Evaluation of the effect of hyperthermia and electron radiation on prostate cancer stem cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-05

AUTHORS

Zhila Rajaee, Samideh Khoei, Seied Rabi Mahdavi, Marzieh Ebrahimi, Sakine Shirvalilou, Alireza Mahdavian

ABSTRACT

The aim of this study was to investigate the effect of hyperthermia, 6 MeV electron radiation and combination of these treatments on cancer cell line DU145 in both monolayer culture and spheroids enriched for prostate cancer stem cells (CSCs). Flowcytometric analysis of the expression of molecular markers CD133+/CD44+ was carried out to determine the prostate CSCs in cell line DU145 grown as spheroids in serum-free medium. Following monolayer and spheroid culture, DU145 cells were treated with different doses of hyperthermia, electron beam and combination of them. The survival and self-renewing of the cells were evaluated by colony formation assay (CFA) and spheroid formation assay (SFA). Flowcytometry results indicated that the percentage of CD133+/CD44+ cells in spheroid culture was 13.9-fold higher than in the monolayer culture. The SFA showed significant difference between monolayer and spheroid culture for radiation treatment (6 Gy) and hyperthermia (60 and 90 min). The CFA showed significantly enhanced radiosensitivity in DU145 cells grown as monolayer as compared to spheroids, but no effect of hyperthermia. In contrast, for the combination of radiation and hyperthermia the results of CFA and SFA showed a reduced survival fraction in both cultures, with larger effects in monolayer than in spheroid culture. Thus, hyperthermia may be a promising approach in prostate cancer treatment that enhances the cytotoxic effect of electron radiation. Furthermore, determination and characterization of radioresistance and thermoresistance of CSCs in the prostate tumor is the key to develop more efficient therapeutic strategies. More... »

PAGES

133-142

References to SciGraph publications

  • 2005-05. Neural stem cells and neurospheres—re-evaluating the relationship in NATURE METHODS
  • 2008-04. Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy in BREAST CANCER RESEARCH
  • 2008-05. Experimental and Systems Biology Studies of the Molecular Basis for the Radioresistance of Prostate Carcinoma Cells in ANNALS OF BIOMEDICAL ENGINEERING
  • 2009-04. Association of reactive oxygen species levels and radioresistance in cancer stem cells in NATURE
  • 2015-06. Radiotherapy-induced plasticity of prostate cancer mobilizes stem-like non-adherent, Erk signaling-dependent cells in CELL DEATH & DIFFERENTIATION
  • 2007-06. Metastasis and stem cell pathways in CANCER AND METASTASIS REVIEWS
  • 2001-11. Stem cells, cancer, and cancer stem cells in NATURE
  • 2008-02. CD44+CD24− prostate cells are early cancer progenitor/stem cells that provide a model for patients with poor prognosis in BRITISH JOURNAL OF CANCER
  • 2011-06. Heating cancer stem cells to reduce tumor relapse in BREAST CANCER RESEARCH
  • 2013-12. Non-small cell lung cancer cells survived ionizing radiation treatment display cancer stem cell and epithelial-mesenchymal transition phenotypes in MOLECULAR CANCER
  • 2002-12. 41.8°C whole body hyperthermia as an adjunct to chemotherapy induces prolonged T cell activation in patients with various malignant diseases in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 1985-12. Cell-cell contact affects cellular sensitivity to hyperthermia in BRITISH JOURNAL OF CANCER
  • 2011-12. Sphere-forming cell subpopulations with cancer stem cell properties in human hepatoma cell lines in BMC GASTROENTEROLOGY
  • 2012-04. Tumorspheres derived from prostate cancer cells possess chemoresistant and cancer stem cell properties in JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • 2006-03. Cancer stem cells in human gastrointestinal cancers in HUMAN CELL
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00411-018-0733-x

    DOI

    http://dx.doi.org/10.1007/s00411-018-0733-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1101080392

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29453555


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