TFIIB and the regulation of transcription by RNA polymerase II View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-10

AUTHORS

Wensheng Deng, Stefan G. E. Roberts

ABSTRACT

Accurate transcription of a gene by RNA polymerase II requires the assembly of a group of general transcription factors at the promoter. The general transcription factor TFIIB plays a central role in preinitiation complex assembly, providing a bridge between promoter-bound TFIID and RNA polymerase II. TFIIB makes extensive contact with the core promoter via two independent DNA-recognition modules. In addition to interacting with other general transcription factors, TFIIB directly modulates the catalytic center of RNA polymerase II in the transcription complex. Moreover, TFIIB has been proposed as a target of transcriptional activator proteins that act to stimulate preinitiation complex assembly. In this review, we will discuss our current understanding of these activities of TFIIB. More... »

PAGES

417-429

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00412-007-0113-9

DOI

http://dx.doi.org/10.1007/s00412-007-0113-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1053621679

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17593382


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