Clinical Features of Patients with Diffuse Alveolar Hemorrhage due to Negative-Pressure Pulmonary Edema View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-04-28

AUTHORS

Damien Contou, Guillaume Voiriot, Michel Djibré, Vincent Labbé, Muriel Fartoukh, Antoine Parrot

ABSTRACT

Purpose Diffuse alveolar hemorrhage (DAH) with negative-pressure pulmonary edema (NPPE) is an uncommon yet life-threatening condition. We aimed at describing the circumstances, clinical, radiological, and bronchoscopic features, as well as the outcome of patients with NPPE-related DAH.MethodsWe performed a retrospective, observational cohort study, using data prospectively collected over 35 years in an intensive care unit (ICU).ResultsOf the 149 patients admitted for DAH, we identified 18 NPPE episodes in 15 patients, one admitted four times for recurrent NPPE-related DAH. The patients were primarily young, male, and athletic. The NPPE setting was postoperative (n = 12/18, 67%) or following generalized tonic–clonic seizures (n = 6/18, 33%). Hemoptysis was almost constant (n = 17/18, 94%), yet rarely massive (>200 cc, n = 1/18, 6%), with anemia observed in 10 (56%) episodes. The DAH triad (hemoptysis, anemia, and pulmonary infiltrates) was observed in 50% of episodes (n = 9/18), and acute respiratory failure in 94% (n = 17/18). Chest computed tomography revealed diffuse bilateral ground glass opacities (n = 10/10, 100%), while bronchoscopy detected bilateral hemorrhage (n = 12/12, 100%) and macroscopically bloody bronchoalveolar lavage, with siderophage absence in most (n = 7/8, 88%), indicating acute DAH. While one episode proved fatal, the other 17 recovered rapidly, with a mean ICU stay lasting 4.6 (2–15) days. Typically, the evolution was rapidly favorable under supportive care.ConclusionNPPE-related DAH is a rare life-threatening condition occurring primarily after tonic–clonic generalized seizure or generalized anesthesia. Clinical circumstances are a key to its diagnosis. Early diagnosis and recognition likely allow for successful management of this potentially serious complication, whereas ictal-DAH appears ominous in epileptic patients. More... »

PAGES

477-487

References to SciGraph publications

  • 1996-01. Bronchoscopic findings in post-obstructive pulmonary oedema in JOURNAL CANADIEN D'ANESTHÉSIE
  • 2008-03-18. Tako-Tsubo Cardiomyopathy Associated with Seizures in NEUROCRITICAL CARE
  • 1997-01. Negative pressure induced airway and pulmonary injury in JOURNAL CANADIEN D'ANESTHÉSIE
  • 2003-07-17. Negative pressure pulmonary oedema in the medical intensive care unit in INTENSIVE CARE MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00408-017-0011-8

    DOI

    http://dx.doi.org/10.1007/s00408-017-0011-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1085093077

