Expression of Cancer-Testis Antigens MAGE-A3/6 and NY-ESO-1 in Non-Small-Cell Lung Carcinomas and Their Relationship with Immune Cell Infiltration View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-10-01

AUTHORS

Sang Hyun Kim, Sangyull Lee, Chang Hun Lee, Min Ki Lee, Young Dae Kim, Dong Hoon Shin, Kyung Un Choi, Jee Yeon Kim, Do Youn Park, Mee Young Sol

ABSTRACT

Cancer-testis antigens (CTAs) are expressed only in many cancers and limited immunoprivileged sites such as the testis and placenta. Dendritic cells (DCs) and CD8+ T lymphocytes (CTLs) play roles in the immune responses to tumor growth and may affect the prognosis of cancers. This study was designed to investigate the clinicopathologic significance of CTA expression in non-small-cell lung carcinomas (NSCLCs) and its relationship with immune cells. Immunohistochemical staining to CTAs such as MAGE-A3/6 and NY-ESO-1 was performed using paraffin blocks from 132 cases of NSCLCs, including 75 cases of squamous cell carcinoma (SqCC) and 57 cases of adenocarcinoma (AdC), and the results were evaluated to correlate with tumor-infiltrating DCs and CTLs and clinicopathologic features. MAGE-A3/6 and NY-ESO-1 were expressed in 50.0% (66/132) and 18.2% (24/132) of NSCLCs, respectively. MAGE-A3/6 was expressed more frequently in SqCC than in AdC, but the expression of NY-ESO-1 showed no difference in both types. CTAs revealed a higher expression in male than in female. In advanced stage III, NY-ESO-1-positive patients showed poorer survival than NY-ESO-1-negative patients. Otherwise, the CTA expression did not correlate with clinicopathologic parameters. No relationship was found between DC and CTL infiltration in all NSCLCs. Regarding DC infiltration, the group showing negative expression to CTAs displayed an even higher number of infiltrating DCs than those showing positivity to one or the other or both CTAs. Although the aberrant expression of MAGE-A3/6 and NY-ESO-1 in NSCLC did not directly influence clinical prognostic factors, the higher expression of MAGE-A3/6 in SqCC suggests its value as a potential target for immunotherapy in this type of NSCLC. The inverse relationship between DCs and CTA expression may indicate that CTA-positive tumor cells would be akin to tumor stem cells escaping host immune response. More... »

PAGES

401

Journal

TITLE

Lung

ISSUE

6

VOLUME

187

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00408-009-9181-3

DOI

http://dx.doi.org/10.1007/s00408-009-9181-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023733553

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19795170


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29 schema:description Cancer-testis antigens (CTAs) are expressed only in many cancers and limited immunoprivileged sites such as the testis and placenta. Dendritic cells (DCs) and CD8+ T lymphocytes (CTLs) play roles in the immune responses to tumor growth and may affect the prognosis of cancers. This study was designed to investigate the clinicopathologic significance of CTA expression in non-small-cell lung carcinomas (NSCLCs) and its relationship with immune cells. Immunohistochemical staining to CTAs such as MAGE-A3/6 and NY-ESO-1 was performed using paraffin blocks from 132 cases of NSCLCs, including 75 cases of squamous cell carcinoma (SqCC) and 57 cases of adenocarcinoma (AdC), and the results were evaluated to correlate with tumor-infiltrating DCs and CTLs and clinicopathologic features. MAGE-A3/6 and NY-ESO-1 were expressed in 50.0% (66/132) and 18.2% (24/132) of NSCLCs, respectively. MAGE-A3/6 was expressed more frequently in SqCC than in AdC, but the expression of NY-ESO-1 showed no difference in both types. CTAs revealed a higher expression in male than in female. In advanced stage III, NY-ESO-1-positive patients showed poorer survival than NY-ESO-1-negative patients. Otherwise, the CTA expression did not correlate with clinicopathologic parameters. No relationship was found between DC and CTL infiltration in all NSCLCs. Regarding DC infiltration, the group showing negative expression to CTAs displayed an even higher number of infiltrating DCs than those showing positivity to one or the other or both CTAs. Although the aberrant expression of MAGE-A3/6 and NY-ESO-1 in NSCLC did not directly influence clinical prognostic factors, the higher expression of MAGE-A3/6 in SqCC suggests its value as a potential target for immunotherapy in this type of NSCLC. The inverse relationship between DCs and CTA expression may indicate that CTA-positive tumor cells would be akin to tumor stem cells escaping host immune response.
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37 ADC
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39 CD8
40 CTA expression
41 CTA-positive tumor cells
42 CTL
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44 Cancer-Testis Antigens MAGE
45 DC infiltration
46 MAGE
47 MAGE-A3/6
48 NSCLC
49 NSCLCs
50 NY-ESO-1
51 NY-ESO-1-negative patients
52 NY-ESO-1-positive patients
53 SqCC
54 aberrant expression
55 adenocarcinoma
56 advanced stage III
57 antigen
58 block
59 cancer
60 cancer-testis antigens
61 carcinoma
62 cases
63 cases of NSCLCs
64 cases of adenocarcinoma
65 cell carcinoma
66 cell infiltration
67 cell lung carcinoma
68 cells
69 clinical prognostic factors
70 clinicopathologic features
71 clinicopathologic parameters
72 clinicopathologic significance
73 dendritic cells
74 differences
75 expression
76 factors
77 features
78 females
79 group
80 growth
81 high expression
82 higher number
83 host immune response
84 immune cell infiltration
85 immune cells
86 immune response
87 immunoprivileged site
88 immunotherapy
89 infiltration
90 inverse relationship
91 limited immunoprivileged sites
92 lung carcinoma
93 lymphocytes
94 males
95 negative expression
96 number
97 paraffin blocks
98 parameters
99 patients
100 placenta
101 poor survival
102 positivity
103 potential target
104 prognosis
105 prognosis of cancer
106 prognostic factors
107 relationship
108 response
109 results
110 role
111 significance
112 sites
113 squamous cell carcinoma
114 stage III
115 stem cells
116 study
117 survival
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119 testis
120 tumor cells
121 tumor growth
122 tumor stem cells
123 tumor-infiltrating dendritic cells
124 types
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