Clinical Features of Patients with Diffuse Alveolar Hemorrhage due to Negative-Pressure Pulmonary Edema View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-04-28

AUTHORS

Damien Contou, Guillaume Voiriot, Michel Djibré, Vincent Labbé, Muriel Fartoukh, Antoine Parrot

ABSTRACT

Purpose Diffuse alveolar hemorrhage (DAH) with negative-pressure pulmonary edema (NPPE) is an uncommon yet life-threatening condition. We aimed at describing the circumstances, clinical, radiological, and bronchoscopic features, as well as the outcome of patients with NPPE-related DAH.MethodsWe performed a retrospective, observational cohort study, using data prospectively collected over 35 years in an intensive care unit (ICU).ResultsOf the 149 patients admitted for DAH, we identified 18 NPPE episodes in 15 patients, one admitted four times for recurrent NPPE-related DAH. The patients were primarily young, male, and athletic. The NPPE setting was postoperative (n = 12/18, 67%) or following generalized tonic–clonic seizures (n = 6/18, 33%). Hemoptysis was almost constant (n = 17/18, 94%), yet rarely massive (>200 cc, n = 1/18, 6%), with anemia observed in 10 (56%) episodes. The DAH triad (hemoptysis, anemia, and pulmonary infiltrates) was observed in 50% of episodes (n = 9/18), and acute respiratory failure in 94% (n = 17/18). Chest computed tomography revealed diffuse bilateral ground glass opacities (n = 10/10, 100%), while bronchoscopy detected bilateral hemorrhage (n = 12/12, 100%) and macroscopically bloody bronchoalveolar lavage, with siderophage absence in most (n = 7/8, 88%), indicating acute DAH. While one episode proved fatal, the other 17 recovered rapidly, with a mean ICU stay lasting 4.6 (2–15) days. Typically, the evolution was rapidly favorable under supportive care.ConclusionNPPE-related DAH is a rare life-threatening condition occurring primarily after tonic–clonic generalized seizure or generalized anesthesia. Clinical circumstances are a key to its diagnosis. Early diagnosis and recognition likely allow for successful management of this potentially serious complication, whereas ictal-DAH appears ominous in epileptic patients. More... »

PAGES

477-487

References to SciGraph publications

  • 1996-01. Bronchoscopic findings in post-obstructive pulmonary oedema in JOURNAL CANADIEN D'ANESTHÉSIE
  • 1997-01. Negative pressure induced airway and pulmonary injury in JOURNAL CANADIEN D'ANESTHÉSIE
  • 2008-03-18. Tako-Tsubo Cardiomyopathy Associated with Seizures in NEUROCRITICAL CARE
  • 2003-07-17. Negative pressure pulmonary oedema in the medical intensive care unit in INTENSIVE CARE MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00408-017-0011-8

    DOI

    http://dx.doi.org/10.1007/s00408-017-0011-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1085093077