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28455784


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adolescent", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Anesthesia, General", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Bronchoscopy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Diagnosis, Differential", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Early Diagnosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Epilepsy, Generalized", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Epilepsy, Tonic-Clonic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hemoptysis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hemorrhage", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Intensive Care Units", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Length of Stay", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Predictive Value of Tests", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pulmonary Edema", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Retrospective Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Risk Factors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Time Factors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tomography, X-Ray Computed", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Treatment Outcome", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Young Adult", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "R\u00e9animation Polyvalente, H\u00f4pital Victor Dupouy, 69 Rue du Lieutenant Colonel Prudhon, 95100, Argenteuil, France", 
              "id": "http://www.grid.ac/institutes/grid.414474.6", 
              "name": [
                "Service de R\u00e9animation m\u00e9dico-chirurgicale, H\u00f4pital Tenon, Assistance Publique - H\u00f4pitaux de Paris, Universit\u00e9 Pierre et Marie Curie, Paris, France", 
                "R\u00e9animation Polyvalente, H\u00f4pital Victor Dupouy, 69 Rue du Lieutenant Colonel Prudhon, 95100, Argenteuil, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Contou", 
            "givenName": "Damien", 
            "id": "sg:person.01020102105.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020102105.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Service de R\u00e9animation m\u00e9dico-chirurgicale, H\u00f4pital Tenon, Assistance Publique - H\u00f4pitaux de Paris, Universit\u00e9 Pierre et Marie Curie, Paris, France", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Service de R\u00e9animation m\u00e9dico-chirurgicale, H\u00f4pital Tenon, Assistance Publique - H\u00f4pitaux de Paris, Universit\u00e9 Pierre et Marie Curie, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Voiriot", 
            "givenName": "Guillaume", 
            "id": "sg:person.0702067731.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702067731.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Service de R\u00e9animation m\u00e9dico-chirurgicale, H\u00f4pital Tenon, Assistance Publique - H\u00f4pitaux de Paris, Universit\u00e9 Pierre et Marie Curie, Paris, France", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Service de R\u00e9animation m\u00e9dico-chirurgicale, H\u00f4pital Tenon, Assistance Publique - H\u00f4pitaux de Paris, Universit\u00e9 Pierre et Marie Curie, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Djibr\u00e9", 
            "givenName": "Michel", 
            "id": "sg:person.01145736640.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145736640.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Service de R\u00e9animation m\u00e9dico-chirurgicale, H\u00f4pital Tenon, Assistance Publique - H\u00f4pitaux de Paris, Universit\u00e9 Pierre et Marie Curie, Paris, France", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Service de R\u00e9animation m\u00e9dico-chirurgicale, H\u00f4pital Tenon, Assistance Publique - H\u00f4pitaux de Paris, Universit\u00e9 Pierre et Marie Curie, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Labb\u00e9", 
            "givenName": "Vincent", 
            "id": "sg:person.0615327252.69", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615327252.69"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Service de R\u00e9animation m\u00e9dico-chirurgicale, H\u00f4pital Tenon, Assistance Publique - H\u00f4pitaux de Paris, Universit\u00e9 Pierre et Marie Curie, Paris, France", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Service de R\u00e9animation m\u00e9dico-chirurgicale, H\u00f4pital Tenon, Assistance Publique - H\u00f4pitaux de Paris, Universit\u00e9 Pierre et Marie Curie, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fartoukh", 
            "givenName": "Muriel", 
            "id": "sg:person.01121246407.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121246407.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Service de R\u00e9animation m\u00e9dico-chirurgicale, H\u00f4pital Tenon, Assistance Publique - H\u00f4pitaux de Paris, Universit\u00e9 Pierre et Marie Curie, Paris, France", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Service de R\u00e9animation m\u00e9dico-chirurgicale, H\u00f4pital Tenon, Assistance Publique - H\u00f4pitaux de Paris, Universit\u00e9 Pierre et Marie Curie, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Parrot", 
            "givenName": "Antoine", 
            "id": "sg:person.01031630117.71", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031630117.71"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/bf03015962", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049974490", 
              "https://doi.org/10.1007/bf03015962"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12028-008-9075-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042962989", 
              "https://doi.org/10.1007/s12028-008-9075-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf03014328", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005913284", 
              "https://doi.org/10.1007/bf03014328"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-003-1896-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000743636", 
