Pleural Effusions in Diffuse Large B-Cell Lymphoma: Clinical and Prognostic Significance View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-02

AUTHORS

José M. Porcel, Irene Cuadrat, Tomás García-Cerecedo, Marina Pardina, Silvia Bielsa

ABSTRACT

PURPOSE: Pleural effusion (PEs) may complicate diffuse large B-cell lymphomas (DLBCL). However, their real prevalence and prognostic significance have seldom been approached systematically. METHODS: Retrospective single-center evaluation of consecutive patients with DLBCL was conducted. Baseline characteristics, PEs on CT imaging, pleural fluid analyses, and outcome until death or censoring date were collected. RESULTS: Of 185 DLBCL patients, 55 (30%) had PEs, of which 27 (49%) were analyzed. Most tapped PEs were malignant (n = 24) and cytological and/or flow cytometric analyses provided the diagnosis in about 70% of the cases. Malignant PEs were exudates with adenosine deaminase levels > 35 U/L in 35% of the cases. More than one-third of lymphomatous PEs required definitive pleural procedures for symptomatic relief. PEs greater than 200 mL on CT scans were an independent predictor of poor survival in Cox regression modeling (hazard ratio 1.9). CONCLUSIONS: PEs are common in DLBCL and foreshadow a poor prognosis. More... »

PAGES

1-5

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00408-018-0182-y

DOI

http://dx.doi.org/10.1007/s00408-018-0182-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1110281391

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30506166


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