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28455784


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adolescent", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Anesthesia, General", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Bronchoscopy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Diagnosis, Differential", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Early Diagnosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Epilepsy, Generalized", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Epilepsy, Tonic-Clonic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hemoptysis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hemorrhage", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Intensive Care Units", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Length of Stay", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Predictive Value of Tests", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pulmonary Edema", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Retrospective Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Risk Factors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Time Factors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tomography, X-Ray Computed", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Treatment Outcome", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Young Adult", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "R\u00e9animation Polyvalente, H\u00f4pital Victor Dupouy, 69 Rue du Lieutenant Colonel Prudhon, 95100, Argenteuil, France", 
              "id": "http://www.grid.ac/institutes/grid.414474.6", 
              "name": [
                "Service de R\u00e9animation m\u00e9dico-chirurgicale, H\u00f4pital Tenon, Assistance Publique - H\u00f4pitaux de Paris, Universit\u00e9 Pierre et Marie Curie, Paris, France", 
                "R\u00e9animation Polyvalente, H\u00f4pital Victor Dupouy, 69 Rue du Lieutenant Colonel Prudhon, 95100, Argenteuil, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Contou", 
            "givenName": "Damien", 
            "id": "sg:person.01020102105.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020102105.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Service de R\u00e9animation m\u00e9dico-chirurgicale, H\u00f4pital Tenon, Assistance Publique - H\u00f4pitaux de Paris, Universit\u00e9 Pierre et Marie Curie, Paris, France", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Service de R\u00e9animation m\u00e9dico-chirurgicale, H\u00f4pital Tenon, Assistance Publique - H\u00f4pitaux de Paris, Universit\u00e9 Pierre et Marie Curie, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Voiriot", 
            "givenName": "Guillaume", 
            "id": "sg:person.0702067731.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702067731.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Service de R\u00e9animation m\u00e9dico-chirurgicale, H\u00f4pital Tenon, Assistance Publique - H\u00f4pitaux de Paris, Universit\u00e9 Pierre et Marie Curie, Paris, France", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Service de R\u00e9animation m\u00e9dico-chirurgicale, H\u00f4pital Tenon, Assistance Publique - H\u00f4pitaux de Paris, Universit\u00e9 Pierre et Marie Curie, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Djibr\u00e9", 
            "givenName": "Michel", 
            "id": "sg:person.01145736640.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145736640.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Service de R\u00e9animation m\u00e9dico-chirurgicale, H\u00f4pital Tenon, Assistance Publique - H\u00f4pitaux de Paris, Universit\u00e9 Pierre et Marie Curie, Paris, France", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Service de R\u00e9animation m\u00e9dico-chirurgicale, H\u00f4pital Tenon, Assistance Publique - H\u00f4pitaux de Paris, Universit\u00e9 Pierre et Marie Curie, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Labb\u00e9", 
            "givenName": "Vincent", 
            "id": "sg:person.0615327252.69", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615327252.69"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Service de R\u00e9animation m\u00e9dico-chirurgicale, H\u00f4pital Tenon, Assistance Publique - H\u00f4pitaux de Paris, Universit\u00e9 Pierre et Marie Curie, Paris, France", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Service de R\u00e9animation m\u00e9dico-chirurgicale, H\u00f4pital Tenon, Assistance Publique - H\u00f4pitaux de Paris, Universit\u00e9 Pierre et Marie Curie, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fartoukh", 
            "givenName": "Muriel", 
            "id": "sg:person.01121246407.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121246407.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Service de R\u00e9animation m\u00e9dico-chirurgicale, H\u00f4pital Tenon, Assistance Publique - H\u00f4pitaux de Paris, Universit\u00e9 Pierre et Marie Curie, Paris, France", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Service de R\u00e9animation m\u00e9dico-chirurgicale, H\u00f4pital Tenon, Assistance Publique - H\u00f4pitaux de Paris, Universit\u00e9 Pierre et Marie Curie, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Parrot", 
            "givenName": "Antoine", 
            "id": "sg:person.01031630117.71", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031630117.71"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s00134-003-1896-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000743636", 
              "https://doi.org/10.1007/s00134-003-1896-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12028-008-9075-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042962989", 
              "https://doi.org/10.1007/s12028-008-9075-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf03014328", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005913284", 
              "https://doi.org/10.1007/bf03014328"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf03015962", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049974490", 