              "https://doi.org/10.1007/s00134-003-1896-7"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-04-28", 
        "datePublishedReg": "2017-04-28", 
        "description": "Purpose Diffuse alveolar hemorrhage (DAH) with negative-pressure pulmonary edema (NPPE) is an uncommon yet life-threatening condition. We aimed at describing the circumstances, clinical, radiological, and bronchoscopic features, as well as the outcome of patients with NPPE-related DAH.MethodsWe performed a retrospective, observational cohort study, using data prospectively collected over 35\u00a0years in an intensive care unit (ICU).ResultsOf the 149 patients admitted for DAH, we identified 18 NPPE episodes in 15 patients, one admitted four times for recurrent NPPE-related DAH. The patients were primarily young, male, and athletic. The NPPE setting was postoperative (n\u00a0=\u00a012/18, 67%) or following generalized tonic\u2013clonic seizures (n\u00a0=\u00a06/18, 33%). Hemoptysis was almost constant (n\u00a0=\u00a017/18, 94%), yet rarely massive (>200\u00a0cc, n\u00a0=\u00a01/18, 6%), with anemia observed in 10 (56%) episodes. The DAH triad (hemoptysis, anemia, and pulmonary infiltrates) was observed in 50% of episodes (n\u00a0=\u00a09/18), and acute respiratory failure in 94% (n\u00a0=\u00a017/18). Chest computed tomography revealed diffuse bilateral ground glass opacities (n\u00a0=\u00a010/10, 100%), while bronchoscopy detected bilateral hemorrhage (n\u00a0=\u00a012/12, 100%) and macroscopically bloody bronchoalveolar lavage, with siderophage absence in most (n\u00a0=\u00a07/8, 88%), indicating acute DAH. While one episode proved fatal, the other 17 recovered rapidly, with a mean ICU stay lasting 4.6 (2\u201315)\u00a0days. Typically, the evolution was rapidly favorable under supportive care.ConclusionNPPE-related DAH is a rare life-threatening condition occurring primarily after tonic\u2013clonic generalized seizure or generalized anesthesia. Clinical circumstances are a key to its diagnosis. Early diagnosis and recognition likely allow for successful management of this potentially serious complication, whereas ictal-DAH appears ominous in epileptic patients.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s00408-017-0011-8", 
        "inLanguage": "en", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1054004", 
            "issn": [
              "0341-2040", 
              "1432-1750"
            ], 
            "name": "Lung", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "4", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "195"
          }
        ], 
        "keywords": [
          "diffuse alveolar hemorrhage", 
          "intensive care unit", 
          "negative-pressure pulmonary edema", 
          "life-threatening condition", 
          "alveolar hemorrhage", 
          "pulmonary edema", 
          "diffuse bilateral ground glass opacities", 
          "tonic-clonic generalized seizure", 
          "rare life-threatening condition", 
          "bilateral ground glass opacities", 
          "acute diffuse alveolar hemorrhage", 
          "mean intensive care unit", 
          "tonic-clonic seizures", 
          "acute respiratory failure", 
          "outcome of patients", 
          "observational cohort study", 
          "pressure pulmonary edema", 
          "ground glass opacity", 
          "bronchoscopic features", 
          "bilateral hemorrhage", 
          "respiratory failure", 
          "supportive care", 
          "cohort study", 
          "generalized seizures", 
          "serious complications", 
          "clinical features", 
          "care unit", 
          "bronchoalveolar lavage", 
          "glass opacity", 
          "clinical circumstances", 
          "early diagnosis", 
          "epileptic patients", 
          "patients", 
          "hemorrhage", 
          "successful management", 
          "edema", 
          "episodes", 
          "seizures", 
          "diagnosis", 
          "hemoptysis", 
          "complications", 
          "lavage", 
          "anesthesia", 
          "anemia", 
          "MethodsWe", 
          "chest", 
          "ResultsOf", 
          "care", 
          "tomography", 
          "outcomes", 
          "days", 
          "failure", 
          "opacity", 
          "years", 
          "setting", 
          "management", 
          "absence", 
          "triad", 
          "study", 
          "circumstances", 
          "features", 
          "data", 
          "conditions", 
          "units", 
          "time", 
          "recognition", 
          "key", 
          "evolution", 
          "Purpose Diffuse alveolar hemorrhage", 
          "NPPE-related DAH", 
          "NPPE episodes", 
          "recurrent NPPE-related DAH", 
          "NPPE setting", 
          "DAH triad", 
          "bloody bronchoalveolar lavage", 
          "siderophage absence", 
          "ConclusionNPPE-related DAH"
        ], 
        "name": "Clinical Features of Patients with Diffuse Alveolar Hemorrhage due to Negative-Pressure Pulmonary Edema", 
        "pagination": "477-487", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1085093077"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00408-017-0011-8"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "28455784"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00408-017-0011-8", 
          "https://app.dimensions.ai/details/publication/pub.1085093077"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2021-11-01T18:32", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20211101/entities/gbq_results/article/article_748.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s00408-017-0011-8"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00408-017-0011-8'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00408-017-0011-8'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00408-017-0011-8'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00408-017-0011-8'


