Associations of TIM-1 Genetic Polymorphisms with Asthma: A Meta-analysis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-06

AUTHORS

Xiaochuan Xie, Xiaohan Shi, Peng Chen, Li Rao

ABSTRACT

PURPOSE: Recently, the roles of TIM-1 genetic polymorphisms in asthma have been extensively studied, with conflicting results. Therefore, we performed the present meta-analysis to better assess potential associations of TIM-1 genetic polymorphisms with asthma. METHODS: Eligible articles were searched in PubMed, Medline, EMBASE, Google Scholar, and CNKI up to December 2016. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to detect any potential associations between TIM-1 genetic polymorphisms and asthma. RESULTS: A total of 12 articles including 3120 asthma patients and 2825 control subjects were analyzed. The overall and subgroup analyses revealed that TIM-1-416G>C single nucleotide polymorphism was significantly associated with asthma for the Asian population in the codominant (G/G vs. G/C, p = 0.0003, OR 1.86, 95% CI 1.33-2.60) and dominant (G/G vs. G/C + C/C, p < 0.0001, OR 1.94, 95% CI 1.40-2.69) genetic models. Nevertheless, we failed to detect any significant associations between TIM-1-416G>C single nucleotide polymorphism and asthma in Caucasians. Additionally, according to our analyses, TIM-1 5383_5397 insertion/deletion polymorphism was not correlated with asthma in both Asians and Caucasians. CONCLUSIONS: In conclusion, our findings suggest that TIM-1-416G>C single nucleotide polymorphism is associated with asthma susceptibility for the Asian ethnicity in certain genetic models. However, TIM-1 5383_5397 insertion/deletion polymorphism may not be correlated with the risk of asthma. More... »

PAGES

353-360

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00408-017-0006-5

DOI

http://dx.doi.org/10.1007/s00408-017-0006-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1085044221

