Scanning irradiation device for mice in vivo with pulsed and continuous proton beams View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-08

AUTHORS

Christoph Greubel, Walter Assmann, Christian Burgdorf, Günther Dollinger, Guanghua Du, Volker Hable, Alexander Hapfelmeier, Ralf Hertenberger, Peter Kneschaurek, Dörte Michalski, Michael Molls, Sabine Reinhardt, Barbara Röper, Stefan Schell, Thomas E. Schmid, Christian Siebenwirth, Tatiana Wenzl, Olga Zlobinskaya, Jan J. Wilkens

ABSTRACT

A technical set-up for irradiation of subcutaneous tumours in mice with nanosecond-pulsed proton beams or continuous proton beams is described and was successfully used in a first experiment to explore future potential of laser-driven particle beams, which are pulsed due to the acceleration process, for radiation therapy. The chosen concept uses a microbeam approach. By focusing the beam to approximately 100 × 100 μm(2), the necessary fluence of 10(9) protons per cm(2) to deliver a dose of 20 Gy with one-nanosecond shot in the Bragg peak of 23 MeV protons is achieved. Electrical and mechanical beam scanning combines rapid dose delivery with large scan ranges. Aluminium sheets one millimetre in front of the target are used as beam energy degrader, necessary for adjusting the depth-dose profile. The required procedures for treatment planning and dose verification are presented. In a first experiment, 24 tumours in mice were successfully irradiated with 23 MeV protons and a single dose of 20 Gy in pulsed or continuous mode with dose differences between both modes of 10%. So far, no significant difference in tumour growth delay was observed. More... »

PAGES

339-344

References to SciGraph publications

  • 2006. Physical Optimization in IMAGE-GUIDED IMRT
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00411-011-0365-x

    DOI

    http://dx.doi.org/10.1007/s00411-011-0365-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1017141689

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21556847


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    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00411-011-0365-x'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00411-011-0365-x'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00411-011-0365-x'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00411-011-0365-x'


     

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