Alveolar Lymphocytosis in Patients with Chronic Uveitis: Relationship to Sarcoidosis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-10

AUTHORS

Stéphane Jouveshomme, Christine Fardeau, Jean-François Finet, Jean-Paul Akakpo, Catherine Beigelman, Phuc Le Hoang, Jean-Philippe Derenne

ABSTRACT

Bronchoalveolar lavage (BAL) is frequently performed in patients with suspected ocular sarcoidosis. This study describes the immunogenetical, immunological, radiological, and functional features of a subclinical alveolar lymphocytosis unrelated to sarcoidosis in patients with chronic uveitis. Two hundred and ten patients with chronic uveitis of unknown origin, who underwent fiber-optic bronchoscopy with BAL as part of a prospective protocol over a three-year period, were evaluable for retrospective analysis. Sixty-five patients had alveolar lymphocytosis: Sarcoidosis was diagnosed in 13 (6%) patients, whereas alveolar lymphocytosis was considered unrelated to sarcoidosis in 52 (25%). Alveolar lymphocytosis unrelated to sarcoidosis was not associated with radiologically detectable interstitial lung disease or pulmonary function impairment. CD4/CD8 lymphocyte ratio was 3.7 +/- 3.0. Total cell count, total lymphocyte, and CD4 lymphocyte percentage were significantly lower when compared with sarcoidosis-related alveolitis (129,000 +/- 80,000 vs. 218,000 +/- 117,000, p <0.05; 33.1% +/- 13.2 vs. 39.7% +/- 13.2, p <0.05; and 54.3% +/- 18.2 vs. 65.4% +/- 10.1, p <0.05, respectively). Patients with alveolar lymphocytosis unrelated to sarcoidosis were older (47.8 +/- 17.7 years vs. 42.7 +/- 14.2 years, p <0.05) and more likely to carry the HLA-B51 allele (19.7% vs. 7.1%, p <0.01) than patients with chronic uveitis without alveolar lymphocytosis. They did not appear to be at risk of developing clinically apparent interstitial lung disease on followup. We conclude that alveolar lymphocytosis is frequently observed in patients with chronic uveitis. It is generally unrelated to sarcoidosis and may then be associated with a distinctive immunogenetic phenotype. More... »

PAGES

305-317

References to SciGraph publications

  • 1989-08. Risk factors for ocular sarcoidosis in DOCUMENTA OPHTHALMOLOGICA
  • 1990-12. Subclinical alveolitis in immunologic systemic disorders in LUNG
  • 1986-12. Sixteen cases of uveitis associated with sarcoidosis in INTERNATIONAL OPHTHALMOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s004080000070