              "https://doi.org/10.1007/bf03015962"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-04-28", 
        "datePublishedReg": "2017-04-28", 
        "description": "Purpose Diffuse alveolar hemorrhage (DAH) with negative-pressure pulmonary edema (NPPE) is an uncommon yet life-threatening condition. We aimed at describing the circumstances, clinical, radiological, and bronchoscopic features, as well as the outcome of patients with NPPE-related DAH.MethodsWe performed a retrospective, observational cohort study, using data prospectively collected over 35\u00a0years in an intensive care unit (ICU).ResultsOf the 149 patients admitted for DAH, we identified 18 NPPE episodes in 15 patients, one admitted four times for recurrent NPPE-related DAH. The patients were primarily young, male, and athletic. The NPPE setting was postoperative (n\u00a0=\u00a012/18, 67%) or following generalized tonic\u2013clonic seizures (n\u00a0=\u00a06/18, 33%). Hemoptysis was almost constant (n\u00a0=\u00a017/18, 94%), yet rarely massive (>200\u00a0cc, n\u00a0=\u00a01/18, 6%), with anemia observed in 10 (56%) episodes. The DAH triad (hemoptysis, anemia, and pulmonary infiltrates) was observed in 50% of episodes (n\u00a0=\u00a09/18), and acute respiratory failure in 94% (n\u00a0=\u00a017/18). Chest computed tomography revealed diffuse bilateral ground glass opacities (n\u00a0=\u00a010/10, 100%), while bronchoscopy detected bilateral hemorrhage (n\u00a0=\u00a012/12, 100%) and macroscopically bloody bronchoalveolar lavage, with siderophage absence in most (n\u00a0=\u00a07/8, 88%), indicating acute DAH. While one episode proved fatal, the other 17 recovered rapidly, with a mean ICU stay lasting 4.6 (2\u201315)\u00a0days. Typically, the evolution was rapidly favorable under supportive care.ConclusionNPPE-related DAH is a rare life-threatening condition occurring primarily after tonic\u2013clonic generalized seizure or generalized anesthesia. Clinical circumstances are a key to its diagnosis. Early diagnosis and recognition likely allow for successful management of this potentially serious complication, whereas ictal-DAH appears ominous in epileptic patients.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s00408-017-0011-8", 
        "inLanguage": "en", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1054004", 
            "issn": [
              "0341-2040", 
              "1432-1750"
            ], 
            "name": "Lung", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "4", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "195"
          }
        ], 
        "keywords": [
          "diffuse alveolar hemorrhage", 
          "intensive care unit", 
          "negative-pressure pulmonary edema", 
          "life-threatening condition", 
          "alveolar hemorrhage", 
          "pulmonary edema", 
          "diffuse bilateral ground glass opacities", 
          "tonic-clonic generalized seizure", 
          "rare life-threatening condition", 
          "bilateral ground glass opacities", 
          "acute diffuse alveolar hemorrhage", 
          "mean intensive care unit", 
          "tonic-clonic seizures", 
          "acute respiratory failure", 
          "outcome of patients", 
          "observational cohort study", 
          "pressure pulmonary edema", 
          "ground glass opacity", 
          "bronchoscopic features", 
          "bilateral hemorrhage", 
          "respiratory failure", 
          "supportive care", 
          "cohort study", 
          "generalized seizures", 
          "serious complications", 
          "clinical features", 
          "care unit", 
          "bronchoalveolar lavage", 
          "glass opacity", 
          "clinical circumstances", 
          "early diagnosis", 
          "epileptic patients", 
          "patients", 
          "hemorrhage", 
          "successful management", 
          "edema", 
          "episodes", 
          "seizures", 
          "diagnosis", 
          "hemoptysis", 
          "complications", 
          "lavage", 
          "anesthesia", 
          "anemia", 
          "MethodsWe", 
          "chest", 
          "ResultsOf", 
          "care", 
          "tomography", 
          "outcomes", 
          "days", 
          "failure", 
          "opacity", 
          "years", 
          "setting", 
          "management", 
          "absence", 
          "triad", 
          "study", 
          "circumstances", 
          "features", 
          "data", 
          "conditions", 
          "units", 
          "time", 
          "recognition", 
          "key", 
          "evolution", 
          "Purpose Diffuse alveolar hemorrhage", 
          "NPPE-related DAH", 
          "NPPE episodes", 
          "recurrent NPPE-related DAH", 
          "NPPE setting", 
          "DAH triad", 
          "bloody bronchoalveolar lavage", 
          "siderophage absence", 
          "ConclusionNPPE-related DAH"
        ], 
        "name": "Clinical Features of Patients with Diffuse Alveolar Hemorrhage due to Negative-Pressure Pulmonary Edema", 
        "pagination": "477-487", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1085093077"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00408-017-0011-8"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "28455784"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00408-017-0011-8", 
          "https://app.dimensions.ai/details/publication/pub.1085093077"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-01-01T18:45", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_740.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s00408-017-0011-8"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00408-017-0011-8'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00408-017-0011-8'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00408-017-0011-8'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00408-017-0011-8'