     

    This table displays all metadata directly associated to this object as RDF triples.

    290 TRIPLES      22 PREDICATES      131 URIs      119 LITERALS      31 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00408-017-0011-8 schema:about N0cbba8c3bec740a59a7c2bffa936eb38
    2 N19f29140359348dcab1d80206a67e0d9
    3 N1a2388a6ddc84d5297d60542e484ca09
    4 N2412e7a279064e8586d6c7fb8eec6f99
    5 N3d80dbe705c04a2198b40629db52d3e4
    6 N4c825c9c1e2547b4a4ceb68c6e5ca39c
    7 N53695cd196db45a3977d40c840425007
    8 N68e5e6c185244e47b7ce5245e6c40dec
    9 N6e271625b9d34df69155a576463878ae
    10 N88bc83fee59d45a780bf78c2ee066e38
    11 Na6658f5b966f49a9878c3edbdc7f4305
    12 Na82af784ee724dc0b0e505a4a8ae76ca
    13 Nab0f8221a1004045a8dbb76b78beb70f
    14 Nb0fab30950984fc58219d02a7588388e
    15 Nb445ed06b80f4bdda3fa12398c477bba
    16 Ncc21002cec914fc092aefdfab2c62f53
    17 Nd06fcd15525046ddaf9a88f7cbe80747
    18 Nd902f13375b740dba7b3cfc5be470b02
    19 Ne856fc66c17d4d78878e38df60782916
    20 Nf0ef99b531b74e9882d65b952c839582
    21 Nf26d62e6512d4756bc9e9b75fe39eb55
    22 Nf65a13d1285840728df2654fdd11f8e4
    23 Nfc61f355f5d34703b11e65bbf6cf6eeb
    24 Nfdf49d66b8624f4789df4e5baae4fb51
    25 anzsrc-for:11
    26 anzsrc-for:1103
    27 schema:author Nfba10441adfe402fac2f4d8555d513f8
    28 schema:citation sg:pub.10.1007/bf03014328
    29 sg:pub.10.1007/bf03015962
    30 sg:pub.10.1007/s00134-003-1896-7
    31 sg:pub.10.1007/s12028-008-9075-x
    32 schema:datePublished 2017-04-28
    33 schema:datePublishedReg 2017-04-28
    34 schema:description Purpose Diffuse alveolar hemorrhage (DAH) with negative-pressure pulmonary edema (NPPE) is an uncommon yet life-threatening condition. We aimed at describing the circumstances, clinical, radiological, and bronchoscopic features, as well as the outcome of patients with NPPE-related DAH.MethodsWe performed a retrospective, observational cohort study, using data prospectively collected over 35 years in an intensive care unit (ICU).ResultsOf the 149 patients admitted for DAH, we identified 18 NPPE episodes in 15 patients, one admitted four times for recurrent NPPE-related DAH. The patients were primarily young, male, and athletic. The NPPE setting was postoperative (n = 12/18, 67%) or following generalized tonic–clonic seizures (n = 6/18, 33%). Hemoptysis was almost constant (n = 17/18, 94%), yet rarely massive (>200 cc, n = 1/18, 6%), with anemia observed in 10 (56%) episodes. The DAH triad (hemoptysis, anemia, and pulmonary infiltrates) was observed in 50% of episodes (n = 9/18), and acute respiratory failure in 94% (n = 17/18). Chest computed tomography revealed diffuse bilateral ground glass opacities (n = 10/10, 100%), while bronchoscopy detected bilateral hemorrhage (n = 12/12, 100%) and macroscopically bloody bronchoalveolar lavage, with siderophage absence in most (n = 7/8, 88%), indicating acute DAH. While one episode proved fatal, the other 17 recovered rapidly, with a mean ICU stay lasting 4.6 (2–15) days. Typically, the evolution was rapidly favorable under supportive care.ConclusionNPPE-related DAH is a rare life-threatening condition occurring primarily after tonic–clonic generalized seizure or generalized anesthesia. Clinical circumstances are a key to its diagnosis. Early diagnosis and recognition likely allow for successful management of this potentially serious complication, whereas ictal-DAH appears ominous in epileptic patients.
    35 schema:genre article
    36 schema:inLanguage en
    37 schema:isAccessibleForFree false
    38 schema:isPartOf Nbc1f0efea5cd41d8989ca92c8916698a
    39 Ndb5bb213730b4facb8d685a95a3ab005
    40 sg:journal.1054004
    41 schema:keywords ConclusionNPPE-related DAH
    42 DAH triad
    43 MethodsWe
    44 NPPE episodes
