How we improve the transoral resection for oral and oropharyngeal cancer: the CO2 waveguide laser View Full Text


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Article Info

DATE

2019-05-21

AUTHORS

G. Tirelli, F. Boscolo Nata, R. Bussani, A. Gatto, E. Quatela, S. Rigo, M. Piovesana

ABSTRACT

PurposeThe main aim of this study was to evaluate the CO2 waveguide laser (CO2 WGL) with flexible fiber (Lumenis, Santa Clara, CA) in the treatment of oral and oropharyngeal cancers specifically focusing on the lateral thermal damage (LTD) induced by this instrument and therefore on the reliability of the analysis of frozen sections collected during margin mapping.MethodsA total of 48 patients with oral and oropharyngeal cancers from T1 to T4a were prospectively enrolled in the study. We collected data about LTD, pathologic tumor and node stage (pTNM), surgical intervention, kind of reconstruction (no flap, local vs free flap), need for tracheotomy and time of removal, postoperative complications (such as bleeding, mucosal dehiscence, and fistula), need for feeding tube and time of removal.ResultsMean LTD was 164.7 ± 92.4 μm. Comparing frozen section histology before and after formalin embedding we found 5 true positives, 170 true negatives, 4 false positives and 4 false negatives, with a sensitivity, specificity, positive predictive value, negative predictive value and accuracy of 55.6%, 98%, 55.6%, 98%, and 96.1%, respectively.ConclusionCO2 WGL is a very manageable tool, which allows a precise cut. However, its high costs, the inability to re-use the fibers and its low coagulation capability must be considered. More... »

PAGES

2301-2310

References to SciGraph publications

  • 2011-11-20. Combining a new CO2 laser wave guide with transoral robotic surgery: a feasibility study on four patients with malignant tumors in EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
  • 2016-08-04. Will the mininvasive approach challenge the old paradigms in oral cancer surgery? in EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
  • 2009-09-27. Is frozen section reliable in transoral CO2 laser-assisted cordectomies? in EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
  • 2011-11-06. Reliability and efficacy of a new CO2 laser hollow fiber: a prospective study of 39 patients in EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
  • 2017-08-17. Laser-assisted surgery of the upper aero-digestive tract: a clarification of nomenclature. A consensus statement of the European Laryngological Society in EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
  • 2017-01-24. A randomized controlled clinical and histopathological trial comparing excisional biopsies of oral fibrous hyperplasias using CO2 and Er:YAG laser in LASERS IN MEDICAL SCIENCE
  • 2012-07-05. Oncologic and functional results after transoral laser microsurgery of tongue base carcinoma in EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
  • 2016-02-15. The diagnostic value of narrow band imaging in different oral and oropharyngeal subsites in EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
  • 2011-08-01. Harmonic scalpel versus flexible CO2 laser for tongue resection: A histopathological analysis of thermal damage in human cadavers in WORLD JOURNAL OF SURGICAL ONCOLOGY
  • 2010-04-15. Nd:YAG laser versus traditional scalpel. A preliminary histological analysis of specimens from the human oral mucosa in LASERS IN MEDICAL SCIENCE
  • 2016-11-23. Narrow band imaging for early diagnosis of epithelial dysplasia and microinvasive tumors in the upper aerodigestive tract in HNO
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    http://scigraph.springernature.com/pub.10.1007/s00405-019-05473-x

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    http://dx.doi.org/10.1007/s00405-019-05473-x

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/31115687


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    34 schema:description PurposeThe main aim of this study was to evaluate the CO2 waveguide laser (CO2 WGL) with flexible fiber (Lumenis, Santa Clara, CA) in the treatment of oral and oropharyngeal cancers specifically focusing on the lateral thermal damage (LTD) induced by this instrument and therefore on the reliability of the analysis of frozen sections collected during margin mapping.MethodsA total of 48 patients with oral and oropharyngeal cancers from T1 to T4a were prospectively enrolled in the study. We collected data about LTD, pathologic tumor and node stage (pTNM), surgical intervention, kind of reconstruction (no flap, local vs free flap), need for tracheotomy and time of removal, postoperative complications (such as bleeding, mucosal dehiscence, and fistula), need for feeding tube and time of removal.ResultsMean LTD was 164.7 ± 92.4 μm. Comparing frozen section histology before and after formalin embedding we found 5 true positives, 170 true negatives, 4 false positives and 4 false negatives, with a sensitivity, specificity, positive predictive value, negative predictive value and accuracy of 55.6%, 98%, 55.6%, 98%, and 96.1%, respectively.ConclusionCO2 WGL is a very manageable tool, which allows a precise cut. However, its high costs, the inability to re-use the fibers and its low coagulation capability must be considered.
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    42 ConclusionCO2 WGL
    43 ResultsMean LTD
    44 T1
    45 T4a
    46 WGL
    47 accuracy
    48 aim
    49 analysis
    50 cancer
    51 capability
    52 coagulation capability
    53 complications
    54 cost
    55 cut
    56 damage
    57 data
    58 false negatives
    59 false positives
    60 fibers
    61 flexible fibers
    62 formalin
    63 frozen section histology
    64 frozen sections
    65 high cost
    66 histology
    67 inability
    68 instrument
    69 intervention
    70 laser
    71 lateral thermal damage
    72 low coagulation capability
    73 main aim
    74 manageable tool
    75 mapping
    76 margin mapping
    77 negative predictive value
    78 negatives
    79 node stage
    80 oropharyngeal cancer
    81 pathologic tumor
    82 patients
    83 positive predictive value
    84 positives
    85 postoperative complications
    86 precise cut
    87 predictive value
    88 reconstruction
    89 reliability
    90 removal
    91 resection
    92 section histology
    93 sections
    94 sensitivity
    95 specificity
    96 stage
    97 study
    98 surgical intervention
    99 thermal damage
    100 time
    101 time of removal
    102 tool
    103 total
    104 tracheotomy
    105 transoral resection
    106 treatment
    107 true negatives
    108 true positives
    109 tube
    110 tumors
    111 values
    112 waveguide laser
    113 schema:name How we improve the transoral resection for oral and oropharyngeal cancer: the CO2 waveguide laser
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