    DOI

    http://dx.doi.org/10.1007/s004080000070

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1037377804

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/11976898


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Cardiorespiratory Medicine and Haematology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Bronchoalveolar Lavage Fluid", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Bronchoscopy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "CD4-CD8 Ratio", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chronic Disease", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lymphocytosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pulmonary Alveoli", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Respiratory Function Tests", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Sarcoidosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Uveitis", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Piti\u00e9-Salp\u00eatri\u00e8re Hospital", 
              "id": "https://www.grid.ac/institutes/grid.411439.a", 
              "name": [
                "Department of Respiratory and Critical Care Medicine, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Assistance Publique des H\u00f4pitaux de Paris, Paris, France, FR"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jouveshomme", 
            "givenName": "St\u00e9phane", 
            "id": "sg:person.0612231620.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612231620.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Piti\u00e9-Salp\u00eatri\u00e8re Hospital", 
              "id": "https://www.grid.ac/institutes/grid.411439.a", 
              "name": [
                "Department of Respiratory and Critical Care Medicine, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Assistance Publique des H\u00f4pitaux de Paris, Paris, France, FR"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fardeau", 
            "givenName": "Christine", 
            "id": "sg:person.01076035503.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076035503.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Piti\u00e9-Salp\u00eatri\u00e8re Hospital", 
              "id": "https://www.grid.ac/institutes/grid.411439.a", 
              "name": [
                "Department of Respiratory and Critical Care Medicine, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Assistance Publique des H\u00f4pitaux de Paris, Paris, France, FR"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Finet", 
            "givenName": "Jean-Fran\u00e7ois", 
            "id": "sg:person.01144353340.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144353340.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Piti\u00e9-Salp\u00eatri\u00e8re Hospital", 
              "id": "https://www.grid.ac/institutes/grid.411439.a", 
              "name": [
                "Department of Respiratory and Critical Care Medicine, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Assistance Publique des H\u00f4pitaux de Paris, Paris, France, FR"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Akakpo", 
            "givenName": "Jean-Paul", 
            "id": "sg:person.01113671233.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113671233.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Piti\u00e9-Salp\u00eatri\u00e8re Hospital", 
              "id": "https://www.grid.ac/institutes/grid.411439.a", 
              "name": [
                "Department of Respiratory and Critical Care Medicine, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Assistance Publique des H\u00f4pitaux de Paris, Paris, France, FR"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Beigelman", 
            "givenName": "Catherine", 
            "id": "sg:person.0630250664.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630250664.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Piti\u00e9-Salp\u00eatri\u00e8re Hospital", 
              "id": "https://www.grid.ac/institutes/grid.411439.a", 
              "name": [
                "Department of Respiratory and Critical Care Medicine, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Assistance Publique des H\u00f4pitaux de Paris, Paris, France, FR"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hoang", 
            "givenName": "Phuc Le", 
            "id": "sg:person.0634255545.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634255545.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Piti\u00e9-Salp\u00eatri\u00e8re Hospital", 
              "id": "https://www.grid.ac/institutes/grid.411439.a", 
              "name": [
                "Department of Respiratory and Critical Care Medicine, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Assistance Publique des H\u00f4pitaux de Paris, Paris, France, FR"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Derenne", 
            "givenName": "Jean-Philippe", 
            "id": "sg:person.016651113264.24", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016651113264.24"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/0002-9343(74)90160-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000733359"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archopht.1993.01090050076033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010907396"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0002-9394(86)90001-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011354189"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archopht.1996.01100130585016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011450830"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1165/ajrcmb/8.5.461", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012406247"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1183/09031936.96.09061201", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014471841"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1749-6632.1986.tb18496.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017907949"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1378/chest.94.1.115", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018134114"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1755-3768.1987.tb07075.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026332862"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1755-3768.1987.tb07075.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026332862"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00137537", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028839912", 
