss of "silent" and appearance of "active" epigenetic marks, recruitment of RNA polymerase II, and formation of a puff. The activated region is now early replicating and shows increased level of DNA polytenization. Notably, all these changes are restricted to the area around the inserts, whereas the rest of the band remains inactive and late replicating. Although only a short area near the insertion site is transcribed, it results in an "open" chromatin conformation in a much broader region. We conclude that regions of intercalary heterochromatin do not form stand-alone units of late replication and under-replication. Every part of such regions can be activated and polytenized independently of other parts.
    67 schema:genre research_article
    68 schema:inLanguage en
    69 schema:isAccessibleForFree false
    70 schema:isPartOf N83abb49345204d1b9c9c996517d46903
    71 N906ccb46a644464584069374acdd01a0
    72 sg:journal.1312277
    73 schema:name Induced transcription results in local changes in chromatin structure, replication timing, and DNA polytenization in a site of intercalary heterochromatin
    74 schema:pagination 573-583
    75 schema:productId N2effc85785af4ca2a03bbb9c6e0b28fb
    76 N408262d3baaf4ddd8eaeaae0a12c28c6
    77 N68a2de931db841eab9890433c6bfc440
    78 N87b32520b9b84467bc20e2f02870812d
    79 Na58882f385564ad8a19d351854f4943e
    80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000633926
    81 https://doi.org/10.1007/s00412-012-0382-9
    82 schema:sdDatePublished 2019-04-10T21:30
    83 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    84 schema:sdPublisher Nc4a68c0b8483469fb9a49b7328b35461
    85 schema:url http://link.springer.com/10.1007/s00412-012-0382-9
    86 sgo:license sg:explorer/license/
    87 sgo:sdDataset articles
    88 rdf:type schema:ScholarlyArticle
    89 N006f621a17324685ab684db36fad18d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    90 schema:name Epigenesis, Genetic
    91 rdf:type schema:DefinedTerm
    92 N00f8c9dd46474bdd90441f36b952c7ec rdf:first sg:person.01135023306.81
    93 rdf:rest N31631115b336492c9a8ad2282da38f6c
    94 N02def10acd8a49f5b7e34ab296696759 rdf:first sg:person.01233437350.58
    95 rdf:rest Ne807b742c3fb4c63b4f950917b9829ba
    96 N04aa5ea7d4f242e8b184c70c233dd319 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    97 schema:name Drosophila melanogaster
    98 rdf:type schema:DefinedTerm
    99 N04c8938a3794429cbd21ad6f8b3aed38 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    100 schema:name Polytene Chromosomes
    101 rdf:type schema:DefinedTerm
    102 N1b6c44eca29c41a4b17e5c805594e85e rdf:first sg:person.063215502.19
    103 rdf:rest N02def10acd8a49f5b7e34ab296696759
    104 N1dde44eff51f4f668be09c4f9504561c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    105 schema:name Endoreduplication
    106 rdf:type schema:DefinedTerm
    107 N1fa5186f65224fe78856c867abb2eefe schema:name Institute of Molecular and Cellular Biology SB RAS, 630090, Novosibirsk, Russia
    108 rdf:type schema:Organization
    109 N24a5ce5b628a4d7981433e141a7fa5b3 schema:name Institute of Molecular and Cellular Biology SB RAS, 630090, Novosibirsk, Russia
    110 rdf:type schema:Organization
    111 N24fcefa243b4487983700f3b00a9021c schema:name Institute of Molecular and Cellular Biology SB RAS, 630090, Novosibirsk, Russia
    112 rdf:type schema:Organization
    113 N2875003996c146dc8b6c52fb91d6d76b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    114 schema:name Chromatin
    115 rdf:type schema:DefinedTerm
    116 N2b56a8a5a66e428dba4502a1308f751d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    117 schema:name RNA Polymerase II
    118 rdf:type schema:DefinedTerm
    119 N2effc85785af4ca2a03bbb9c6e0b28fb schema:name doi
    120 schema:value 10.1007/s00412-012-0382-9
    121 rdf:type schema:PropertyValue
    122 N2f478d3e3c59458097d871bc5d24da62 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    123 schema:name Animals
    124 rdf:type schema:DefinedTerm
    125 N31631115b336492c9a8ad2282da38f6c rdf:first sg:person.01203136506.00
    126 rdf:rest rdf:nil
    127 N408262d3baaf4ddd8eaeaae0a12c28c6 schema:name readcube_id