     

    This table displays all metadata directly associated to this object as RDF triples.

    290 TRIPLES      22 PREDICATES      131 URIs      119 LITERALS      31 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00408-017-0011-8 schema:about N1262874314114748a0bad00a1bee2bfa
    2 N17ba507aaeca4958b22a9c68f5b75fdc
    3 N18a02eaee33946e99a608f63b5315751
    4 N265a1554d5414b1daefc22c1a901e0da
    5 N3bd4a038b69b497782b0c97acae50112
    6 N44cb9d8d4cd24bd7995148fdad2f32ca
    7 N5bb716b9ebb444609fe3d320227c1c3e
    8 N63c3933a1dc24b468414598492195798
    9 N6dd2920065b848ad9624d6c87ce2a61f
    10 N6e72e270aadc4cc9afde1df82726c6c6
    11 N8c9f07eb8d8c45a899c6c8810aa53892
    12 N8ee51bc33ada44a1acd830548f8b5436
    13 N911f86e16569422984405a6ee599a159
    14 N94bb18039f2348d2836c6ad5db3694b0
    15 N965faae239a845a5b2fb629e446102a1
    16 Na6dcdb57f94648c8b973287729051c12
    17 Na981849d36fa4dc1950edaacd0e0b08f
    18 Nbcfa91d77c104cea95047d97088597dc
    19 Nca40547e22f9480fbfbbc49fceae9924
    20 Ne0e36c5d63634634b4b67b4a7e2ccd0d
    21 Nedfa083bd9aa40b19b538a6ab86d1550
    22 Nf4bc87d0a6784877a21427a383b955fc
    23 Nfda883d7852d4854a8f21e7b7509aa67
    24 Nfff6a2db5a134539b9b63adfa551b128
    25 anzsrc-for:11
    26 anzsrc-for:1103
    27 schema:author N9005cc5a1ff74394882b89b36a645fd3
    28 schema:citation sg:pub.10.1007/bf03014328
    29 sg:pub.10.1007/bf03015962
    30 sg:pub.10.1007/s00134-003-1896-7
    31 sg:pub.10.1007/s12028-008-9075-x
    32 schema:datePublished 2017-04-28
    33 schema:datePublishedReg 2017-04-28
    34 schema:description Purpose Diffuse alveolar hemorrhage (DAH) with negative-pressure pulmonary edema (NPPE) is an uncommon yet life-threatening condition. We aimed at describing the circumstances, clinical, radiological, and bronchoscopic features, as well as the outcome of patients with NPPE-related DAH.MethodsWe performed a retrospective, observational cohort study, using data prospectively collected over 35 years in an intensive care unit (ICU).ResultsOf the 149 patients admitted for DAH, we identified 18 NPPE episodes in 15 patients, one admitted four times for recurrent NPPE-related DAH. The patients were primarily young, male, and athletic. The NPPE setting was postoperative (n = 12/18, 67%) or following generalized tonic–clonic seizures (n = 6/18, 33%). Hemoptysis was almost constant (n = 17/18, 94%), yet rarely massive (>200 cc, n = 1/18, 6%), with anemia observed in 10 (56%) episodes. The DAH triad (hemoptysis, anemia, and pulmonary infiltrates) was observed in 50% of episodes (n = 9/18), and acute respiratory failure in 94% (n = 17/18). Chest computed tomography revealed diffuse bilateral ground glass opacities (n = 10/10, 100%), while bronchoscopy detected bilateral hemorrhage (n = 12/12, 100%) and macroscopically bloody bronchoalveolar lavage, with siderophage absence in most (n = 7/8, 88%), indicating acute DAH. While one episode proved fatal, the other 17 recovered rapidly, with a mean ICU stay lasting 4.6 (2–15) days. Typically, the evolution was rapidly favorable under supportive care.ConclusionNPPE-related DAH is a rare life-threatening condition occurring primarily after tonic–clonic generalized seizure or generalized anesthesia. Clinical circumstances are a key to its diagnosis. Early diagnosis and recognition likely allow for successful management of this potentially serious complication, whereas ictal-DAH appears ominous in epileptic patients.
    35 schema:genre article
    36 schema:inLanguage en
    37 schema:isAccessibleForFree false
    38 schema:isPartOf N4308ab0a498a4093af34a1720a7ec8af
    39 N5d509be4974d433e9e6e330c8828f675
    40 sg:journal.1054004
    41 schema:keywords ConclusionNPPE-related DAH
    42 DAH triad
    43 MethodsWe
    44 NPPE episodes
    45 NPPE setting
