Assessment of Pathologically Diagnosed Patients with Castleman’s Disease associated with Diffuse Parenchymal Lung Involvement Using the Diagnostic Criteria for IgG4-Related ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-08-13

AUTHORS

Takaaki Ogoshi, Takashi Kido, Kazuhiro Yatera, Keishi Oda, Toshinori Kawanami, Hiroshi Ishimoto, Noriho Sakamoto, Arisa Sano, Chiharu Yoshii, Shohei Shimajiri, Hiroshi Mukae

ABSTRACT

BackgroundIgG4-related disease (IgG4RD) is a recently recognized disease entity. Differentiating IgG4RD from plasma cell type Castleman’s disease (PCD) is important but also difficult using only pathological findings. In addition, little is known about the association between these two diseases with diffuse parenchymal lung involvement.MethodsWe analyzed the serum IgG4 levels and the ratio of IgG4/IgG-positive plasmacytes in the lung and lymph node specimens of eight patients previously pathologically diagnosed of PCD with diffuse parenchymal lung involvement (DL-PCD). We also compared the clinical and laboratory findings observed in these patients.ResultsSix of the eight patients exhibited abundant IgG4-positive plasmacytes in the lung and lymph node tissues and elevated serum IgG4 levels, thereby fulfilling the diagnostic criteria of IgG4RD with DL (DL-IgG4RD) in addition to having obstructive phlebitis and massive lymphoplasmacytic infiltration with fibrosis. However, three of these six patients exhibited higher levels of serum interleukin-6 and were still diagnosed with DL-PCD. Accordingly, three of these eight patients were considered as IgG4RD with DL (DL-IgG4RD), and the other five patients were ultimately given a diagnosis of DL-PCD. These two diseases have different characteristics in terms of age, symptoms, serum levels of C-reactive protein, and IgA, complicating allergic disorders, response to corticosteroids, and prognosis.ConclusionsThis is the first report to show a high prevalence of DL-IgG4RD in DL-PCD patients, although additional large investigations are necessary. Clinical and laboratory findings are important for distinguishing between these two diseases in other organs, as previously described. More... »

PAGES

575-583

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00408-013-9497-x

DOI

http://dx.doi.org/10.1007/s00408-013-9497-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045657750

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23942842


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32 schema:description BackgroundIgG4-related disease (IgG4RD) is a recently recognized disease entity. Differentiating IgG4RD from plasma cell type Castleman’s disease (PCD) is important but also difficult using only pathological findings. In addition, little is known about the association between these two diseases with diffuse parenchymal lung involvement.MethodsWe analyzed the serum IgG4 levels and the ratio of IgG4/IgG-positive plasmacytes in the lung and lymph node specimens of eight patients previously pathologically diagnosed of PCD with diffuse parenchymal lung involvement (DL-PCD). We also compared the clinical and laboratory findings observed in these patients.ResultsSix of the eight patients exhibited abundant IgG4-positive plasmacytes in the lung and lymph node tissues and elevated serum IgG4 levels, thereby fulfilling the diagnostic criteria of IgG4RD with DL (DL-IgG4RD) in addition to having obstructive phlebitis and massive lymphoplasmacytic infiltration with fibrosis. However, three of these six patients exhibited higher levels of serum interleukin-6 and were still diagnosed with DL-PCD. Accordingly, three of these eight patients were considered as IgG4RD with DL (DL-IgG4RD), and the other five patients were ultimately given a diagnosis of DL-PCD. These two diseases have different characteristics in terms of age, symptoms, serum levels of C-reactive protein, and IgA, complicating allergic disorders, response to corticosteroids, and prognosis.ConclusionsThis is the first report to show a high prevalence of DL-IgG4RD in DL-PCD patients, although additional large investigations are necessary. Clinical and laboratory findings are important for distinguishing between these two diseases in other organs, as previously described.
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38 schema:keywords C-reactive protein
39 Castleman's disease
40 ConclusionsThis
41 IgA
42 IgG4
43 IgG4 levels
44 IgG4-positive plasmacytes
45 IgG4RD
46 MethodsWe
47 Pathologically
48 ResultsSix
49 addition
50 age
51 allergic disorders
52 assessment
53 association
54 characteristics
55 corticosteroids
56 criteria
57 diagnosis
58 diagnostic criteria
59 different characteristics
60 disease
61 disease entity
62 disorders
63 dl
64 entities
65 fibrosis
66 findings
67 first report
68 high levels
69 high prevalence
70 infiltration
71 interleukin-6
72 investigation
73 involvement
74 laboratory findings
75 larger investigation
76 levels
77 lung
78 lung involvement
79 lymph node specimens
80 lymph node tissue
81 lymphoplasmacytic infiltration
82 massive lymphoplasmacytic infiltration
83 node specimens
84 node tissue
85 obstructive phlebitis
86 organs
87 parenchymal lung involvement
88 pathological findings
89 patients
90 phlebitis
91 plasma cell-type Castleman disease
92 plasmacytes
93 prevalence
94 prognosis
95 protein
96 ratio
97 report
98 response
99 serum IgG4 levels
100 serum interleukin-6
101 serum levels
102 specimens
103 symptoms
104 terms
105 terms of age
106 tissue
107 type Castleman's disease
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