    128 schema:value 0304bd29ce2f99a2522bde18fa5a8988b85074bd1c8241d2579e7b8371e01e74
    129 rdf:type schema:PropertyValue
    130 N47ea63832b804a9487a0168d0cd4249d schema:name Institute of Molecular and Cellular Biology SB RAS, 630090, Novosibirsk, Russia
    131 rdf:type schema:Organization
    132 N4b6ad2ed1d824ec5ad8883a69a47559d schema:name Institute of Molecular and Cellular Biology SB RAS, 630090, Novosibirsk, Russia
    133 rdf:type schema:Organization
    134 N68a2de931db841eab9890433c6bfc440 schema:name dimensions_id
    135 schema:value pub.1000633926
    136 rdf:type schema:PropertyValue
    137 N702c77ca19f14aae81eeda8395f9c8d9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Animals, Genetically Modified
    139 rdf:type schema:DefinedTerm
    140 N83abb49345204d1b9c9c996517d46903 schema:volumeNumber 121
    141 rdf:type schema:PublicationVolume
    142 N87b32520b9b84467bc20e2f02870812d schema:name nlm_unique_id
    143 schema:value 2985138R
    144 rdf:type schema:PropertyValue
    145 N906ccb46a644464584069374acdd01a0 schema:issueNumber 6
    146 rdf:type schema:PublicationIssue
    147 Na58882f385564ad8a19d351854f4943e schema:name pubmed_id
    148 schema:value 23015267
    149 rdf:type schema:PropertyValue
    150 Na6ee2952733a4f279aa9987f84204527 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    151 schema:name DNA Replication Timing
    152 rdf:type schema:DefinedTerm
    153 Na874b78c47524e37bacb0d1820bbb64e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    154 schema:name Drosophila Proteins
    155 rdf:type schema:DefinedTerm
    156 Nb15b8408bd41490499ca7530cef417f7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    157 schema:name Transgenes
    158 rdf:type schema:DefinedTerm
    159 Nc4a68c0b8483469fb9a49b7328b35461 schema:name Springer Nature - SN SciGraph project
    160 rdf:type schema:Organization
    161 Nc4c9493093da4964bf72732b499a9b24 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    162 schema:name Genes, Reporter
    163 rdf:type schema:DefinedTerm
    164 Ncd2cc81a43b34102a9c6676b9fe83c68 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    165 schema:name Heterochromatin
    166 rdf:type schema:DefinedTerm
    167 Ndd985dcf32074467bf9c6f0af66a78d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    168 schema:name Transcription, Genetic
    169 rdf:type schema:DefinedTerm
    170 Ne4c965e4ef504f839bae638bc2d6d5e1 rdf:first sg:person.01117210750.79
    171 rdf:rest N1b6c44eca29c41a4b17e5c805594e85e
    172 Ne807b742c3fb4c63b4f950917b9829ba rdf:first sg:person.01301552550.92
    173 rdf:rest N00f8c9dd46474bdd90441f36b952c7ec
    174 Nee25efdf67cf479cb04cee2681d68088 schema:name Institute of Molecular and Cellular Biology SB RAS, 630090, Novosibirsk, Russia
    175 rdf:type schema:Organization
    176 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    177 schema:name Biological Sciences
    178 rdf:type schema:DefinedTerm
    179 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    180 schema:name Genetics
    181 rdf:type schema:DefinedTerm
    182 sg:grant.5335796 http://pending.schema.org/fundedItem sg:pub.10.1007/s00412-012-0382-9
    183 rdf:type schema:MonetaryGrant
    184 sg:journal.1312277 schema:issn 0009-5915
    185 1432-0886
    186 schema:name Chromosoma
    187 rdf:type schema:Periodical
    188 sg:person.01117210750.79 schema:affiliation N1fa5186f65224fe78856c867abb2eefe
    189 schema:familyName Koryakov
    190 schema:givenName Dmitry E.
    191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117210750.79
    192 rdf:type schema:Person
    193 sg:person.01135023306.81 schema:affiliation N24fcefa243b4487983700f3b00a9021c
    194 schema:familyName Belyaeva
    195 schema:givenName Elena S.
    196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01135023306.81
    197 rdf:type schema:Person
    198 sg:person.01203136506.00 schema:affiliation N24a5ce5b628a4d7981433e141a7fa5b3
    199 schema:familyName Zhimulev
    200 schema:givenName Igor F.
    201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203136506.00
    202 rdf:type schema:Person
    203 sg:person.01233437350.58 schema:affiliation N4b6ad2ed1d824ec5ad8883a69a47559d
    204 schema:familyName Maksimov
    205 schema:givenName Daniil A.
