Expression of Cancer-Testis Antigens MAGE-A3/6 and NY-ESO-1 in Non-Small-Cell Lung Carcinomas and Their Relationship with Immune Cell Infiltration View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-10-01

AUTHORS

Sang Hyun Kim, Sangyull Lee, Chang Hun Lee, Min Ki Lee, Young Dae Kim, Dong Hoon Shin, Kyung Un Choi, Jee Yeon Kim, Do Youn Park, Mee Young Sol

ABSTRACT

Cancer-testis antigens (CTAs) are expressed only in many cancers and limited immunoprivileged sites such as the testis and placenta. Dendritic cells (DCs) and CD8+ T lymphocytes (CTLs) play roles in the immune responses to tumor growth and may affect the prognosis of cancers. This study was designed to investigate the clinicopathologic significance of CTA expression in non-small-cell lung carcinomas (NSCLCs) and its relationship with immune cells. Immunohistochemical staining to CTAs such as MAGE-A3/6 and NY-ESO-1 was performed using paraffin blocks from 132 cases of NSCLCs, including 75 cases of squamous cell carcinoma (SqCC) and 57 cases of adenocarcinoma (AdC), and the results were evaluated to correlate with tumor-infiltrating DCs and CTLs and clinicopathologic features. MAGE-A3/6 and NY-ESO-1 were expressed in 50.0% (66/132) and 18.2% (24/132) of NSCLCs, respectively. MAGE-A3/6 was expressed more frequently in SqCC than in AdC, but the expression of NY-ESO-1 showed no difference in both types. CTAs revealed a higher expression in male than in female. In advanced stage III, NY-ESO-1-positive patients showed poorer survival than NY-ESO-1-negative patients. Otherwise, the CTA expression did not correlate with clinicopathologic parameters. No relationship was found between DC and CTL infiltration in all NSCLCs. Regarding DC infiltration, the group showing negative expression to CTAs displayed an even higher number of infiltrating DCs than those showing positivity to one or the other or both CTAs. Although the aberrant expression of MAGE-A3/6 and NY-ESO-1 in NSCLC did not directly influence clinical prognostic factors, the higher expression of MAGE-A3/6 in SqCC suggests its value as a potential target for immunotherapy in this type of NSCLC. The inverse relationship between DCs and CTA expression may indicate that CTA-positive tumor cells would be akin to tumor stem cells escaping host immune response. More... »

PAGES

401

Journal

TITLE

Lung

ISSUE

6

VOLUME

187

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00408-009-9181-3

DOI

http://dx.doi.org/10.1007/s00408-009-9181-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023733553

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19795170


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29 schema:description Cancer-testis antigens (CTAs) are expressed only in many cancers and limited immunoprivileged sites such as the testis and placenta. Dendritic cells (DCs) and CD8+ T lymphocytes (CTLs) play roles in the immune responses to tumor growth and may affect the prognosis of cancers. This study was designed to investigate the clinicopathologic significance of CTA expression in non-small-cell lung carcinomas (NSCLCs) and its relationship with immune cells. Immunohistochemical staining to CTAs such as MAGE-A3/6 and NY-ESO-1 was performed using paraffin blocks from 132 cases of NSCLCs, including 75 cases of squamous cell carcinoma (SqCC) and 57 cases of adenocarcinoma (AdC), and the results were evaluated to correlate with tumor-infiltrating DCs and CTLs and clinicopathologic features. MAGE-A3/6 and NY-ESO-1 were expressed in 50.0% (66/132) and 18.2% (24/132) of NSCLCs, respectively. MAGE-A3/6 was expressed more frequently in SqCC than in AdC, but the expression of NY-ESO-1 showed no difference in both types. CTAs revealed a higher expression in male than in female. In advanced stage III, NY-ESO-1-positive patients showed poorer survival than NY-ESO-1-negative patients. Otherwise, the CTA expression did not correlate with clinicopathologic parameters. No relationship was found between DC and CTL infiltration in all NSCLCs. Regarding DC infiltration, the group showing negative expression to CTAs displayed an even higher number of infiltrating DCs than those showing positivity to one or the other or both CTAs. Although the aberrant expression of MAGE-A3/6 and NY-ESO-1 in NSCLC did not directly influence clinical prognostic factors, the higher expression of MAGE-A3/6 in SqCC suggests its value as a potential target for immunotherapy in this type of NSCLC. The inverse relationship between DCs and CTA expression may indicate that CTA-positive tumor cells would be akin to tumor stem cells escaping host immune response.
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37 CD8
38 CTA expression
39 CTL
40 CTL infiltration
41 DC infiltration
42 MAGE
43 MAGE-A3/6
44 NSCLC
45 NSCLCs
46 NY-ESO-1
47 SqCC
48 T lymphocytes
49 aberrant expression
50 adenocarcinoma
51 advanced stage III
52 antigen
53 block
54 cancer
55 cancer-testis antigens
56 carcinoma
57 cases
58 cases of adenocarcinoma
59 cell carcinoma
60 cell infiltration
61 cell lung carcinoma
62 cells
63 clinical prognostic factors
64 clinicopathologic features
65 clinicopathologic parameters
66 clinicopathologic significance
67 dendritic cells
68 differences
69 expression
70 factors
71 features
72 females
73 group
74 growth
75 high expression
76 higher number
77 host immune response
78 immune cell infiltration
79 immune cells
80 immune response
81 immunoprivileged site
82 immunotherapy
83 infiltration
84 inverse relationship
85 lung carcinoma
86 lymphocytes
87 males
88 negative expression
89 number
90 paraffin blocks
91 parameters
92 patients
93 placenta
94 poor survival
95 positivity
96 potential target
97 prognosis
98 prognosis of cancer
99 prognostic factors
100 relationship
101 response
102 results
103 role
104 significance
105 sites
106 squamous cell carcinoma
107 stage III
108 stem cells
109 study
110 survival
111 target
112 testis
113 tumor cells
114 tumor growth
115 tumor stem cells
116 tumor-infiltrating dendritic cells
117 types
118 types of NSCLC
119 values
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