    46 NPPE-related DAH
    47 Purpose Diffuse alveolar hemorrhage
    48 ResultsOf
    49 absence
    50 acute diffuse alveolar hemorrhage
    51 acute respiratory failure
    52 alveolar hemorrhage
    53 anemia
    54 anesthesia
    55 bilateral ground glass opacities
    56 bilateral hemorrhage
    57 bloody bronchoalveolar lavage
    58 bronchoalveolar lavage
    59 bronchoscopic features
    60 care
    61 care unit
    62 chest
    63 circumstances
    64 clinical circumstances
    65 clinical features
    66 cohort study
    67 complications
    68 conditions
    69 data
    70 days
    71 diagnosis
    72 diffuse alveolar hemorrhage
    73 diffuse bilateral ground glass opacities
    74 early diagnosis
    75 edema
    76 epileptic patients
    77 episodes
    78 evolution
    79 failure
    80 features
    81 generalized seizures
    82 glass opacity
    83 ground glass opacity
    84 hemoptysis
    85 hemorrhage
    86 intensive care unit
    87 key
    88 lavage
    89 life-threatening condition
    90 management
    91 mean intensive care unit
    92 negative-pressure pulmonary edema
    93 observational cohort study
    94 opacity
    95 outcome of patients
    96 outcomes
    97 patients
    98 pressure pulmonary edema
    99 pulmonary edema
    100 rare life-threatening condition
    101 recognition
    102 recurrent NPPE-related DAH
    103 respiratory failure
    104 seizures
    105 serious complications
    106 setting
    107 siderophage absence
    108 study
    109 successful management
    110 supportive care
    111 time
    112 tomography
    113 tonic-clonic generalized seizure
    114 tonic-clonic seizures
    115 triad
    116 units
    117 years
    118 schema:name Clinical Features of Patients with Diffuse Alveolar Hemorrhage due to Negative-Pressure Pulmonary Edema
    119 schema:pagination 477-487
    120 schema:productId N18b5ceb86fdb436d875f4e90bf81a73a
    121 N23231ea2dff049f89d5b1f01b2c1ee7f
    122 N317bf68b8c1d46de85d4bb0d6c19b965
    123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085093077
    124 https://doi.org/10.1007/s00408-017-0011-8
    125 schema:sdDatePublished 2022-01-01T18:45
    126 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    127 schema:sdPublisher Nebf96b1fd864497cbaed1174ad9f989a
    128 schema:url https://doi.org/10.1007/s00408-017-0011-8
    129 sgo:license sg:explorer/license/
    130 sgo:sdDataset articles
    131 rdf:type schema:ScholarlyArticle
    132 N1262874314114748a0bad00a1bee2bfa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name Retrospective Studies
    134 rdf:type schema:DefinedTerm
    135 N17ba507aaeca4958b22a9c68f5b75fdc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    136 schema:name Female
    137 rdf:type schema:DefinedTerm
    138 N18a02eaee33946e99a608f63b5315751 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    139 schema:name Predictive Value of Tests
    140 rdf:type schema:DefinedTerm
    141 N18b5ceb86fdb436d875f4e90bf81a73a schema:name dimensions_id
    142 schema:value pub.1085093077
    143 rdf:type schema:PropertyValue
    144 N18d3d3613f0d44c3993305ba3dace5cd rdf:first sg:person.0702067731.39
    145 rdf:rest N277c40f423f44798bb7207c5d6d0202f
    146 N23231ea2dff049f89d5b1f01b2c1ee7f schema:name pubmed_id
    147 schema:value 28455784
    148 rdf:type schema:PropertyValue
    149 N265a1554d5414b1daefc22c1a901e0da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Diagnosis, Differential
    151 rdf:type schema:DefinedTerm
    152 N277c40f423f44798bb7207c5d6d0202f rdf:first sg:person.01145736640.39
    153 rdf:rest N4c85af3efdfa471c89aeae1b4e635b4c
    154 N317bf68b8c1d46de85d4bb0d6c19b965 schema:name doi
    155 schema:value 10.1007/s00408-017-0011-8
    156 rdf:type schema:PropertyValue