              "https://doi.org/10.1007/bf00137537"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00137537", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028839912", 
              "https://doi.org/10.1007/bf00137537"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1183/09031936.01.99104501", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031615431"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00153496", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033487937", 
              "https://doi.org/10.1007/bf00153496"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00153496", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033487937", 
              "https://doi.org/10.1007/bf00153496"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/bjo.76.3.137", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040531717"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000194916", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042886271"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2169/internalmedicine1962.28.50", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042970509"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.1780400221", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045737009"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02718235", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048805475", 
              "https://doi.org/10.1007/bf02718235"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02718235", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048805475", 
              "https://doi.org/10.1007/bf02718235"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1183/09031936.97.10122722", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051042456"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2001-10", 
        "datePublishedReg": "2001-10-01", 
        "description": "Bronchoalveolar lavage (BAL) is frequently performed in patients with suspected ocular sarcoidosis. This study describes the immunogenetical, immunological, radiological, and functional features of a subclinical alveolar lymphocytosis unrelated to sarcoidosis in patients with chronic uveitis. Two hundred and ten patients with chronic uveitis of unknown origin, who underwent fiber-optic bronchoscopy with BAL as part of a prospective protocol over a three-year period, were evaluable for retrospective analysis. Sixty-five patients had alveolar lymphocytosis: Sarcoidosis was diagnosed in 13 (6%) patients, whereas alveolar lymphocytosis was considered unrelated to sarcoidosis in 52 (25%). Alveolar lymphocytosis unrelated to sarcoidosis was not associated with radiologically detectable interstitial lung disease or pulmonary function impairment. CD4/CD8 lymphocyte ratio was 3.7 +/- 3.0. Total cell count, total lymphocyte, and CD4 lymphocyte percentage were significantly lower when compared with sarcoidosis-related alveolitis (129,000 +/- 80,000 vs. 218,000 +/- 117,000, p <0.05; 33.1% +/- 13.2 vs. 39.7% +/- 13.2, p <0.05; and 54.3% +/- 18.2 vs. 65.4% +/- 10.1, p <0.05, respectively). Patients with alveolar lymphocytosis unrelated to sarcoidosis were older (47.8 +/- 17.7 years vs. 42.7 +/- 14.2 years, p <0.05) and more likely to carry the HLA-B51 allele (19.7% vs. 7.1%, p <0.01) than patients with chronic uveitis without alveolar lymphocytosis. They did not appear to be at risk of developing clinically apparent interstitial lung disease on followup. We conclude that alveolar lymphocytosis is frequently observed in patients with chronic uveitis. It is generally unrelated to sarcoidosis and may then be associated with a distinctive immunogenetic phenotype.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s004080000070", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1054004", 
            "issn": [
              "0341-2040", 
              "1432-1750"
            ], 
            "name": "Lung", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "5", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "179"
          }
        ], 
        "name": "Alveolar Lymphocytosis in Patients with Chronic Uveitis: Relationship to Sarcoidosis", 
        "pagination": "305-317", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "b20d52072dd05e867c5179003bd1561ff2310242164d856b49d88f1ef10dade2"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "11976898"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "7701875"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s004080000070"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1037377804"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s004080000070", 
          "https://app.dimensions.ai/details/publication/pub.1037377804"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T13:22", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000533.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1007%2Fs004080000070"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s004080000070'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s004080000070'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s004080000070'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s004080000070'


