Association of Depression with Disease Severity in Patients with Chronic Obstructive Pulmonary Disease View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-01-07

AUTHORS

Ki Uk Kim, Hye-Kyung Park, Hee Young Jung, Jong-Joon Ahn, Eunsoo Moon, Yun Seong Kim, Min Ki Lee, Haejung Lee

ABSTRACT

PurposePatients with chronic obstructive pulmonary disease (COPD), which is predicted to be the third most common cause of death worldwide by 2020, often suffer from depression, one of the most common and modifiable comorbidities of COPD. This study assessed the prevalence of depression in patients with COPD and the association of depression with disease severity.MethodsThis was a multicenter, prospective cross-sectional study of 245 patients with stable COPD. Disease severity was assessed using two scales: the global initiative for chronic obstructive lung disease (GOLD) stage and BODE index. Depression was measured using the Centers for Epidemiologic Studies Depression (CES-D) scales. Data were analyzed using descriptive statistics, Spearman correlation, and multivariate logistic regression.ResultsDepression defined as a CES-D score of 24 and higher was observed in 17.6 % of patients with COPD. The prevalence of depression increased with disease severity based on the BODE quartile (r = 0.16; P = 0.014). By contrast, no difference was observed in the prevalence of depression among the severity groups using the GOLD staging system (r = − 0.01; P = 0.898). Elementary school graduates were more likely to experience depression than graduates of high school and above [odds ratio (OR) = 3.67; 95 % confidence interval (CI) 1.37–9.85] and patients in BODE quartile II were more likely to experience depression than those with BODE quartile I (OR = 2.5; 95 % CI 1.04–6.06).ConclusionsDepression was associated with disease severity according to the BODE quartile in patients with COPD. BODE quartile II was a significant predictor of depression. Screening patients with a high risk of depression and proactive intervention for those patients are needed. More... »

PAGES

243-249

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00408-013-9547-4

DOI

http://dx.doi.org/10.1007/s00408-013-9547-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034738083

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24395127


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