    157 N3bd4a038b69b497782b0c97acae50112 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Pulmonary Edema
    159 rdf:type schema:DefinedTerm
    160 N4308ab0a498a4093af34a1720a7ec8af schema:volumeNumber 195
    161 rdf:type schema:PublicationVolume
    162 N44cb9d8d4cd24bd7995148fdad2f32ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name Length of Stay
    164 rdf:type schema:DefinedTerm
    165 N4c85af3efdfa471c89aeae1b4e635b4c rdf:first sg:person.0615327252.69
    166 rdf:rest Nc6eff8d54f9c4983be7f1aea48380e39
    167 N55ad363ace8c49a69ae1a7faad0d2869 rdf:first sg:person.01031630117.71
    168 rdf:rest rdf:nil
    169 N5bb716b9ebb444609fe3d320227c1c3e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name Epilepsy, Tonic-Clonic
    171 rdf:type schema:DefinedTerm
    172 N5d509be4974d433e9e6e330c8828f675 schema:issueNumber 4
    173 rdf:type schema:PublicationIssue
    174 N63c3933a1dc24b468414598492195798 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    175 schema:name Humans
    176 rdf:type schema:DefinedTerm
    177 N6dd2920065b848ad9624d6c87ce2a61f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    178 schema:name Middle Aged
    179 rdf:type schema:DefinedTerm
    180 N6e72e270aadc4cc9afde1df82726c6c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    181 schema:name Intensive Care Units
    182 rdf:type schema:DefinedTerm
    183 N8c9f07eb8d8c45a899c6c8810aa53892 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    184 schema:name Hemorrhage
    185 rdf:type schema:DefinedTerm
    186 N8ee51bc33ada44a1acd830548f8b5436 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    187 schema:name Male
    188 rdf:type schema:DefinedTerm
    189 N9005cc5a1ff74394882b89b36a645fd3 rdf:first sg:person.01020102105.08
    190 rdf:rest N18d3d3613f0d44c3993305ba3dace5cd
    191 N911f86e16569422984405a6ee599a159 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    192 schema:name Bronchoscopy
    193 rdf:type schema:DefinedTerm
    194 N94bb18039f2348d2836c6ad5db3694b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    195 schema:name Adult
    196 rdf:type schema:DefinedTerm
    197 N965faae239a845a5b2fb629e446102a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    198 schema:name Epilepsy, Generalized
    199 rdf:type schema:DefinedTerm
    200 Na6dcdb57f94648c8b973287729051c12 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    201 schema:name Treatment Outcome
    202 rdf:type schema:DefinedTerm
    203 Na981849d36fa4dc1950edaacd0e0b08f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    204 schema:name Risk Factors
    205 rdf:type schema:DefinedTerm
    206 Nbcfa91d77c104cea95047d97088597dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    207 schema:name Time Factors
    208 rdf:type schema:DefinedTerm
    209 Nc6eff8d54f9c4983be7f1aea48380e39 rdf:first sg:person.01121246407.03
    210 rdf:rest N55ad363ace8c49a69ae1a7faad0d2869
    211 Nca40547e22f9480fbfbbc49fceae9924 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    212 schema:name Young Adult
    213 rdf:type schema:DefinedTerm
    214 Ne0e36c5d63634634b4b67b4a7e2ccd0d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    215 schema:name Hemoptysis
    216 rdf:type schema:DefinedTerm
    217 Nebf96b1fd864497cbaed1174ad9f989a schema:name Springer Nature - SN SciGraph project
    218 rdf:type schema:Organization
    219 Nedfa083bd9aa40b19b538a6ab86d1550 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    220 schema:name Early Diagnosis
    221 rdf:type schema:DefinedTerm
    222 Nf4bc87d0a6784877a21427a383b955fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    223 schema:name Adolescent
    224 rdf:type schema:DefinedTerm
    225 Nfda883d7852d4854a8f21e7b7509aa67 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    226 schema:name Tomography, X-Ray Computed
