Aerosolized Polymerized Type I Collagen Reduces Airway Inflammation and Remodelling in a Guinea Pig Model of Allergic Asthma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-12-09

AUTHORS

Paola Moreno-Alvarez, Edgar Sánchez-Guerrero, Erasmo Martínez-Cordero, Rogelio Hernández-Pando, María G. Campos, Lucely Cetina, Blanca Bazán-Perkins

ABSTRACT

Collagen-polyvinylpyrrolidone (Collagen-PVP) has been demonstrated to elicit immunomodulatory properties in different chronic inflammatory diseases. Nevertheless, its effects on asthma are still unknown. We have evaluated whether collagen-PVP could modulate airway inflammation and remodelling in a guinea pig model of allergic asthma. Sensitized guinea pigs were challenged with the allergen (ovalbumin) six times (at 10-day intervals). From the third challenge on, animals were treated every 5 days with saline aerosols containing 0.16, 0.33, or 0.66 mg/ml of collagen-PVP (n = 5, respectively). Some guinea pigs, sensitized and challenged with saline as well as treated with 0 or 0.66 mg/ml collagen-PVP, were included in the study as control (n = 7) and sham groups (n = 5), respectively. From the first challenge on, ovalbumin induced a transient airway obstruction, measured by barometric plethysmography, which was not modified by collagen-PVP treatments. After the last allergen challenge, guinea pigs were anesthetized to obtain bronchoalveolar lavage (BAL) and the left lung caudal lobe. As expected, BAL cell count from allergen-challenged guinea pigs showed abundant neutrophils and eosinophils, as well as numerous tumor necrosis factor (TNF)-α-expressing granulocytes and macrophages in airway wall (determined by immunohistochemical assay). Neutrophilia and TNF-α-expressing leukocytes, from collagen-PVP treated animals, diminished from 0.16 mg/ml, and eosinophilia from 0.66 mg/ml of collagen-PVP doses. Histological changes induced by allergen challenges include thickening of connective tissue below airway epithelium and vascular wall widening of airway adjacent vessels; these changes were reduced by collagen-PVP treatment. Collagen-PVP seems to have anti-inflammatory and antifibrotic properties in this guinea pig asthma model. More... »

PAGES

97-105

References to SciGraph publications

Journal

TITLE

Lung

ISSUE

2

VOLUME

188

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00408-009-9202-2

DOI

http://dx.doi.org/10.1007/s00408-009-9202-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008515207

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19998041


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36 schema:description Collagen-polyvinylpyrrolidone (Collagen-PVP) has been demonstrated to elicit immunomodulatory properties in different chronic inflammatory diseases. Nevertheless, its effects on asthma are still unknown. We have evaluated whether collagen-PVP could modulate airway inflammation and remodelling in a guinea pig model of allergic asthma. Sensitized guinea pigs were challenged with the allergen (ovalbumin) six times (at 10-day intervals). From the third challenge on, animals were treated every 5 days with saline aerosols containing 0.16, 0.33, or 0.66 mg/ml of collagen-PVP (n = 5, respectively). Some guinea pigs, sensitized and challenged with saline as well as treated with 0 or 0.66 mg/ml collagen-PVP, were included in the study as control (n = 7) and sham groups (n = 5), respectively. From the first challenge on, ovalbumin induced a transient airway obstruction, measured by barometric plethysmography, which was not modified by collagen-PVP treatments. After the last allergen challenge, guinea pigs were anesthetized to obtain bronchoalveolar lavage (BAL) and the left lung caudal lobe. As expected, BAL cell count from allergen-challenged guinea pigs showed abundant neutrophils and eosinophils, as well as numerous tumor necrosis factor (TNF)-α-expressing granulocytes and macrophages in airway wall (determined by immunohistochemical assay). Neutrophilia and TNF-α-expressing leukocytes, from collagen-PVP treated animals, diminished from 0.16 mg/ml, and eosinophilia from 0.66 mg/ml of collagen-PVP doses. Histological changes induced by allergen challenges include thickening of connective tissue below airway epithelium and vascular wall widening of airway adjacent vessels; these changes were reduced by collagen-PVP treatment. Collagen-PVP seems to have anti-inflammatory and antifibrotic properties in this guinea pig asthma model.
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44 Collagen-PVP
45 TNF
46 abundant neutrophils
47 adjacent vessels
48 aerosols
49 airway epithelium
50 airway inflammation
51 airway obstruction
52 airway wall
53 allergen challenge
54 allergens
55 allergic asthma
56 animals
57 antifibrotic properties
58 asthma
59 asthma model
60 barometric plethysmography
61 bronchoalveolar lavage
62 caudal lobe
63 cell count
64 challenges
65 changes
66 chronic inflammatory disease
67 connective tissue
68 control
69 count
70 days
71 different chronic inflammatory diseases
72 disease
73 doses
74 effect
75 eosinophilia
76 eosinophils
77 epithelium
78 factors
79 first challenge
80 granulocytes
81 group
82 guinea pig asthma model
83 guinea pig model
84 guinea pigs
85 histological changes
86 immunomodulatory properties
87 inflammation
88 inflammatory diseases
89 last allergen challenge
90 lavage
91 leukocytes
92 lobe
93 macrophages
94 model
95 necrosis factor
96 neutrophilia
97 neutrophils
98 obstruction
99 ovalbumin
100 pig model
101 pigs
102 plethysmography
103 properties
104 saline
105 saline aerosol
106 sensitized guinea pigs
107 sham group
108 six times
109 study
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111 time
112 tissue
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114 treatment
115 tumor necrosis factor
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