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28434117


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Asian Continental Ancestry Group", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Asthma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Case-Control Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chi-Square Distribution", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Association Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Predisposition to Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hepatitis A Virus Cellular Receptor 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heterozygote", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Homozygote", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Odds Ratio", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phenotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Single Nucleotide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Assessment", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "West China Hospital of Sichuan University", 
          "id": "https://www.grid.ac/institutes/grid.412901.f", 
          "name": [
            "Department of Cardiology, West China Hospital of Sichuan University, 610041, Chengdu, Sichuan, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xie", 
        "givenName": "Xiaochuan", 
        "id": "sg:person.01252022733.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252022733.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "West China Second University Hospital of Sichuan University", 
          "id": "https://www.grid.ac/institutes/grid.461863.e", 
          "name": [
            "Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital of Sichuan University, 610041, Chengdu, Sichuan, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shi", 
        "givenName": "Xiaohan", 
        "id": "sg:person.01320136133.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320136133.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "West China Second University Hospital of Sichuan University", 
          "id": "https://www.grid.ac/institutes/grid.461863.e", 
          "name": [
            "Laboratory of Molecular Translational Medicine, West China Second University Hospital of Sichuan University, 610041, Chengdu, Sichuan, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Peng", 
        "id": "sg:person.0646325650.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646325650.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "West China Hospital of Sichuan University", 
          "id": "https://www.grid.ac/institutes/grid.412901.f", 
          "name": [
            "Department of Cardiology, West China Hospital of Sichuan University, 610041, Chengdu, Sichuan, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rao", 
        "givenName": "Li", 
        "id": "sg:person.01274216105.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274216105.48"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.3109/02770903.2012.694539", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002234330"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molmed.2005.06.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004802603"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molmed.2005.06.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004802603"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mcp.0b013e32834dc532", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005340557"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mcp.0b013e32834dc532", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005340557"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.0105-2896.2010.00903.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007187335"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/iji.12209", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007590716"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg1326", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011038021", 
          "https://doi.org/10.1038/nrg1326"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg1326", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011038021", 
          "https://doi.org/10.1038/nrg1326"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1744-313x.2006.00634.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013809590"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2005.01.035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015782185"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1034/j.1398-9995.2001.056008749.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017045434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.172.11.7169", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025305169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11033-014-3676-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025421714", 
          "https://doi.org/10.1007/s11033-014-3676-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11033-014-3676-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025421714", 
          "https://doi.org/10.1007/s11033-014-3676-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-065x.2011.01029.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026572337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni1186", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034745567", 
          "https://doi.org/10.1038/ni1186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni1186", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034745567", 
          "https://doi.org/10.1038/ni1186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/ajrccm.153.4.8616554", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034895464"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.humimm.2003.09.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035154559"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.humimm.2003.09.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035154559"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/13993003.01084-2015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035304372"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/13993003.01084-2015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035304372"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/13993003.01084-2015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035304372"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/aci.0b013e32834ec13b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036917491"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/aci.0b013e32834ec13b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036917491"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/aci.0b013e32834ec13b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036917491"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/ajrccm.156.5.9702084", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038477555"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00408-014-9653-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049228628", 
          "https://doi.org/10.1007/s00408-014-9653-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2003.10.125", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049853882"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000103992", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050376162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri1111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051865327", 
          "https://doi.org/10.1038/nri1111"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri1111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051865327", 
          "https://doi.org/10.1038/nri1111"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076876128", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077905834", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078931284", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-06", 
    "datePublishedReg": "2017-06-01", 
    "description": "PURPOSE: Recently, the roles of TIM-1 genetic polymorphisms in asthma have been extensively studied, with conflicting results. Therefore, we performed the present meta-analysis to better assess potential associations of TIM-1 genetic polymorphisms with asthma.\nMETHODS: Eligible articles were searched in PubMed, Medline, EMBASE, Google Scholar, and CNKI up to December 2016. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to detect any potential associations between TIM-1 genetic polymorphisms and asthma.\nRESULTS: A total of 12 articles including 3120 asthma patients and 2825 control subjects were analyzed. The overall and subgroup analyses revealed that TIM-1-416G>C single nucleotide polymorphism was significantly associated with asthma for the Asian population in the codominant (G/G vs. G/C, p\u00a0=\u00a00.0003, OR 1.86, 95% CI 1.33-2.60) and dominant (G/G vs. G/C\u00a0+\u00a0C/C, p\u00a0<\u00a00.0001, OR 1.94, 95% CI 1.40-2.69) genetic models. Nevertheless, we failed to detect any significant associations between TIM-1-416G>C single nucleotide polymorphism and asthma in Caucasians. Additionally, according to our analyses, TIM-1 5383_5397 insertion/deletion polymorphism was not correlated with asthma in both Asians and Caucasians.\nCONCLUSIONS: In conclusion, our findings suggest that TIM-1-416G>C single nucleotide polymorphism is associated with asthma susceptibility for the Asian ethnicity in certain genetic models. However, TIM-1 5383_5397 insertion/deletion polymorphism may not be correlated with the risk of asthma.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00408-017-0006-5", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.7199183", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7199441", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1054004", 
        "issn": [
          "0341-2040", 
          "1432-1750"
        ], 
        "name": "Lung", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "195"
      }
    ], 
    "name": "Associations of TIM-1 Genetic Polymorphisms with Asthma: A Meta-analysis", 
    "pagination": "353-360", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "879261c057253ef74d80f98d23ace65cf59fba145c672b6feab9b69c572ada6a"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28434117"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7701875"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00408-017-0006-5"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1085044221"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00408-017-0006-5", 
      "https://app.dimensions.ai/details/publication/pub.1085044221"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:36", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000349_0000000349/records_113670_00000004.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs00408-017-0006-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00408-017-0006-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00408-017-0006-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00408-017-0006-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00408-017-0006-5'


 

This table displays all metadata directly associated to this object as RDF triples.

