Ontology type: schema:ScholarlyArticle
2018-06
AUTHORSJoao Henrique Neves Soares, Alysson Roncally Carvalho, Bruno Curty Bergamini, Maria Alice Kuster Gress, Frederico Caetano Jandre, Walter Araujo Zin, Antonio Giannella-Neto
ABSTRACTPURPOSE: We compared respiratory mechanics between the positive end-expiratory pressure of minimal respiratory system elastance (PEEPminErs) and three levels of PEEP during low-tidal-volume (6 mL/kg) ventilation in rats. METHODS: Twenty-four rats were anesthetized, paralyzed, and mechanically ventilated. Airway pressure (Paw), flow (F), and volume (V) were fitted by a linear single compartment model (LSCM) Paw(t) = Ers × V(t) + Rrs × F(t) + PEEP or a volume- and flow-dependent SCM (VFDSCM) Paw(t) = (E1 + E2 × V(t)) × V(t) + (K1 + K2 × |F(t)|) × F(t) + PEEP, where Ers and Rrs are respiratory system elastance and resistance, respectively; E1 and E2× V are volume-independent and volume-dependent Ers, respectively; and K1 and K2 × F are flow-independent and flow-dependent Rrs, respectively. Animals were ventilated for 1 h at PEEP 0 cmH2O (ZEEP); PEEPminErs; 2 cmH2O above PEEPminErs (PEEPminErs+2); or 4 cmH2O above PEEPminErs (PEEPminErs+4). Alveolar tidal recruitment/derecruitment and overdistension were assessed by the index %E2 = 100 × [(E2 × VT)/(E1 + |E2| × VT)], and alveolar stability by the slope of Ers(t). RESULTS: %E2 varied between 0 and 30% at PEEPminErs in most respiratory cycles. Alveolar Tidal recruitment/derecruitment (%E2 < 0) and overdistension (%E2 > 30) were predominant in the absence of PEEP and in PEEP levels higher than PEEPminErs, respectively. The slope of Ers(t) was different from zero in all groups besides PEEPminErs+4. CONCLUSIONS: PEEPminErs presented the best compromise between alveolar tidal recruitment/derecruitment and overdistension, during 1 h of low-VT mechanical ventilation. More... »
PAGES335-342
http://scigraph.springernature.com/pub.10.1007/s00408-018-0096-8
DOIhttp://dx.doi.org/10.1007/s00408-018-0096-8
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1100995650
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/29435738
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"description": "PURPOSE: We compared respiratory mechanics between the positive end-expiratory pressure of minimal respiratory system elastance (PEEPminErs) and three levels of PEEP during low-tidal-volume (6\u00a0mL/kg) ventilation in rats.\nMETHODS: Twenty-four rats were anesthetized, paralyzed, and mechanically ventilated. Airway pressure (Paw), flow (F), and volume (V) were fitted by a linear single compartment model (LSCM) Paw(t)\u2009=\u2009Ers\u2009\u00d7\u2009V(t)\u2009+\u2009Rrs\u2009\u00d7\u2009F(t)\u2009+\u2009PEEP or a volume- and flow-dependent SCM (VFDSCM) Paw(t)\u2009=\u2009(E1\u2009+\u2009E2\u2009\u00d7\u2009V(t))\u2009\u00d7\u2009V(t)\u00a0+\u00a0(K1\u2009+\u2009K2\u2009\u00d7\u2009|F(t)|)\u2009\u00d7\u2009F(t)\u2009+\u2009PEEP, where Ers and Rrs are respiratory system elastance and resistance, respectively; E1 and E2\u00d7\u2009V are volume-independent and volume-dependent Ers, respectively; and K1 and K2\u2009\u00d7\u2009F are flow-independent and flow-dependent Rrs, respectively. Animals were ventilated for 1\u00a0h at PEEP 0\u00a0cmH2O (ZEEP); PEEPminErs; 2\u00a0cmH2O above PEEPminErs (PEEPminErs+2); or 4\u00a0cmH2O above PEEPminErs (PEEPminErs+4). Alveolar tidal recruitment/derecruitment and overdistension were assessed by the index %E2\u2009=\u2009100\u2009\u00d7\u2009[(E2\u2009\u00d7\u2009VT)/(E1\u00a0+\u00a0|E2|\u2009\u00d7\u2009VT)], and alveolar stability by the slope of Ers(t).\nRESULTS: %E2 varied between 0 and 30% at PEEPminErs in most respiratory cycles. Alveolar Tidal recruitment/derecruitment (%E2\u2009<\u20090) and overdistension (%E2\u2009>\u200930) were predominant in the absence of PEEP and in PEEP levels higher than PEEPminErs, respectively. The slope of Ers(t) was different from zero in all groups besides PEEPminErs+4.\nCONCLUSIONS: PEEPminErs presented the best compromise between alveolar tidal recruitment/derecruitment and overdistension, during 1\u00a0h of low-VT mechanical ventilation.",
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]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00408-018-0096-8'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00408-018-0096-8'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00408-018-0096-8'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00408-018-0096-8'
This table displays all metadata directly associated to this object as RDF triples.
256 TRIPLES
21 PREDICATES
73 URIs
21 LITERALS
9 BLANK NODES