Meta-analysis of case–control studies on the relationship between lung cancer and indoor radon exposure View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03

AUTHORS

Georgy Malinovsky, Ilia Yarmoshenko, Aleksey Vasilyev

ABSTRACT

Indoor exposure to natural radon is a factor that influences lung cancer risk worldwide. The present study includes a meta-analysis of epidemiological data on the relationship between lung cancer and indoor radon. Altogether, 31 case-control studies with 20,703 cases, 34,518 controls and 140 individual odds ratio (OR) estimates are included in the meta-analysis. Weighted median OR was calculated for five radon intervals. The following parameters were used for the weighting: standard error of OR, duration of radon concentration measurement, and relative number of controls in reference intervals. The dependence of the weighted median OR on the radon concentration was estimated applying linear non-threshold and threshold models. The results obtained suggest a significant linear no-threshold exposure-effect relationship for radon concentrations above 100 Bq/m3, with a slope of 0.14 (95% confidence interval 0.08-0.21) per 100 Bq/m3. More... »

PAGES

39-47

References to SciGraph publications

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  • 2014-01. Geographic variation in radon and associated lung cancer risk in Canada in CANADIAN JOURNAL OF PUBLIC HEALTH
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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00411-018-0770-5

    DOI

    http://dx.doi.org/10.1007/s00411-018-0770-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1110481080

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30535840


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