239 TRIPLES      21 PREDICATES      70 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00408-017-0006-5 schema:about N0d37e07f0cf346719c5bf169599956d5
2 N130b0ae8c49c45d49cc94b0bd9f53b33
3 N262294b17e8b4c67ad9240409f883407
4 N2ebdb34ad9504cc6a1466918731ae5ea
5 N36a6af1979a84107aab614494f374581
6 N49be08f5ed274663a1ed535bfcd4a529
7 N5631538998254244a47324b69e34b9d0
8 N56353166c798462ba9588879456e5141
9 N8cc8c429ebe74cbc96c69e11520bb17f
10 Na25391daedc04a1a86dc521dbaa19415
11 Na59150e1d91843118e59294c0cc6ce99
12 Nbebcf3024f4643bcae4f0330ff91770f
13 Ncdbdec3c40b84dd7ac081d3de47204f8
14 Nd7c8e55e5e52410c83f82683599ccd28
15 Ne451b9ed0ef1429f9593716919d1d4ff
16 Nf5d975a2bfa54ee4ace3f5fcea9153e9
17 anzsrc-for:11
18 anzsrc-for:1102
19 schema:author N13c0137ec8f449238262595f40c973a2
20 schema:citation sg:pub.10.1007/s00408-014-9653-y
21 sg:pub.10.1007/s11033-014-3676-6
22 sg:pub.10.1038/ni1186
23 sg:pub.10.1038/nrg1326
24 sg:pub.10.1038/nri1111
25 https://app.dimensions.ai/details/publication/pub.1076876128
26 https://app.dimensions.ai/details/publication/pub.1077905834
27 https://app.dimensions.ai/details/publication/pub.1078931284
28 https://doi.org/10.1016/j.bbrc.2003.10.125
29 https://doi.org/10.1016/j.humimm.2003.09.011
30 https://doi.org/10.1016/j.jaci.2005.01.035
31 https://doi.org/10.1016/j.molmed.2005.06.008
32 https://doi.org/10.1034/j.1398-9995.2001.056008749.x
33 https://doi.org/10.1097/aci.0b013e32834ec13b
34 https://doi.org/10.1097/mcp.0b013e32834dc532
35 https://doi.org/10.1111/iji.12209
36 https://doi.org/10.1111/j.0105-2896.2010.00903.x
37 https://doi.org/10.1111/j.1600-065x.2011.01029.x
38 https://doi.org/10.1111/j.1744-313x.2006.00634.x
39 https://doi.org/10.1159/000103992
40 https://doi.org/10.1164/ajrccm.153.4.8616554
41 https://doi.org/10.1164/ajrccm.156.5.9702084
42 https://doi.org/10.1183/13993003.01084-2015
43 https://doi.org/10.3109/02770903.2012.694539
44 https://doi.org/10.4049/jimmunol.172.11.7169
45 schema:datePublished 2017-06
46 schema:datePublishedReg 2017-06-01
47 schema:description PURPOSE: Recently, the roles of TIM-1 genetic polymorphisms in asthma have been extensively studied, with conflicting results. Therefore, we performed the present meta-analysis to better assess potential associations of TIM-1 genetic polymorphisms with asthma. METHODS: Eligible articles were searched in PubMed, Medline, EMBASE, Google Scholar, and CNKI up to December 2016. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to detect any potential associations between TIM-1 genetic polymorphisms and asthma. RESULTS: A total of 12 articles including 3120 asthma patients and 2825 control subjects were analyzed. The overall and subgroup analyses revealed that TIM-1-416G>C single nucleotide polymorphism was significantly associated with asthma for the Asian population in the codominant (G/G vs. G/C, p = 0.0003, OR 1.86, 95% CI 1.33-2.60) and dominant (G/G vs. G/C + C/C, p < 0.0001, OR 1.94, 95% CI 1.40-2.69) genetic models. Nevertheless, we failed to detect any significant associations between TIM-1-416G>C single nucleotide polymorphism and asthma in Caucasians. Additionally, according to our analyses, TIM-1 5383_5397 insertion/deletion polymorphism was not correlated with asthma in both Asians and Caucasians. CONCLUSIONS: In conclusion, our findings suggest that TIM-1-416G>C single nucleotide polymorphism is associated with asthma susceptibility for the Asian ethnicity in certain genetic models. However, TIM-1 5383_5397 insertion/deletion polymorphism may not be correlated with the risk of asthma.
48 schema:genre research_article
49 schema:inLanguage en
50 schema:isAccessibleForFree true
51 schema:isPartOf N4a7b8f8fb36a42478a1bdeceef5edc4f
52 N6ff1d7687dc3426bb7e8957a1f3f6e6a
53 sg:journal.1054004
54 schema:name Associations of TIM-1 Genetic Polymorphisms with Asthma: A Meta-analysis
55 schema:pagination 353-360
56 schema:productId N305a865741384202997679d58a40d368
57 N442ea75501254a189095732e0a818912
58 N9860d213004a4acdbe2eda1b8d03e17d
59 Nb8c9a33e410b4efab4d31fba56b203aa
60 Ne379720c8f5f42489c03320bdae0a972
61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085044221
62 https://doi.org/10.1007/s00408-017-0006-5
63 schema:sdDatePublished 2019-04-11T10:36
64 schema:sdLicense https://scigraph.springernature.com/explorer/license/
65 schema:sdPublisher Na041224559a24313928d432af0df6e1a
66 schema:url https://link.springer.com/10.1007%2Fs00408-017-0006-5
67 sgo:license sg:explorer/license/
68 sgo:sdDataset articles
69 rdf:type schema:ScholarlyArticle
70 N0d37e07f0cf346719c5bf169599956d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
71 schema:name Risk Assessment
72 rdf:type schema:DefinedTerm