     

    This table displays all metadata directly associated to this object as RDF triples.

    220 TRIPLES      21 PREDICATES      60 URIs      34 LITERALS      22 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s004080000070 schema:about N037061c1996a43b38fd223ccbfdc831f
    2 N03ea8fcd0b694d98aa3a9108818d0ba4
    3 N24b88c488f1d49fb9f1b1488971a08ee
    4 N27a217e3708d4e43a922ce83906a0f9b
    5 N2b39b8a77bfe4a978a4ebb780dcc7fed
    6 N36933ae9bc3343e89d4af0f43889748f
    7 N4b2c8f46906d4a5aa58997a85a192e56
    8 N5b9c6a4419f44274a0a9af26a13952b5
    9 N5e2c30a11eb04a61a7b42b717cce5d4b
    10 N9edce6dc4b4a40cab203ef57be2a9cd2
    11 Na78dfe9809fe412fa87bedb28c853c68
    12 Nac1c962152a54c2bac441973f05d6877
    13 Nf9bcaf8be0fc460cbf0d1dc2f59a4e47
    14 anzsrc-for:11
    15 anzsrc-for:1102
    16 schema:author N8c37fc8d36544a81b0a8fe3cae513e79
    17 schema:citation sg:pub.10.1007/bf00137537
    18 sg:pub.10.1007/bf00153496
    19 sg:pub.10.1007/bf02718235
    20 https://doi.org/10.1001/archopht.1993.01090050076033
    21 https://doi.org/10.1001/archopht.1996.01100130585016
    22 https://doi.org/10.1002/art.1780400221
    23 https://doi.org/10.1016/0002-9343(74)90160-0
    24 https://doi.org/10.1016/0002-9394(86)90001-2
    25 https://doi.org/10.1111/j.1749-6632.1986.tb18496.x
    26 https://doi.org/10.1111/j.1755-3768.1987.tb07075.x
    27 https://doi.org/10.1136/bjo.76.3.137
    28 https://doi.org/10.1159/000194916
    29 https://doi.org/10.1165/ajrcmb/8.5.461
    30 https://doi.org/10.1183/09031936.01.99104501
    31 https://doi.org/10.1183/09031936.96.09061201
    32 https://doi.org/10.1183/09031936.97.10122722
    33 https://doi.org/10.1378/chest.94.1.115
    34 https://doi.org/10.2169/internalmedicine1962.28.50
    35 schema:datePublished 2001-10
    36 schema:datePublishedReg 2001-10-01
    37 schema:description Bronchoalveolar lavage (BAL) is frequently performed in patients with suspected ocular sarcoidosis. This study describes the immunogenetical, immunological, radiological, and functional features of a subclinical alveolar lymphocytosis unrelated to sarcoidosis in patients with chronic uveitis. Two hundred and ten patients with chronic uveitis of unknown origin, who underwent fiber-optic bronchoscopy with BAL as part of a prospective protocol over a three-year period, were evaluable for retrospective analysis. Sixty-five patients had alveolar lymphocytosis: Sarcoidosis was diagnosed in 13 (6%) patients, whereas alveolar lymphocytosis was considered unrelated to sarcoidosis in 52 (25%). Alveolar lymphocytosis unrelated to sarcoidosis was not associated with radiologically detectable interstitial lung disease or pulmonary function impairment. CD4/CD8 lymphocyte ratio was 3.7 +/- 3.0. Total cell count, total lymphocyte, and CD4 lymphocyte percentage were significantly lower when compared with sarcoidosis-related alveolitis (129,000 +/- 80,000 vs. 218,000 +/- 117,000, p <0.05; 33.1% +/- 13.2 vs. 39.7% +/- 13.2, p <0.05; and 54.3% +/- 18.2 vs. 65.4% +/- 10.1, p <0.05, respectively). Patients with alveolar lymphocytosis unrelated to sarcoidosis were older (47.8 +/- 17.7 years vs. 42.7 +/- 14.2 years, p <0.05) and more likely to carry the HLA-B51 allele (19.7% vs. 7.1%, p <0.01) than patients with chronic uveitis without alveolar lymphocytosis. They did not appear to be at risk of developing clinically apparent interstitial lung disease on followup. We conclude that alveolar lymphocytosis is frequently observed in patients with chronic uveitis. It is generally unrelated to sarcoidosis and may then be associated with a distinctive immunogenetic phenotype.
    38 schema:genre research_article
    39 schema:inLanguage en
    40 schema:isAccessibleForFree false
    41 schema:isPartOf N8a53f72a26574f8496b1142dd0e0b116
    42 Na8f85c6f819d4b74b137901371e31def
    43 sg:journal.1054004
    44 schema:name Alveolar Lymphocytosis in Patients with Chronic Uveitis: Relationship to Sarcoidosis
    45 schema:pagination 305-317
    46 schema:productId N206b4768262f43d599845237cbf5b1a8
    47 N56e4e139a5c64beba36d009da4a4e683
    48 N98703a0c1e44450b8f2a3077095d1efc
    49 Nac49bbc7357747c0815012c925bc329b
    50 Nc2073775377047e5a42fa062a2a13829
    51 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037377804
    52 https://doi.org/10.1007/s004080000070
    53 schema:sdDatePublished 2019-04-10T13:22
    54 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    55 schema:sdPublisher N1f1b4db605dd4ab9afb86e4e6027a3a9
    56 schema:url http://link.springer.com/10.1007%2Fs004080000070
    57 sgo:license sg:explorer/license/
    58 sgo:sdDataset articles
    59 rdf:type schema:ScholarlyArticle