    45 NPPE setting
    46 NPPE-related DAH
    47 Purpose Diffuse alveolar hemorrhage
    48 ResultsOf
    49 absence
    50 acute diffuse alveolar hemorrhage
    51 acute respiratory failure
    52 alveolar hemorrhage
    53 anemia
    54 anesthesia
    55 bilateral ground glass opacities
    56 bilateral hemorrhage
    57 bloody bronchoalveolar lavage
    58 bronchoalveolar lavage
    59 bronchoscopic features
    60 care
    61 care unit
    62 chest
    63 circumstances
    64 clinical circumstances
    65 clinical features
    66 cohort study
    67 complications
    68 conditions
    69 data
    70 days
    71 diagnosis
    72 diffuse alveolar hemorrhage
    73 diffuse bilateral ground glass opacities
    74 early diagnosis
    75 edema
    76 epileptic patients
    77 episodes
    78 evolution
    79 failure
    80 features
    81 generalized seizures
    82 glass opacity
    83 ground glass opacity
    84 hemoptysis
    85 hemorrhage
    86 intensive care unit
    87 key
    88 lavage
    89 life-threatening condition
    90 management
    91 mean intensive care unit
    92 negative-pressure pulmonary edema
    93 observational cohort study
    94 opacity
    95 outcome of patients
    96 outcomes
    97 patients
    98 pressure pulmonary edema
    99 pulmonary edema
    100 rare life-threatening condition
    101 recognition
    102 recurrent NPPE-related DAH
    103 respiratory failure
    104 seizures
    105 serious complications
    106 setting
    107 siderophage absence
    108 study
    109 successful management
    110 supportive care
    111 time
    112 tomography
    113 tonic-clonic generalized seizure
    114 tonic-clonic seizures
    115 triad
    116 units
    117 years
    118 schema:name Clinical Features of Patients with Diffuse Alveolar Hemorrhage due to Negative-Pressure Pulmonary Edema
    119 schema:pagination 477-487
    120 schema:productId N33cf5bf7abb74691aa7df760c87c2954
    121 Nd835c55ad1304ba3bfd44e3d3d14307e
    122 Ne0e4ddbdd2e746219a2ba0236eaca62c
    123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085093077
    124 https://doi.org/10.1007/s00408-017-0011-8
    125 schema:sdDatePublished 2021-11-01T18:32
    126 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    127 schema:sdPublisher N377f1527f9ef40519bc0c0322e7f2ed0
    128 schema:url https://doi.org/10.1007/s00408-017-0011-8
    129 sgo:license sg:explorer/license/
    130 sgo:sdDataset articles
    131 rdf:type schema:ScholarlyArticle
    132 N0cbba8c3bec740a59a7c2bffa936eb38 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name Predictive Value of Tests
    134 rdf:type schema:DefinedTerm
    135 N19f29140359348dcab1d80206a67e0d9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    136 schema:name Hemorrhage
    137 rdf:type schema:DefinedTerm
    138 N1a2388a6ddc84d5297d60542e484ca09 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    139 schema:name Young Adult
    140 rdf:type schema:DefinedTerm
    141 N2412e7a279064e8586d6c7fb8eec6f99 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    142 schema:name Male
    143 rdf:type schema:DefinedTerm
    144 N33cf5bf7abb74691aa7df760c87c2954 schema:name doi
    145 schema:value 10.1007/s00408-017-0011-8
    146 rdf:type schema:PropertyValue
    147 N377f1527f9ef40519bc0c0322e7f2ed0 schema:name Springer Nature - SN SciGraph project
    148 rdf:type schema:Organization
    149 N3d80dbe705c04a2198b40629db52d3e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Treatment Outcome
    151 rdf:type schema:DefinedTerm
    152 N4c825c9c1e2547b4a4ceb68c6e5ca39c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Anesthesia, General
    154 rdf:type schema:DefinedTerm
    155 N53695cd196db45a3977d40c840425007 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    156 schema:name Diagnosis, Differential