73 N130b0ae8c49c45d49cc94b0bd9f53b33 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Asian Continental Ancestry Group
75 rdf:type schema:DefinedTerm
76 N13c0137ec8f449238262595f40c973a2 rdf:first sg:person.01252022733.23
77 rdf:rest N6059104d1b514750ae6cf13c599dd5bb
78 N262294b17e8b4c67ad9240409f883407 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Case-Control Studies
80 rdf:type schema:DefinedTerm
81 N2ebdb34ad9504cc6a1466918731ae5ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Heterozygote
83 rdf:type schema:DefinedTerm
84 N305a865741384202997679d58a40d368 schema:name nlm_unique_id
85 schema:value 7701875
86 rdf:type schema:PropertyValue
87 N36a6af1979a84107aab614494f374581 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Phenotype
89 rdf:type schema:DefinedTerm
90 N442ea75501254a189095732e0a818912 schema:name dimensions_id
91 schema:value pub.1085044221
92 rdf:type schema:PropertyValue
93 N49be08f5ed274663a1ed535bfcd4a529 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Risk Factors
95 rdf:type schema:DefinedTerm
96 N4a7b8f8fb36a42478a1bdeceef5edc4f schema:issueNumber 3
97 rdf:type schema:PublicationIssue
98 N5631538998254244a47324b69e34b9d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Odds Ratio
100 rdf:type schema:DefinedTerm
101 N56353166c798462ba9588879456e5141 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Models, Genetic
103 rdf:type schema:DefinedTerm
104 N6059104d1b514750ae6cf13c599dd5bb rdf:first sg:person.01320136133.65
105 rdf:rest Nbfe2643107614318987f9ab9f0186439
106 N6ff1d7687dc3426bb7e8957a1f3f6e6a schema:volumeNumber 195
107 rdf:type schema:PublicationVolume
108 N8cc8c429ebe74cbc96c69e11520bb17f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Polymorphism, Single Nucleotide
110 rdf:type schema:DefinedTerm
111 N9860d213004a4acdbe2eda1b8d03e17d schema:name doi
112 schema:value 10.1007/s00408-017-0006-5
113 rdf:type schema:PropertyValue
114 Na041224559a24313928d432af0df6e1a schema:name Springer Nature - SN SciGraph project
115 rdf:type schema:Organization
116 Na25391daedc04a1a86dc521dbaa19415 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Genetic Predisposition to Disease
118 rdf:type schema:DefinedTerm
119 Na59150e1d91843118e59294c0cc6ce99 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Chi-Square Distribution
121 rdf:type schema:DefinedTerm
122 Nb8c9a33e410b4efab4d31fba56b203aa schema:name readcube_id
123 schema:value 879261c057253ef74d80f98d23ace65cf59fba145c672b6feab9b69c572ada6a
124 rdf:type schema:PropertyValue
125 Nbebcf3024f4643bcae4f0330ff91770f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Hepatitis A Virus Cellular Receptor 1
127 rdf:type schema:DefinedTerm
128 Nbfe2643107614318987f9ab9f0186439 rdf:first sg:person.0646325650.89
129 rdf:rest Nffaf5dd9285242989ffccf5cc63a8e30
130 Ncdbdec3c40b84dd7ac081d3de47204f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Genetic Association Studies
132 rdf:type schema:DefinedTerm
133 Nd7c8e55e5e52410c83f82683599ccd28 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Homozygote
135 rdf:type schema:DefinedTerm
136 Ne379720c8f5f42489c03320bdae0a972 schema:name pubmed_id
137 schema:value 28434117
138 rdf:type schema:PropertyValue
139 Ne451b9ed0ef1429f9593716919d1d4ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Humans
141 rdf:type schema:DefinedTerm
142 Nf5d975a2bfa54ee4ace3f5fcea9153e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Asthma
144 rdf:type schema:DefinedTerm
145 Nffaf5dd9285242989ffccf5cc63a8e30 rdf:first sg:person.01274216105.48
146 rdf:rest rdf:nil
147 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
148 schema:name Medical and Health Sciences
149 rdf:type schema:DefinedTerm
150 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
151 schema:name Cardiorespiratory Medicine and Haematology
152 rdf:type schema:DefinedTerm
153 sg:grant.7199183 http://pending.schema.org/fundedItem sg:pub.10.1007/s00408-017-0006-5
154 rdf:type schema:MonetaryGrant
155 sg:grant.7199441 http://pending.schema.org/fundedItem sg:pub.10.1007/s00408-017-0006-5
156 rdf:type schema:MonetaryGrant
157 sg:journal.1054004 schema:issn 0341-2040
158 1432-1750
159 schema:name Lung
160 rdf:type schema:Periodical
161 sg:person.01252022733.23 schema:affiliation https://www.grid.ac/institutes/grid.412901.f
162 schema:familyName Xie
163 schema:givenName Xiaochuan
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252022733.23
165 rdf:type schema:Person
166 sg:person.01274216105.48 schema:affiliation https://www.grid.ac/institutes/grid.412901.f
167 schema:familyName Rao
168 schema:givenName Li
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274216105.48
170 rdf:type schema:Person