    227 rdf:type schema:DefinedTerm
    228 Nfff6a2db5a134539b9b63adfa551b128 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    229 schema:name Anesthesia, General
    230 rdf:type schema:DefinedTerm
    231 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    232 schema:name Medical and Health Sciences
    233 rdf:type schema:DefinedTerm
    234 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    235 schema:name Clinical Sciences
    236 rdf:type schema:DefinedTerm
    237 sg:journal.1054004 schema:issn 0341-2040
    238 1432-1750
    239 schema:name Lung
    240 schema:publisher Springer Nature
    241 rdf:type schema:Periodical
    242 sg:person.01020102105.08 schema:affiliation grid-institutes:grid.414474.6
    243 schema:familyName Contou
    244 schema:givenName Damien
    245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020102105.08
    246 rdf:type schema:Person
    247 sg:person.01031630117.71 schema:affiliation grid-institutes:None
    248 schema:familyName Parrot
    249 schema:givenName Antoine
    250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031630117.71
    251 rdf:type schema:Person
    252 sg:person.01121246407.03 schema:affiliation grid-institutes:None
    253 schema:familyName Fartoukh
    254 schema:givenName Muriel
    255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121246407.03
    256 rdf:type schema:Person
    257 sg:person.01145736640.39 schema:affiliation grid-institutes:None
    258 schema:familyName Djibré
    259 schema:givenName Michel
    260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145736640.39
    261 rdf:type schema:Person
    262 sg:person.0615327252.69 schema:affiliation grid-institutes:None
    263 schema:familyName Labbé
    264 schema:givenName Vincent
    265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615327252.69
    266 rdf:type schema:Person
    267 sg:person.0702067731.39 schema:affiliation grid-institutes:None
    268 schema:familyName Voiriot
    269 schema:givenName Guillaume
    270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702067731.39
    271 rdf:type schema:Person
    272 sg:pub.10.1007/bf03014328 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005913284
    273 https://doi.org/10.1007/bf03014328
    274 rdf:type schema:CreativeWork
    275 sg:pub.10.1007/bf03015962 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049974490
    276 https://doi.org/10.1007/bf03015962
    277 rdf:type schema:CreativeWork
    278 sg:pub.10.1007/s00134-003-1896-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000743636
    279 https://doi.org/10.1007/s00134-003-1896-7
    280 rdf:type schema:CreativeWork
    281 sg:pub.10.1007/s12028-008-9075-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042962989
    282 https://doi.org/10.1007/s12028-008-9075-x
    283 rdf:type schema:CreativeWork
    284 grid-institutes:None schema:alternateName Service de Réanimation médico-chirurgicale, Hôpital Tenon, Assistance Publique - Hôpitaux de Paris, Université Pierre et Marie Curie, Paris, France
    285 schema:name Service de Réanimation médico-chirurgicale, Hôpital Tenon, Assistance Publique - Hôpitaux de Paris, Université Pierre et Marie Curie, Paris, France
    286 rdf:type schema:Organization
    287 grid-institutes:grid.414474.6 schema:alternateName Réanimation Polyvalente, Hôpital Victor Dupouy, 69 Rue du Lieutenant Colonel Prudhon, 95100, Argenteuil, France
    288 schema:name Réanimation Polyvalente, Hôpital Victor Dupouy, 69 Rue du Lieutenant Colonel Prudhon, 95100, Argenteuil, France
    289 Service de Réanimation médico-chirurgicale, Hôpital Tenon, Assistance Publique - Hôpitaux de Paris, Université Pierre et Marie Curie, Paris, France
    290 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...