    157 rdf:type schema:DefinedTerm
    158 N6045a4abc9134ff28da9c8641c70360f rdf:first sg:person.01031630117.71
    159 rdf:rest rdf:nil
    160 N68e5e6c185244e47b7ce5245e6c40dec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    161 schema:name Middle Aged
    162 rdf:type schema:DefinedTerm
    163 N6e271625b9d34df69155a576463878ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Epilepsy, Generalized
    165 rdf:type schema:DefinedTerm
    166 N88bc83fee59d45a780bf78c2ee066e38 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Humans
    168 rdf:type schema:DefinedTerm
    169 Na6658f5b966f49a9878c3edbdc7f4305 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name Length of Stay
    171 rdf:type schema:DefinedTerm
    172 Na82af784ee724dc0b0e505a4a8ae76ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name Time Factors
    174 rdf:type schema:DefinedTerm
    175 Nab0f8221a1004045a8dbb76b78beb70f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    176 schema:name Adolescent
    177 rdf:type schema:DefinedTerm
    178 Nb0fab30950984fc58219d02a7588388e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    179 schema:name Epilepsy, Tonic-Clonic
    180 rdf:type schema:DefinedTerm
    181 Nb445ed06b80f4bdda3fa12398c477bba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    182 schema:name Retrospective Studies
    183 rdf:type schema:DefinedTerm
    184 Nb7ca5b2ef43b4e4db1a189fe92bc5fc6 rdf:first sg:person.0702067731.39
    185 rdf:rest Neb1b7468140e445c97b6ee9ea797db3c
    186 Nbc1f0efea5cd41d8989ca92c8916698a schema:issueNumber 4
    187 rdf:type schema:PublicationIssue
    188 Ncc21002cec914fc092aefdfab2c62f53 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    189 schema:name Intensive Care Units
    190 rdf:type schema:DefinedTerm
    191 Nd06fcd15525046ddaf9a88f7cbe80747 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    192 schema:name Female
    193 rdf:type schema:DefinedTerm
    194 Nd835c55ad1304ba3bfd44e3d3d14307e schema:name pubmed_id
    195 schema:value 28455784
    196 rdf:type schema:PropertyValue
    197 Nd902f13375b740dba7b3cfc5be470b02 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    198 schema:name Tomography, X-Ray Computed
    199 rdf:type schema:DefinedTerm
    200 Ndb5bb213730b4facb8d685a95a3ab005 schema:volumeNumber 195
    201 rdf:type schema:PublicationVolume
    202 Ne0e4ddbdd2e746219a2ba0236eaca62c schema:name dimensions_id
    203 schema:value pub.1085093077
    204 rdf:type schema:PropertyValue
    205 Ne856fc66c17d4d78878e38df60782916 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    206 schema:name Pulmonary Edema
    207 rdf:type schema:DefinedTerm
    208 Neb1b7468140e445c97b6ee9ea797db3c rdf:first sg:person.01145736640.39
    209 rdf:rest Nf063087ec1354d10a0da2eeed9af86b9
    210 Neff8be17de214c3bbcccb3159fd33601 rdf:first sg:person.01121246407.03
    211 rdf:rest N6045a4abc9134ff28da9c8641c70360f
    212 Nf063087ec1354d10a0da2eeed9af86b9 rdf:first sg:person.0615327252.69
    213 rdf:rest Neff8be17de214c3bbcccb3159fd33601
    214 Nf0ef99b531b74e9882d65b952c839582 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    215 schema:name Adult
    216 rdf:type schema:DefinedTerm
    217 Nf26d62e6512d4756bc9e9b75fe39eb55 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    218 schema:name Early Diagnosis
    219 rdf:type schema:DefinedTerm
    220 Nf65a13d1285840728df2654fdd11f8e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    221 schema:name Bronchoscopy
    222 rdf:type schema:DefinedTerm
    223 Nfba10441adfe402fac2f4d8555d513f8 rdf:first sg:person.01020102105.08
    224 rdf:rest Nb7ca5b2ef43b4e4db1a189fe92bc5fc6
    225 Nfc61f355f5d34703b11e65bbf6cf6eeb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    226 schema:name Hemoptysis