    206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233437350.58
    207 rdf:type schema:Person
    208 sg:person.01301552550.92 schema:affiliation N47ea63832b804a9487a0168d0cd4249d
    209 schema:familyName Belyakin
    210 schema:givenName Stepan N.
    211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301552550.92
    212 rdf:type schema:Person
    213 sg:person.063215502.19 schema:affiliation Nee25efdf67cf479cb04cee2681d68088
    214 schema:familyName Pokholkova
    215 schema:givenName Galina V.
    216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.063215502.19
    217 rdf:type schema:Person
    218 sg:pub.10.1007/bf00292947 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024910392
    219 https://doi.org/10.1007/bf00292947
    220 rdf:type schema:CreativeWork
    221 sg:pub.10.1007/bf00319871 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049651559
    222 https://doi.org/10.1007/bf00319871
    223 rdf:type schema:CreativeWork
    224 sg:pub.10.1007/bf00326362 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029537623
    225 https://doi.org/10.1007/bf00326362
    226 rdf:type schema:CreativeWork
    227 sg:pub.10.1007/s00412-002-0218-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009725234
    228 https://doi.org/10.1007/s00412-002-0218-0
    229 rdf:type schema:CreativeWork
    230 sg:pub.10.1007/s00412-006-0063-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031108552
    231 https://doi.org/10.1007/s00412-006-0063-7
    232 rdf:type schema:CreativeWork
    233 sg:pub.10.1007/s00412-008-0163-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023402249
    234 https://doi.org/10.1007/s00412-008-0163-7
    235 rdf:type schema:CreativeWork
    236 sg:pub.10.1007/s00412-010-0280-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1016839486
    237 https://doi.org/10.1007/s00412-010-0280-y
    238 rdf:type schema:CreativeWork
    239 sg:pub.10.1007/s10577-005-1508-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011155639
    240 https://doi.org/10.1007/s10577-005-1508-1
    241 rdf:type schema:CreativeWork
    242 sg:pub.10.1007/s10577-008-1244-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052532157
    243 https://doi.org/10.1007/s10577-008-1244-4
    244 rdf:type schema:CreativeWork
    245 sg:pub.10.1007/s10577-009-9100-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014936006
    246 https://doi.org/10.1007/s10577-009-9100-8
    247 rdf:type schema:CreativeWork
    248 sg:pub.10.1038/nature02694 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040566175
    249 https://doi.org/10.1038/nature02694
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1038/nature09715 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031240109
    252 https://doi.org/10.1038/nature09715
    253 rdf:type schema:CreativeWork
    254 sg:pub.10.1038/ng2049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051956862
    255 https://doi.org/10.1038/ng2049
    256 rdf:type schema:CreativeWork
    257 sg:pub.10.1186/1471-2164-11-318 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031269250
    258 https://doi.org/10.1186/1471-2164-11-318
    259 rdf:type schema:CreativeWork
    260 https://app.dimensions.ai/details/publication/pub.1075016600 schema:CreativeWork
    261 https://app.dimensions.ai/details/publication/pub.1079817085 schema:CreativeWork
    262 https://doi.org/10.1016/j.ceb.2011.04.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051072032
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.1016/j.cell.2008.05.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052336087
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.1016/j.cell.2010.09.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006611187
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.1016/j.gde.2006.02.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050200703
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1016/j.molcel.2005.10.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014310642
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1016/j.tig.2005.05.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013777992
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1016/s0092-8674(00)81181-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021548250
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1016/s0092-8674(01)00281-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002057901
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1073/pnas.0408170101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021434572
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1073/pnas.0502702102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001009961
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1073/pnas.25.11.571 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014206963
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1083/jcb.145.7.1341 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048460927
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1083/jcb.201007125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021100696
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1093/molbev/msr178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003530082
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1093/nar/gkf496 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011937384
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1093/oxfordjournals.jhered.a104022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083617386
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1101/gad.1246404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030113964
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1101/gad.292104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002405627
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1101/gad.511809 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004061649
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1101/gr.097873.109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036947984
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1101/gr.114611.110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028065372
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1101/gr.116038.110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047024052
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1101/gr.126003.111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029186812
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1101/gr.6276007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015510707
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1371/journal.pcbi.1002225 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020861181
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1371/journal.pcbi.1002322 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039584318
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1371/journal.pone.0030035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015847115
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1534/genetics.104.026427 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043091524
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.4161/epi.4.2.7772 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072302890
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.4161/fly.5.3.16729 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072303511
    321 rdf:type schema:CreativeWork
     




    Preview window. Press ESC to close (or click here)


    ...