Association of Tumor Necrosis Factor-α-863C/A Gene Polymorphism with Chronic Obstructive Pulmonary Disease View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-03-30

AUTHORS

Yung-Che Chen, Shih-Feng Liu, Chien-Hung Chin, Chao-Chien Wu, Chung-Jen Chen, Hsueh-Wen Chang, Yi-Hsi Wang, Yu-Hsiu Chung, Tung-Ying Chao, Meng-Chih Lin

ABSTRACT

The aim of this study was to investigate genetic effects on the pathogenesis of chronic obstructive pulmonary disease (COPD). The study was conducted as a prospective case–control study in a medical center in southern Taiwan. The patient group consisted of 145 male patients with smoking-related COPD and a control group of 139 resistant smokers from July 2004 to September 2009. We compared allele and genotype frequencies of three tag single nucleotide polymorphisms (SNP) of the TNF-α gene promoter region at −308, −863, and −1031 in all subjects. We also analyzed the influence of each genetic variant on pulmonary function parameters, body mass index (BMI), serum TNF-α levels, and outcomes among heavy smokers with or without COPD. COPD patients had a significantly lower A allele frequency (9.7 vs. 15.1%, OR = 0.6, p = 0.048, false discovery rate q = 0.144) and a significantly lower A carrier genotype frequency (19.3 vs. 30.2%, OR = 0.52, p = 0.042, q = 0.135) than resistant smokers. The −863 CA genotype was associated with a better FEV1/FVC ratio (79 vs. 71.5%, p = 0.034), and higher BMI (24.9 vs. 23.6 kg/m2, p = 0.048). In addition, COPD patients with the −1031 C carrier genotype had higher serum TNF-α levels (20.9 vs. 16.2 pg/ml, p = 0.01). BMI (hazard ratio = 0.84, 95% CI = 0.74–0.96, p = 0.008) was the only independent predictor for mortality. The TNF-α −863 A allele may confer a degree of resistance to the susceptibility to and muscle wasting of COPD among heavy smokers. More... »

PAGES

339-347

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00408-010-9236-5

DOI

http://dx.doi.org/10.1007/s00408-010-9236-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050806720

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20352242


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54 degree
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61 gene polymorphisms
62 gene promoter region
63 genetic effects
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65 genotype frequencies
66 genotypes
67 group
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70 higher serum TNF-α levels
71 independent predictors
72 index
73 influence
74 levels
75 male patients
76 mass index
77 mortality
78 muscle wasting
79 necrosis factor
80 nucleotide polymorphisms
81 obstructive pulmonary disease
82 only independent predictor
83 outcomes
84 parameters
85 pathogenesis
86 patient group
87 patients
88 polymorphism
89 predictors
90 promoter region
91 prospective case-control study
92 pulmonary disease
93 pulmonary function parameters
94 ratio
95 region
96 resistance
97 resistant smokers
98 serum TNF-α levels
99 single nucleotide polymorphisms
100 smokers
101 smoking-related chronic obstructive pulmonary disease
102 southern Taiwan
103 study
104 subjects
105 susceptibility
106 tag single nucleotide polymorphisms
107 tumor necrosis factor
108 variants
109 wasting
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