Prognostic Value of Central Venous Oxygen Saturation and Blood Lactate Levels Measured Simultaneously in the Same Patients with Severe Systemic ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-02-19

AUTHORS

Ju-Hee Park, Jinwoo Lee, Young Sik Park, Chang-Hoon Lee, Sang-Min Lee, Jae-Joon Yim, Young Whan Kim, Sung Koo Han, Chul-Gyu Yoo

ABSTRACT

Background Blood lactate levels and central venous oxygen saturation (ScvO2) are known to be useful indicators of global tissue hypoxia. However, it is unclear whether ScvO2 correlates with lactate levels when measured simultaneously and whether changes in ScvO2 or lactate levels in serial measurements have prognostic value. We investigated the correlation between ScvO2 and lactate levels measured simultaneously and their association with clinical outcomes. MethodsWe performed a prospective observational study of patients with severe systemic inflammatory response syndrome (SIRS) and severe sepsis who were admitted to the medical intensive care unit. ScvO2 and lactate levels were measured simultaneously at the time of study enrollment, every 6 h for 24 h, and then every 24 h until the goal was reached.ResultsTwenty-five patients were enrolled in the study; 13 have died and 12 have survived. There was no correlation between lactate levels and ScvO2. Neither lactate levels nor ScvO2 at the time of admission differed between nonsurvivors and survivors. Normalization of lactate levels within 48 h was significantly associated with survival.ConclusionsIn patients with severe SIRS and severe sepsis, simultaneously measured ScvO2 and lactate levels showed no correlation, and normalization of lactate levels within 48 h was a predictive factor for survival. More... »

PAGES

435-440

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00408-014-9564-y

DOI

http://dx.doi.org/10.1007/s00408-014-9564-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011421819

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24549333


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