    227 rdf:type schema:DefinedTerm
    228 Nfdf49d66b8624f4789df4e5baae4fb51 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    229 schema:name Risk Factors
    230 rdf:type schema:DefinedTerm
    231 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    232 schema:name Medical and Health Sciences
    233 rdf:type schema:DefinedTerm
    234 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    235 schema:name Clinical Sciences
    236 rdf:type schema:DefinedTerm
    237 sg:journal.1054004 schema:issn 0341-2040
    238 1432-1750
    239 schema:name Lung
    240 schema:publisher Springer Nature
    241 rdf:type schema:Periodical
    242 sg:person.01020102105.08 schema:affiliation grid-institutes:grid.414474.6
    243 schema:familyName Contou
    244 schema:givenName Damien
    245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020102105.08
    246 rdf:type schema:Person
    247 sg:person.01031630117.71 schema:affiliation grid-institutes:None
    248 schema:familyName Parrot
    249 schema:givenName Antoine
    250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031630117.71
    251 rdf:type schema:Person
    252 sg:person.01121246407.03 schema:affiliation grid-institutes:None
    253 schema:familyName Fartoukh
    254 schema:givenName Muriel
    255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121246407.03
    256 rdf:type schema:Person
    257 sg:person.01145736640.39 schema:affiliation grid-institutes:None
    258 schema:familyName Djibré
    259 schema:givenName Michel
    260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145736640.39
    261 rdf:type schema:Person
    262 sg:person.0615327252.69 schema:affiliation grid-institutes:None
    263 schema:familyName Labbé
    264 schema:givenName Vincent
    265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615327252.69
    266 rdf:type schema:Person
    267 sg:person.0702067731.39 schema:affiliation grid-institutes:None
    268 schema:familyName Voiriot
    269 schema:givenName Guillaume
    270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702067731.39
    271 rdf:type schema:Person
    272 sg:pub.10.1007/bf03014328 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005913284
    273 https://doi.org/10.1007/bf03014328
    274 rdf:type schema:CreativeWork
    275 sg:pub.10.1007/bf03015962 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049974490
    276 https://doi.org/10.1007/bf03015962
    277 rdf:type schema:CreativeWork
    278 sg:pub.10.1007/s00134-003-1896-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000743636
    279 https://doi.org/10.1007/s00134-003-1896-7
    280 rdf:type schema:CreativeWork
    281 sg:pub.10.1007/s12028-008-9075-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042962989
    282 https://doi.org/10.1007/s12028-008-9075-x
    283 rdf:type schema:CreativeWork
    284 grid-institutes:None schema:alternateName Service de Réanimation médico-chirurgicale, Hôpital Tenon, Assistance Publique - Hôpitaux de Paris, Université Pierre et Marie Curie, Paris, France
    285 schema:name Service de Réanimation médico-chirurgicale, Hôpital Tenon, Assistance Publique - Hôpitaux de Paris, Université Pierre et Marie Curie, Paris, France
    286 rdf:type schema:Organization
    287 grid-institutes:grid.414474.6 schema:alternateName Réanimation Polyvalente, Hôpital Victor Dupouy, 69 Rue du Lieutenant Colonel Prudhon, 95100, Argenteuil, France
    288 schema:name Réanimation Polyvalente, Hôpital Victor Dupouy, 69 Rue du Lieutenant Colonel Prudhon, 95100, Argenteuil, France
    289 Service de Réanimation médico-chirurgicale, Hôpital Tenon, Assistance Publique - Hôpitaux de Paris, Université Pierre et Marie Curie, Paris, France
    290 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...