    60 N037061c1996a43b38fd223ccbfdc831f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    61 schema:name Uveitis
    62 rdf:type schema:DefinedTerm
    63 N03ea8fcd0b694d98aa3a9108818d0ba4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    64 schema:name Female
    65 rdf:type schema:DefinedTerm
    66 N084f3ad71cac404c88692ab734534a14 rdf:first sg:person.016651113264.24
    67 rdf:rest rdf:nil
    68 N1f1b4db605dd4ab9afb86e4e6027a3a9 schema:name Springer Nature - SN SciGraph project
    69 rdf:type schema:Organization
    70 N206b4768262f43d599845237cbf5b1a8 schema:name pubmed_id
    71 schema:value 11976898
    72 rdf:type schema:PropertyValue
    73 N24b88c488f1d49fb9f1b1488971a08ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    74 schema:name Sarcoidosis
    75 rdf:type schema:DefinedTerm
    76 N27a217e3708d4e43a922ce83906a0f9b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    77 schema:name Male
    78 rdf:type schema:DefinedTerm
    79 N2b39b8a77bfe4a978a4ebb780dcc7fed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    80 schema:name Respiratory Function Tests
    81 rdf:type schema:DefinedTerm
    82 N2c0ae8b1abb2419d95984577c6ce463e rdf:first sg:person.01113671233.41
    83 rdf:rest Ncbb6141f6b8d4df7b5fb755cbc6b8ca8
    84 N36933ae9bc3343e89d4af0f43889748f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    85 schema:name Bronchoscopy
    86 rdf:type schema:DefinedTerm
    87 N4b2c8f46906d4a5aa58997a85a192e56 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    88 schema:name Bronchoalveolar Lavage Fluid
    89 rdf:type schema:DefinedTerm
    90 N56e4e139a5c64beba36d009da4a4e683 schema:name nlm_unique_id
    91 schema:value 7701875
    92 rdf:type schema:PropertyValue
    93 N5b9c6a4419f44274a0a9af26a13952b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    94 schema:name Middle Aged
    95 rdf:type schema:DefinedTerm
    96 N5e2c30a11eb04a61a7b42b717cce5d4b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    97 schema:name Chronic Disease
    98 rdf:type schema:DefinedTerm
    99 N6647bb0bda814400950aaee0f3d0321b rdf:first sg:person.01144353340.14
    100 rdf:rest N2c0ae8b1abb2419d95984577c6ce463e
    101 N8a53f72a26574f8496b1142dd0e0b116 schema:volumeNumber 179
    102 rdf:type schema:PublicationVolume
    103 N8c37fc8d36544a81b0a8fe3cae513e79 rdf:first sg:person.0612231620.33
    104 rdf:rest Ne8afcc7aa69f4b79942bf15b0dcf0252
    105 N98703a0c1e44450b8f2a3077095d1efc schema:name dimensions_id
    106 schema:value pub.1037377804
    107 rdf:type schema:PropertyValue
    108 N9edce6dc4b4a40cab203ef57be2a9cd2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    109 schema:name CD4-CD8 Ratio
    110 rdf:type schema:DefinedTerm
    111 Na78dfe9809fe412fa87bedb28c853c68 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    112 schema:name Lymphocytosis
    113 rdf:type schema:DefinedTerm
    114 Na8f85c6f819d4b74b137901371e31def schema:issueNumber 5
    115 rdf:type schema:PublicationIssue
    116 Nac1c962152a54c2bac441973f05d6877 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    117 schema:name Humans
    118 rdf:type schema:DefinedTerm
    119 Nac49bbc7357747c0815012c925bc329b schema:name readcube_id
    120 schema:value b20d52072dd05e867c5179003bd1561ff2310242164d856b49d88f1ef10dade2
    121 rdf:type schema:PropertyValue
    122 Naf0d40b3ad554786882e2dd3aebd9760 rdf:first sg:person.0634255545.51
    123 rdf:rest N084f3ad71cac404c88692ab734534a14
    124 Nc2073775377047e5a42fa062a2a13829 schema:name doi
    125 schema:value 10.1007/s004080000070
    126 rdf:type schema:PropertyValue
    127 Ncbb6141f6b8d4df7b5fb755cbc6b8ca8 rdf:first sg:person.0630250664.34
    128 rdf:rest Naf0d40b3ad554786882e2dd3aebd9760
    129 Ne8afcc7aa69f4b79942bf15b0dcf0252 rdf:first sg:person.01076035503.03
    130 rdf:rest N6647bb0bda814400950aaee0f3d0321b
    131 Nf9bcaf8be0fc460cbf0d1dc2f59a4e47 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    132 schema:name Pulmonary Alveoli
    133 rdf:type schema:DefinedTerm
    134 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    135 schema:name Medical and Health Sciences
    136 rdf:type schema:DefinedTerm
    137 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
    138 schema:name Cardiorespiratory Medicine and Haematology
    139 rdf:type schema:DefinedTerm
    140 sg:journal.1054004 schema:issn 0341-2040
    141 1432-1750
    142 schema:name Lung
    143 rdf:type schema:Periodical
    144 sg:person.01076035503.03 schema:affiliation https://www.grid.ac/institutes/grid.411439.a
    145 schema:familyName Fardeau
    146 schema:givenName Christine
    147 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076035503.03
    148 rdf:type schema:Person