171 sg:person.01320136133.65 schema:affiliation https://www.grid.ac/institutes/grid.461863.e
172 schema:familyName Shi
173 schema:givenName Xiaohan
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320136133.65
175 rdf:type schema:Person
176 sg:person.0646325650.89 schema:affiliation https://www.grid.ac/institutes/grid.461863.e
177 schema:familyName Chen
178 schema:givenName Peng
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646325650.89
180 rdf:type schema:Person
181 sg:pub.10.1007/s00408-014-9653-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1049228628
182 https://doi.org/10.1007/s00408-014-9653-y
183 rdf:type schema:CreativeWork
184 sg:pub.10.1007/s11033-014-3676-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025421714
185 https://doi.org/10.1007/s11033-014-3676-6
186 rdf:type schema:CreativeWork
187 sg:pub.10.1038/ni1186 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034745567
188 https://doi.org/10.1038/ni1186
189 rdf:type schema:CreativeWork
190 sg:pub.10.1038/nrg1326 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011038021
191 https://doi.org/10.1038/nrg1326
192 rdf:type schema:CreativeWork
193 sg:pub.10.1038/nri1111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051865327
194 https://doi.org/10.1038/nri1111
195 rdf:type schema:CreativeWork
196 https://app.dimensions.ai/details/publication/pub.1076876128 schema:CreativeWork
197 https://app.dimensions.ai/details/publication/pub.1077905834 schema:CreativeWork
198 https://app.dimensions.ai/details/publication/pub.1078931284 schema:CreativeWork
199 https://doi.org/10.1016/j.bbrc.2003.10.125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049853882
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1016/j.humimm.2003.09.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035154559
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1016/j.jaci.2005.01.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015782185
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1016/j.molmed.2005.06.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004802603
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1034/j.1398-9995.2001.056008749.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017045434
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1097/aci.0b013e32834ec13b schema:sameAs https://app.dimensions.ai/details/publication/pub.1036917491
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1097/mcp.0b013e32834dc532 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005340557
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1111/iji.12209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007590716
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1111/j.0105-2896.2010.00903.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007187335
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1111/j.1600-065x.2011.01029.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1026572337
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1111/j.1744-313x.2006.00634.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1013809590
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1159/000103992 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050376162
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1164/ajrccm.153.4.8616554 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034895464
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1164/ajrccm.156.5.9702084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038477555
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1183/13993003.01084-2015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035304372
228 rdf:type schema:CreativeWork
229 https://doi.org/10.3109/02770903.2012.694539 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002234330
230 rdf:type schema:CreativeWork
231 https://doi.org/10.4049/jimmunol.172.11.7169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025305169
232 rdf:type schema:CreativeWork
233 https://www.grid.ac/institutes/grid.412901.f schema:alternateName West China Hospital of Sichuan University
234 schema:name Department of Cardiology, West China Hospital of Sichuan University, 610041, Chengdu, Sichuan, People’s Republic of China
235 rdf:type schema:Organization
236 https://www.grid.ac/institutes/grid.461863.e schema:alternateName West China Second University Hospital of Sichuan University
237 schema:name Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital of Sichuan University, 610041, Chengdu, Sichuan, People’s Republic of China
238 Laboratory of Molecular Translational Medicine, West China Second University Hospital of Sichuan University, 610041, Chengdu, Sichuan, People’s Republic of China
239 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...