    149 sg:person.01113671233.41 schema:affiliation https://www.grid.ac/institutes/grid.411439.a
    150 schema:familyName Akakpo
    151 schema:givenName Jean-Paul
    152 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113671233.41
    153 rdf:type schema:Person
    154 sg:person.01144353340.14 schema:affiliation https://www.grid.ac/institutes/grid.411439.a
    155 schema:familyName Finet
    156 schema:givenName Jean-François
    157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144353340.14
    158 rdf:type schema:Person
    159 sg:person.016651113264.24 schema:affiliation https://www.grid.ac/institutes/grid.411439.a
    160 schema:familyName Derenne
    161 schema:givenName Jean-Philippe
    162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016651113264.24
    163 rdf:type schema:Person
    164 sg:person.0612231620.33 schema:affiliation https://www.grid.ac/institutes/grid.411439.a
    165 schema:familyName Jouveshomme
    166 schema:givenName Stéphane
    167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612231620.33
    168 rdf:type schema:Person
    169 sg:person.0630250664.34 schema:affiliation https://www.grid.ac/institutes/grid.411439.a
    170 schema:familyName Beigelman
    171 schema:givenName Catherine
    172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630250664.34
    173 rdf:type schema:Person
    174 sg:person.0634255545.51 schema:affiliation https://www.grid.ac/institutes/grid.411439.a
    175 schema:familyName Hoang
    176 schema:givenName Phuc Le
    177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634255545.51
    178 rdf:type schema:Person
    179 sg:pub.10.1007/bf00137537 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028839912
    180 https://doi.org/10.1007/bf00137537
    181 rdf:type schema:CreativeWork
    182 sg:pub.10.1007/bf00153496 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033487937
    183 https://doi.org/10.1007/bf00153496
    184 rdf:type schema:CreativeWork
    185 sg:pub.10.1007/bf02718235 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048805475
    186 https://doi.org/10.1007/bf02718235
    187 rdf:type schema:CreativeWork
    188 https://doi.org/10.1001/archopht.1993.01090050076033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010907396
    189 rdf:type schema:CreativeWork
    190 https://doi.org/10.1001/archopht.1996.01100130585016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011450830
    191 rdf:type schema:CreativeWork
    192 https://doi.org/10.1002/art.1780400221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045737009
    193 rdf:type schema:CreativeWork
    194 https://doi.org/10.1016/0002-9343(74)90160-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000733359
    195 rdf:type schema:CreativeWork
    196 https://doi.org/10.1016/0002-9394(86)90001-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011354189
    197 rdf:type schema:CreativeWork
    198 https://doi.org/10.1111/j.1749-6632.1986.tb18496.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017907949
    199 rdf:type schema:CreativeWork
    200 https://doi.org/10.1111/j.1755-3768.1987.tb07075.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1026332862
    201 rdf:type schema:CreativeWork
    202 https://doi.org/10.1136/bjo.76.3.137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040531717
    203 rdf:type schema:CreativeWork
    204 https://doi.org/10.1159/000194916 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042886271
    205 rdf:type schema:CreativeWork
    206 https://doi.org/10.1165/ajrcmb/8.5.461 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012406247
    207 rdf:type schema:CreativeWork
    208 https://doi.org/10.1183/09031936.01.99104501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031615431
    209 rdf:type schema:CreativeWork
    210 https://doi.org/10.1183/09031936.96.09061201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014471841
    211 rdf:type schema:CreativeWork
    212 https://doi.org/10.1183/09031936.97.10122722 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051042456
    213 rdf:type schema:CreativeWork
    214 https://doi.org/10.1378/chest.94.1.115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018134114
    215 rdf:type schema:CreativeWork
    216 https://doi.org/10.2169/internalmedicine1962.28.50 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042970509
    217 rdf:type schema:CreativeWork
    218 https://www.grid.ac/institutes/grid.411439.a schema:alternateName Pitié-Salpêtrière Hospital
    219 schema:name Department of Respiratory and Critical Care Medicine, Pitié-Salpêtrière Hospital, Assistance Publique des Hôpitaux de Paris, Paris, France, FR
    220 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...